Intracellular uptake and inhibitory activity of aromatic fluorinated amino acids in human breast cancer cells

ChemMedChem

Volumn 3, Issue 9, 2008, Pages 1449-1456

  Giese, Christoph ^a,c   Lepthien, Sandra ^b   Metzner, Linda ^a   Brandsch, Matthias ^a   Budisa, Nediljko ^b   Lilie, Hauke ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c ETH ZURICH   (Switzerland)

Author keywords

Amino acid transport system L; Amino acids; Antitumor agents; Fluorine

Indexed keywords

4 FLUOROPHENYLALANINE; 4 FLUOROTRYPTOPHAN; 4-FLUOROTRYPTOPHAN; 6 FLUOROTRYPTOPHAN; 6-FLUOROTRYPTOPHAN; AMINO ACID TRANSPORTER; DRUG DERIVATIVE; TRYPTOPHAN;

ARTICLE; BREAST TUMOR; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; HUMAN; METABOLISM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; TIME; TUMOR CELL CULTURE;

AMINO ACID TRANSPORT SYSTEM L; BREAST NEOPLASMS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; P-FLUOROPHENYLALANINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRYPTOPHAN; TUMOR CELLS, CULTURED;

EID: 54849405131     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800108     Document Type: Article

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