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Volumn 31, Issue 8, 2008, Pages 697-707

Design, fabrication, and characterization of a composite scaffold for bone tissue engineering

Author keywords

Bone scaffold; Design parameters; Mechanical characterization

Indexed keywords

BIOCOMPATIBILITY; BONE; CELL CULTURE; DESIGN; ELASTIC MODULI; EMULSIFICATION; FABRICATION; FIBROBLASTS; HYDROXYAPATITE; PORE SIZE; SCAFFOLDS (BIOLOGY); SINTERING;

EID: 55249112251     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880803100803     Document Type: Article
Times cited : (17)

References (63)
  • 1
    • 4544273208 scopus 로고    scopus 로고
    • Bone tissue engineering: State of the art and future trends
    • Salgado AJ, Coutinho OP, Reis RL. Bone tissue engineering: state of the art and future trends. Macromol Biosci 2004; 4: 743-65.
    • (2004) Macromol Biosci , vol.4 , pp. 743-765
    • Salgado, A.J.1    Coutinho, O.P.2    Reis, R.L.3
  • 2
    • 0024377022 scopus 로고
    • Morbidity at bone graft donor sites
    • Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma 1989; 3: 192-5.
    • (1989) J Orthop Trauma , vol.3 , pp. 192-195
    • Younger, E.M.1    Chapman, M.W.2
  • 3
    • 0028922670 scopus 로고
    • Iliac crest bone graft harvest donor site morbidity: A statistical evaluation
    • Banwart JC, Asher MA, Hassanein RS. Iliac crest bone graft harvest donor site morbidity: a statistical evaluation. Spine 1995; 20: 1055-60.
    • (1995) Spine , vol.20 , pp. 1055-1060
    • Banwart, J.C.1    Asher, M.A.2    Hassanein, R.S.3
  • 5
    • 0027595948 scopus 로고
    • Tissue engineering
    • Langer R, Vacanti JR Tissue engineering. Science 1993; 260: 920-6.
    • (1993) Science , vol.260 , pp. 920-926
    • Langer, R.1    Vacanti, J.R.2
  • 7
    • 0034580476 scopus 로고    scopus 로고
    • Biomaterial developments for bone tissue engineering
    • Burg KJ, Porter S, Kellam JF. Biomaterial developments for bone tissue engineering. Biomaterials 2000; 21: 2347-59.
    • (2000) Biomaterials , vol.21 , pp. 2347-2359
    • Burg, K.J.1    Porter, S.2    Kellam, J.F.3
  • 11
    • 0017461730 scopus 로고
    • The restoration of the articular surfaces overlying Replamineform porous biomaterials
    • Chiroff RT, White RA, White EW, Weber JN, Roy D. The restoration of the articular surfaces overlying Replamineform porous biomaterials. J Biomed Mater Res 1977; 11: 165-78.
    • (1977) J Biomed Mater Res , vol.11 , pp. 165-178
    • Chiroff, R.T.1    White, R.A.2    White, E.W.3    Weber, J.N.4    Roy, D.5
  • 12
    • 0036131575 scopus 로고    scopus 로고
    • Tissue engineered microsphere-based matrices for bone repair: Design and evaluation
    • Borden M, Attawia M, Khan Y, Laurencin CT. Tissue engineered microsphere-based matrices for bone repair: design and evaluation. Biomaterials 2002; 23: 551-9.
    • (2002) Biomaterials , vol.23 , pp. 551-559
    • Borden, M.1    Attawia, M.2    Khan, Y.3    Laurencin, C.T.4
  • 13
    • 0037026409 scopus 로고    scopus 로고
    • The sintered microsphere matrix for bone tissue engineering: In vitro osteoconductivity studies
    • Borden M, Attawia M, Laurencin CT. The sintered microsphere matrix for bone tissue engineering: in vitro osteoconductivity studies. J Biomed Mater Res 2002; 61: 421-9.
