메뉴 건너뛰기




Volumn 78, Issue 11, 2008, Pages 955-967

Selective targeting of the tumour vasculature

Author keywords

Angiogenesis; Anti angiogenic agents; Chemotherapy; Clinical trials; Combretastatins; Neovasculature; OXi 4503; Solid organ malignancies; Tumour vasculature; Vascular disrupting agents

Indexed keywords

AE 941; ANGIOGENESIS INHIBITOR; ANGIOSTATIN; BATIMASTAT; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CILENGITIDE; CISPLATIN; COLCHICINE; COMBRETASTATIN; COMBRETASTATIN A1 PHOSPHATE; DOCETAXEL; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GEMCITABINE; IMATINIB; IRINOTECAN; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; MONOCLONAL ANTIBODY LM 609; N ACETYLPROLYLHISTIDYLSERYLCYSTEINYLASPARAGINE AMIDE; OXALIPLATIN; PACLITAXEL; PRINOMASTAT; TANOMASTAT; UNINDEXED DRUG; VASCULAR TARGETING AGENT;

EID: 54349097093     PISSN: 14451433     EISSN: 14452197     Source Type: Journal    
DOI: 10.1111/j.1445-2197.2008.04712.x     Document Type: Review
Times cited : (15)

References (181)
  • 1
    • 85013312416 scopus 로고
    • Tumour angiogenesis: Therapeutic implications
    • Folkman J. Tumour angiogenesis: therapeutic implications. N. Engl. J. Med. 1971 285 : 1182 6.
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-6
    • Folkman, J.1
  • 2
    • 12244294062 scopus 로고    scopus 로고
    • Biology of angiogenesis in tumours of the gastrointestinal tract
    • Reinmuth N, Parikh AA, Ahmad SA et al. Biology of angiogenesis in tumours of the gastrointestinal tract. Microsc. Res. Tech. 2003 60 : 199 207.
    • (2003) Microsc. Res. Tech. , vol.60 , pp. 199-207
    • Reinmuth, N.1    Parikh, A.A.2    Ahmad, S.A.3
  • 3
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996 86 : 353 64.
    • (1996) Cell , vol.86 , pp. 353-64
    • Hanahan, D.1    Folkman, J.2
  • 4
    • 0021978223 scopus 로고
    • Tumour angiogenesis
    • Folkman J. Tumour angiogenesis. Adv. Cancer Res. 1985 43 : 175 203.
    • (1985) Adv. Cancer Res. , vol.43 , pp. 175-203
    • Folkman, J.1
  • 5
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000 407 : 249 57.
    • (2000) Nature , vol.407 , pp. 249-57
    • Carmeliet, P.1    Jain, R.K.2
  • 6
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat. Med. 2003 9 : 653 60.
    • (2003) Nat. Med. , vol.9 , pp. 653-60
    • Carmeliet, P.1
  • 7
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 2003 9 : 677 84.
    • (2003) Nat. Med. , vol.9 , pp. 677-84
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 8
    • 0029117223 scopus 로고
    • Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
    • Ikeda E, Achen MG, Breier G, Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J. Biol. Chem. 1995 270 : 19761 6.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19761-6
    • Ikeda, E.1    Achen, M.G.2    Breier, G.3    Risau, W.4
  • 9
    • 0036006171 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF), a survival factor for tumour cells: Implications for anti-angiogenic therapy
    • Harmey JH, Bouchier-Hayes D. Vascular endothelial growth factor (VEGF), a survival factor for tumour cells: implications for anti-angiogenic therapy. Bioessays 2002 24 : 280 83.
    • (2002) Bioessays , vol.24 , pp. 280-83
    • Harmey, J.H.1    Bouchier-Hayes, D.2
  • 10
    • 0015311426 scopus 로고
    • Anti-angiogenesis: New concept for therapy of solid tumours
    • Folkman J. Anti-angiogenesis: new concept for therapy of solid tumours. Ann. Surg. 1972 175 : 409 16.
