Improving pregnancy outcome for IVF patients with preimplantation genetic screening

Expert Review of Obstetrics and Gynecology

Volumn 3, Issue 5, 2008, Pages 635-646

  Munné, Santiago ^a  

^a Reprogenetics LLC   (United States)

Author keywords

Advanced maternal age; Aneuploidy; Embryo biopsy; Miscarriage; Preimplantation genetic dignosis; Recurrent pregnancy loss

Indexed keywords

DNA;

ANALYTICAL ERROR; ANEUPLOIDY; BIOPSY TECHNIQUE; BLASTOMERE; CELL COUNT; CELL SELECTION; CHROMOSOME 15; CHROMOSOME 22; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME MOSAICISM; CHROMOSOME NUMBER; CLINICAL TRIAL; COMPARATIVE GENOMIC HYBRIDIZATION; CRYOPRESERVATION; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FERTILIZATION IN VITRO; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC SCREENING; GENETIC SELECTION; HUMAN; INFERTILITY; INFERTILITY THERAPY; MATERNAL AGE; MICROARRAY ANALYSIS; PRACTICE GUIDELINE; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; PRENATAL DIAGNOSIS; QUALITATIVE ANALYSIS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SPONTANEOUS ABORTION; TREATMENT INDICATION; TRISOMY;

EID: 55149091532     PISSN: 17474108     EISSN: None     Source Type: Journal    
DOI: 10.1586/17474108.3.5.635     Document Type: Review

References (117)