    • (2002) J Biomed Mater Res , vol.61 , pp. 421-429
    • Borden, M.1    Attawia, M.2    Laurencin, C.T.3
  • 16
    • 0033622838 scopus 로고    scopus 로고
    • Growth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro
    • Murphy WL, Kohn DH, Mooney DJ. Growth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro. J Biomed Mater Res 2000; 50: 50-8.
    • (2000) J Biomed Mater Res , vol.50 , pp. 50-58
    • Murphy, W.L.1    Kohn, D.H.2    Mooney, D.J.3
  • 17
    • 0036148896 scopus 로고    scopus 로고
    • Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered bone
    • El-Amin SF, Attawia M, Lu HH, Shah AK, Chang R, Hickok NJ, Tuan RS, Laurencin CT. Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered bone. J Orthop Res 2002; 20: 20-8.
    • (2002) J Orthop Res , vol.20 , pp. 20-28
    • El-Amin, S.F.1    Attawia, M.2    Lu, H.H.3    Shah, A.K.4    Chang, R.5    Hickok, N.J.6    Tuan, R.S.7    Laurencin, C.T.8
  • 18
  • 20
    • 0344584399 scopus 로고    scopus 로고
    • Tissue engineering for bone regeneration using differentiated alveolar bone cells in collagen scaffolds
    • Xiao Y, Qian H, Young WG, Bartold PM. Tissue engineering for bone regeneration using differentiated alveolar bone cells in collagen scaffolds. Tissue Eng 2003; 9: 1167-77.
    • (2003) Tissue Eng , vol.9 , pp. 1167-1177
    • Xiao, Y.1    Qian, H.2    Young, W.G.3    Bartold, P.M.4
  • 21
    • 0026442602 scopus 로고
    • Haemopoietic long-term bone marrow cultures from adult mice show osteogenic capacity in vitro on 3-dimensional collagen sponges
    • Schoeters G, Leppens H, Van Gorp U, Van Den Heuvel R. Haemopoietic long-term bone marrow cultures from adult mice show osteogenic capacity in vitro on 3-dimensional collagen sponges. Cell Prolif 1992; 25: 587-603.
    • (1992) Cell Prolif , vol.25 , pp. 587-603
    • Schoeters, G.1    Leppens, H.2    Van Gorp, U.3    Van Den Heuvel, R.4
  • 22
    • 2342505788 scopus 로고    scopus 로고
    • Novel starch-based scaffolds for bone tissue engineering: Cytotoxicity, cell culture, and protein expression
    • Salgado AJ, Coutinho OR, Reis RL. Novel starch-based scaffolds for bone tissue engineering: cytotoxicity, cell culture, and protein expression. Tissue Eng 2004; 10: 465-74.
    • (2004) Tissue Eng , vol.10 , pp. 465-474
    • Salgado, A.J.1    Coutinho, O.R.2    Reis, R.L.3
  • 24
    • 0032949031 scopus 로고    scopus 로고
    • Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage
    • Solchaga LA, Dennis JE, Goldberg VM, Caplan AI. Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage. J Orthop Res 1999; 17: 205-13.
    • (1999) J Orthop Res , vol.17 , pp. 205-213
    • Solchaga, L.A.1    Dennis, J.E.2    Goldberg, V.M.3    Caplan, A.I.4
  • 25
    • 33750489941 scopus 로고    scopus 로고
    • Coralline hydroxyapatite bone graft substitute: A review of experimental studies and biomedical applications
    • Damien E, Revell PA. Coralline hydroxyapatite bone graft substitute: a review of experimental studies and biomedical applications. Journal of Applied Biomaterials & Biomechanics 2004; 2: 65-73.
    • (2004) Journal of Applied Biomaterials & Biomechanics , vol.2 , pp. 65-73
    • Damien, E.1    Revell, P.A.2
  • 26
    • 0033379360 scopus 로고    scopus 로고
    • Biomechanical evaluation of cell-loaded and cell-free hydroxyapatite implants for the reconstruction of segmental bone defects
    • Chistolini P, Ruspantini I, Bianco P, Corsi A, Cancedda R, Quarto R. Biomechanical evaluation of cell-loaded and cell-free hydroxyapatite implants for the reconstruction of segmental bone defects. J Mater Sci Mater Med 1999; 10: 739-42.
