Defects in β-cell function in functional ovarian hyperandrogenism

Journal of Clinical Endocrinology and Metabolism

Volumn 76, Issue 5, 1993, Pages 1241-1247

  O’mearat, Niall M ^a   Blackman, John D ^a   Ehrmann, David A ^a   Barnes, Randall B ^a   Jaspan, Jonathan B ^a   Rosenfield, Robert L ^a   Polonsky, Kenneth S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; PRASTERONE SULFATE; TESTOSTERONE;

ADULT; ANDROGEN BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HIRSUTISM; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OVARY POLYCYSTIC DISEASE; PANCREAS ISLET BETA CELL; POSTPRANDIAL STATE; PRIORITY JOURNAL;

ADULT; ANDROGENS; BLOOD GLUCOSE; C-PEPTIDE; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPERINSULINISM; INSULIN; ISLETS OF LANGERHANS; OSMOLAR CONCENTRATION; OVARIAN DISEASES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027278472     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem.76.5.8496316     Document Type: Article

References (30)

1. Ehrmann DA, Rosenfield RL, Barnes RB, Brigell DF, Sheikh Z. 1992 Detection of functional ovarian hyperandrogenism in women with androgen excess. N Engl J Med. 327:157-162.
2. Burghen GA, Givens JR, Kitabchi AE. 1980 Correlation of hyperandrogenism with hyperinsulinemia in polycystic ovarian disease. J Clin Endocrinol Metab. 50:113-116.
3. Chang RJ, Nakamura R, Judd HL, Kaplan SA. 1983 Insulin resistance in non-obese patients with polycystic ovarian disease. J Clin Endocrinol Metab. 57:356-359.
4. Shoupe D, Kumar DD, Lobo RA. 1983 Insulin resistance in polycystic ovary syndrome. Am J Obstet Gynecol. 147:588-592.
5. Cotrozzi G, Matteino M, Reilli P, Lazzari T. 1983 Hyperinsulinism and insulin resistance in polycystic ovarian syndrome: a verification using oral glucose, i.v. glucose and tolbutamide. Acta Diabetol Lat. 20:135-141.
6. Dunaif A, Graf M, Mandeli J, Laumas V, Dobrjansky A. 1987 Characterization of groups of hyperandrogénie women with acanthosis nigricans, impaired glucose tolerance and/or hyperinsulinemia. J Clin Endocrinol Metab. 65:499-507.
7. Geffner ME, Kaplan SA, Bersch N, Golde DW, Landaw EM, Chang RJ. 1986 Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion. Fertil Steril 45:327-333.
8. Dunaif A, Mandeli J, Fluhr H, Dobrjansky A. 1988 The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome. J Clin Endocrinol Metab. 66:131-131.
9. Nestler JE, Barlascini CO, Matt DW, et al. 1989 Suppression of serum insulin levels by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 68:1027-1032.
10. Lanzone A, Fulghesu AM, Andreani CL, et al. 1990 Insulin secretion in polycystic ovarian disease: effect of ovarian suppression by GnRH agonist. Hum Reprod. 5:143-149.
11. Farah MJ, Givens JR, Kitabchi AE. 1990 Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans. J Clin Endocrinol Metab. 70:1075—1081.
12. Peiris AN, Mueller RA, Struve MF, Smith GA, Kissebah AH. 1987 Relationship of androgenic activity to splanchnic insulin metabolism and peripheral glucose utilization in premenopausal women. J Clin Endocrinol Metab. 64:162-169.
13. Polonsky K, Jaspan J, Emmanouel D, et al. 1983 Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism. Acta Endocrinol (Copenh). 102:420-427.
14. Eaton RP, Allen RC, Schade DS, Erickson KM, Standefer J. 1980 Prehepatic insulin production in man: kinetic analysis using peripheral connecting peptide behavior. J Clin Endocrinol Metab. 51:520-528.
15. Hatch R, Rosenfield RL, Kim MH, Tredway D. 1981 Hirsutism: implications, aetiology and management. Am J Obstet Gynecol. 140:815-830.
16. Ferriman D, Gallwey JD. 1961 Clinical assessment of body hair growth in women. J Clin Endocrinol Metab. 21:1440-1447.
17. Polonsky KS, Licinio-Paixao J, Given BD, et al. 1986 Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type 1 diabetic patients. J Clin Invest. 77:98-105.
18. Polonsky KS, Given BD, Hirsch LJ, et al. 1988 Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med. 318:1231-1239.
19. Polonsky KS, Given BD, Hirsch L, et al. 1988 Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest. 81:435-441.
20. DeFronzo RA, Tobin JD, Andres R. 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237:E214-E223.
21. Morgan CR, Lazarow A. 1963 Immunoassay of insulin: two antibody systems: plasma insulin levels of normal, subdiabetic and diabetic rats. Diabetes. 12:115-126.
22. Faber OK, Binder C, Markussen J, et al. 1978 Characterization of seven C-peptide antisera. Diabetes. 27(Suppl 1): 170—177.
23. Moll Jr GW, Rosenfield RL, Heike JH. 1981 Estradiol-testosterone binding interactions and free plasma estradiol under physiological conditions. J Clin Endocrinol Metab. 52:868-874.
24. Glickman SP, Rosenfield RL, Bergenstal RM, Heike J. 1982 Multiple androgenic abnormalities including elevated free testosterone in hyperprolactinemic women. J Clin Endocrinol Metab. 55:251-257.
25. Van Cauter E. 1988 Estimating false-positive and false-negative errors in analyses of hormonal pulsatility. Am J Physiol. 254:E786-E794.
26. Shapiro ET, Tillil H, Polonsky KS, Fang VS, Rubenstein AH, Van Cauter E. 1988 Oscillations in insulin secretion during constant glucose infusion in normal man: relationship to changes in plasma glucose. J Clin Endocrinol Metab. 67:307-314.
27. Nestler JE, Clore JN, Blackard WG. 1988 Reduced insulin clearance in normal subjects due to extreme hyperinsulinemia. Am J Med Sci. 295:15-22.
28. Lang DA, Matthews DR, Peto J, Turner RC. 1979 Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings. N Engl J Med. 301:1023-1027.
29. Hansen BC, Jen KC, Pek SB, Wolfe RA. 1982 Rapid oscillations in plasma insulin, glucagon and glucose in obese and normal weight humans. J Clin Endocrinol Metab. 54:785-792.
30. Sturis J, Polonsky KS, Shapiro ET, Blackman JD, O'Meara NM, Van Cauter E. 1992 Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 35:681-689.