Mercury in first-cut baby hair of children with autism versus typically-developing children

Toxicological and Environmental Chemistry

Volumn 90, Issue 4, 2008, Pages 739-753

  Adams, J B ^a   Romdalvik, J ^a   Levine, K E ^b   Hu, L W ^c  

^a ARIZONA STATE UNIVERSITY   (United States)

^b RTI INTERNATIONAL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Amalgams; Antibiotics; Autism; Baby hair; Mercury

Indexed keywords

ACTIVATION ANALYSIS; ALLOYS; ANTIBIOTICS; BIOCHEMISTRY; DENTAL AMALGAMS; DENTAL MATERIALS; FILLING; FLUORESCENCE SPECTROSCOPY; MERCURY AMALGAMS; NEUTRON ACTIVATION ANALYSIS; PHYSIOLOGY; REGRESSION ANALYSIS;

AMALGAMS; ATOMIC FLUORESCENCE SPECTROMETRIES; AUTISM; BABY HAIR; BODY BURDENS; CHILDREN WITH AUTISMS; COLD VAPORS; CONSISTENT; HIGH INCIDENCES; LOGISTIC REGRESSION ANALYSIS; MERCURY; MERCURY EXPOSURES;

MERCURY (METAL);

ANTIBIOTICS; BRAIN; CHILD HEALTH; COMPARATIVE STUDY; CORRELATION; DISEASE INCIDENCE; EXCRETION; HAIR; MERCURY (ELEMENT); POLLUTION EXPOSURE; REGRESSION ANALYSIS; SEAFOOD; SPECTROMETRY;

RATTUS;

EID: 54349099506     PISSN: 02772248     EISSN: 10290486     Source Type: Journal    
DOI: 10.1080/02772240701699294     Document Type: Article

References (57)