    • (1999) J Mater Sci Mater Med , vol.10 , pp. 739-742
    • Chistolini, P.1    Ruspantini, I.2    Bianco, P.3    Corsi, A.4    Cancedda, R.5    Quarto, R.6
  • 27
    • 1842854135 scopus 로고    scopus 로고
    • Hydroxyapatite cement scaffolds with controlled macroporosity: Fabrication protocol and mechanical properties
    • Charriere E, Lemaitre J, Zysset P. Hydroxyapatite cement scaffolds with controlled macroporosity: fabrication protocol and mechanical properties. Biomaterials 2003; 24: 809-17.
    • (2003) Biomaterials , vol.24 , pp. 809-817
    • Charriere, E.1    Lemaitre, J.2    Zysset, P.3
  • 28
    • 0344306399 scopus 로고    scopus 로고
    • Performance of degradable composite bone repair products made via three-dimensional fabrication techniques
    • Roy TD, Simon JL, Ricci JL, Rekow ED, Thompson VP, Parsons JR. Performance of degradable composite bone repair products made via three-dimensional fabrication techniques. J Biomed Mater Res A 2003; 66: 283-91.
    • (2003) J Biomed Mater Res A , vol.66 , pp. 283-291
    • Roy, T.D.1    Simon, J.L.2    Ricci, J.L.3    Rekow, E.D.4    Thompson, V.P.5    Parsons, J.R.6
  • 30
    • 2942586896 scopus 로고    scopus 로고
    • Novel polymer-synthesized ceramic composite-based system for bone repair: An in vitro evaluation
    • Khan YM, Katti DS, Laurancin CT. Novel polymer-synthesized ceramic composite-based system for bone repair: an in vitro evaluation. J Biomed Mater Res A 2004; 69: 728-37.
    • (2004) J Biomed Mater Res A , vol.69 , pp. 728-737
    • Khan, Y.M.1    Katti, D.S.2    Laurancin, C.T.3
  • 31
    • 2442637814 scopus 로고    scopus 로고
    • Custom-shaping system for bone regeneration by seeding marrow stromal cells onto a web-like biodegradable hybrid sheet
    • Tsuchiya K, Mori T, Chen G, Ushida T, Tateishi T, Matsuno T, Sakamoto M, Umezawa A. Custom-shaping system for bone regeneration by seeding marrow stromal cells onto a web-like biodegradable hybrid sheet. Cell Tissue Ras 2004; 316: 141-53.
    • (2004) Cell Tissue Ras , vol.316 , pp. 141-153
    • Tsuchiya, K.1    Mori, T.2    Chen, G.3    Ushida, T.4    Tateishi, T.5    Matsuno, T.6    Sakamoto, M.7    Umezawa, A.8
  • 32
    • 0034000413 scopus 로고    scopus 로고
    • Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures
    • Furukawa T, Matsusue Y, Yasunaga T, Shikinami Y, Okuno M, Nakamura T. Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures, Biomaterials 2000; 21: 889-98.
    • (2000) Biomaterials , vol.21 , pp. 889-898
    • Furukawa, T.1    Matsusue, Y.2    Yasunaga, T.3    Shikinami, Y.4    Okuno, M.5    Nakamura, T.6
  • 34
    • 0347568470 scopus 로고    scopus 로고
    • Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro
    • Res A
    • Lu HH, El-Amin SF, Scott KD, Laurencin CT. Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro. J Biomed Mater Res A 2003; 64: 465-74.
    • (2003) J Biomed Mater , vol.64 , pp. 465-474
    • Lu, H.H.1    El-Amin, S.F.2    Scott, K.D.3    Laurencin, C.T.4
  • 35
    • 20444469558 scopus 로고    scopus 로고
    • Compositional effects on the formation of a calcium phosphate layer and the response of osteoblast-like cells on polymer-bioactive glass composites
    • Lu HH, Tang A, Oh SC, Spalazzi JP, Dionisio K. Compositional effects on the formation of a calcium phosphate layer and the response of osteoblast-like cells on polymer-bioactive glass composites. Biomaterials 2005; 26: 6323-34.