1. Navot D, Bergh PA, Williams MA et al. Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility. Lancet 337, 1375-1377 (1991).
2. Munné S, Lee A, Rosenwaks Z, Grifo J, Cohen J. Diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum. Reprod. 8, 2185-2191 (1993).
3. Alikani M, Calderon G, Tomkin G, Garrisi J, Kokot M, Cohen J. Cleavage anomalies in human embryos and survival after prolonged culture in-vitro. Hum. Reprod. 15, 2634-2643 (2000).
4. Racowsky C, Combelles CMH, Nureddin A et al. Day 3 and day 5 morphological predictors of embryo viability. Reprod. Biomed. Online 6, 323-331 (2003).
5. Gardner DK, Schoolcraft WB, Wagley L, Schlenker T, Stevens J, Hesla J. A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Hum. Reprod. 13, 3434-3440 (1998).
6. Munné S, Alikani M, Tomkin G, Grifo J, Cohen J. Embryo morphology, developmental rates and maternal age are correlated with chromosome abnormalities. Fertil. Steril. 64, 382-391 (1995).
7. Munné S, Serena C, Colls P et al. Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos. Reprod. Biomed. Online 14, 628-634 (2007).
8. Delhanty JDA, Harper JC, Ao A, Handyside AH, Winston RML. Multicolour FISH detects frequent chromosomal mosaicism and chaotic division in normal preimplantation embryos from fertile patients. Hum. Genetics 99, 755-760 (1997).
9. Márquez C, Sandalinas M, Bahçe M, Alikani M, Munné S. Chromosome abnormalities in 1255 cleavage-stage human embryos. Reprod. Biomed. Online 1, 17-27 (2000).
10. Verlinsky Y, Cieslak V, Ivakhnenko S et al. Chromosomal abnormalities in the first and second polar body. Mol. Cell. Endocrinol. 183, S47-S49 (2001).
11. Bielanska M, Tan SL, Ao A. Chromosomal mosaicism throughout human preimplantation development in-vitro: incidence, type, and relevance to embryo outcome. Hum. Reprod. 17, 413-419 (2002).
12. Magli MC, Gianaroli L, Ferrareti AP. Chromosomal abnormalities in embryos. Mol. Cell. Endocrinol. 22(183 Suppl. 1), S29-S34 (2001).
13. Magli MC, Sandalinas M, Escudero T et al. Double locus analysis of chromosome 21 for preimplantation genetic diagnosis of aneuploidy. Pren. Diagn. 21, 1080-1085 (2001).
14. Magli MC, Gianaroli L, Ferrareti AP, Lappi M, Ruberti A, Farfalli V. Embryo morphology and development are dependent on the chromosome complement. Fertil. Steril. 87, 534-541 (2007).
15. Sandalinas M, Sadowy S, Alikani M, Calderon G, Cohen J, Munné S. Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage. Hum. Reprod. 16, 1954-1958 (2001).
16. Magli MC, Jones GM, Gras L, Gianaroli L, Korman I, Trounson AO. Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in-vitro. Hum, Reprod. 15, 1781-1786 (2000).
17. Li M, Marin DeUgarte C, Surrey M, Danzer H, DeCherney A, Hill DL. Fluorescence in-situ hybridization reanalysis of day-6 human blastocysts diagnosed with aneuploidy on day 3. Fertil. Steril. 84, 1395-1400 (2005).
18. Elder K, Cohen J. Human Preimplantation Embryo Selection. Taylor & Francis, FL, USA (2007).
19. Alikani M, Schimmel T, Willadsen SM. Cytoplasmic fragmentation in activated eggs occurs in the cytokinetic phase of the cell cycle, in lieu of normal cytokinesis, and in response to cytoskeletal disorder. Mol. Hum. Reprod. 11, 335-344. (2005).
20. Cohen J, Wells D, Munné S. Removal of two cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests employed to enhance implantation rates. Fertil. Steril. 87, 496-503 (2007).
21. Goossens V, De Rycke M, De Vos A et al. Diagnostic efficiency, embryonic development and clinical outcome after the biopsy of one or two blastomeres for preimplantation genetic diagnosis. Hum. Reprod. 23, 481-492 (2008).
22. Colls P, Escudero T, Zheng X et al. Increased efficiency of preimplantation genetic diagnosis for infertility through reanalysis of dubious signals. Fertil. Steril. 88, 53-61 (2007).
23. Baart E, Van Opstal D, Los FJ, Fauser BCJM, Martini E. Fluorescence in-situ hybridization analysis of two blastomeres from day-3 frozen-thawed embryos followed by analysis of the remaining embryo on day-5. Hum. Reprod. 19, 685-693 (2004).
24. Gianaroli L, Magli C, Ferraretti AP, Munné S. Preimplantation diagnosis for aneuploidies in patients undergoing in-vitro fertilization with a poor prognosis: identification of the categories for which it should be proposed. Fertil. Steril. 72, 837-844 (1999).