    • (1972) Ann. Surg. , vol.175 , pp. 409-16
    • Folkman, J.1
  • 11
    • 0002399005 scopus 로고    scopus 로고
    • Mechanisms of tumour angiogenesis and therapeutic implications: Angiogenesis inhibitors
    • Malonne H, Langer I, Kiss R, Atassi G. Mechanisms of tumour angiogenesis and therapeutic implications: angiogenesis inhibitors. Clin. Exp. Metastasis 1999 17 : 1 14.
    • (1999) Clin. Exp. Metastasis , vol.17 , pp. 1-14
    • Malonne, H.1    Langer, I.2    Kiss, R.3    Atassi, G.4
  • 13
    • 0037223577 scopus 로고    scopus 로고
    • Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix
    • Li J, Zhang YP, Kirsner RS. Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix. Microsc. Res. Tech. 2003 60 : 107 14.
    • (2003) Microsc. Res. Tech. , vol.60 , pp. 107-14
    • Li, J.1    Zhang, Y.P.2    Kirsner, R.S.3
  • 14
    • 0034255151 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an in vivo survival factor for tumour endothelium in a murine model of colorectal carcinoma liver metastases
    • Bruns CJ, Liu W, Davis DW et al. Vascular endothelial growth factor is an in vivo survival factor for tumour endothelium in a murine model of colorectal carcinoma liver metastases. Cancer 2000 89 : 488 99.
    • (2000) Cancer , vol.89 , pp. 488-99
    • Bruns, C.J.1    Liu, W.2    Davis, D.W.3
  • 15
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and tumour growth
    • O'Reilly MS, Boehm T, Shing Y et al. Endostatin: an endogenous inhibitor of angiogenesis and tumour growth. Cell 1997 88 : 277 85.
    • (1997) Cell , vol.88 , pp. 277-85
    • O'Reilly, M.S.1    Boehm, T.2    Shing, Y.3
  • 16
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of human primary tumours in mice
    • O'Reilly MS, Holmgren L, Chen C, Folkman J. Angiostatin induces and sustains dormancy of human primary tumours in mice. Nat. Med. 1996 2 : 689 92.
    • (1996) Nat. Med. , vol.2 , pp. 689-92
    • O'Reilly, M.S.1    Holmgren, L.2    Chen, C.3    Folkman, J.4
  • 17
    • 0343293956 scopus 로고    scopus 로고
    • Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepatectomy
    • Drixler TA, Rinkes IH, Ritchie ED, van Vroonhoven TJ, Gebbink MF, Voest EE. Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepatectomy. Cancer Res. 2000 60 : 1761 5.
    • (2000) Cancer Res. , vol.60 , pp. 1761-5
    • Drixler, T.A.1    Rinkes, I.H.2    Ritchie, E.D.3    Van Vroonhoven, T.J.4    Gebbink, M.F.5    Voest, E.E.6
  • 18
    • 0035187305 scopus 로고    scopus 로고
    • Tissue examination to monitor antiangiogenic therapy: A phase I clinical trial with endostatin
    • Mundhenke C, Thomas JP, Wilding G et al. Tissue examination to monitor antiangiogenic therapy: a phase I clinical trial with endostatin. Clin. Cancer Res. 2001 7 : 3366 74.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3366-74
    • Mundhenke, C.1    Thomas, J.P.2    Wilding, G.3
  • 19
    • 33747072903 scopus 로고    scopus 로고
    • Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumours
    • Kulke MH, Bergsland EK, Ryan DP et al. Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumours. J. Clin. Oncol. 2006 24 : 3555 61.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3555-61
    • Kulke, M.H.1    Bergsland, E.K.2    Ryan, D.P.3
  • 20
    • 29844452745 scopus 로고    scopus 로고
    • Recombinant human angiostatin (rhAngiostatin) in combination with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer: A phase II study from Indiana University
    • Kurup A, Lin CW, Murry DJ et al. Recombinant human angiostatin (rhAngiostatin) in combination with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer: a phase II study from Indiana University. Ann. Oncol. 2006 17 : 97 103.
