Long-term moderate ethanol consumption restores insulin sensitivity in high-fat-fed rats by increasing SLC2A4 (GLUT4) in the adipose tissue by AMP-activated protein kinase activation

Journal of Endocrinology

Volumn 199, Issue 1, 2008, Pages 95-104

  Feng, Li ^a,b   Gao, Ling ^a   Guan, Qingbo ^a   Hou, Xiaolei ^a   Wan, Qiang ^a   Wang, Xiangdong ^c   Zhao, Jiajun ^a  

^a SHANDONG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MYOCYTE ENHANCER FACTOR 2; SATURATED FATTY ACID;

ADIPOCYTE; ADIPOSE TISSUE; ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DIETARY INTAKE; ENZYME ACTIVATION; FAT INTAKE; FATTY ACID ANALYSIS; GLUCOSE INTOLERANCE; INCUBATION TIME; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LONG TERM CARE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION;

ADIPOCYTES; ADIPONECTIN; ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DIETARY FATS; ENZYME ACTIVATION; ETHANOL; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 4; MALE; MYOGENIC REGULATORY FACTORS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 55049140007     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0026     Document Type: Article

References (48)

1. Abel ED, Peroni O, Kim JK, Kim Y-B, Boss O, Hadro E, Minnemann T, Shulman GI & Kahn BB 2001 Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409 729-733.
2. Belfort R, Mandarino L, Kashyap S, Wirfel K, Pratipanawatr T, Berria R, DeFronzo RA & Cusi K 2005 Dose-response effect of elevated plasma free fatty acid on insulin signaling. Diabetes 54 1640-1648.
3. Beulens JW, van Beers RM, Stolk RP, Schaafsma G & Hendriks HF 2006 The effect of moderate alcohol consumption on fat distribution and adipocytokines. Obesity 14 60-66.
4. Beulens JW, van Loon LJ, Kok FJ, Pelsers M, Bobbert T, Spranger J, Helander A & Hendriks HT 2007 The effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: a human intervention study. Diabetologia 50 1388-1392.
5. Boden G & Chen X 1995 Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes.Journal of Clinical Investigation 96 1261-1268.
6. Buhl ES, Jessen N, Schmitz O, Pedersen SB, Pedersen O, Holman GD & Lund S 2001 Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner. Diabetes 50 12-17.
7. Carling D 2004 The AMP-activated protein kinase cascade - a unifying system for energy control. Trends in Biochemical Sciences 29 18-24.
8. Cunningham CC, Coleman WB & Spach PI 1990 The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism. Alcohol and Alcoholism 25 127-136.
9. Furuya DT, Binsack R & Machado UF 2003 Low ethanol consumption increases insulin sensitivity in Wistar rats. Brazilian Journal of Medical and Biological Research 36 125-130.
10. Gaidhu MP, Fediuc S & Ceddia RB 2006 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes. Journal of Biological Chemistry 281 25956-25964.
11. Hawley SA, Davison M, Woods A, Davies SP Beri RK, Carling D & Hardie DG 1996 Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. Journal of Biological Chemistry 271 27879-27887.
12. Holmes BF, Sparling Dp, Olson AL, Winder WW & Dohm GL 2005 Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase. American Journal of Physiology. Endocrinology and Metabolism 289 E1071-E1076.
13. Hong-Brown LQ, Brown CR, Huber DS & Lang CH 2007 Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes. Journal of Biological Chemistry 282 3702-3712.
14. Jessen N, Pold R, Buhl ES, Jensen LS, Schmitz O & Lund S 2003 Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles. Journal of Applied Physiology 94 1373-1379.
15. Jing M & Ismail-Beigi F 2006 Role of 5′-AMP-activated protein kinase in stimulation of glucose transport in response to inhibition of oxidative phosphorylation. American Journal of Physiology. Cell Physiology 290 C484-C491.
16. Kao WH, Puddey IB, Boland LL, Watson RL & Brancati FL 2001 Alcohol consumption and the risk of type 2 diabetes mellitus: atherosclerosis risk in communities study. American Journal of Epidemiology 154 748-757.
17. Kemp BE, Mitchelhill KI, Stapleton D, Michell BJ, Chen ZP & Witters LA 1999 Dealing with energy demand: the AMP-activated protein kinase. Trends in Biochemical Sciences 24 22-25.
18. Kiechl S, Willeit J, Poewe W, Egger G, Oberhollenzer F, Muggeo M & Bonora E 1996 Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study). BMJ 313 1040-1044.
19. Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD & Wallberg-Henriksson H 2003 5-Amino-imidazole carboxamide, riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes 52 1066-1072.
20. Koppes LL, Dekker JM, Hendriks HF, Bouter LM & Heine RJ 2005 Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care 28 719-725.
21. Kurth-Kraczek EJ, Hirshman MF, Goodyear LJ & Winder VTW 1999 5′ AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes 48 1667-1671.