    • (2005) Biomaterials , vol.26 , pp. 6323-6334
    • Lu, H.H.1    Tang, A.2    Oh, S.C.3    Spalazzi, J.P.4    Dionisio, K.5
  • 36
    • 0037290212 scopus 로고    scopus 로고
    • Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair
    • Borden M, El-Amin SF, Attawia M, Laurencin CT. Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair. Biomaterials 2003; 24: 597-609.
    • (2003) Biomaterials , vol.24 , pp. 597-609
    • Borden, M.1    El-Amin, S.F.2    Attawia, M.3    Laurencin, C.T.4
  • 37
    • 33750502474 scopus 로고    scopus 로고
    • Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix
    • Shen FH, Zeng Q, Lv Q, Choi L, Balian G, Li X, Laurencin CT. Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix. Spine J 2006; 6: 615-23.
    • (2006) Spine J , vol.6 , pp. 615-623
    • Shen, F.H.1    Zeng, Q.2    Lv, Q.3    Choi, L.4    Balian, G.5    Li, X.6    Laurencin, C.T.7
  • 39
    • 0028564916 scopus 로고
    • Biodegradation of PLA/GA polymers: Increasing complexity
    • Vert M, Mauduit J, Li S. Biodegradation of PLA/GA polymers: increasing complexity. Biomaterials 1994; 15: 1209-13.
    • (1994) Biomaterials , vol.15 , pp. 1209-1213
    • Vert, M.1    Mauduit, J.2    Li, S.3
  • 40
    • 0032144180 scopus 로고    scopus 로고
    • Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers
    • Ishaug-Riley SL, Crane-Kruger GM, Yaszemski MJ, Mikos AG. Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers. Biomaterials 1998; 19: 1405-12.
    • (1998) Biomaterials , vol.19 , pp. 1405-1412
    • Ishaug-Riley, S.L.1    Crane-Kruger, G.M.2    Yaszemski, M.J.3    Mikos, A.G.4
  • 41
    • 0033563980 scopus 로고    scopus 로고
    • Porous poly(L-lactic acid)/apatite composites created by biomimetic process
    • Zhang R, Ma PX. Porous poly(L-lactic acid)/apatite composites created by biomimetic process. J Biomed Mater Res 1999; 45: 285-93.
    • (1999) J Biomed Mater Res , vol.45 , pp. 285-293
    • Zhang, R.1    Ma, P.X.2
  • 42
    • 33845473046 scopus 로고    scopus 로고
    • A poly(lactide-co-glycolide)/hydroxyapatite composite scaffold with enhanced osteoconductivity
    • Kim SS, Ahn KM, Park MS, Lee JH, Choi CY, Kim BS. A poly(lactide-co-glycolide)/hydroxyapatite composite scaffold with enhanced osteoconductivity. J Biomed Mater Res A 2007; 80: 206-15.
    • (2007) J Biomed Mater Res A , vol.80 , pp. 206-215
    • Kim, S.S.1    Ahn, K.M.2    Park, M.S.3    Lee, J.H.4    Choi, C.Y.5    Kim, B.S.6
  • 44
    • 8644281120 scopus 로고    scopus 로고
    • Preparation and characterization of bioactive and biodegradable wollastonite/poly(D,L-lactic acid) composite scaffolds
    • Li H, Chang J. Preparation and characterization of bioactive and biodegradable wollastonite/poly(D,L-lactic acid) composite scaffolds. J Mater Sci Mater Med 2004; 15: 1089-95.
    • (2004) J Mater Sci Mater Med , vol.15 , pp. 1089-1095
    • Li, H.1    Chang, J.2
  • 45
    • 0026538166 scopus 로고
    • Gel casting of resorbable polymers: Part 1: processing and applications
    • Coombes AG, Heckman JD. Gel casting of resorbable polymers: Part 1: processing and applications. Biomaterials 1992; 13: 217-24.
