Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes

Diabetologia

Volumn 48, Issue 12, 2005, Pages 2661-2666

  Holloway, A C ^a   Lim, G E ^a,c   Petrik, J J ^b   Foster, W G ^a   Morrison, K M ^a   Gerstein, H C ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Adult onset disease; Beta cell apoptosis; Dyslipidaemia; Glucose homeostasis; Nicotine; Type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN; NICOTINE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETOGENESIS; DYSLIPIDEMIA; FEMALE; GLUCOSE HOMEOSTASIS; INSULIN BLOOD LEVEL; LACTATION; MEDICAL ASSESSMENT; METABOLIC CAPACITY; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PERINATAL DRUG EXPOSURE; POSTNATAL GROWTH; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT;

ADIPOSITY; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FEMALE; FETUS; GLUCOSE; GLUCOSE TOLERANCE TEST; HEMOSTASIS; INSULIN; INSULIN-SECRETING CELLS; NICOTINE; OBESITY; PREGNANCY; PREGNANCY, ANIMAL; PRENATAL EXPOSURE DELAYED EFFECTS; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 28444469821     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-0022-5     Document Type: Article

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