Effects of ibuprofen on the physiology and survival of hypothermic sepsis

Critical Care Medicine

Volumn 27, Issue 4, 1999, Pages 699-707

  Arons, Murray M ^a   Wheeler, Arthur P ^a,e   Bernard, Gordon R ^a,e   Christman, Brian W ^a,e   Russell, James A ^a,b   Schein, Roland ^a,c   Summer, Warren R ^a,d   Steinberg, Kenneth P ^a,g   Fulkerson, William ^a,i   Wright, Patrick ^a   Dupont, William D ^a,e   Swindell, Bridgett B ^a,e   Drummond, Alana ^b   Pena, Maria ^c   DeBoisblanc, Bennett ^d   Everett, Brenda ^d   Glenn, Chris ^d   Tebbe, Denise ^d   Carmichael, Laurence C ^e   Stroud, Mary J ^e   Higgins, Stanley B ^f   Jiang, Keyuan ^f   Plummer Jr , Walton D ^e   Carroll, Frank E ^e   Hudson, Leonard D ^g   Anardi, Doreen ^g   Abernathy, Mary Jo ^h   Mallatratt, Lee ^h   Weston, Pat ^h   Wright, Patrick E ⁱ   Colvin, Kelly ⁱ   more..

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST PAUL S HOSPITAL   (Canada)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^f VANDERBILT UNIVERSITY   (United States)

^g UNIVERSITY OF WASHINGTON   (United States)

^h DUKE UNIVERSITY MEDICAL CENTER   (United States)

ⁱ METHODIST HOSPITAL   (United States)

Author keywords

Cytokines; Eicosinoids; Human; Hypothermia; Ibuprofen; Interleukins; Prostaglandins; Sepsis; Thromboxane; Tumor necrosis factor

Indexed keywords

IBUPROFEN; INTERLEUKIN 6; PROSTACYCLIN; THROMBOXANE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; BLOOD LEVEL; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORE TEMPERATURE; FEMALE; FEVER; HUMAN; HYPOTHERMIA; INTENSIVE CARE UNIT; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; SEPSIS; SEPTIC SHOCK;

EID: 0032944741     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199904000-00020     Document Type: Review

References (34)

1. Hodgin UG, Sanford JP: Gram negative rod bacteremia. Am J Med 1965; 39:952-960
2. Dupont HL, Spink WW: Infections due to gram-negative organisms: an analysis of 860 patients with bacteremia at the University of Minnesota Medical Center. Medicine 1969; 48:307-332
3. Bryant RE, Hood AF, Hood CE: Factors affecting mortality of gram negative rod bacteremia. Arch Intern Med 1971; 127:120-128
4. Kreger BE, Craven DE, Mcabe WR: Gram negative bacteremia, re-evaluation of clinical features and treatment in 612 patients. Am J Med 1980; 68: 344-355
5. Clemmer TP, Fisher CJ, Bone RC, et al: Hypothermia in the sepsis syndrome and clinical outcome. Crit Care Med 1992; 20:1395-1401
6. Anonymous: Effect of high dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. The Veterans Administration Systemic Sepsis Cooperative Study Group. N Engl J Med 1987; 11:659-665
7. Sprung CL, Peduzzi PN, Clayton HS, et al: Impact of encephalopathy on mortality in the sepsis syndrome. Crit Care Med 1990; 18:801-806
8. Villar J, Balzquez M, Manzano JL: Hypothermia decreases mortality in human septic adult respiratory distress syndrome (ARDS). Abstr. Crit Care Med 1991; 19:(Suppl)S90
9. Blair E, Henning G, Hornick R, et al: Hypothermia in bacteremic shock. Arch Surg 1964; 89:619-629
10. Atwood RP, Kass EH: Relationship of body temperature to the lethal action of bacterial endotoxin. J Clin Invest 1964; 2:151-159
11. Cooper KE: Fever and antipyresis the role of the nervous system. Cambridge, Cambridge University Press, 1995
12. 2 formation is increased in human sepsis syndrome: Effects of cyclooxygenase inhibition. Am Rev Respir Dis 1991; 144:1095-1101
13. Holtzman MJ: Arachadonic acid metabolism. Implications of biological chemistry for lung function and disease. Am Rev Respir Dis 1991; 143: 188-203
14. Mitchie HR, Manogue KR, Spriggs DR, et al: Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 1988; 318: 1481-1486
15. Kluger MJ: Fever: Role of pyrogens and cryogens. Physiol Rev 1991; 71:93-127
16. Bernard GR, Wheeler AP, Russell JA, et al: The effects of ibuprofen on the physiology and survival of patients with sepsis. N Engl J Med 1997; 336: 912-918
17. Members of the American Collage of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee: American Collage of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
18. 2 mechanism. J Immunology 1993; 151:2096-2104
19. Bernard GR, Doig G, Hudson LD, et al: Quantification of organ failure for clinical trials and clinical practice. Abstr. Am J Respir Crit Care Med 1995; 151:A323
20. Bernard GR: The Brussels Score. Sepsis 1998; 1:43-44
21. Bernard GR, Wheeler AP, Arons MM, et al: A trial of antioxidants N-acetyleysteine and procysteine in the acute respiratory distress syndrome. Chest 1997; 112:167-172
22. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
23. Deboisblanc BP, Summer WR, Christman BW, et al: Lactic acidosis predicts severe sepsis mortality independent of arterial pH. Abstr. Am J Respir Crit Care Med 1996; 153:A834
24. Styrt B, Sugarman B: Antipyresis and fever. Arch Intern Med 1990; 150:1589-1597
25. Kluger MJ: Fever: Its biology, evolution, and function. Princeton, NJ, Princeton University Press, 1979
26. Snapper JR, Hutchinson AA, Ogletree ML, et al: Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in unanesthetized sheep. J Clin Invest 1983; 72:63-76
27. Fink MP, MacVittie TJ, Casey LC: Effects of nonsteroidal anti-inflammatory drugs on renal function in septic dogs. J Surg Res 1984; 36516-3625
28. Barriere SL, Lowry SF: An overview of mortality risk prediction in sepsis. Crit Care Med 1995; 23:376-393
29. Marks JD, Marks CB, Luce JM, et al: Plasma tumor necrosis factor in patients with septic shock. Am Rev Respir Dis 1990; 141:94-97
30. Calandra T, Gerain J, Heumen D: High circulating levels of interleukin-6 in patients with septic shock. Evolution during sepsis, prognostic value and interplay with other cytokines. Am J Med 1991; 91:23-29
31. Casey LC, Balk RA, Bone RC: Plasma cytokine levels and endotoxin levels correlate with survival in patients with sepsis syndrome. Ann Intern Med 1993; 119:771-778
32. Fletcher JR, Collins JN, Graves ED III, et al: Tumor necrosis factor induced mortality is reversed with cyclooxygenase inhibition. Ann Surg 1993; 217:668-674
33. 2 receptor antagonist, inhibits tumor necrosis factor-alpha biosynthesis. Eur J Pharm 1995; 286:31-39
34. 2, cholera toxin and 8-bromo-cyclic AMP on lipopolysaccharide-induced gene expression of cytokines in human macrophages. Immunology 1995; 84:446-452