    • (2006) Ann. Oncol. , vol.17 , pp. 97-103
    • Kurup, A.1    Lin, C.W.2    Murry, D.J.3
  • 21
    • 0034789517 scopus 로고    scopus 로고
    • Receptor tyrosine kinase signalling as a target for cancer intervention strategies
    • Zwick E, Bange J, Ullrich A. Receptor tyrosine kinase signalling as a target for cancer intervention strategies. Endocr. Relat. Cancer 2001 8 : 161 73.
    • (2001) Endocr. Relat. Cancer , vol.8 , pp. 161-73
    • Zwick, E.1    Bange, J.2    Ullrich, A.3
  • 22
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. 2003 21 : 60 65.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 23
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar FF, Hambleton J, Mass RD, Hurwitz HI, Bergsland E, Sarkar S. Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J. Clin. Oncol. 2005 23 : 3706 12.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3706-12
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3    Hurwitz, H.I.4    Bergsland, E.5    Sarkar, S.6
  • 24
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J. Clin. Oncol. 2005 23 : 3697 705.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3697-705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 25
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 2004 350 : 2335 42.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2335-42
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 26
    • 33750366159 scopus 로고    scopus 로고
    • Bevacizumab in the treatment of metastatic colorectal cancer (mCRC) in second- and third-line settings
    • Giantonio BJ. Bevacizumab in the treatment of metastatic colorectal cancer (mCRC) in second- and third-line settings. Semin. Oncol. 2006 33 : S15 18.
    • (2006) Semin. Oncol. , vol.33
    • Giantonio, B.J.1
  • 27
    • 33746833739 scopus 로고    scopus 로고
    • Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: An NCI treatment referral center trial TRC-0301
    • Chen HX, Mooney M, Boron M et al. Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: an NCI treatment referral center trial TRC-0301. J. Clin. Oncol. 2006 24 : 3354 60.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3354-60
    • Chen, H.X.1    Mooney, M.2    Boron, M.3
  • 28
    • 33744812137 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in combination with weekly docetaxel in metastatic breast cancer patients
    • Ramaswamy B, Elias AD, Kelbick NT et al. Phase II trial of bevacizumab in combination with weekly docetaxel in metastatic breast cancer patients. Clin. Cancer Res. 2006 12 : 3124 9.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 3124-9
    • Ramaswamy, B.1    Elias, A.D.2    Kelbick, N.T.3
  • 29
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N. Engl. J. Med. 2003 349 : 427 34.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 427-34
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 31
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J. Clin. Oncol. 2004 22 : 2184 91.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2184-91
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 32
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • Herbst RS, Johnson DH, Mininberg E et al. Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J. Clin. Oncol. 2005 23 : 2544 55.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2544-55
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 33
    • 27244450145 scopus 로고    scopus 로고
    • Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas
    • D'Adamo DR, Anderson SE, Albritton K et al. Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. J. Clin. Oncol. 2005 23 : 7135 42.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7135-42
    • D'Adamo, D.R.1    Anderson, S.E.2    Albritton, K.3
  • 34
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • Kindler HL, Friberg G, Singh DA et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J. Clin. Oncol. 2005 23 : 8033 40.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8033-40
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3
  • 35
    • 33646351795 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
    • Zhu AX, Blaszkowsky LS, Ryan DP et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 2006 24 : 1898 903.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1898-903
    • Zhu, A.X.1    Blaszkowsky, L.S.2    Ryan, D.P.3
  • 36
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    • Fukuoka M, Yano S, Giaccone G et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J. Clin. Oncol. 2003 21 : 2237 46.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2237-46
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 37
    • 32044472843 scopus 로고    scopus 로고
    • Single-agent gefitinib in patients with untreated advanced non-small-cell lung cancer and poor performance status: A minnie pearl cancer research network phase II trial
    • Spigel DR, Hainsworth JD, Burkett ER et al. Single-agent gefitinib in patients with untreated advanced non-small-cell lung cancer and poor performance status: a minnie pearl cancer research network phase II trial. Clin. Lung Cancer 2005 7 : 127 32.
