A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding

Molecular Cancer

Volumn 7, Issue , 2008, Pages

  Ko, Emily Ray ^a   Ko, Dennis ^a   Chen, Carolyn ^a   Lipsick, Joseph S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; HISTONE H4; PROTEIN C MYB; PROTEIN MYB; DNA; ONCOPROTEIN;

ACIDITY; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CELL NUCLEUS; CHROMATIN; CONTROLLED STUDY; GENE ACTIVATION; GENE TARGETING; GENETIC CONSERVATION; HUMAN; HUMAN CELL; MUTAGENESIS; PHYLOGENY; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RESIDUE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL NUCLEUS; CHROMATIN; CONSERVED SEQUENCE; DNA; HUMANS; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS V-MYB; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; TRANSCRIPTIONAL ACTIVATION;

EID: 55049129939     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-7-77     Document Type: Article

References (65)

1. Ganter B Lipsick JS Myb and oncogenesis Adv Cancer Res 1999, 76:21-60 10218098
2. Mucenski ML McLain K Kier AB Swerdlow SH Schreiner CM Miller TA Pietryga DW Scott WJ Jr Potter SS A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis Cell 1991, 65(4):677-689 1709592
3. Malaterre J Carpinelli M Ernst M Alexander W Cooke M Sutton S Dworkin S Heath JK Frampton J McArthur G Clevers H Hilton D Mantamadiotis T Ramsay RG c-Myb is required for progenitor cell homeostasis in colonic crypts Proc Natl Acad Sci USA 2007, 104(10):3829-3834 1820669 17360438
4. Toscani A Mettus RV Coupland R Simpkins H Litvin J Orth J Hatton KS Reddy EP Arrest of spermatogenesis and defective breast development in mice lacking A-myb Nature 1997, 386(6626):713-717 9109487
5. Tanaka Y Patestos NP Maekawa T Ishii S B-myb is required for inner cell mass formation at an early stage of development J Biol Chem 1999, 274(40):28067-28070 10497154
6. Davidson CJ Ray E Lipsick J Evolution of Myb Proteins Myb Transcription Factors: Their Role in Growth, Differentiation and Disease Norwell, MA, USA: Kluwer Academic Publishers Frampton J 1 2005, 2:1-34
7. Rabinowicz PD Braun EL Wolfe AD Bowen B Grotewold E Maize R2R3 Myb genes: Sequence analysis reveals amplification in the higher plants Genetics 1999, 153(1):427-444 1460732 10471724
8. Sterner DE Wang X Bloom MH Simon GM Berger SL The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex J Biol Chem 2002, 277(10):8178-8186 11777910
9. Boyer LA Langer MR Crowley KA Tan S Denu JM Peterson CL Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes Mol Cell 2002, 10(4):935-942 12419236
10. Boyer LA Latek RR Peterson CL The SANT domain: A unique histone-tail-binding module? Nat Rev Mol Cell Biol 2004, 5(2):158-163 15040448
11. Grune T Brzeski J Eberharter A Clapier CR Corona DF Becker PB Muller CW Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI Mol Cell 2003, 12(2):449-460 14536084
12. Lefstin JA Yamamoto KR Allosteric effects of DNA on transcriptional regulators Nature 1998, 392(6679):885-888 9582068
13. Yu L Sabet N Chambers A Morse RH The N-terminal and C-terminal domains of RAP1 are dispensable for chromatin opening and GCN4-mediated HIS4 activation in budding yeast J Biol Chem 2001, 276(35):33257-33264 11413146
14. Graham IR Haw RA Spink KG Halden KA Chambers A In vivo analysis of functional regions within yeast Rap1p Mol Cell Biol 1999, 19(11):7481-7490 84746 10523636
15. Lane T Ibanez C Garcia A Graf T Lipsick J Transformation by v-myb correlates with trans-activation of gene expression Mol Cell Biol 1990, 10(6):2591-2598 360617 2160580
16. Grasser FA LaMontagne K Whittaker L Stohr S Lipsick JS A highly conserved cysteine in the v-Myb DNA-binding domain is essential for transformation and transcriptional trans-activation Oncogene 1992, 7(5):1005-1009 1570148
17. Mink S Kerber U Klempnauer KH Interaction of C/EBPbeta and v-Myb is required for synergistic activation of the mim-1 gene Mol Cell Biol 1996, 16(4):1316-1325 231115 8657104
18. Tahirov TH Sato K Ichikawa-Iwata E Sasaki M Inoue-Bungo T Shiina M Kimura K Takata S Fujikawa A Morii H Kumasaka T Yamamoto M Ishii S Ogata K Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter Cell 2002, 108(1):57-70 11792321
