Effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on endothelial dysfunction, lipid peroxidation, and hepatocyte morphology in rats with sepsis-induced liver damage

Current Therapeutic Research - Clinical and Experimental

Volumn 65, Issue 3, 2004, Pages 278-291

  Kara, Eray ^a,b   Var, Ahmet ^a   Vatansever, Seda ^a   Cilaker, Serap ^a   Kaya, Yavuz ^a   Coşkun, Teoman ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

^b Karatas Izmir Turkey ^*  (Turkey)

Author keywords

experimental sepsis; lipid peroxidation; nitric oxide; selective COX 2 inhibitor

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ROFECOXIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENDOTHELIUM; ENDOTHELIUM LESION; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; LAPAROTOMY; LIPID PEROXIDATION; LIVER CELL; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; STATISTICAL SIGNIFICANCE;

EID: 5444221769     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(04)80087-0     Document Type: Article

References (38)

1. Pastor CM, Billiar TR, Losser MR, and Payen DM Liver injury during sepsis J Crit Care Med 10 1995 183 197
2. Jabs CM, Heglen P, and Eklof B Breakdown of adenine nucleotides, formation of oxygen free radicals, and early markers of cellular injury in endotoxic shock Eur J Surg 161 1995 147 155
3. Strassburg CP Gastrointestinal disorders of the critically ill Shock liver Best Pract Res Clin Gastroenterol 17 2003 369 381
4. Strassheim D, Park JS, and Abraham E Sepsis: Current concepts in intracellular signaling Int J Biochem Cell Biol 34 2002 1527 1533
5. James PE, Madhani M, and Roebuck W Endotoxin-induced liver hypoxia: Defective oxygen delivery versus oxygen consumption Nitric Oxide 6 2002 18 28
6. Vincent JL Update on sepsis: Pathophysiology and treatment Acta Clin Belg 55 2000 79 87
7. Casey LC Immunologic response to infection and its role in septic shock Crit Care Clin 16 2000 193 213
8. Shah AM Inducible nitric oxide synthase and cardiovascular disease Cardiovasc Res 45 2000 148 155
9. Karima R, Matsumoto S, Higashi H, and Matsushima R The molecular pathogenesis of endotoxic shock and organ failure Mol Med Today 5 1999 123 132
10. Szabo G, Romics L Jr, and Frendl G Liver in sepsis and systemic inflammatory response syndrome Clin Liver Dis 6 2002 1045 1066
11. Maynard ND, Bihari DJ, and Dalton RN Liver function and splanchnic ischemia in critically ill patients Chest 111 1997 180 187
12. Schoonover LL, Stewart AS, and Clifton GD Hemodynamic and cardiovascular effects of nitric oxide modulation in the therapy of septic shock Pharmacotherapy 20 2000 1184 1197
13. Titheradge MA Nitric oxide in septic shock Biochim Biophys Acta 1411 1999 437 455
14. Strand OA, Leone A, Giercksky KE, and Kirkeboen KA Nitric oxide indices in human septic shock Crit Care Med 28 2000 2779 2785
15. Wray GM, Foster SJ, Hinds CJ, and Thiermermann C A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the rat Shock 15 2001 135 142
16. Reilly PM, Schiller HJ, and Bulkley GB Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites Am J Surg 161 1991 488 503
17. Olinescu R, Bartoc R, and Milltaru M The changes of peroxides and total antioxidants in the plasma of patients who received 1311 therapeutically Rom J Intern Med 30 1992 113 117
18. Jaeschke H Mechanisms of oxidant stress-induced acute tissue injury Proc Soc Exp Biol Med 209 1995 104 111
19. Simpson R, Alon R, and Kobzik L Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion Ann Surg 218 1993 444 454
20. Broner CW, Shenep JL, and Stidham GY Effect of scavengers on survival in sepsis Am Surg 57 1991 86 88
21. Wei H, and Frenkel K Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters Carcinogenesis 14 1993 1195 1201
22. Lalonde C, Daryani R, and Campbell C Relationship between liver oxidant stress and antioxidant activity after zymosan peritonitis in the rat Crit Care Med 21 1993 894 900
23. Goode HF, and Webster NR Free radicals and antioxidants in sepsis Crit Care Med 11 1993 1770 1776
24. Ohkawa H, Ohishi N, and Yagi K Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 1979 351 358
25. Sugeno K, Dahi K, and Yamada K The role of lipid peroxidation in endotoxin induced hepatic damage and the protective effect of antioxidants Surgery 101 1987 746 752
26. Bernard GR, Wheeler AP, Russell JA for the Ibuprofen in Sepsis Study Group The effects of ibuprofen on the physiology and survival of patients with sepsis N Engl J Med 336 1997 912 918
27. Cortas NK, and Wakid NW Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method Clin Chem 36 1990 1440 1443
28. Halliwell B, and Chirico S Lipid peroxidation: Its mechanism, measurement, and significance Am J Clin Nutr 57 Suppl 5 1993 7155 7245
29. Konukoglu D, Iynem H, and Ziylan E Antioxidant status in experimental peritonitis: Effects of alpha tocopherol and taurolin Pharmacol Res 39 1999 247 251
30. Warner BW, Hassergier PO, and James HJ Superoxide dismutase in rats with sepsis Effect on survival rate and amino acid transport Arch Surg 122 1987 1142 1146
31. Tunctan B, Altug S, and Uludag O Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis Pharmacol Res 48 2003 37 48
32. 2 levels induced by lipopolysaccharide in mice Biol Rhythm Res 31 2000 499 513
33. Cantoni L, Di Nicolantonio F, and Barelli D Modulation of cerebellar and hepatic nitric oxide synthase by exogenous arginine and endotoxin Nitric Oxide 5 2001 198 207
34. Vodovotz Y, Kopp JB, and Takeguchi H Increased mortality, blunted production of nitric oxide, and increased production of TNF-α in endotoxemic TGF-β1 transgenic mice J Leukocyte Biol 63 1998 31 39
35. Salter M, Duffy C, Garthwaite J, and Strijbos PJ Ex vivo measurement of brain tissue nitrite and nitrate accurately reflects nitric oxide synthase activity in vivo J Neurochem 66 1996 1683 1690
36. Arons MM, Wheeler AP, Bernard GR for the Ibuprofen in Sepsis Study Group Effect of ibuprofen on the physiology and survival of patients with sepsis Crit Care Med 27 1999 699 707
37. Pairet M, Van Ryn J, and Mauz AM Differential inhibition of COX-1 and COX-2 by NSAIDs: A summary of Results obtained using various test systems Vane SR Botting JH Selective COX-2 Inhibitors Pharmacology, Clinical Effects and Therapeutical Potential 1998 Kluwer Academic Publishers Geneva, Switzerland 27 46
38. 2formation is increased in human sepsis syndrome Effects of cyclooxygenase inhibition Am Rev Respir Dis 144 1991 1095 1101