    • (2005) Clin. Lung Cancer , vol.7 , pp. 127-32
    • Spigel, D.R.1    Hainsworth, J.D.2    Burkett, E.R.3
  • 38
    • 33644845421 scopus 로고    scopus 로고
    • First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: A phase II study
    • Niho S, Kubota K, Goto K et al. First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: a phase II study. J. Clin. Oncol. 2006 24 : 64 9.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 64-9
    • Niho, S.1    Kubota, K.2    Goto, K.3
  • 39
    • 30744447907 scopus 로고    scopus 로고
    • Gefitinib treatment is highly effective in non-small-cell lung cancer patients failing previous chemotherapy in Taiwan: A prospective phase II study
    • Chen YM, Perng RP, Tsai CM. Gefitinib treatment is highly effective in non-small-cell lung cancer patients failing previous chemotherapy in Taiwan: a prospective phase II study. J. Chemother. 2005 17 : 679 84.
    • (2005) J. Chemother. , vol.17 , pp. 679-84
    • Chen, Y.M.1    Perng, R.P.2    Tsai, C.M.3
  • 40
    • 33745230152 scopus 로고    scopus 로고
    • A phase II study of single-agent gefitinib as first-line therapy in patients with stage IV non-small-cell lung cancer
    • Suzuki R, Hasegawa Y, Baba K et al. A phase II study of single-agent gefitinib as first-line therapy in patients with stage IV non-small-cell lung cancer. Br. J. Cancer 2006 94 : 1599 603.
    • (2006) Br. J. Cancer , vol.94 , pp. 1599-603
    • Suzuki, R.1    Hasegawa, Y.2    Baba, K.3
  • 41
    • 33746789922 scopus 로고    scopus 로고
    • Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
    • Inoue A, Suzuki T, Fukuhara T et al. Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J. Clin. Oncol. 2006 24 : 3340 46.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3340-46
    • Inoue, A.1    Suzuki, T.2    Fukuhara, T.3
  • 42
    • 33750205340 scopus 로고    scopus 로고
    • A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
    • Asahina H, Yamazaki K, Kinoshita I et al. A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations. Br. J. Cancer 2006 95 : 998 1004.
    • (2006) Br. J. Cancer , vol.95 , pp. 998-1004
    • Asahina, H.1    Yamazaki, K.2    Kinoshita, I.3
  • 43
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1
    • Giaccone G, Herbst RS, Manegold C et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1. J. Clin. Oncol. 2004 22 : 777 84.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 777-84
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 44
    • 33750962024 scopus 로고    scopus 로고
    • Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer
    • Hirsch FR, Varella-Garcia M, Bunn PA Jr. et al. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J. Clin. Oncol. 2006 24 : 5034 42.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5034-42
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3
  • 45
    • 27644484102 scopus 로고    scopus 로고
    • Gefitinib in the adjuvant setting: Safety results from a phase III study in patients with completely resected non-small cell lung cancer
    • Tsuboi M, Kato H, Nagai K et al. Gefitinib in the adjuvant setting: safety results from a phase III study in patients with completely resected non-small cell lung cancer. Anticancer Drugs 2005 16 : 1123 8.
    • (2005) Anticancer Drugs , vol.16 , pp. 1123-8
    • Tsuboi, M.1    Kato, H.2    Nagai, K.3
  • 46
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 2
    • Herbst RS, Giaccone G, Schiller JH et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2. J. Clin. Oncol. 2004 22 : 785 94.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 785-94
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 47
    • 33646356205 scopus 로고    scopus 로고
    • A phase I/II trial of weekly docetaxel and gefitinib in elderly patients with stage IIIB/IV non-small cell lung cancer
    • Stinchcombe TE, Buzkova P, Choksi J et al. A phase I/II trial of weekly docetaxel and gefitinib in elderly patients with stage IIIB/IV non-small cell lung cancer. Lung Cancer 2006 52 : 305 11.
