A customized genetic approach to the number one killer: Coronary artery disease

Current Opinion in Cardiology

Volumn 23, Issue 6, 2008, Pages 629-633

  Roberts, Robert ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

9p21 variant; Coronary artery disease; Genetic susceptibility; Risk variant; Single nucleotide polymorphisms

Indexed keywords

ANTICOAGULANT AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; WARFARIN;

AFRICAN AMERICAN; ASIAN; BRUGADA SYNDROME; CARDIOVASCULAR DISEASE; CAUCASIAN; CHROMOSOME 9P; CHROMOSOME 9P21; CLINICAL TRIAL; CORONARY ARTERY DISEASE; CORONARY RISK; DNA MICROARRAY; DRUG COST; ETHNIC DIFFERENCE; ETHNIC GROUP; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HEART ARRHYTHMIA; HEART VENTRICLE ARRHYTHMIA; HEREDITY; HETEROZYGOSITY; HETEROZYGOTE; HIGH THROUGHPUT SCREENING; HOMOZYGOSITY; HOMOZYGOTE; HUMAN; HUMAN GENOME PROJECT; HYPERTROPHIC CARDIOMYOPATHY; LONG QT SYNDROME; LOW DRUG DOSE; NOTE; PHARMACOGENETICS; PRIORITY JOURNAL; RISK FACTOR; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; SUDDEN DEATH;

CHROMOSOMES, HUMAN, PAIR 9; CORONARY ARTERY DISEASE; DEATH, SUDDEN, CARDIAC; EVIDENCE-BASED MEDICINE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; RISK FACTORS;

EID: 55149090262     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/HCO.0b013e32830e6b4e     Document Type: Note

References (50)

