Metabolic challenge to glia activates an adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 11, 2008, Pages 1835-1844

  Canals, Santiago ^a,b   Larrosa, Belén ^c   Pintor, Jesús ^d   Mena, María A ^e   Herreras, Oscar ^c  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b MAX PLANCK INSTITUTE FOR BIOLOGICAL CYBERNETICS   (Germany)

^c INSTITUTO CAJAL   (Spain)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Adenosine; Glia; Ischemia; Penumbra; Spreading depression

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; FLUOROACETIC ACID;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; BRAIN NERVE CELL; BRAIN SLICE; CELL ENERGY; CELL METABOLISM; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; GLIA CELL; HIPPOCAMPUS; METABOLIC STRESS; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SPREADING CORTICAL DEPRESSION; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION;

ADENOSINE; ANIMALS; ANIMALS, NEWBORN; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CEREBRAL INFARCTION; CITRIC ACID CYCLE; ELECTROPHYSIOLOGY; FEMALE; GLIOTOXIN; HIPPOCAMPUS; NEUROGLIA; NEURONS; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; SAFETY; SPREADING CORTICAL DEPRESSION; SYNAPTIC TRANSMISSION;

EID: 54949086334     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2008.71     Document Type: Article

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