Mercury, lead, and zinc in baby teeth of children with autism versus controls

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 70, Issue 12, 2007, Pages 1046-1051

  Adams, James B ^a,c   Romdalvik, Jane ^a   Ramanujam, V M Sadagopa ^b   Legator, Marvin S ^b  

^a Arizona State University   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEAD; MERCURY; ZINC;

ARTICLE; AUTISM; BODY BURDEN; CHILD; CHILD DEVELOPMENT; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DECIDUOUS TOOTH; DRUG USE; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS DEVELOPMENT; GASTROINTESTINAL DISEASE; HUMAN; INTESTINE FLORA; LEAD BLOOD LEVEL; MALE; MERCURY BLOOD LEVEL; PRIORITY JOURNAL; TRACE METAL BLOOD LEVEL; ZINC BLOOD LEVEL;

ADMINISTRATION, ORAL; ANTI-BACTERIAL AGENTS; AUTISTIC DISORDER; BODY BURDEN; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; HUMANS; LEAD; MERCURY; TOOTH, DECIDUOUS; ZINC;

RATTUS;

EID: 34248580747     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390601172080     Document Type: Article

References (37)

1. Adams, J. B., Holloway, C. E., George, F., and Quig, D. 2006. Toxic metals and essential minerals in the hair of children with autism and their mothers. Biol. Trace Element Res. 110:193-209.
2. Adams, J. B., Holloway, C., Margolis, M., and George, F. 2003. Exposure to heavy metals, physical symptoms, and developmental milestones in children with autism. Fall 2003 conference proceedings of Defeat Autism Now!, Portland, OR.
3. Andrews, N., Miller, E., Grant, A., Stowe, J., Osborne, V., and Taylor, B. 2004. Thimerosal exposure in infants and developmental disorders: A retrospective cohort study in the United Kingdom does not support a causal association. Pediatrics 114:584-591.
4. Audhya, T. 2004. Nutritional abnormalities in children with autism. AutismOne Conference, Chicago.
5. Ballatori, N., and Clarkson, T. W. 1985. Biliary secretion of glutathione and of glutathione-metal complexes. Fundam. Appl. Toxicol. 5:816-831.
6. Ballatori, N., and Clarkson, T. W. 1984. Dependence of biliary secretion of inorganic mercury on the biliary transport of glutathione. Biochem. Pharmacol. 33:1093-1098.
7. Bernard, S., Enayati, A., Redwood, L., Roger, H., and Binstock, T. 2001. Autism: A novel form of mercury poisoning. Med. Hypoth. 56:462-471.
8. Bradstreet, J., Geier, D. A., Kartzinel, J. J., Adams, J. B., and Geier, M. R. 2003. A case-control study of mercury burden in children with autistic spectrum disorders. J. Am. Phys. Surg. 8:76-79.
9. Burbacher, T. M., Shen, D. D., Liberato, N., Grant, K. S., Cernichiari, E., and Clarkson, T. 2005. Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. Environ. Health Perspect. 113:1015-1021.
10. Eide, R., Wesenberg, G. B., and Fosse, G. 1993. Mercury in primary teeth in preindustrial Norway. Scand. J. Dent. Res. 101:1-4.
11. Geier, D. A., and Geier, M. R. 2003a. An assessment of the impact of thimerosal on childhood neurodevelopmental disorders. Pediatr. Rehab. 6:97-102.
12. Geier, M. R., and Geier, D. A. 2003b. Neurodevelopmental disorders after thimerosal-containing vaccines: a brief communication. Exp. Biol. Med. (Maywood) 228:660-664.
13. Geier, M. R., and Geier, D. A. 2003c. Thimerosal in childhood vaccines, neurodevelopment disorders, and heart disease in the United States. J. Am. Phys. Surg. 8:6-11.
14. Geier, M. R., and Geier, D. A. 2004. A comparative evaluation of the effects of MMR immunization and mercury doses from thimerosal-containing childhood vaccines on the population prevalence of autism. Med. Sci. Monit. 10:PI33-PI39. Epub March 1.
15. Geier, M. R., and Geier, D. A. 2005. A two-phased population epidemiological study of the safety of thimerosal-containing vaccines: A follow-up analysis. Med. Sci. Monit. 11:CR160-170. Epub March 24.
16. Haley, B. E. 2005. Mercury toxicity: Genetic susceptibility and synergistic effects. Med. Veritas 2:535-542.
17. Holmes, A. S., Blaxill, M. F., and Haley, B. E. 2003. Reduced levels of mercury in first baby haircuts of autistic children. Int. J. Toxicol. 22:277-285.