    • (2006) Lung Cancer , vol.52 , pp. 305-11
    • Stinchcombe, T.E.1    Buzkova, P.2    Choksi, J.3
  • 48
    • 21044438337 scopus 로고    scopus 로고
    • Paclitaxel and carboplatin as first-line chemotherapy combined with gefitinib (IRESSA) in patients with advanced breast cancer: A phase I/II study conducted by the Hellenic Cooperative Oncology Group
    • Fountzilas G, Pectasides D, Kalogera-Fountzila A et al. Paclitaxel and carboplatin as first-line chemotherapy combined with gefitinib (IRESSA) in patients with advanced breast cancer: a phase I/II study conducted by the Hellenic Cooperative Oncology Group. Breast Cancer Res. Treat. 2005 92 : 1 9.
    • (2005) Breast Cancer Res. Treat. , vol.92 , pp. 1-9
    • Fountzilas, G.1    Pectasides, D.2    Kalogera-Fountzila, A.3
  • 49
    • 23944464495 scopus 로고    scopus 로고
    • Phase II and tumour pharmacodynamic study of gefitinib in patients with advanced breast cancer
    • Baselga J, Albanell J, Ruiz A et al. Phase II and tumour pharmacodynamic study of gefitinib in patients with advanced breast cancer. J. Clin. Oncol. 2005 23 : 5323 33.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5323-33
    • Baselga, J.1    Albanell, J.2    Ruiz, A.3
  • 50
    • 33745277110 scopus 로고    scopus 로고
    • Phase II study of gefitinib in combination with docetaxel as first-line therapy in metastatic breast cancer
    • Ciardiello F, Troiani T, Caputo F et al. Phase II study of gefitinib in combination with docetaxel as first-line therapy in metastatic breast cancer. Br. J. Cancer 2006 94 : 1604 9.
    • (2006) Br. J. Cancer , vol.94 , pp. 1604-9
    • Ciardiello, F.1    Troiani, T.2    Caputo, F.3
  • 51
    • 20344380924 scopus 로고    scopus 로고
    • A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer
    • Veronese ML, Sun W, Giantonio B et al. A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer. Br. J. Cancer 2005 92 : 1846 9.
    • (2005) Br. J. Cancer , vol.92 , pp. 1846-9
    • Veronese, M.L.1    Sun, W.2    Giantonio, B.3
  • 52
    • 23244446134 scopus 로고    scopus 로고
    • Phase I/II trial of gefitinib and oxaliplatin in patients with advanced colorectal cancer
    • Kindler HL, Friberg G, Skoog L, Wade-Oliver K, Vokes EE. Phase I/II trial of gefitinib and oxaliplatin in patients with advanced colorectal cancer. Am. J. Clin. Oncol. 2005 28 : 340 44.
    • (2005) Am. J. Clin. Oncol. , vol.28 , pp. 340-44
    • Kindler, H.L.1    Friberg, G.2    Skoog, L.3    Wade-Oliver, K.4    Vokes, E.E.5
  • 53
    • 33644822287 scopus 로고    scopus 로고
    • Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma
    • Rothenberg ML, LaFleur B, Levy DE et al. Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. J. Clin. Oncol. 2005 23 : 9265 74.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 9265-74
    • Rothenberg, M.L.1    Lafleur, B.2    Levy, D.E.3
  • 54
    • 24944484717 scopus 로고    scopus 로고
    • Phase II study of gefitinib, fluorouracil, leucovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancer
    • Kuo T, Cho CD, Halsey J et al. Phase II study of gefitinib, fluorouracil, leucovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancer. J. Clin. Oncol. 2005 23 : 5613 19.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5613-19
    • Kuo, T.1    Cho, C.D.2    Halsey, J.3
  • 55
    • 12744255161 scopus 로고    scopus 로고
    • Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non-small-cell lung cancer
    • Perez-Soler R. Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non-small-cell lung cancer. Clin. Lung Cancer 2004 6 (Suppl. 1 S20 23.
