Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells

European Journal of Immunology

Volumn 38, Issue 9, 2008, Pages 2528-2533

  Gogishvili, Tea ^a   Elias, Fernando ^a   Emery, Juliet L ^b   McPherson, Kirsty ^a   Okkenhaug, Klaus ^b   Hünig, Thomas ^a   Dennehy, Kevin M ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cellular proliferation; Co stimulatory molecules; Immune responses; Signal transduction; T cells

Indexed keywords

CD28 ANTIGEN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MONOCLONAL ANTIBODY CD28; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE LCK; PROTEIN P110; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VAV PROTEIN; VAV1 PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL KINASE; VAV1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WILD TYPE; ANIMAL; CELL PROLIFERATION; CHEMISTRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE MUTANT; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 4-KINASE; AMINO ACID MOTIFS; ANIMALS; ANTIGENS, CD28; CELL PROLIFERATION; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-VAV; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 55249113027     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838223     Document Type: Article

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