25. Munné S, Magli C, Cohen J et al. Positive outcome after preimplantation diagnosis of aneuploidy in human embryos. Hum. Reprod. 14, 2191-2199 (1999).
26. Munné S, Sandalinas M, Escudero T et al. Improved implantation after preimplantation genetic diagnosis of aneuploidy. Reprod. Biomed. Online 7, 91-97 (2003).
27. Munné S, Fischer J, Warner A et al. Preimplantation genetic diagnosis significantly reduces pregnancy loss in infertile couples: a multi-center study. Fertil. Steril. 85, 326-332 (2006).
28. Munné S, Dailey T, Sultan KM, Grifo J, Cohen J. The use of first polar bodies for preimplantation diagnosis of aneuploidy. Hum. Reprod. 10, 1015-1021 (1995).
29. Verlinsky Y, Cieslak J, Frieidine M et al. Pregnancies following pre-conception diagnosis of common aneuploidies by fluorescence in-situ hybridization. Hum. Reprod. 10, 1923-1927 (1995).
30. Verlinsky Y, Cieslak J, Ivakhnenko V et al. Birth of healthy children after preimplantation diagnosis of common aneuploidies by polar body fluorescent in-situ hybridization analysis. Fertil. Steril. 66, 126-129 (1996).
31. Magli MC, Gianaroli L, Ferraretti AP, Toschi M, Esposito F, Fasolino MC. The combination of polar body and embryo biopsy does not affect embryo viability. Hum. Reprod. 19, 1163-1169 (2004).
32. Cieslak-Janzen J, Tur-Kaspa I, Ilkevitch Y, Bernal A, Morris R, Verlinsky Y. Multiple micromanipulations for preimplantation genetic diagnosis do not affect embryo development to the blastocyst stage. Fertil. Steril. 85, 1826-1829 (2006).
33. Staessen C, Platteau P, Van Assche E et al. Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial. Hum. Reprod. 19, 2849-2858 (2004).
34. De Boer KA, Catt JW, Jansen RPS, Leigh D, McArthur S. Moving to blastocyst biopsy for preimplantation genetic diagnosis and single embryo transfer at Sydney IVF. Fertil. Steril. 82, 295-298 (2004).
35. Hardy K, Martin KL, Leese HJ, Winston RML, Handyside AH. Human preimplantation development in-vitro is not adversely affected by biopsy at the 8-cell stage. Hum. Reprod. 5(6), 708-714 (1990).
36. Mastenbroek S, Twisk M, Van Echten-arends J et al. Preimplantation genetic screening in women of advanced maternal age. N. Engl. J. Med. 357, 9-17 (2007).
37. Munné S, Gianaroli L, Tur-Kaspa I et al. Sub-standard application of PGS may interfere with its clinical success. Fertil. Steril. 88, 781-784 (2007).
38. Cohen J, Grifo J. Multicenter trial of preimplantation genetic screening reported in the New England Journal of Medicine: an in-depth look at the findings. Reprod. Biomed. Online 15, 365-366 (2007).
39. Kuliev A, Verlinsky Y. Impact of preimplantation genetic diagnosis for chromosomal disorders on reproductive outcome. Reprod. Biomed. Online 16, 9-10 (2007).
40. Chatzimeletiou K, Morrison E, Panagiotidis Y et al. Comparison of the effects of zona drilling by non-contact infrared laser or acid Tyrode's on the development of human biopsied embryos as revealed by blastomere viability, cytoskeletal analysis and molecular cytogenetics. Reprod. Biol. Online 11, 697-710 (2005).
41. Joris H, De Vos A, Janssens R, Devroey P, Liebaers L, Van Steirteghem A. Comparison of the results of human embryo biopsy and outcome of PGS after zona drilling using acid tyrode medium or laser. Hum. Reprod. 18, 1896-1902 (2003).
42. Tarkowski AK. An air drying method for chromosome preparations from mouse eggs. Cytogenetics 5, 394-400 (1966).
43. Munné S, Máquez C, Magli C, Morton P, Morrison L. Scoring criteria for preimplantation genetic diagnosis of numerical abnormalities for chromosomes X, Y, 13, 16, 18 and 21. Molec. Hum. Reprod. 4, 863-870 (1998).
44. Velilla E, Escudero T, Munné S. Blastomere fixation techniques and risk of misdiagnosis for PGS of aneuploidy. Reprod. Biomed. Online 4, 210-217 (2002).
45. Coonen E, Dumoulin JCM, Ramackers FCS, Hopman AHN. Optimal preparation of preimplantation embryo interphase nuclei for analysis by fluorescence in-situ hybridization. Hum. Reprod. 9, 533-537 (1994).
46. Harper JC, Robinson F, Duffy S et al. Detection of fertilization in embryos with accelerated cleavage by fluorescence in-situ hybridization (FISH). Human Reprod. 9, 1733-1737 (1994).
47. Dozortsev DI, Mc Ginnis KT. An improved fixation technique for fluorescence in-situ hybridization for preimplantation genetic diagnosis. Fertil. Steril. 76, 186-188 (2001).