    • (2004) Clin. Lung Cancer , vol.6 , Issue.SUPPL. 1
    • Perez-Soler, R.1
  • 56
    • 33750700477 scopus 로고    scopus 로고
    • Erlotinib for frontline treatment of advanced non-small cell lung cancer: A phase II study
    • Giaccone G, Gallegos Ruiz M, Le Chevalier T et al. Erlotinib for frontline treatment of advanced non-small cell lung cancer: a phase II study. Clin. Cancer Res. 2006 12 : 6049 55.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6049-55
    • Giaccone, G.1    Gallegos Ruiz, M.2    Le Chevalier, T.3
  • 57
    • 33747886041 scopus 로고    scopus 로고
    • A phase I/II study of weekly high-dose erlotinib in previously treated patients with non small cell lung cancer
    • Milton DT, Azzoli CG, Heelan RT et al. A phase I/II study of weekly high-dose erlotinib in previously treated patients with non small cell lung cancer. Cancer 2006 107 : 1034 41.
    • (2006) Cancer , vol.107 , pp. 1034-41
    • Milton, D.T.1    Azzoli, C.G.2    Heelan, R.T.3
  • 58
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst RS, Prager D, Hermann R et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J. Clin. Oncol. 2005 23 : 5892 9.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5892-9
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 59
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J. Clin. Oncol. 2004 22 : 77 85.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarwala, S.S.5    Siu, L.L.6
  • 60
    • 27244447373 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer
    • Philip PA, Mahoney MR, Allmer C et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J. Clin. Oncol. 2005 23 : 6657 63.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6657-63
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 61
    • 33646361363 scopus 로고    scopus 로고
    • Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastatic colorectal cancer
    • Meyerhardt JA, Zhu AX, Enzinger PC et al. Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastatic colorectal cancer. J. Clin. Oncol. 2006 24 : 1892 7.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1892-7
    • Meyerhardt, J.A.1    Zhu, A.X.2    Enzinger, P.C.3
  • 62
    • 0036498781 scopus 로고    scopus 로고
    • Cardiac dysfunction in the trastuzumab clinical trials experience
    • Seidman A, Hudis C, Pierri MK et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J. Clin. Oncol. 2002 20 : 1215 21.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1215-21
    • Seidman, A.1    Hudis, C.2    Pierri, M.K.3
  • 63
    • 0035210658 scopus 로고    scopus 로고
    • Imatinib mesylate: Clinical results in Philadelphia chromosome-positive leukemias
    • Kantarjian HM, Talpaz M. Imatinib mesylate: clinical results in Philadelphia chromosome-positive leukemias. Semin. Oncol. 2001 28 : 9 18.
    • (2001) Semin. Oncol. , vol.28 , pp. 9-18
    • Kantarjian, H.M.1    Talpaz, M.2
  • 64
    • 20844463222 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate for patients in the first chronic phase of chronic myeloid leukemia: Results of a Japanese phase II clinical study
    • Morishima Y, Ogura M, Nishimura M et al. Efficacy and safety of imatinib mesylate for patients in the first chronic phase of chronic myeloid leukemia: results of a Japanese phase II clinical study. Int. J. Hematol. 2004 80 : 261 6.
    • (2004) Int. J. Hematol. , vol.80 , pp. 261-6
    • Morishima, Y.1    Ogura, M.2    Nishimura, M.3
  • 65
    • 18044381919 scopus 로고    scopus 로고
    • Imatinib mesylate lacks activity in small cell lung carcinoma expressing c-kit protein: A phase II clinical trial
    • Krug LM, Crapanzano JP, Azzoli CG et al. Imatinib mesylate lacks activity in small cell lung carcinoma expressing c-kit protein: a phase II clinical trial. Cancer 2005 103 : 2128 31.
    • (2005) Cancer , vol.103 , pp. 2128-31
    • Krug, L.M.1    Crapanzano, J.P.2    Azzoli, C.G.3
  • 66
    • 29144474459 scopus 로고    scopus 로고
    • Pharmacokinetic and clinical phase II trial of imatinib in patients with impaired liver function and advanced hepatocellular carcinoma
    • Eckel F, von Delius S, Mayr M et al. Pharmacokinetic and clinical phase II trial of imatinib in patients with impaired liver function and advanced hepatocellular carcinoma. Oncology 2005 69 : 363 71.
    • (2005) Oncology , vol.69 , pp. 363-71
    • Eckel, F.1    Von Delius, S.2    Mayr, M.3
  • 67
    • 21044460131 scopus 로고    scopus 로고
    • Lack of clinical efficacy of imatinib in metastatic melanoma
    • Ugurel S, Hildenbrand R, Zimpfer A et al. Lack of clinical efficacy of imatinib in metastatic melanoma. Br. J. Cancer 2005 92 : 1398 405.