1. Adams, J.B., C.E. Holloway, M. Margolis, and F. George. 2003. Heavy metal exposures, developmental milestones, and physical symptoms in children with autism, Conference Proceedings of the Fall 2003 Defeat Autism Now! Conference on 3-5 October 2003 in Portland, Oregon, pp. 71-75.
2. Adams, J.B., C.E. Holloway, F. George, and D. Quig. 2006. Toxic metals and essential minerals in the hair of children with autism and their mothers. Biol. Trace El. Res. 110: 193-209.
3. Adams, J.B., J. Romdalvik, V.M.S. Ramanujam, and M.S. Legator. 2007. Mercury, lead, and zinc in baby teeth of children with autism vs. controls. Journal of Toxicology and Environmental Health Part A 70: 1046-1051.
4. Agency for toxic substances and disease registry (ATSDR). 1999. Toxicological Profile for Mercury, US Department of Health and Human Services, section 1.6.
5. American Academy of Pediatrics, Committee on Infectious Disease. 1999. Joint Statement of the American Academy of Pediatrics and the United States Health Service, Pediatrics, 104: 568-569.
6. Andrews, N., E. Miller, A. Grant, J. Stowe, V. Osborne, and B. Taylor. 2004. Thimerosal exposure in infants and developmental disorders: A retrospective cohort study in the United Kingdom does not support a causal association. Pediatrics 114: 584-591.
7. Audhya T., 2004. Nutritional abnormalities in children with autism. AutismOne Conference in Chicago: IL.
8. Ballatori, N., and T.W. Clarkson. 1984. Dependence of biliary secretion of inorganic mercury on the biliary transport of glutathione. Biochem. Pharmacol. Apr. 1; 33(7): 1093-1098.
9. Ballatori, N., and T.W. Clarkson. 1985. Biliary secretion of glutathione and of glutathione-metal complexes. Fundam Appl. Toxicol. Oct; 5(5): 816-831.
10. Bernard, S., A. Enayati, H. Roger, and T. Binstock. 2001. Autism: A novel form of mercury poisoning. Medicine Hypotheses 56: 462-471.
11. Bradstreet, J., D.A. Geier, J.J. Kartzinel, J.B. Adams, and M.R. Geier. 2003. A case-control study of mercury burden in children with autistic spectrum disorders. Journal of American Physical Surgery 8: 76-79.
12. Dally, A. 1997. The rise and fall of pink disease. Social History of Medicine 10: 291-304.
13. Danscher, G., P. Horsted-Bindslev, and J. Rungby. 1990. Traces of mercury in organs from primates with amalgam fillings. Experimental and Molecular Pathology 52: 291-299.
14. Fombonne, E., R. Zakarian, A. Bennett, L. Meng, and D. McClean-Heywood. 2006. Pervasive developmental disorders in Montreal, Quebec. Canada: prevalence and links with immunizations. Pediatrics 118: e139-e150.
15. Geier, D.A., and M.R. Geier. 2003. An assessment of the impact of thimerosal on childhood neurodevelopmental disorders. Pediatric Rehabilitation 6: 97-102.
16. Geier, D.A., and M.R. Geier. 2004a. A comparative evaluation of the effects of MMR immunization and mercury doses from thimerosal-containing childhood vaccines on the population prevalence of autism. Medical Science Monitor 10: P133-P139.
17. Geier, D.A., and M.R. Geier. 2004b. Neurodevelopmental disorders after thimerosal-containing vaccines: A brief communication. Experimental Biology and Medicine (Maywood). 228: 660-664.
18. Geier, D.A., and M.R. Geier. 2005. A two-phased population epidemiological study of the safety of thimerosal-containing vaccines: A follow-up analysis. Medical Science Monitor 11: CR160-CR170.
19. Geier, D.A., and M.R. Geier. 2006a. A meta-analysis epidemiological assessment of neurodevelopmental disorders following vaccines administered from 1994 through 2000 in the United States. Neuro Endocrinology Letters 27: 401-413.
20. Geier, D.A., and M.R. Geier. 2006b. A prospective assessment of porphyrins in autistic disorders: a potential marker for heavy metal exposure. Neurotoxicology Research 10: 57-64.
21. Geier, D.A., and M.R. Geier. 2006c. An assessment of downward trends in neurodevelopmental disorders in the United States following removal of thimerosal from childhood vaccines. Medical Science Monitor 12: CR231-CR239.
22. Geier, D.A., and M.R. Geier. 2006d. An evaluation of the effects of thimerosal on neurodevelopmental disorders reported following DTP and Hib vaccines in comparison to DTPH vaccine in the United States. Journal of Toxicology and Environmental Health A69: 1481-1491.
23. Geier, D.A., and M.R. Geier. 2006e. Early downward trends in neurodevelopmental disorders following removal of thimerosal-containing vaccines. Journal of American Physical Surgeons 11: 8-13.
24. Geier, M.R., and D.A. Geier. 2003a. Neurodevelopmental disorders after thimerosal-containing vaccines: A brief communication. Proceedings of the Experimental Biology and Medicine 228: 660-664.
25. Geier, M.R., and D.A. Geier. 2003b. Thimerosal in childhood vaccines, neurodevelopment disorders, and heart disease in the United States. Journal of American Physical Surgeons 8: 6-11.
26. Hahn, L.J., R. Kloiber, M.J. Vimy, Y. Takahashi, and F.L. Lorscheider. 1989. Dental "silver" tooth fillings: a source of mercury exposure revealed by whole body image scan and tissue analysis. FASEB J. 3: 2641-2646.
27. Haley, B.E. 2005. Mercury toxicity: Genetic susceptibility and synergistic effects. Medical Veritas 2: 535-542.
28. Holmes, A.S., M.F. Blaxill, and B.E. Haley. 2003. Reduced levels of mercury in first baby haircuts of autistic children'. International Journal of Toxicology 22: 277-285.
29. Hornig, M., D. Chian, and W.I. Lipkin. 2004. Neurotoxic effects of postnatal thimerosal are mouse strain dependent. Molecular Psychiatry 9: 833-845.