1. Investing in our Future: Preventing Chronic Diseases in Canada. Chronic Disease Prevention Alliance of Canada: 2003.
2. Genest JJ, Martin-Munley SS, McNamara JR, et al. Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation 1992; 85:2025-2033.
3. Chaer RA, Billeh R, Massed MG. Genetics and gene manipulation therapy of premature coronary artery disease. Cardiology 2004; 101:122-130.
4. American Heart Association: Heart and Stroke Statistical Update. American Heart Association. 2000 ed. Dallas: 2000.
5. Lloyd-Jones DM, Larson MR, Beiser A, et al. Lifetime risk of developing coronary heart disease. Lancet 1999; 353:89-92.
6. Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study case-control study). Lancet 2004; 364:937-952.
7. Raben N, Plotz P, Byrne BJ. Acid alpha-glucosidase deficiency (glycogenosis type II, Pompe disease). Curr Mol Med 2002; 2:145-166.
8. Gertler M, White PD. Coronary heart disease in young adults: a multidiscipllnary study. Cambridge, Mass: Harvard University Press; 1954.
9. Thomas CB, Cohen BH. The familial occurrence of hypertension and coronary artery disease, with observations concerning obesity and diabetes. Ann Intern Med 1955; 42:90-127.
10. Rose GC. Familial patterns in ischemic heart disease. Br J Prev Soc Med 1964; (18):75-80.
11. Slack J, Evans KA. The increased risk of death from ischaemic heart disease in first-degree relatives of 121 men and 96 women with ischaemic heart disease. J Med Genet 2004; 3:239-257.
12. Rissanen A. Familial occurrence of coronary heart disease: effect of age at diagnosis. Am J Cardiol 1979; 44:60-66.
13. Hamsten A, de Faire U. Risk factors for coronary artery disease in families of young men with myocardial infarction. Am J Cardiol 1987; 59:14-19. Outlines factors of risk for CAD.
14. ten Kate LP, Boman H, Daiger SP, et al. Familial aggregation of coronary heart disease and its relation to known genetic risk factors. Am J Cardiol 1982; 50:945-953.
15. Allen G, Harvald B, Shields JP. Measures of twin concordance. Acta Genet Stat Med 1967; 17:475-481. Outlines the evidence for genetic susceptibility for CAD.
16. McPherson R, Pertsemlidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease. Science 2007; 316:1488-1491. The first common gene, 9p21, for CAD.
17. Helgadottir A, Thorleifsson G, Manolescu A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 2007; 316:1491-1493. Confirmation of 9p21 as a risk factor for MI.
18. Wellcome Trust Case Consortium. Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447:661-678. Confirmation of 9p21 as a risk factor for CAD and MI.
19. Samani NJ, Erdmann J, Hall AS, et al. Genome-wide association analysis of coronary artery disease. N Eng J Med 2007; 357:443-453.
20. Broadbent HM, Peden JF, Lorkowski S, et al. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked, SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet 2008; 17:806-814.
21. Service RF. Pharmacogenomics: going from genome to pill. Science 2005; 308:1858-1860.
22. Holden C. Race and medicine. Science 2003; 302:594-596.
23. National Heart LaBI. NHLBI Fact Book, Fiscal Year 2002. Bethesda, MD: 2003.
24. Bristow MR, O'Connell JB. Myocardial diseases. In: Kelley WN, Watanabe AM, editors. Textbook of Internal Medicine. Philadelphia: J.B. Lippincott Co.; 1992. pp. 150-157.
25. Zipes DP, Wellens HJJ. Sudden cardiac death. Circ Res 1998; 98:2334-2351.
26. Roberts R. Genomics and cardiac arrhythmias. J Am Coll Cardiol 2006; 47:9-21.
27. Marian AJ, Roberts R. Molecular basis of hypertrophic and dilated cardiomyo-pathy. Tex Heart Inst J 1994; 21:6-15.
28. Roberts R. Mechanisms of disease: genetic mechanisms of atrial fibrillation. Nat Clin Pract 2006; 3:276-282.
29. Friedlander Y, Siscovick DS, Weinmann S, et al. Family history as a risk factor for primary cardiac arrest. Circ Res 1998; 97:155-160.
30. Jouven X, Desnos M, Guerot C, Ducimetiere P. Predicting sudden death in the population: the Paris Prospective Study I. Circulation 1999; 97:1978-1983.
31. Marinucci P. Risk of torsades de pointes with noncardiac drugs: grapefruit juice is source of potentially life threatening adverse drug reactions. BMJ 2001; 322-347.
32. Splawski I, Timothy KW, Tateyama M, et al. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science 2002; 297:1333-1336.
33. Marian AJ, Roberts R. The molecular genetic basis for hypertrophic cardiomyopathy. J Mol Cell Cardiol 2001; 33:655-670.
34. Geisterfer-Lowrance AA, Christe M, Conner DA, et al. A mouse model of familial hypertrophic cardiomyopathy. Science 1996; 272:731-734.
35. Adam MD, Kelley JM, Gocayne JD, et al. Complementary DNA sequencing: expressed sequence tags and human genome project. Science 1991; 252:1651-1656.
36. Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science 2001; 291:1304-1351.
37. Hirshhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 2005; 6:95-108. Outlines the basis for Case Control Association Studies.
38. Roberts R, Stewart AFR. Personalized medicine: a future prerequisite for the prevention of coronary artery disease. Am Heart J 2006; 4:222-227. Implications of personalized medicine.
39. Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445:881-885.
40. Amundadottir LT, Sulem P, Gudmundsson J, et al. A common variant associated with prostate cancer in European and African populations. Nat Genet 2006; 38:652-658.
41. Graham RR, Kozyrev SV, Baechler EC, et al. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 2006; 38:550-555.
42. Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005; 308:385-389.
43. Kyndt F, Probst V, Potet F, et al. Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family. Circulation 2001; 104:3081-3086.
44. Frigola J, Song J, Stirzaker C, et al. Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet 2006; 38:540-549.
45. Talmud PJ, Copper JA, Palmen J, et al. Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men. Clin Chem 2008; 54:467-474.
46. Chen Z, Qian Q, Wang J, et al. A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease. Mol Biol Rep 2008:1-5.
47. Hinohara K, Nakajima T, Takahashi M, et al. Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations. J Hum Genet 2008; 53:357-359.
48. Helgadottir A, Thornleifsson G, Magnusson KP, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008; 40:217-224. 9p21, a risk variant for aneurysms.
49. Matarin M, Brown WM, Singleton A, et al. Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21. Stroke 2008; 39:1586-1589. 9p21, a risk variant for stroke.
50. Bush Signs Genetic Nondiscrimination Bill Into Law. http://www.genomeweb. com/issues/news/147069-1.html 2008 May 21. Passing of GINA, which will significantly facilitate the introduction and application of personalized medicine.