19. Sieweke MH Tekotte H Frampton J Graf T MafB represses erythroid genes and differentiation through direct interaction with c-Ets-1 Leukemia 1997, 11(Suppl 3):486-488 9209434
20. Ganter B Fu S Lipsick JS D-type cyclins repress transcriptional activation by the v-Myb but not the c-Myb DNA-binding domain Embo J 1998, 17(1):255-268 1170376 9427759
21. Ogata K Morikawa S Nakamura H Sekikawa A Inoue T Kanai H Sarai A Ishii S Nishimura Y Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices Cell 1994, 79(4):639-648 7954830
22. Konig P Giraldo R Chapman L Rhodes D The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA Cell 1996, 85(1):125-136 8620531
23. Hanaoka S Nagadoi A Nishimura Y Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities Protein Sci 2005, 14(1):119-130 2253311 15608118
24. Thompson JD Gibson TJ Plewniak F Jeanmougin F Higgins DG The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools Nucleic Acids Res 1997, 25(24):4876-4882 147148 9396791
25. Chen RH Lipsick JS Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae Mol Cell Biol 1993, 13(7):4423-4431 360011 8321242
26. Ness SA Marknell A Graf T The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene Cell 1989, 59(6):1115-1125 2688896
27. Dash AB Orrico FC Ness SA The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb Genes Dev 1996, 10(15):1858-1869 8756344
28. Dubendorff JW Whittaker LJ Eltman JT Lipsick JS Carboxy-terminal elements of c-Myb negatively regulate transcriptional activation in cis and in trans Genes Dev 1992, 6(12B):2524-2535 1340467
29. Hu YL Ramsay RG Kanei-Ishii C Ishii S Gonda TJ Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain Oncogene 1991, 6(9):1549-1553 1923521
30. Sakura H Kanei-Ishii C Nagase T Nakagoshi H Gonda TJ Ishii S Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene Proc Natl Acad Sci USA 1989, 86(15):5758-5762 297709 2668947
31. Ibanez CE Garcia A Stober-Grasser U Lipsick JS DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation J Virol 1988, 62(11):4398-4402 253882 2845150
32. Smith CL Hager GL Transcriptional regulation of mammalian genes in vivo. A tale of two templates J Biol Chem 1997, 272(44):27493-27496 9346875
33. Ness SA Kowenz-Leutz E Casini T Graf T Leutz A Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types Genes Dev 1993, 7(5):749-759 7684005
34. Ruthenburg AJ Li H Patel DJ Allis CD Multivalent engagement of chromatin modifications by linked binding modules Nat Rev Mol Cell Biol 2007, 8(12):983-994 18037899
35. Oelgeschlager M Janknecht R Krieg J Schreek S Luscher B Interaction of the co-activator CBP with Myb proteins: Effects on Myb-specific transactivation and on the cooperativity with NF-M Embo J 1996, 15(11):2771-2780 450213 8654374
36. Dai P Akimaru H Tanaka Y Hou DX Yasukawa T Kanei-Ishii C Takahashi T Ishii S CBP as a transcriptional coactivator of c-Myb Genes Dev 1996, 10(5):528-540 8598284
37. Luger K Mader AW Richmond RK Sargent DF Richmond TJ Crystal structure of the nucleosome core particle at 2.8 A resolution Nature 1997, 389(6648):251-260 9305837
38. Wu J Grunstein M 25 years after the nucleosome model: Chromatin modifications Trends Biochem Sci 2000, 25(12):619-623 11116189
39. Ling X Harkness TA Schultz MC Fisher-Adams G Grunstein M Yeast histone H3 and H4 amino termini are important for nucleosome assembly in vivo and in vitro: Redundant and position-independent functions in assembly but not in gene regulation Genes Dev 1996, 10(6):686-699 8598296
40. Mo X Kowenz-Leutz E Laumonnier Y Xu H Leutz A Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain Genes Dev 2005, 19(20):2447-2457 1257399 16195416
41. Georlette D Ahn S MacAlpine DM Cheung E Lewis PW Beall EL Bell SP Speed T Manak JR Botchan MR Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells Genes Dev 2007, 21(22):2880-2896 2049191 17978103
42. Aasland R Stewart AF Gibson T The sant domain: A putative dna-binding domain in the swi-snf and ada complexes, the transcriptional co-repressor n-cor and tfiiib Trends In Biochemical Sciences 1996, 21(3):87-88 8882580
