Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa

British Journal of Cancer

Volumn 94, Issue 4, 2006, Pages 586-592

  Klimek Tomczak, K ^a   Mikula, M ^a   Dzwonek, A ^a   Paziewska, A ^a   Karczmarski, J ^a   Hennig, E ^a   Bujnicki, J M ^b   Bragoszewski P ^a   Denisenko, O ^c   Bomsztyk, K ^c   Ostrowski, J ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

^b INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Colorectal cancer; hnRNP K protein; Phosphorylation; RNA editing

Indexed keywords

ALANINE; GENOMIC DNA; GLYCINE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K; ISOPROTEIN; MESSENGER RNA;

ADENOCARCINOMA; AMINO ACID SUBSTITUTION; ARTICLE; CANCER SURGERY; COLON MUCOSA; COLORECTAL CARCINOMA; CONTROLLED STUDY; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM MUCOSA; RNA EDITING; RNA ISOLATION; RNA SEQUENCE; WILD TYPE;

BREAST NEOPLASMS; COLONIC NEOPLASMS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN K; HUMANS; PHOSPHORYLATION; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN ISOFORMS; RNA EDITING; SEQUENCE ANALYSIS, DNA; THYROID NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 33344474543     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602938     Document Type: Article

References (36)

1. Aasheim H-C, Loukianova T, Deggerdal A, Smeland EB (1994) Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K. Nucleic Acids Res 22: 959-964
2. Bhalla T, Rosenthal JJ, Holmgren M, Reenan R (2004) Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nat Struct Mol Biol 11: 950-956
3. Blom N, Gammeltoft S, Brunak S (1999) Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 294: 1351-1362
4. Blow M, Futreal PA, Wooster R, Stratton MR (2004) A survey of RNA editing in human brain. Genome Res 14: 2379-2387
5. Bomsztyk K, Denisenko O, Ostrowski J (2004) hnRNP K: one protein multiple processes. Bioessays 26: 629-638
6. Bomsztyk K, Van Seuningen I, Suzuki H, Denisenko O, Ostrowski J (1997) Diverse molecular interactions of the hnRNP K protein. FEBS Lett 403: 113-115
7. Bourara K, Litvak S, Araya A (2000) Generation of G-to-A and C-to-U changes in HIV-1 transcripts by RNA editing. Science 289: 1564-1566
8. Braddock DT, Baber JL, Levens D, Clore GM (2002) Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA. EMBO J 21: 3476-3485
9. Davidson NO (2002) The challenge of target sequence specificity in C-> U RNA editing. J Clin Invest 109: 291-294
10. Decatur WA, Fournier MJ (2003) RNA-guided nucleotide modification of ribosomal and other RNAs. J Biol Chem 278: 695-698
11. Dejgaard K, Leffers H, Rasmussen HH, Madsen P, Kruse TA, Gesser B, Nilesen H, Celis JE (1994) Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing. J Mol Biol 236: 33-48
12. Didkowska J, Wojciechowska W, Tarkowski W, Zatonski W (2003) Cancer in Poland in 2000. Bulletin of the Maria Sklowska-Curie Memorial Cancer Center, Warsaw (http://148.81.190.231/krn)
13. Eisenberg E, Nemzer S, Kinar Y, Sorek R, Rechavi G, Levanon EY (2005) Is abundant A-to-I RNA editing primate-specific? Trends Genet 21: 77-81
14. Gerber AP, Keller W (2001) RNA editing by base deamination: more enzymes, more targets, new mysteries. Trends Biochem Sci 26: 376-384
15. Geslain R, Ribas de Pouplana L (2004) Regulation of RNA function by aminoacylation and editing? Trends Genet 20: 604-610
16. Gott JM, Emeson RB (2000) Functions and mechanisms of RNA editing. Annu Rev Genet 34: 499-531
17. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ (2005) Cancer statistics, 2005. CA Cancer J Clin 55: 10-30
18. Jenkins GJ (2004) The restriction site mutation (RSM) method: clinical applications. Mutagenesis 19: 3-11
19. Lee RM, Hirano K, Anant S, Baunoch D, Davidson NO (1998) An alternatively spliced form of apobec-1 messenger RNA is overexpressed in human colon cancer. Gastroenterology 115: 1096-1103
20. Li C, Hong Y, Tan YX, Zhou H, Ai JH, Li SJ, Zhang L, Xia QC, Wu JR, Wang HY, Zeng R (2004) Accurate qualitative and quantitative proteomic analysis of clinical hepatocellular carcinoma using laser capture microdissection coupled with isotope-coded affinity tag and two-dimensional liquid chromatography mass spectrometry. Mol Cell Proteomics 3: 399-409
21. Maas S, Rich A (2000) Changing genetic information through RNA editing. Bioessays 22: 790-802
22. Maas S, Rich A, Nishikura K (2003) A-to-I RNA editing: recent news and residual mysteries. J Biol Chem 278: 1391-1394
23. Makeyev AV, Liebhaber SA (2002) The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. RNA 8: 265-278
24. Mandal M, Vadlamudi R, Nguyen D, Wang RA, Costa L, Bagheri-Yarmand R, Mendelsohn J, Kumar R (2001) Growth factors regulate heterogeneous nuclear ribonucleoprotein K expression and function. J Biol Chem 276: 9699-9704
25. Michelotti EF, Michelotti GA, Aronsohn AI, Levens D (1996) Heterogenous nuclear ribonucleoprotein K is a transcription factor. Mol Cell Biol 16: 2350-2360
26. Michelotti EF, Tomonaga T, Krutzsch H, Levens D. (1995) Cellular nucleic acid binding protein regulates the CT element of the human c-myc protooncogene. J Biol Chem 270: 9494-9499
27. Nutt SL, Hoo KH, Rampersad V, Deverill RM, Elliott CE, Fletcher EJ, Adams SL, Korczak B, Foldes RL, Kamboj RK (1994) Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites. Receptors Channels 2: 315-326
28. Ostrowski J, Bomsztyk K (2003) Nuclear shift of hnRNP K protein in neoplasm and other states of enhanced cell proliferation. Br J Cancer 89: 1493-1501
29. Ostrowski J, Kawata Y, Schullery DS, Denisenko ON, Bomsztyk K (2003) Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci. Nucleic Acids Res 31: 3954-3962
30. Ostrowski J, Klimek-Tomczak K, Wyrwicz LS, Mikula M, Schullery DS, Bomsztyk K (2004) hnRNP K enhances insulin-induced expression of mitochondrial UCP2 protein. J Biol Chem 279: 54599-54609
31. Paziewska A, Wyrwicz LS, Bujnicki JM, Bomsztyk K, Ostrowski J (2004) Cooperative binding of the hnRNP K three KH domains to mRNA targets. FEBS Lett 577: 134-140
32. Peitsch MC (1996) ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling. Biochem Soc Trans 24: 274-279
33. Schaub M, Keller W (2002) RNA editing by adenosine deaminases generates RNA and protein diversity. Biochimie 84: 791-803
34. Turelli P, Trono D (2005) Editing at the crossroad of innate and adaptive immunity. Science 307: 1061-1065
35. Vitali P, Basyuk E, Le Meur E, Bertrand E, Muscatelli F, Cavaille J, Huttenhofer A (2005) ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs. J Cell Biol 169: 745-753
36. Yang W, Wang Q, Howell KL, Lee JT, Cho DS, Murray JM, Nishikura K (2005) ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells. J Biol Chem 280: 3946-3953