48. Coulam CB, Jeyendram RS, Fiddler M, Pergament E. Discordance among blastomeres renders preimplantation genetic diagnosis for aneuploidy ineffective. J. Assist. Reprod. Genet. 24, 37-41 (2007).
49. Munné S, Sandalinas M, Escudero T, Márquez C, Cohen J. Chromosome mosaicism in cleavage stage human embryos: evidence of a maternal age effect. Reprod. Biomed. Online 4, 223-232 (2002).
50. Munné S, Bahçe M, Sandalinas M et al. Differences in chromosome susceptibility to aneuploidy and survival to first trimester. Reprod. Biomed. Online 8, 81-90 (2004).
51. Jobanputra V, Sobrino A, Kinney A, Kline J, Warburton D. Multiplex interphase FISH as a screen for common aneuploidies in spontaneous abortions. Hum. Reprod. 17, 1166-1170 (2002).
52. Gutiérez-Mateo C, Benet J, Wells D et al. Aneuploidy study of human oocytes first polar body comparative genomic hybridization and metaphase II fluorescence in-situ hybridization analysis. Hum. Reprod. 19, 2859-2868 (2004).
53. Gutiérrez-Mateo C, Wells D, Benet J et al. Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes. Hum. Reprod. 19, 2118-2125 (2004).
54. Fragouli E, Wells D, Thornhill A et al. Comparative genomic hybridization analysis of human oocytes and polar bodies. Hum. Reprod. 21, 2319-2328 (2006).
55. Lathi RB, Westphal LM, Milki AA. Aneuploidy in the miscarriages of infertile women and the potential benefit of preimplantation genetic diagnosis. Fertil. Steril. 89, 353-357 (2007).
56. Munné S, Chen S, Fischer J et al. Preimplantation genetic diagnosis reduces pregnancy loss in women 35 and older with a history of recurrent miscarriages. Fertil. Steril. 84, 331-335 (2005).
57. Gianaroli L, Magli C, Ferraretti AP et al. The beneficial effects of PGS for aneuploidy support extensive clinical application. Reprod. Biomed. Online 10, 633-640 (2004).
58. Munné S, Morrison L, Fung J et al. Spontaneous abortions are reduced after pre-conception diagnosis of translocations. JARG 15, 290-296 (1998).
59. Colls P, Sandalinas M, Pagidas K, Munné S. PGS analysis for aneuploidy in a patient heterozygous for a polymorphism of chromosome 16 (16qh-). Prenat. Diagn. 24, 741-744 (2004).
60. Delhanty JDA, Griffin DK, Handyside AH et al. Detection of aneuploidy and chromosomal mosaicism in human embryos during preimplantation sex determination by fluorescent in-situ hybridization (FISH). Hum. Mol. Genet. 2, 1183-1185 (1993).
61. Munné S. Chromosome abnormalities and their relationship to morphology and development of human embryos. Reprod. Biomed. Online 12, 234-253 (2006).
62. Munné S, Magli C, Adler A et al. Treatment-related chromosome abnormalities in human embryos. Hum. Reprod. 12, 780-784 (1997).
63. Eiben B, Goebel R, Hansen S, Hammans W. Early amniocentesis. A cytogenetic evaluation of over 1500 cases. Prenat. Diagn. 14, 497-501 (1994).
64. Twisk M, Haadsma ML, Van der Veen F et al. Preimplantation genetic screening as an alternative to prenatal testing for Down syndrome: preferences of women undergoing in-vitro fertilization/ intracytoplasmic sperm injection treatment. Fertil. Steril. 88, 804-810 (2007).
65. Regan L, Braude PR, Trembath PL. Influence of past reproductive performance on risk of spontaneous abortion. Br. Med. J. 299, 541-545 (1989).
66. Fretts RC, Schmittdiel J, Mclean FH et al. Increased maternal age and the risk of fetal death. N. Engl. J. Med. 333, 953-957 (1995).
67. La Rochebrochard E, Thonneau P. Paternal age and maternal age are risk factors for miscarriage; results of a multi-centre European study. Hum. Reprod. 17, 1649-1656 (2000).
68. Kupka MS, Dorn C, Montag M et al. Previous miscarriages influence IVF and intracytoplasmic sperm injection pregnancy outcome. Reprod. Biomed. Online 8, 349-357 (2004).
69. Spandorfer SD, Davis OK, Barmat LI, Chung PH, Rosenwaks Z. Relationship between maternal age and aneuploidy in in-vitro fertilization pregnancy loss. Fertil. Steril. 81, 1265-1269 (2004).
70. Gianaroli L, Magli MC, Ferraretti AP. The in-vivo and in-vitro efficiency and efficacy of PGS for aneuploidy (2001). Mol. Cell. Endocrinol. 183, S13-S18 (2001).
71. Gianaroli L, Magli MC, Ferraretti AP, Tabanelli C, Trombetta C, Boudjema E. The role of preimplantation diagnosis for aneuploidy. Reprod. Biomed. Online 4, 31-36 (2001).
72. Verlinsky Y, Tur-Kaspa I, Cieslak J et al. Preimplantation testing for chromosomal disorders improves reproductive outcome of poor prognosis patients. Reprod. Biomed. Online 11, 219-225 (2005).