    • (1992) Biomaterials , vol.13 , pp. 217-224
    • Coombes, A.G.1    Heckman, J.D.2
  • 46
    • 0029898997 scopus 로고    scopus 로고
    • Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair
    • Devin JE, Attawia MA, Laurencin CT. Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. J Biomater Sci Polym Ed 1996; 7: 661-9.
    • (1996) J Biomater Sci Polym Ed , vol.7 , pp. 661-669
    • Devin, J.E.1    Attawia, M.A.2    Laurencin, C.T.3
  • 47
    • 0030055972 scopus 로고    scopus 로고
    • Tissue engineered bone-regeneration using degradable polymers: The formation of mineralized matrices
    • Laurencin CT, Attawia MA, Elgendy HE, Herbert KM. Tissue engineered bone-regeneration using degradable polymers: the formation of mineralized matrices. Bone 1996; 19: 93S-99S.
    • (1996) Bone , vol.19
    • Laurencin, C.T.1    Attawia, M.A.2    Elgendy, H.E.3    Herbert, K.M.4
  • 48
    • 28444469126 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering
    • Kim SS, Sun Park M, Jeon O, Yong Choi C, Kim BS. Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering. Biomaterials 2006; 27: 1399-409.
    • (2006) Biomaterials , vol.27 , pp. 1399-1409
    • Kim, S.S.1    Sun Park, M.2    Jeon, O.3    Yong Choi, C.4    Kim, B.S.5
  • 49
    • 15244353095 scopus 로고    scopus 로고
    • Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold
    • Li WJ, Tuli R, Huang X, Laquerriere P, Tuan RS. Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials 2005; 26: 5158-66.
    • (2005) Biomaterials , vol.26 , pp. 5158-5166
    • Li, W.J.1    Tuli, R.2    Huang, X.3    Laquerriere, P.4    Tuan, R.S.5
  • 50
    • 2342428707 scopus 로고    scopus 로고
    • Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering
    • Wei G, Ma PX. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials 2004; 25: 4749-57.
    • (2004) Biomaterials , vol.25 , pp. 4749-4757
    • Wei, G.1    Ma, P.X.2
  • 51
    • 8444237104 scopus 로고    scopus 로고
    • Preparation and characterization of a highly macroporous biodegradable composite tissue engineering scaffold
    • Guan L, Davies JE. Preparation and characterization of a highly macroporous biodegradable composite tissue engineering scaffold. J Biomed Mater Res A 2004; 71: 480-7.
    • (2004) J Biomed Mater Res A , vol.71 , pp. 480-487
    • Guan, L.1    Davies, J.E.2
  • 52
    • 33846414393 scopus 로고    scopus 로고
    • Accelerated bonelike apatite growth on porous polymer/ceramic composite scaffolds in vitro
    • Kim SS, Park MS, Gwak SJ, Choi CY, Kim BS. Accelerated bonelike apatite growth on porous polymer/ceramic composite scaffolds in vitro. Tissue Eng 2006; 12: 2997-3006.
    • (2006) Tissue Eng , vol.12 , pp. 2997-3006
    • Kim, S.S.1    Park, M.S.2    Gwak, S.J.3    Choi, C.Y.4    Kim, B.S.5
  • 53
    • 0343683341 scopus 로고    scopus 로고
    • Preparation of microspheres by the solvent evaporation technique
    • McGinity JW, O'Donnell PB. Preparation of microspheres by the solvent evaporation technique. Adv Drug Deliv Rev 1997; 28: 25-42.
    • (1997) Adv Drug Deliv Rev , vol.28 , pp. 25-42
    • McGinity, J.W.1    O'Donnell, P.B.2
  • 54
    • 0018931332 scopus 로고
    • Isolation and growth of endothelial cells from the microvessels of the newborn human foreskin in cell culture
    • Davison PM, Bensch K, Karasek MA. Isolation and growth of endothelial cells from the microvessels of the newborn human foreskin in cell culture. J Invest Dermatol 1980; 75: 316-21.
