Embryonic stem cells as a platform for analyzing neural gene transcription

Stem Cells

Volumn 26, Issue 7, 2008, Pages 1841-1849

  Zhang, Xiaodong ^a   Horrell, Scott A ^a   Delaney, Deany ^a   Gottlieb, David I ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Embryonic stem cells; Gene targeting; Neural differentiation; Olig2; Promoter; Transcription

Indexed keywords

OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; RETINOIC ACID; SONIC HEDGEHOG PROTEIN;

ARTICLE; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL LINEAGE; EMBRYONIC STEM CELL; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; DNA; EMBRYO CULTURE TECHNIQUES; EMBRYONIC STEM CELLS; GENE DELETION; HEDGEHOG PROTEINS; HUMANS; MICE; MODELS, GENETIC; NERVE TISSUE PROTEINS; NEURONS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRETINOIN;

ERINACEIDAE; MAMMALIA; MUS;

EID: 55049098278     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0902     Document Type: Article

References (40)

1. Allis CD, Jenuwein T, Reinberg D. 2007. Epigenetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2007.
2. Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 2005;19:1129 -1155.
3. Ligon KL, Fancy SP, Franklin RJ et al. Olig gene function in CNS development and disease. Glia 2006;54:1-10.
4. Lu QR, Yuk D, Alberta JA et al. Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 2000;25:317-329.
5. Zhou Q, Anderson DJ. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 2002;109:61-73.
6. Zhou Q, Choi G, Anderson DJ. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron 2001;31:791-807.
7. Novitch BG, Chen AI, Jessell TM. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 2001;31:773-789.
8. Lu QR, Sun T, Zhu Z et al. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 2002;109:75-86.
9. Takebayashi H, Nabeshima Y, Yoshida S et al. The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr Biol 2002;12:1157-1163.
10. Zhou Q, Wang S, Anderson DJ. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 2000;25:331-343.
11. Takebayashi H, Yoshida S, Sugimori M et al. Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech Dev 2000;99:143-148.
12. Shirasaki R, Pfaff SL. Transcriptional codes and the control of neuronal identity. Annu Rev Neurosci 2002;25:251-281.
13. Lin YW, Deveney R, Barbara M et al. OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. Cancer Res 2005;65:7151-7158.
14. Sun T, Hafler BP, Kaing S et al. Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol 2006;292:152-164.
15. Xian HQ, Werth K, Gottlieb DI. Promoter analysis in ES cell-derived neural cells. Biochem Biophys Res Commun 2005;327:155-162.
16. Alvarez M, Rhodes SJ, Bidwell JP. Context-dependent transcription: all politics is local. Gene 2003;313:43-57.
17. Bender MA, Byron R, Ragoczy T et al. Flanking HS-62.5 and 3′ HS1, and regions upstream of the LCR, are not required for β-globin transcription. Blood 2006;108:1395-1401.
18. Hu X, Eszterhas S, Pallazzi N et al. Transcriptional interference among the murine β-like globin genes. Blood 2007;109:2210-2216.
19. Misteli T. Beyond the sequence: cellular organization of genome function. Cell 2007;128:787-800.
20. Toledo F, Liu CW, Lee CJ et al. RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. Nucleic Acids Res 2006;34:e92.
21. Wichterle H, Lieberam I, Porter J et al. Directed differentiation of embryonic stem cells into motor neurons. Cell 2002;110:385-397.
22. Miles GB, Yohn DC, Wichterle H et al. Functional properties of motoneurons derived from mouse embryonic stem cells. J Neurosci 2004;24:7848-7858.
23. Soundararajan P, Miles GB, Rubin LL et al. Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. J Neurosci 2006;26:3256-3268.
24. Kawasaki H, Mizuseki K, Nishikawa S et al. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 2000;28:31-40.
25. Lee SH, Lumelsky N, Studer L et al. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 2000;18:675-679.
26. Nistor GI, Totoiu MO, Haque N et al. Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia 2005;49:385-396.
27. Chung S, Shin BS, Hwang M et al. Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro. STEM CELLS 2006;24:1583-1593.
28. Lamba DA, Karl MO, Ware CB et al. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci U S A 2006;103:12769-12774.
29. Salero E, Hatten ME. Differentiation of ES cells into cerebellar neurons. Proc Natl Acad Sci U S A 2007;104:2997-3002.
30. Bain G, Kitchens D, Yao M et al. Embryonic stem cells express neuronal properties in vitro. Dev Biol 1995;168:342-357.
31. Sambrook J, Russell D. Molecular Cloning - A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2001.
32. Wu X, Li Y, Crise B et al. Transcription start regions in the human genome are favored targets for MLV integration. Science 2003;300:1749-1751.
33. Zhang X, Cai J, Klueber KM et al. Induction of oligodendrocytes from adult human olfactory epithelial-derived progenitors by transcription factors. STEM CELLS 2005;23:442-453.
34. Zhang X, Cai J, Klueber KM et al. Role of transcription factors in motoneuron differentiation of adult human olfactory neuroepithelial-derived progenitors. STEM CELLS 2006;24:434-442.
35. Xian HQ, McNichols E, St Clair A et al. A subset of ES-cell-derived neural cells marked by gene targeting. STEM CELLS 2003;21:41-49.
36. Xian H, Gottlieb DI. Dividing Olig2-expressing progenitor cells derived from ES cells. Glia 2004;47:88-101.
37. Shin S, Xue H, Mattson MP et al. Stage-dependent Olig2 expression in motor neurons and oligodendrocytes differentiated from embryonic stem cells. Stem Cells Dev 2007;16:131-141.
38. Billon N, Jolicoeur C, Ying QL et al. Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells. J Cell Sci 2002;115:3657-3665.
39. Wallace HA, Marques-Kranc F, Richardson M et al. Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell 2007;128:197-209.
40. Ribich S, Tasic B, Maniatis T. Identification of long-range regulatory elements in the protocadherin-α gene cluster. Proc Natl Acad Sci U S A 2006;103:19719-19724.