73. Munné S, Garrisi J, Barnes F, Wedin L, Schoolcraft W, Kaplan B. Reduced spontaneous abortion and increased live birth rate after PGS for advanced maternal age. Fertil. Steril. 88 (Suppl. 1), S85-S86 (2007).
74. Reis Soares S, Rubio C, Rodrigo L, Simon C, Remohi J, Pellicer A. High frequency of chromosomal abnormalities in embryos obtained from oocyte donation cycles. Fertil. Steril. 80, 656-657 (2003).
75. Munné S, Ary J, Zouves C et al. Wide range of chromosome abnormalities in the embryos of young egg donors. Reprod. Biomed. Online 12, 340-346 (2006).
76. Crosignani PC, Rubin BL. Recurrent spontaneous miscarriage. The recommendations of the ESHRE workshop on recurrent spontaneous miscarriages held in Anacapri on September 9-11, 1990. Hum. Reprod. 6, 609-610 (1991).
77. Stephenson MD. Frequency of factors associated with habitual abortion in 197 couples. Fertil. Steril. 66, 24-29 (1996).
78. Simpson JL. Incidence and timing of pregnancy losses: relevance to evaluating safety of early prenatal diagnosis. Am. J. Med. Genet. 35, 165-173 (1990).
79. Clifford K, Rai R, Watson H, Regan L. An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases. Hum. Reprod. 9, 1328-1332 (1994).
80. Quenby S, Vince G, Farquharson R, Aplin J. Recurrent miscarriage: a defect in nature's quality control? Hum. Reprod. 17, 1959-1963 (2002).
81. Ogasawara M, Aoki K, Okada S, Suzumori K. Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil. Steril. 73, 300-304 (2000).
82. Stephenson MD, Awartani KA, Robinson WP. Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: a case-control study. Hum. Reprod. 17, 446-451 (2002).
83. Vidal F, Gimenez C, Rubio C et al. FISH preimplantation diagnosis of chromosome aneuploidy in recurrent pregnancy wastage. J. Assist. Reprod. Genet. 15, 310-313 (1998).
84. Simon C, Rubio C, Vidal F, Moreno C, Parrilla JJ, Pellicer A. Increased chromosome abnormalities in human preimplantation embryos after in-vitro fertilization in patients with recurrent miscarriages. Reprod. Fertil. Devel. 10, 987-992 (1998).
85. Rubio C, Simon C, Vidal F et al. Chromosomal abnormalities and embryo development in recurrent miscarriage couples. Hum. Reprod. 18, 182-188 (2003).
86. Pellicer A, Rubio C, Vidal F et al. In-vitro fertilization plus preimplantation genetic diagnosis in patients with recurrent miscarriage: an analysis of chromosome abnormalities in human preimplantation embryos. Fertil. Steril. 71, 1033-1039 (1999).
87. Garrisi J, Cohen J, Ferry KM, Colls P, Garrisi MG, Munné S. Preimplantation genetic diagnosis effectively reduces idiopathic recurrent pregnancy loss among patients with up to five previous miscarriages after natural conception. Fertil. Steril. 88 (Suppl. 1), S85 (2007).
88. Werlin L, Rodi I, DeCherney A, Marello E, Hill D, Munné S. Preimplantation genetic diagnosis (PGS) as both a therapeutic and diagnostic tool in assisted reproductive technology. Fertil. Steril. 80, 467-468 (2003).
89. Platteau P, Staessen C, Michiels A, Van Steirteghem A, Liebaers I, Devroey P. Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages. Fertil. Steril. 83, 393-397 (2005).
90. Brigham SA, Colon C, Farquharson RG. A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. Hum. Reprod. 14, 2868-2871 (1999).
91. Munné S, Sandalinas M, Escudero T, Fung J, Gianaroli L, Cohen J. Outcome of preimplantation genetic diagnosis of translocations. Fertil. Steril. 73, 1209-1218 (2000).
92. Munné S. Preimplantation genetic diagnosis for translocations. Hum. Reprod. 21, 839-840 (2006).
93. Verlinsky Y, Cieslak V, Evsikov G, Galat V, Kuliev A. nuclear transfer for full karyotyping and preimplantation diagnosis for translocations. Reprod. Biomed. Online 5, 300-305 (2002).
94. Gianaroli L, Magli C, Fiorentino F, Baldi M, Ferraretti AP. Clinical value of preimplantiation genetic diagnosis. Placenta 24, S77-S83 (2003).
95. Lim CK, Jum JH, Min DM et al. Efficacy and clinical outcome of preimplantation genetic diagnosis using FISH for couples of reciprocal and Robertsonian translocations: the Korean experience. Prenat. Diagn. 24, 556-561 (2004).
96. Otani T, Roche M, Mizuikea M, Colls P, Escudero T, Munné S. Preimplantation genetic diagnosis significantly improves the pregnancy outcome of translocation carriers with a history of recurrent miscarriage and failing to produce a live birth. Reprod. Biomed. Online 13, 879-894 (2006).
