Regulatory T cells and the induction of IL-17

Mucosal Immunology

Volumn 1, Issue , 2008, Pages 43-46

  Kitani, A ^a   Xu, L ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

AUTOIMMUNE DISEASE; CD4+ CD25+ FOXP3+ T LYMPHOCYTE; CD4+ CD25- T LYMPHOCYTE; DENDRITIC CELL; ENTERITIS; HELPER CELL; HUMAN; INFLAMMATION; INFLAMMATORY DISEASE; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE; TH17 CELL;

ANIMALS; CELL DIFFERENTIATION; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-17; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 54349097553     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2008.51     Document Type: Review

References (18)

1. Park, H. et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6, 1133-1141 (2005).
2. Fuss, I. J. et al. Both IL-12p70 and IL-23 are synthesized during active Crohn’s disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12, 9-15 (2006).
3. Fantini, M. C., Becker, C., Monteleone, G., Pallone, F., Galle, P. R. & Neurath, M. F. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25 − T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172, 5149-5153 (2004).
4. Veldhoen, M. Hocking, R.J., Atkins, C.J., Locksley, R.M., & Stockinger, B. TGF-b in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189 (2006).
5. Bettelli, E. et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235-238 (2006).
6. Ivanov, I. I. et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121-1133 (2006).
7. Nakamura, K., Kitani, A. & Strober, W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194, 629-644 (2001).
8. Nakamura, K. et al. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J. Immunol. 172, 834-842 (2004).
9. Oida, T., Xu, L., Weiner, H. L., Kitani, A. & Strober, W. TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling. J. Immunol. 177, 2331-2339 (2006).
10. Xu, L., Kitani, A., Fuss, I. & Strober, W. Cutting edge: regulatory T cells induce CD4+CD25 − Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 178, 6725-6729 (2007).
11. Mottet, C., Uhlig, H. H. & Powrie, F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J. Immunol. 170, 3939-3943 (2003).
12. Tang, Q. et al. Visualizing regulatory T cell control of autoimmune responses in non-obese diabetic mice. Nat. Immunol. 7, 83-92 (2005).
13. Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8, 942-949 (2007).
14. van Beelen, A. J. et al. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27, 660-669 (2007).
15. Mangan, P. R. et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441, 231-234 (2006).
16. Makita, S. et al. CD4+CD25 bright T cells in human intestinal lamina propria as regulatory cells. J. Immunol. 173, 3119-3130 (2004).
17. Uhlig, H. H. et al. Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J. Immunol. 177, 5852-5860 (2006).
18. McGeachy, M. J. et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 8, 1390-1397 (2007).