    • (2005) Br. J. Cancer , vol.92 , pp. 1398-405
    • Ugurel, S.1    Hildenbrand, R.2    Zimpfer, A.3
  • 68
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
    • Wyman K, Atkins MB, Prieto V et al. Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer 2006 106 : 2005 11.
    • (2006) Cancer , vol.106 , pp. 2005-11
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3
  • 69
    • 33644977853 scopus 로고    scopus 로고
    • Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumour)
    • Heinrich MC, McArthur GA, Demetri GD et al. Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumour). J. Clin. Oncol. 2006 24 : 1195 203.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1195-203
    • Heinrich, M.C.1    McArthur, G.A.2    Demetri, G.D.3
  • 71
    • 0346117570 scopus 로고    scopus 로고
    • Recent insights into angiogenesis, apoptosis, invasion, and metastasis in colorectal carcinoma
    • Boedefeld WM 2nd., Bland KI, Heslin MJ. Recent insights into angiogenesis, apoptosis, invasion, and metastasis in colorectal carcinoma. Ann. Surg. Oncol. 2003 10 : 839 51.
    • (2003) Ann. Surg. Oncol. , vol.10 , pp. 839-51
    • Boedefeld II, W.M.1    Bland, K.I.2    Heslin, M.J.3
  • 72
    • 24044459285 scopus 로고    scopus 로고
    • Matrix metalloproteinases and angiogenesis
    • Rundhaug JE. Matrix metalloproteinases and angiogenesis. J. Cell. Mol. Med. 2005 9 : 267 85.
    • (2005) J. Cell. Mol. Med. , vol.9 , pp. 267-85
    • Rundhaug, J.E.1
  • 73
    • 0031657033 scopus 로고    scopus 로고
    • New drugs on the horizon: Matrix metalloproteinase inhibitors
    • Rothenberg ML, Nelson AR, Hande KR. New drugs on the horizon: matrix metalloproteinase inhibitors. Oncologist 1998 3 : 271 4.
    • (1998) Oncologist , vol.3 , pp. 271-4
    • Rothenberg, M.L.1    Nelson, A.R.2    Hande, K.R.3
  • 74
    • 0029959437 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1
    • Levi E, Fridman R, Miao HQ, Ma YS, Yayon A, Vlodavsky I. Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1. Proc. Natl Acad. Sci. U. S. A. 1996 93 : 7069 74.
    • (1996) Proc. Natl Acad. Sci. U. S. A. , vol.93 , pp. 7069-74
    • Levi, E.1    Fridman, R.2    Miao, H.Q.3    Ma, Y.S.4    Yayon, A.5    Vlodavsky, I.6
  • 75
  • 76
    • 0036267895 scopus 로고    scopus 로고
    • Comparison of matrix metalloproteinase expression between primary tumours with or without liver metastasis in pancreatic and colorectal carcinomas
    • Matsuyama Y, Takao S, Aikou T. Comparison of matrix metalloproteinase expression between primary tumours with or without liver metastasis in pancreatic and colorectal carcinomas. J. Surg. Oncol. 2002 80 : 105 10.
    • (2002) J. Surg. Oncol. , vol.80 , pp. 105-10
    • Matsuyama, Y.1    Takao, S.2    Aikou, T.3
  • 77
    • 0029847630 scopus 로고    scopus 로고
    • Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer
    • Wojtowicz-Praga S, Low J, Marshall J et al. Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer. Invest. New Drugs 1996 14 : 193 202.
    • (1996) Invest. New Drugs , vol.14 , pp. 193-202
    • Wojtowicz-Praga, S.1    Low, J.2    Marshall, J.3
  • 78
    • 0035556141 scopus 로고    scopus 로고
    • A phase II trial of marimastat in advanced pancreatic cancer
    • Evans JD, Stark A, Johnson CD et al. A phase II trial of marimastat in advanced pancreatic cancer. Br. J. Cancer 2001 85 : 1865 70.
