Safety of Thimerosal-Containing Vaccines: A Two-Phased Study of Computerized Health Maintenance Organization Databases

Pediatrics

Volumn 112, Issue 5, 2003, Pages 1039-1048

  Verstraeten, Thomas ^a   Davis, Robert L ^b   DeStefano, Frank ^a   Lieu, Tracy A ^c   Rhodes, Philip H ^a   Black, Steven B ^d   Shinefield, Henry ^d   Chen, Robert T ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d KAISER PERMANENTE   (United States)

Author keywords

Cohort study; Computerized medical record systems; Language development disorders; Speech disorders; Thimerosal; Vaccines

Indexed keywords

DIPHTHERIA PERTUSSIS TETANUS VACCINE; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; HEPATITIS B VACCINE; THIOMERSAL;

ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; AUTOMATION; DRUG SAFETY; HEALTH MAINTENANCE ORGANIZATION; HUMAN; INFANT; LANGUAGE DISABILITY; MAJOR CLINICAL STUDY; MEDICAL RECORD; NEWBORN; PRIORITY JOURNAL; SPEECH DISORDER; TIC;

COHORT STUDIES; DATABASES, FACTUAL; DEVELOPMENTAL DISABILITIES; FEMALE; HEALTH MAINTENANCE ORGANIZATIONS; HUMANS; INFANT; INFANT, NEWBORN; MALE; PRESERVATIVES, PHARMACEUTICAL; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK; SAFETY; THIMEROSAL; VACCINES;

EID: 0242300675     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Ball LK, Ball R, Pratt RD. An assessment of thimerosal use in childhood vaccines. Pediatrics. 2001;107:1147-1154
2. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Mercury (Update). Atlanta, GA: Agency for Toxic Substances and Disease Registry; 1999
3. Bakir F, Damluji SF, Amin-Zaki L, et al. Methylmercury poisoning in Iraq. Science. 1973;181:230-241
4. Igata A. Epidemiological and clinical features of Minamata disease. Environ Res. 1993;63:157-169
5. Davidson PW, Myers GJ, Cox C, et al. Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from maternal fish ingestion: outcomes at 19 and 29 months. Neurotoxicology. 1995;16:677-688
6. Mahaffey KR, Rice G. An assessment of Exposure to Mercury in the United States: Mercury Report to Congress. Washington, DC: US Environmental Protection Agency; 1997
7. Grandjean P, Weihe P, White RF, et al. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol. 1997;19:417-428
8. WHO. Environmental Health Criteria: Mercury. Geneva, Switzerland: World Health Organization; 1976.
9. US Environmental Protection Agency. Mercury Study Report to Congress. Volume V: Health Effects of Mercury and Mercury Compounds. Washington, DC: Office of Air Quality Planning and Standards and Office of Research and Development; 1997
10. 21 USC, 397 Section 413; 2001
11. Verstraeten T, Gu D, Chen R. Exposure to Ethylmercury From Thimerosal Containing Vaccines in Infants. Presented at the 127th Annual Meeting of the American Public Health Association; November 9, 1999; Chicago, IL
12. Thimerosal in vaccines: a joint statement of the American Academy of Pediatrics and the Public Health Service. Neonatal Netw. 1999;18:65-72
13. Centers for Disease Control and Prevention. Recommendations regarding the use of vaccines that contain thimerosal as a preservative. JAMA. 1999;282:2114-2115
14. Centers for Disease Control and Prevention. Availability of hepatitis B vaccine that does not contain thimerosal as a preservative. JAMA. 1999;282:1219-1220
15. Jessen P, Verdiere B, Moriet G, Boule D, Rhaoui A, Fraisse F. [An original mechanism of acute mercury poisoning: ritual injection]. Presse Med. 1991;20:1625-1626
16. Lowell JA, Burgess S, Shenoy S, Curci JA, Peters M, Howard TK. Mercury poisoning associated with hepatitis-B immunoglobulin. Lancet. 1996;347:480
17. Netscher DT, Friedland JA, Guzewicz RM. Mercury poisoning from intravenous injection: treatment by granuloma resection. Ann Plast Surg. 1991;26:592-596
18. Zosin C, Manescu N, Gluhovschi G, Nicolcioiu M, Golea O, Bignion H. [Acute mercury poisoning due to intravenous injection of metallic mercury]. MMW Munch Med Wochenschr. 1977;119:1537-1538
19. Chen RT, Glasser JW, Rhodes PR, et al. Vaccine Safety Datalink project: a new tool for improving vaccine safety monitoring in the United States. The Vaccine Safety Datalink Team. Pediatrics. 1997;99:765-773
20. Chen RT, DeStefano F, Davis RL, et al. The Vaccine Safety Datalink: immunization research in health maintenance organizations in the USA. Bull World Health Organ. 2000;78:186-194
21. Wassilak SG, Glasser JW, Chen RT, Hadler SC. Utility of large-linked databases in vaccine safety, particularly in distinguishing independent and synergistic effects. The Vaccine Safety Datalink Investigators. Ann N Y Acad Sci. 1995;754:377-382
22. Crump KS, Van Landingham C, Shamlaye C, et al. Benchmark concentrations for methylmercury obtained from the Seychelles Child Development Study. Environ Health Perspect. 2000;108:257-263
23. Grandjean P, White RF, Nielsen A, Cleary D, De Oliveira Santos EC. Methylmercury neurotoxicity in Amazonian children downstream from gold mining. Environ Health Perspect. 1999;107:587-591
24. Steuerwald U, Weihe P, Jorgensen PJ, et al. Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J Pediatr. 2000;136:599-605
25. Davidson PW, Myers GJ, Cox C, et al. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study. JAMA. 1998;280:701-707
26. Grandjean P, Budtz-Jorgensen E, White RF, et al. Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years. Am J Epidemiol. 1999;150:301-305
27. Marsh DO, Myers GJ, Clarkson TW, Amin-Zaki L, Tikriti S, Majeed MA. Fetal methylmercury poisoning: clinical and toxicological data on 29 cases. Am J Neurol. 1980;7:348-353
28. Grandjean P, Weihe P, White RF, Debes F. Cognitive performance of children prenatally exposed to "safe" levels of methylmercury. Environ Res. 1998;77:165-172
29. Stajich GV, Lopez GP, Harry SW, Sexson WR. Iatrogenic exposure to mercury after hepatitis B vaccination in preterm infants. J Pediatr. 2000; 136:679-681
30. Pichichero ME, Cernichiari E, Lopreiato J, Treanor J. Mercury concentrations and metabolism in infants receiving vaccines containing thimerosal: a descriptive study. Lancet. 2002;360:1737-1741
31. Stratton K, Gable A, McCormick MC, eds. Immunization Safety Review: Thimerosal-Containing Vaccines and Neurodevelopmental Disorders. Institute of Medicine. Immunization Safety Review Committee. Washington, DC: National Academy Press; 2001
32. Howson CP, Howe CJ, Fineberg HV, eds. Adverse Effects of Pertussis and Rubella Vaccines. Institute of Medicine. Washington, DC: National Academy Press; 1991
33. Mullooly J, Drew L, DeStefano F, et al. Quality of HMO vaccination databases used to monitor childhood vaccine safety. Am J Epidemiol. 1999;149:186-194
34. Davis RL, Rubanowice D, Shinefield HR, et al. Immunization levels among premature and low-birth-weight infants and risk factors for delayed up-to-date immunization status. JAMA. 1999;282:547-53
35. Anderson P, Doyle LW. Neurobehavioral outcomes of school-age children born extremely low birth weight or very preterm in the 1990s. JAMA. 2003;289:3264-3272