30. Hu, L.-W., J. Machuzak, J.A. Bernard, G. Grady, and J. Che. 2004. Development of a biomarker for monitoring the elimination of heavy metals from autistic children. Transactions of the American Nuclear Society 91: 833-835.
31. Hu, L.-W., J.A. Bernard, and J. Che. 2003. Neutron activation analysis of hair samples for the identification of autism. Transactions of the American Nuclear Society 89: 681-682.
32. Hviid, A., M. Stellfeld, J. Wohlfahrt, and M. Melbye. 2003. Association between thimerosal-containing vaccine and autism. Journal of American Medical Association 290: 1763-1766.
33. Ip, P., V. Wong, M. Ho, J. Lee, and W. Wong. 2004. Mercury exposure in children with autistic spectrum disorder: Case-control study. Journal of Child Neurology 19: 431-434.
34. James, S.J., P. Cutler, S. Melnyk, S. Jernigan, L. Janak, D.W. Gaylor, and J.A. Neubrander. 2004. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. American Journal of Clinical Nutrition 80: 1611-1617.
35. James, S.J., S. Melnyk, S. Jernigan, M.A. Cleves, C.H. Halsted, et al. 2006. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. American Journal of Medical Genetics B: Neuropsychiatric Genetics 141: 947-956.
36. Katz, S.A., and A. Chatt. 1988. Hair Analysis. Applications in the biomedical and environmental sciences. New York, NY: VCH Publishers.
37. Kern, J.K., B.D. Grannemann, M.H. Trivedi, and J.B. Adams. 2007. Sulfhydryl-reactive metals in autism. Journal of Toxicology and Environmental Health A70: 1-7.
38. Konstantareas, M.M., and S. Homatidis. 1987. Ear infections in autistic and normal children. Journal of Autism and Developmental Disorders 17: 585-594.
39. Madsen, K.M., M.B. Lauritsen, C.B. Pedersen, P. Thorsen, A.M. Plesner, P.H. Andersen, and P.B. Mortensen. 2003. Thimerosal and the occurrence of autism: Negative ecological evidence from Danish population-based data. Pediatrics 112: 604-606.
40. Mahaffey, K.R., R.P. Clickner, and C.C. Bocurow. 2004. Blood organic mercury and dietary mercury intake: National health and nutrition examination survey, 1999 and 2000. Environmental Health Perspectives 112: 562-570.
41. McDowell, M.A., C.F. Dillon, J. Osterloh, P.M. Bolger, and E. Pellizzari. 2004. Hair mercury levels in U.S. children and women of childbearing age: Reference range data from NHANES 1999-2000. Environmental Health Perspectives 112: 1165-1171.
42. Nataf, R., C. Skorupka, L. Amet, A. Lam, A. Springbett, and R. Lathe. 2006. Porphyrinuria in childhood autistic disorder: Implications for environmental toxicity. Toxicology and Applied Pharmacology 214: 99-108.
43. Nelson, K.B., and M.L. Bauman. 2003. Thimerosal and autism? Pediatrics 111: 674-679.
44. Palmer, R.F., S. Blanchard, Z. Stein, D.Mandell, and C.Miller. 2006. Environmental mercury release, special education rates, and autism disorder: An ecological study of Texas. Health Place 12: 203-209.
45. Pellizzari, E.D., R. Fernando, C.M. Cramer, G.M. Meaburn, and K. Bangerter. 1999. Analysis of mercury in hair of EPA region V population. Journal of Exposure Analysis and Environmental Epidemiology 9: 393-401.
46. Rimland, B., and S.M. Edelson. 1999. Autism treatment evaluation checklist. (ARI/Form, ATEC-1/11-99). San Diego: Autism Research Institute.
47. Rosseneu, S.L.M., H.K.F. van Saene, S. Keady, R. Heuschkel, J.B. Adams, and S.H. Murch. 2003. Aerobic throat and gut flora in children with autistic spectrum disorder and gastrointestinal symptoms. Conference Proceedings of the Defeat Autism Now! Conference on 3-5 October 2003 in Portland, Oregon, pp. 63-70.
48. Rowland, I.R., P. Grasso, and M.J. Davies. 1975. The methylation of mercuric chloride by human intestinal bacteria. Experientia 31: 1064-1065.
49. Rowland, I.R., M. Davies, and J. Evans. 1980. Tissue content of mercury in rats given methylmercury chloride orally: Influence of intestinal flora. Archives of Environmental Health 35: 155-160.
50. Rowland, I.R., R.D. Robinson, R.A. Doherty. 1984. Effect of diet on mercury metabolism and excretion in mice given methylmercury: role of gut flora. Archives of Environmental Health 39: 401-408.
51. Sandler, R.H., S.M. Finegold, E.R. Bolte, C.P. Buchanan, A.P. Maxwell, M.-L. Vaisanen, M.N. Nelson, and H.M. Wexler. 2000. Short-term benefit from oral vancomycin treatment of regressive-onset autism. Journal of Child Neurology 15: 429-435.
52. Stehr-Green, P., P. Tull, M. Stellfeld, P.B. Mortenson, and D. Simpson. 2003. Autism and thimerosal-containing vaccines: Lack of consistent evidence for an association. American Journal of Preventive Medicine 25: 101-106.
53. US Environmental Protection Agency, What you need to know about mercury in fish and shellfish, 2004. EPA and FDA Advice for women who might become pregnant, women who are pregnant, nursing mothers, and young children, US Department of Health and Human Services, 2004; Available from: http://www.cfsan.fda.gov/~dms/admehg3.html.
54. US Environmental Protection Agency, 1997. Mercury study report to congress, Document EPA-452/R-97-007. Research Triangle Park, NC.
55. Verstraeten, T., R.L. Davis, F. DeStefano, T.A. Lieu, P.H. Rhodes, et al. 2003. Safety of thimerosal-containing vaccines: A two-phased study of computerized health maintenance organization databases. Pediatrics 112: 1039-1048.
56. Vimy, M.J., D.E. Hooper, and W.W. King. 1997. Mercury from maternal "silver" tooth fillings in sheep and human breast milk. A source of neonatal exposure. Biological Trace Element Research 56: 143-152.
57. Windham, G.C., L. Zhang, R. Gunier, L.A. Croen, and J.K. Grether. 2006. Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay area. Environmental Health Perspectives 114: 1438-1444.