Post-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury, and lethality in a mouse model

Laboratory Investigation

Volumn 88, Issue 11, 2008, Pages 1178-1191

  Roche, James K ^a   Stone, Matthew K ^a   Gross, Lisa K ^a   Lindner, Matthew ^a   Seaner, Regina ^a   Pincus, Seth H ^b   Obrig, Tom G ^a,c  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Microbiology and Immunology ^*  (United States)

Author keywords

Antibodies; Inflammation; Monocytes macrophages; Neutrophils; Rodent

Indexed keywords

CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; EPITOPE; GLYCOGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY RAC 17; MONOCLONAL ANTIBODY RAC 18; MONOCLONAL ANTIBODY RAC 23; MONOCYTE CHEMOTACTIC PROTEIN 1; RIBONUCLEASE; RICIN; RICIN A; RICIN ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRIN DEPOSITION; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; KUPFFER CELL; LETHALITY; LEUKOCYTE ACTIVATION; LIVER CELL; LIVER INJURY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL;

EID: 54949121317     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2008.83     Document Type: Article

References (30)

1. Choi J, Au JH. Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol 2006;290:G847-G851.
2. Navarro VJ, Senior JR. Drug-related hepatotoxicity. New Engl J Med 2006;354:731-739.
3. Cook DL, David J, Griffiths GD. Retrospective identification of ricin in animal tissues following administration by pulmonary and oral routes. Toxicology 2006;223:61-70.
4. Endo Y, Mitsui K, Motizuki M, et al. The mechanism of action of ricin and related toxin lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28S ribosomal RNA caused by the toxins. J Biol Chem 1987;262:5908-5912.
5. Lord MJ, Jolliffe NA, Marsden CA, et al. Ricin: mechanisms of cytotoxicity. Toxicol Rev 2003;22:53-65.
6. Derenzini M, Bonetti E, Marinozzi V, et al. Toxic effects of ricin. Virchows Arch B Cell Pathol 1976;20:15-28.
7. Bingen A, Creppy EE, Gut JP, et al. The Kupffer cell is the first target in ricin-induced hepatitis. J Submicrosc Cytol 1987;19:247-256.
8. Korcheva V, Wong J, Corless C, et al. Administration of ricin induces a severe inflammatory response via non-redundant stimulation of ERK, JNK, and P38 MAPK and provides a mouse model of hemolytic uremic syndrome. Am J Pathol 2005;166:323-339.
9. Chen UF, Jobanputra P, Barton P, et al. A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness. Health Technol Assess 2006;10:1-22.
10. Bisikirska B, Herold C, Kevan C. Use of anti-CD3 monoclonal antibody to induce immune regulation in type 1 diabetes. Ann NY Acad Sci 2004;1037:1-9.
11. Ferrara N, Damico L, Shams N, et al. Development of Ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment as therapy for neovascular age-related macular degeneration. Retina 2006;26:859-870.
12. Roche JK, Keepers TR, Gross LK, et al. CXCL1/KC and CXCL2/MIP-2 are critical effectors and potential targets for therapy of Escherichia coli 0157:H7-assoicated renal inflammation. Am J Pathol 2007;170:526-537.
13. Maddaloni M, Cooke C, Wilkinson R, et al. Immunological characteristics associated with the protective efficacy of antibodies to ricin. J Immunol 2004;172:6221-6228.
14. Cook HC. Theory and practice of histological techniques. In: Bancroft JD, Stevens A (eds). Manual of Histological Demonstration Techniques, 2nd edn. Butterworths: London, 1974, 134 pp.
15. Keepers T, Psotka M, Gross L, et al. A murine model of HUS: Shiga toxin with lipopolysaccharide mimics the renal damage and physiological response of human disease. J Am Soc Nephrol 2007;17:526-537.
16. Rainey GJA, Young JAT. Anti-toxins: novel strategies to target agents of bioterrorism. Nat Rev Microbiol 2004;2:721-726.
17. Foxwell BMJ, Detre SI, Donovan TA, et al. The use of anti-ricin antibodies to protect mice intoxicated with ricin. Toxicology 1985;34:79-88.
18. Phillips MJ, Poucell S, Patterson J. The normal liver. In: Phillips MJ, Poucell S, Patterson J, Valencia P (eds). The Liver; An Atlas and Text of Ultrastructural Pathology. Raven Press: New York, 1987, pp 1-35.
19. Fox ES, Thomas P, Broitman SA. Comparative studies of endotoxin uptake by isolated rat Kupffer and peritoneal cells. Infect Immun 1987;55:2962-2966.
20. Parker GA, Picut CA. Liver immunobiology. Toxicol Pathol 2005;33:52-62.
21. Perry A, Ofek I. Inhibition of blood clearance and hepatic tissue binding of Escherichia coli by liver lectin-specific sugars and glycoproteins. Infect Immun 1984;41:257-262.
22. Gregory SH, Wing EJ. Neutrophil-Kupffer cell interaction: a critical component of host defenses in systemic bacterial infections. J Leukoc Biol 2002;72:239-248.
23. Fadok VA, Bratton DL, Konowal A, et al. Macrophages that have ingested apoptotic cells in vitro inhibit pro-inflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, E2 and PAF. J Clin Invest 1998;101:890-898.
24. Akerman P, Cote P, Yang SQ, et al. Antibodies to tumor necrosis factor inhibit liver regeneration after partial hepatectomy. Am J Physiol 1992;263:G579-G585.
25. Cressman DE, Greenbaum LE, DeAngelis RA, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996;274:1379-1383.
26. Taniguchi TT, Toyoshima K, Fukao K, et al. Presence of hematopoietic stem cells in the adult liver. Nat Med 1996;2:198-203.
27. Hewetson JF, Rivera VR, Creasia DA, et al. Protection of mice from inhaled ricin by vaccination with ricin or by passive treatment with heterologous antibody. Vaccine 1993;11:743-746.
28. Griffiths GD, Lindsay CD, Allenby AC, et al. Protection against inhalation toxicity of ricin and abrin by immunization. Hum Exp Toxicol 1995;14:155-164.
29. Balint GA. Ultrastructural study of liver cell damage induced by ricin. Exp Toxicol Pathol 2000;52:413-417.
30. Kumar O, Sugendran K, Vijayaraghavan R. Oxidative stress associated hepatic and renal toxicity induced by ricin in mice. Toxicon 2003;41:333-338.