    • (1980) J Invest Dermatol , vol.75 , pp. 316-321
    • Davison, P.M.1    Bensch, K.2    Karasek, M.A.3
  • 55
    • 0025694947 scopus 로고
    • Microencapsulation using emulsification/ solvent evaporation: An overview of techniques and applications
    • Watts PJ, Davies MC, Melia CD. Microencapsulation using emulsification/ solvent evaporation: an overview of techniques and applications. Crit Rev Ther Drug Carrier Syst 1990; 7: 235-59.
    • (1990) Crit Rev Ther Drug Carrier Syst , vol.7 , pp. 235-259
    • Watts, P.J.1    Davies, M.C.2    Melia, C.D.3
  • 56
    • 0034580371 scopus 로고    scopus 로고
    • The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices
    • Jain RA. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 2000; 21: 2475-90.
    • (2000) Biomaterials , vol.21 , pp. 2475-2490
    • Jain, R.A.1
  • 57
    • 0031752709 scopus 로고    scopus 로고
    • Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: Release kinetics and stability issues
    • Crotts G, Park TG. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues. J Microencapsul 1998; 15: 699-713.
    • (1998) J Microencapsul , vol.15 , pp. 699-713
    • Crotts, G.1    Park, T.G.2
  • 58
    • 0034580367 scopus 로고    scopus 로고
    • Effects of fluid flow on the in vitro degradation kinetics of biodegradable scaffolds for tissue engineering
    • Agrawal CM, McKinney JS, Lanctot D, Athanasiou KA. Effects of fluid flow on the in vitro degradation kinetics of biodegradable scaffolds for tissue engineering. Biomaterials 2000; 21: 2443-52.
    • (2000) Biomaterials , vol.21 , pp. 2443-2452
    • Agrawal, C.M.1    McKinney, J.S.2    Lanctot, D.3    Athanasiou, K.A.4
  • 59
    • 0029256583 scopus 로고
    • Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence
    • Grizzi I, Garreau H, Li S, Vert M. Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence. Biomaterials 1995; 16: 305-11.
    • (1995) Biomaterials , vol.16 , pp. 305-311
    • Grizzi, I.1    Garreau, H.2    Li, S.3    Vert, M.4
  • 60
    • 0016952199 scopus 로고
    • Tissue response to implanted polymers: The significance of sample shape
    • Matlaga BF, Yasenchak LP, Salthouse TN. Tissue response to implanted polymers: the significance of sample shape. J Biomed Mater Res 1976; 10: 391-7.
    • (1976) J Biomed Mater Res , vol.10 , pp. 391-397
    • Matlaga, B.F.1    Yasenchak, L.P.2    Salthouse, T.N.3
  • 61
    • 0033151448 scopus 로고    scopus 로고
    • Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro
    • Tracy MA, Ward KL, Firouzabadian L, Wang Y, Dong N, Qian R, Zhang Y. Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro. Biomaterials 1999; 20: 1057-62.
    • (1999) Biomaterials , vol.20 , pp. 1057-1062
    • Tracy, M.A.1    Ward, K.L.2    Firouzabadian, L.3    Wang, Y.4    Dong, N.5    Qian, R.6    Zhang, Y.7
  • 62
    • 0033961642 scopus 로고    scopus 로고
    • Osteoblast adhesion on biomaterials
    • Anselme K. Osteoblast adhesion on biomaterials. Biomaterials 2000; 21: 667-81.
    • (2000) Biomaterials , vol.21 , pp. 667-681
    • Anselme, K.1
  • 63
    • 0036467578 scopus 로고    scopus 로고
    • Anchorage-dependent ERK signaling: Mechanisms and consequences
    • Howe AK, Aplin AE, Juliano RL. Anchorage-dependent ERK signaling: mechanisms and consequences. Curr Opin Genet Dev 2002; 12: 30-5.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 30-35
    • Howe, A.K.1    Aplin, A.E.2    Juliano, R.L.3


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