22. Lee JS, Pinnamaneni SK, Eo SJ, Cho IH, Pyo JH, Kim CK, Sinclair AJ, Febbraio MA & Watt MJ 2006 Saturated, but not N-6 polyunsaturated fatty acids, induce insulin resistance: role of intramuscular accumulation of lipid metabolites. Journal of Applied Physiology 100 1467-1474.
23. Liu ML, Olson AL, Edgington NP, Moye-Rowley WS & Pessin JE 1994 Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/muscle-adipose facilitative glucose transporter gene. Journal of Biological Chemistry 269 28514-28521.
24. Liu Y, Wan Q, Guan Q, Gao L & Zhao J 2006 High-fat diet feeding impairs both the expression and activity of AMPKa in rats'skeletal muscle. Biochemical and Biophysical Research Communications 339 701-707.
25. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF & Turner RC 1985 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 412-419.
26. Minokoshi Y, Kahn CR & Kahn BB 2003 Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. Journal of Biological Chemistry 278 33609-33612.
27. Mora S & Pessin JE 2000 The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter. Journal of Biological Chemistry 275 16323-16328.
28. Olsen GS & Hansen BF 2002 AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism 283 E965-E970.
29. Salt IP, Connell JM & Gould GW 2000 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes 49 1649-1656.
30. Santalucia T, Moreno H, Palacin M, Yacoub MH, Brand NJ & Zorzano A 2001 A novel functional co-operation between MyoD, MEF2 and TRalpha1 is sufficient for the induction of GLUT4 gene transcription. Journal of Molecular Biology 314 195 204.
31. Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F & Kahn BB 1993 Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. Journal of Biological Chemistry 268 22243-22246.
32. Sierksma A, Patel H, Ouchi N, Kihara S, Funahashi T, Heine RJ, Grobbee DE, Kluft C & Hendriks HF 2004 Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care 27 184-189.
33. Sparagna GC, Jones CE & Hickson-Bick DL 2004 Attenuation of fatty acid-induced apoptosis by low-dose alcohol in neonatal rat cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology 287 H2209-H2215.
34. Sriwigitkamol A, Ivy JL, Christ-Roberts C, DeFronzo RA, Mandarino LJ & Musi N 2006 LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training. American Journal of Physiology. Endocrinology and Metabolism 290 E925-E932.
35. Tanaka T, Masuzaki H, Yasue S, Ebihara K, Shiuchi T, Ishii T, Arai N, Hirata M, Yamamoto H, Hayashi T et al. 2007 Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet. Cell Metabolism 5 395-402.
36. Tanti JF, Cormont M, Gremeaux T & Le Marchand-Brustel Y 2001 Assays of glucose entry, glucose transporter amount, and translocation. Methods in Molecular Biology 155 157-165.
37. Thai MV, Gurnswamy S, Cao KT, Pessin JE & Olson AL 1998 Myocyte enhancer factor 2 (MEF2)-binding site is required for GLUT4 gene expression in transgenic mice. Regulation of MEF2 DNA binding activity in insulin-deficient diabetes. Journal of Biological Chemistry 273 14285-14292.
38. Tong Y, Huang DS & Bryer-Ash M 2006 Effects of globular adiponectin, glucose and free fatty acid on AMPK and ACC phosphorylation in INS-1 beta cells. Beying Da Xue Xue Bao 38 609-613.
39. Wannamethee SG, Shaper AG, Perry IJ & Alberti KG 2002 Alcohol consumption and the incidence of type II diabetes. Journal of Epidemiology and Community Health 56 542-548.
40. Wei M, Gibbons LW, Mitchell TL, Kampert JB & Blair SN 2000 Alcohol intake and incidence of type 2 diabetes in men. Diabetes Care 23 18-22.
41. Wilkes JJ, DeForrest LL & Nagy LE 1996 Chronic ethanol feeding in a high-fat diet decreases insulin-stimulated glucose transport in rat adipocytes. American Journal of Physiology 271 E477-E484.
42. Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R & Goldstein BJ 2003 Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of achponectin in primary rat achpocytes. Diabetes 52 1355-1363.
43. Wu Y Song P, Xu J, Zhang M & Zen MH 2007 Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. Journal of Biological Chemistry 282 9777-9788.
44. Yamaguchi S, Katahira H, Ozawa S, Nakamichi Y, Tanaka T, Shimoyama T, Takahashi K, Yoshimoto K, Imaizumi MO, Nagamatsu S et al. 2005 Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. American Journal of Physiology. Endocrinology and Metabolism 289 E643-E649.
45. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K et al. 2002 Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 8 1288-1295.
46. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L & Kahn BB 2005 Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436 356-362.
47. You M, Matsumoto M, Pacold CM, Cho WK & Crabb DW 2004 The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127 1798-1808.
48. You M, Considine RV, Leone TC, Kelly DP & Crabb DW 2005 Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 42 568-577.