Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 13, 2004, Pages 3555-3558

  Ribeiro, Tatiana Santana ^a   Freire De Lima, Leonardo ^b   Previato, José Osvaldo ^b   Mendonça Previato, Lucia ^b   Heise, Norton ^b   De Lima, Marco Edilson Freire ^a  

^a FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Chagas' disease; Piper nigrum; Piperine; Piperine analogues; Trypanosoma cruzi

Indexed keywords

ALKALOID DERIVATIVE; ANTIPROTOZOAL AGENT; PIPERINE;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INDICATION; DRUG SCREENING; DRUG STRUCTURE; EPIMASTIGOTE; NONHUMAN; PROTOZOON; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI;

ALKALOIDS; ANIMALS; BENZODIOXOLES; CELLS, CULTURED; CHAGAS DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOXICITY; HUMANS; INHIBITORY CONCENTRATION 50; PARASITIC SENSITIVITY TESTS; PIPERIDINES; POLYUNSATURATED ALKAMIDES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

PIPER NIGRUM; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 2942527544     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.019     Document Type: Article

References (28)

1. Semler U., Gross G.G. Phytochemistry. 27:1988;1566
2. Ikan R. Natural Products: A Laboratory Guide. 2nd ed. 1991;233-238 Academic Press
3. de Paula V.F., Barbosa L.C.D., Demuner A.J., Pilo-Veloso D., Picanco M.C. Pest Manag. Sci. 56:2000;168
4. Kiuchi F., Nakamura N., Tsuda Y., Kondo K., Yoshimura H. Chem. Pharm. Bull. 36:1988;1452
5. Koul S., Koul J.L., Taneja S.C., Dhar K.L., Jamwal D.S., Singh K., Reen R.K., Sing J. Bioorg. Med. Chem. 8:2000;251
6. Parmar V.S., Jain S.C., Bisht K.S., Jain R., Taneja P., Jha A., Tyagi O.D., Prasad A.K., Wengel J., Olsen C.E., Boll P.M. Phytochemistry. 46:1997;597
7. Tsukamoto S., Cha B.-C., Ohta T. Tetrahedron. 58:2002;1667
8. Kapil A. Planta Med. 59:1993;474
9. Raay B., Medda S., Mukhopadhyay S., Basu M.K. Indian J. Biochem. Biophys. 36:1999;248
10. Moncayo A. Mem. Inst. Oswaldo Cruz. 98:2003;577
11. Coura J.R., DeCastro S.L. Mem. Inst. Oswaldo Cruz. 97:2002;3
12. Cordell G.A. Phytochemistry. 2000;463
13. Mann J. Murder, Magic, and Medicine. 1992;82-96 Oxford University Press, England
14. Gomes D.C.F., Alegrio L.V., Lima M.E.F., Leon L.L., Araújo C.A.C. Arzneim.-Forsch./Drug Res. 52:2002;120
15. Araujo-Junior J.X., Da-Cunha E.V.L., Chaves M.C.O., Gray A.I. Phytochemistry. 44:1997;559
16. Hudlický M. Reductions in Organic Chemistry. 1986;John Wiley & Sons, New York. pp 1-3
17. Szmuszkovice J. J. Org. Chem. 29:1964;843
18. Berardi F., Loiodice F., Frachiolla G., Calabufo N.A., Perrone R., Tortorella V. J. Med. Chem. 46:2003;2117
19. Silva E.F., Canto-Cavalheiro M.M., Braz V.R., Cysne-Finkelstein L., Leon L.L., Echevarria A. Eur. J. Med. Chem. 37:2002;979
20. Loder J.W., Moorhous A., Russell G.B. Austr. J. Chem. 22:1969;1531
21. Marianoff B.E., Reitz A.B. Chem. Rev. 89:1989;863
22. 24
23. Saraiva V.B., Gibaldi D., Previato J.O., Mendonça-Previato L., Bozza M.T., Freire-de-Lima C.G., Heise N. Antimicrob. Agents Chemother. 46:2002;3472
24. Lux H., Heise N., Klenner T., Hart D.T., Opperdoes F.R. Mol. Biochem. Parasitol. 111:2000;1
25. Delorenzi J.C., Freire-de-Lima L., Gattass C.R., Costa D.A., He L., Kuehne M.E., Saraiva E.M.B. Antimicrob. Agents Chemother. 46:2002;2111
26. Neal R.A., Bueren J. Trans. R. Soc. Trop. Med. Hyg. 82:1988;709
27. Martínez-Díaz R.A., Escario J.A., Nogal-Ruiz J.J., Gómez-Barrio A. Mem. Inst. Oswaldo Cruz. 96:2001;53
28. Soares M.J., de Souza W. Parasitol. Res. 77:1991;461