97. The Practice Committee of the Society for Assisted Reproductive Technology and the Practice Committee of the American Society for Reproductive Medicine. Preimplantation genetic testing: a practice committee opinion. Fertil. Steril. 88, 1497-1504 (2007).
98. PGDIS. Guidelines for good practice in PGD: programme requirements and laboratory quality assurance. Reprod. Biomed. Online 16, 134-147 (2008).
99. Taranissi M, El-Toukhy T, Gorgy A, Verlinsky Y. Influence of maternal age on the outcome of PGS for aneuploidy in patients with recurrent implantation failure. Reprod. Biomed. Online 11, 628-632 (2005).
100. Tur-Kaspa I. Optimizing ovarian stimulation and ET for IVF-PGS cycle. Post Graduate Course on PGS. Presented at: The 63 Annual Meeting of the American Society for Reproductive Medicine. Washington DC, USA, 13-17 October 2007.
101. Kallioniemi A, Kallioniemi OP, Sudar D et al. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258, 818-821 (1992).
102. Fragouli E, Wells D, Whalley KM, Mills JA, Faed MJ, Delhanty JD. Increased susceptibility to maternal aneuploidy demonstrated by comparative genomic hybridization analysis of human M-II oocytes and first polar bodies. Cytogenet. Genome Res. 114, 30-38 (2006).
103. Fragouli E, Delhanty JD, Wells D. Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls. Fertil. Steril. 88, 247-248 (2007).
104. Wells D, Delhanty JDA. Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization. Mol. Hum. Reprod. 2000 (6), 1055-1062 (2000).
105. Wells D, Escudero T, Levy B, Hirschhorn K, Delhanty JDA, Munné S. First clinical application of comparative genome hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy. Fertil. Steril. 78, 543-549 (2002).
106. Voullaire L, Wilton L, Slater H, Williamson R. Detection of aneuploidy in single cells using comparative genome hybridization. Prenat. Diagn. 19, 846-851 (1999).
107. Voullaire L, Slater H, Williamson R, Wilton L. Chromosome analysis of blastomeres from human embryos by using comparative genomic hybridization. Hum. Genet. 106, 210-217 (2000).
108. Wilton L, Williamson R, McBain J, Edgar D, Voullaire L. Birth of a healthy infant after preimplantation confirmation of euploidy by comparative genomic hybridization. N. Engl. J. Med. 345, 1537-1541 (2001).
109. Wilton L, Voullaire L, Sargeant P, Williamson R, McBain J. Preimplantation aneuploidy screening using comparative genomic hybridization or fluorescence in-situ hybridization of embryos from patients with recurrent implantation failure. Fertil. Steril. 80 (4), 860-868 (2003).
110. Sher G, Keskintepe L, Keskintepe M et al. Oocyte karyotyping by comparative genome hybridization provides a highly reliable method for selecting 'competent' embryos, markedly improving in-vitro fertilization outcome: a multiphase study. Fertil. Steril. 87, 1033-1040 (2007).
111. Yoon TK, Chung HM, Lim JM, Han SY, Ko JJ, Cha KY. Pregnancy and delivery of healthy infants developed from vitrified oocytes in a stimulated in-vitro fertilization embryo transfer program. Fertil. Steril. 74, 180-181 (2000).
112. Yoon TK, Lee DR, Cha KY, Chung HM, Lee WS, Cha KY. Survival rate of human oocytes and pregnancy outcome after vitrification using slush nitrogen in assisted reproductive technologies. Fertil. Steril. 88, 952-956 (2007).
113. Harper JC, Wells D. Recent advances and future developments in PGS. Prenat. Diagn. 19, 1193-1199 (1999).
114. Weier HUG, Munné S, Lersch RA et al. Towards a full karyotype screening of interphase cells: 'FISH and chip' technology. Mol. Cell. Endocrinol. 183, S41-S45 (2001).
115. Kearns WG, Pen R, Benner A, Widra E, Leach R. Comprehensive genetic analyses using a modified whole genome amplification protocol and microarrays to identify genetic disorders and determine embryo implantation from single cells. Fertil. Steril. 88 (Suppl. 1), S236-S237 (2007).
116. Munné S, Steuerwald NM, Wells D, Bethea S, Nowak NJ, Cohen J. Comprehensive aneuploidy screening in single cells using microarray comparative genomic hybridization methods implications for preimplantation genetic diagnosis. Fertil. Steril. 88 (Suppl. 1), S86 (2007).
117. Treff NR, Su J, Mavrianos J, Bergh PA, Miller KA, Scott RT. Accurate 23 chromosome aneuploidy screening in human blastomeres using single nucleotide polymorphism (SNP) microarrays. Fertil. Steril. 88 (Suppl. 1), S1 (2007).