18. Hviid, A., Stellfeld, M., Wohlfahrt, J., and Melbye, M. 2003. Association between thimerosal-containing vaccine and autism. J. Am. Med. Assoc. 290:1763-1766.
19. Ip, P., Wong, V., Ho, M., Lee, J., and Wong, W. 2004. Mercury exposure in children with autistic spectrum disorder: Case-control study. J. Child Neurol. 19:431-434.
20. James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., and Neubrander, J. A. 2004. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am. J. Clin. Nutr. 80:1611-1617.
21. Konstantareas, M. M., and Homatidis, S. 1987. Ear infections in autistic and normal children. J. Autism Dev. Disord. 17:585-594.
22. Madsen, K. M., Lauritsen, M. B., Pedersen, C. B., Thorsen, P., Plesner, A. M., Andersen, P. H., and Mortensen, P. B. 2003. Thimerosal and the occurrence of autism: Negative ecological evidence from Danish population-based data. Pediatrics 112:604-606.
23. Mahaffey, K. R, Clickner, R. P., and Bocurow, C..C. 2004. Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000. Environ. Health Perspect. 112:562-570.
24. Nataf, R., Skorupka, C., Amet, L., Lam, A., Springbett, A., and Lathe, R. 2006. Porphyrinuria in childhood autistic disorder: Implications for environmental toxicity. Toxicol. Appl. Pharmacol. 214:99-108.
25. Needleman, H. L., Davidson, I., Sewell, E. M., and Shapiro, I. M. 1974. Subclinical lead exposure in Philadelphia schoolchildren. Identification by dentine lead analysis. N. Engl. J. Med. 290:245-248.
26. Palmer R. F., Blanchard S., Stein Z., Mandell D., Miller C. 2006. Environmental mercury release, special education rates, and autism disorder: An ecological study of Texas. Health Place 12:203-209.
27. Ratcliffe, H. E., Swanson, G. M., and Fischer, L. J. 1996 Human exposure to mercury: A critical assessment of the evidence of adverse health effects. J. Toxicol. Environ. Health 49:221-270.
28. Rosseneu, S. L. M., van Saene, H. K. F., Keady, S., Heuschkel, R., Adams, J. B., Murch, S. H. 2003. Aerobic throat and gut flora in children with autistic spectrum disorder and gastrointestinal symptoms. Conference Proceedings of the Defeat Autism Now! Fall 2003 conference, Portland, OR, pp. 57-70.
29. Rowland, I. R., Grasso, P., and Davies, M. J. 1975. The methylation of mercuric chloride by human intestinal bacteria. Experientia 31:1064-1065.
30. Rowland, I. R., Davies, M., and Evans, J. 1980. Tissue content of mercury in rats given methylmercury chloride orally: Influence of intestinal flora. Arch. Environ. Health 35:155-160.
31. Rowland, I. R., Robinson, R. D., and Doherty, R. A. 1984. Effect of diet on mercury metabolism and excretion in mice given methylmercury: Role of gut flora. Arch. Environ. Health 39:401-408.
32. Stehr-Green, P., Tull, P., Stellfeld, M., Mortenson, P. B., and Simpson, D. 2003. Autism and thimerosal-containing vaccines: Lack of consistent evidence for an association. Am. J. Prev. Med. 25:101-106.
33. Sweet L. I., and Zelikoff, J. T. 2001. Toxicology and immunotoxicology of mercury: A comparative review in fish and humans. J. Toxicol Environ Health B 4:161-205.
34. Takeuchi, T., and Eto, K. 1975. Minamata disease; Chronic occurrence from pathological viewpoints. In Studies on the health effects of alkylmercury in Japan, pp. 28-62. Japan Environment Agency (government publication, Tokyo, Japan).
35. Tvinnereim, H. M., Eide, R., and Riise, T. 2000. Heavy metals in human primary teeth: some factors influencing the metal concentrations. Sci. Total Environ. 255:21-27.
36. Verstraeten, T., Davis, R. L., DeStefano, F., Lieu, T. A., Rhodes, P. H., Black, S. B., Shinefield, H., and Chen R. T. 2003. Safety of thimerosal-containing vaccines: A two-phased study of computerized health maintenance organization databases. Pediatrics 112:1039-1048.
37. Windham, G. C., Zhang, L., Gunier, R., Croen, L. A., and Grether, J. K. 2006. Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay area. Environ. Health Perspect. 114:1438-1444.