In vivo induction of tolerance by an lg peptide is not affected by the deletion of FcR or a mutated lgG Fc fragment

International Immunology

Volumn 14, Issue 7, 2002, Pages 761-766

  El Amine, Moustapha ^a   Hinshaw, Jennifer A ^a,b   Scott, David W ^a,b  

^a HOLLAND LABORATORY   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

B cell; FcR; Gene therapy; lgG antigen; Retroviral vector; T cell; Tolerance

Indexed keywords

ANTIGEN; EPITOPE; FC RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; RETROVIRUS VECTOR; IMMUNOSUPPRESSIVE AGENT; ORGANIC COMPOUND; TOLEROGEN;

ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; BLAST CELL; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENE THERAPY; GENETIC TRANSDUCTION; HUMORAL IMMUNITY; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RECEPTOR BINDING; RECIPIENT; T LYMPHOCYTE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL DIVISION; GENE VECTOR; GENETICS; IMMUNOLOGY; MUTATION; RETROVIRUS;

ANIMALS; B-LYMPHOCYTES; CELL DIVISION; EPITOPES; GENETIC VECTORS; IMMUNE TOLERANCE; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUTATION; ORGANIC CHEMICALS; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS; RETROVIRIDAE; T-LYMPHOCYTES; TRANSDUCTION, GENETIC;

EID: 0036319208     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Studies on the induction of immunologic unresponsiveness. II Kinetics
2. Cellular events in tolerance III. Carrier tolerance as a model for T cell unresponsiveness
3. Multiple pathways of B lymphocyte tolerance
4. Haptens bound to self IgG induce immunologic tolerance, while when coupled to syngeneic spleen cells they induce immune suppression
5. Genetically transferred central and peripheral immune tolerance via retroviral-mediated expression of immunogenic epitopes in hematopoietic progenitors or peripheral B lymphocytes
6. Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: The lgG scaffold is important for induction and maintenance of immune hyporesponsiveness
7. Retroviral gene transfer of an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis
8. Mechanisms of tolerance induction by a gene transferred peptide-IgG fusion protein expressed in B-lineage cells
9. The effect of carrier specific helper T cell tolerance on antibody avidity in the anti-hapten response
10. LgG effector mechanisms
11. LgG Fc receptors
12. Augmented humoral and anaphylactic responses in FcγRII-deficient mice
13. FcRγ chain deletion results in pleiotropic effector cell defects
14. Recombinant Fc of human lgG1 prepared in Escherichia coli system escapes recognition by macrophages
15. Oligosaccharide-protein interactions in lgG can modulate recognition by Fcγ receptors
16. The use of haptenated immunoglobulins to induce B cell tolerance in vitro. 1983. The roles of hapten density and the Fc portion of the immunoglobulin carrier
17. Induction of tolerance to human γ-globulin in FcRγ- and FcγRII-deficient mice
18. Enhanced antigen presentation using human Fcγ receptor (monocyte/ macrophage)-specific immunogens
19. Type II and III receptors for immunoglobulin G (IgG) control the presentation of different T cell epitopes from single IgG-complexed antigens
20. Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients
21. Gene therapy for tolerance and autoimmunity: Soon to be fulfilled promises?
22. Gene transfer of immunoglobulin-fusion proteins into B cells prevents and treats autoimmune diseases