43. Ishiguro A Kassavetis GA Geiduschek EP Essential roles of Bdp1, a subunit of RNA polymerase III initiation factor TFIIIB, in transcription and tRNA processing Mol Cell Biol 2002, 22(10):3264-3275 133792 11971960
44. Andres ME Burger C Peral-Rubio MJ Battaglioli E Anderson ME Grimes J Dallman J Ballas N Mandel G CoREST: A functional corepressor required for regulation of neural-specific gene expression Proc Natl Acad Sci USA 1999, 96(17):9873-9878 22303 10449787
45. Codina A Love JD Li Y Lazar MA Neuhaus D Schwabe JW Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors Proc Natl Acad Sci USA 2005, 102(17):6009-6014 1087922 15837933
46. Korenjak M Taylor-Harding B Binne UK Satterlee JS Stevaux O Aasland R White-Cooper H Dyson N Brehm A Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes Cell 2004, 119(2):181-193 15479636
47. Henikoff S Furuyama T Ahmad K Histone variants, nucleosome assembly and epigenetic inheritance Trends Genet 2004, 20(7):320-326 15219397
48. Fourel G Revardel E Koering CE Gilson E Cohabitation of insulators and silencing elements in yeast subtelomeric regions Embo J 1999, 18(9):2522-2537 1171334 10228166
49. Fourel G Miyake T Defossez PA Li R Gilson E General regulatory factors (GRFs) as genome partitioners J Biol Chem 2002, 277(44):41736-41743 12200417
50. Chasman DI Lue NF Buchman AR LaPointe JW Lorch Y Kornberg RD A yeast protein that influences the chromatin structure of UASG and functions as a powerful auxiliary gene activator Genes Dev 1990, 4(4):503-514 2361590
51. Lieb JD Liu X Botstein D Brown PO Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association Nat Genet 2001, 28(4):327-334 11455386
52. Raisner RM Hartley PD Meneghini MD Bao MZ Liu CL Schreiber SL Rando OJ Madhani HD Histone variant H2A.Z marks the 5′ ends of both active and inactive genes in euchromatin Cell 2005, 123(2):233-248 2039754 16239142
53. Goncalves PM Maurer K van Nieuw Amerongen G Bergkamp-Steffens K Mager WH Planta RJ C-terminal domains of general regulatory factors Abf1p and Rap1p in Saccharomyces cerevisiae display functional similarity Mol Microbiol 1996, 19(3):535-543 8830244
54. Guillemette B Bataille AR Gevry N Adam M Blanchette M Robert F Gaudreau L Variant histone H2A.Z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning PLoS Biol 2005, 3(12):e384 1275524 16248679
55. Li B Pattenden SG Lee D Gutierrez J Chen J Seidel C Gerton J Workman JL Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling Proc Natl Acad Sci USA 2005, 102(51):18385-18390 1317944 16344463
56. Zhang H Roberts DN Cairns BR Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss Cell 2005, 123(2):219-231 16239141
57. Biedenkapp H Borgmeyer U Sippel AE Klempnauer KH Viral myb oncogene encodes a sequence-specific DNA-binding activity Nature 1988, 335(6193):835-837 3185713
58. Manak JR Wen H Tran V Andrejka L Lipsick JS Loss of Drosophila Myb interrupts the progression of chromosome condensation Nat Cell Biol 2007, 9(5):581-587 17450131
59. Letunic I Copley RR Pils B Pinkert S Schultz J Bork P SMART 5: Domains in the context of genomes and networks Nucleic Acids Res 2006:34 Database D257-260 1347442 16381859
60. Wells JA Systematic mutational analyses of protein-protein interfaces Methods Enzymol 1991, 202:390-411 1723781
61. Grasser FA Graf T Lipsick JS Protein truncation is required for the activation of the c-myb proto-oncogene Mol Cell Biol 1991, 11(8):3987-3996 361198 2072904
62. Dini PW Lipsick JS Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo Mol Cell Biol 1993, 13(12):7334-7348 364804 8246954
63. Fu SL Lipsick JS FAETL motif required for leukemic transformation by v-Myb J Virol 1996, 70(8):5600-5610 190520 8764074
64. Sleeman JP Xenopus A-myb is expressed during early spermatogenesis Oncogene 1993, 8(7):1931-1941 8510936
65. Evan GI Lewis GK Bishop JM Isolation of monoclonal antibodies specific for products of avian oncogene myb Mol Cell Biol 1984, 4(12):2843-2850 369296 6084811