    • (2001) Br. J. Cancer , vol.85 , pp. 1865-70
    • Evans, J.D.1    Stark, A.2    Johnson, C.D.3
  • 79
    • 0036499078 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme
    • Groves MD, Puduvalli VK, Hess KR et al. Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme. J. Clin. Oncol. 2002 20 : 1383 8.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1383-8
    • Groves, M.D.1    Puduvalli, V.K.2    Hess, K.R.3
  • 80
    • 33749189084 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: A relationship among efficacy, joint toxicity and anticonvulsant status
    • Groves MD, Puduvalli VK, Conrad CA et al. Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status. J. Neurooncol. 2006 80 : 83 90.
    • (2006) J. Neurooncol. , vol.80 , pp. 83-90
    • Groves, M.D.1    Puduvalli, V.K.2    Conrad, C.A.3
  • 81
    • 0036668663 scopus 로고    scopus 로고
    • A randomized phase II pilot trial of adjuvant marimastat in patients with early-stage breast cancer
    • Miller KD, Gradishar W, Schuchter L et al. A randomized phase II pilot trial of adjuvant marimastat in patients with early-stage breast cancer. Ann. Oncol. 2002 13 : 1220 24.
    • (2002) Ann. Oncol. , vol.13 , pp. 1220-24
    • Miller, K.D.1    Gradishar, W.2    Schuchter, L.3
  • 82
    • 16544372352 scopus 로고    scopus 로고
    • Randomized phase III trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy: Eastern Cooperative Oncology Group trial E2196
    • Sparano JA, Bernardo P, Stephenson P et al. Randomized phase III trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy: Eastern Cooperative Oncology Group trial E2196. J. Clin. Oncol. 2004 22 : 4683 90.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4683-90
    • Sparano, J.A.1    Bernardo, P.2    Stephenson, P.3
  • 83
    • 0036830078 scopus 로고    scopus 로고
    • Phase II study of marimastat (BB-2516) in malignant melanoma: A clinical and tumour biopsy study of the National Cancer Institute of Canada Clinical Trials Group
    • Quirt I, Bodurth A, Lohmann R et al. Phase II study of marimastat (BB-2516) in malignant melanoma: a clinical and tumour biopsy study of the National Cancer Institute of Canada Clinical Trials Group. Invest. New Drugs 2002 20 : 431 7.
    • (2002) Invest. New Drugs , vol.20 , pp. 431-7
    • Quirt, I.1    Bodurth, A.2    Lohmann, R.3
  • 84
    • 20444484501 scopus 로고    scopus 로고
    • Marimastat in the treatment of patients with biochemically relapsed prostate cancer: A prospective randomized, double-blind, phase I/II trial
    • Rosenbaum E, Zahurak M, Sinibaldi V et al. Marimastat in the treatment of patients with biochemically relapsed prostate cancer: a prospective randomized, double-blind, phase I/II trial. Clin. Cancer Res. 2005 11 : 4437 43.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4437-43
    • Rosenbaum, E.1    Zahurak, M.2    Sinibaldi, V.3
  • 85
    • 0036668668 scopus 로고    scopus 로고
    • Neovastat (AE-941) in refractory renal cell carcinoma patients: Report of a phase II trial with two dose levels
    • Batist G, Patenaude F, Champagne P et al. Neovastat (AE-941) in refractory renal cell carcinoma patients: report of a phase II trial with two dose levels. Ann. Oncol. 2002 13 : 1259 63.
    • (2002) Ann. Oncol. , vol.13 , pp. 1259-63
    • Batist, G.1    Patenaude, F.2    Champagne, P.3
  • 86
    • 0038546557 scopus 로고    scopus 로고
    • Phase I/II trial of the safety and efficacy of AE-941 (Neovastat) in the treatment of non-small-cell lung cancer
    • Latreille J, Batist G, Laberge F et al. Phase I/II trial of the safety and efficacy of AE-941 (Neovastat) in the treatment of non-small-cell lung cancer. Clin. Lung Cancer 2003 4 : 231 6.
    • (2003) Clin. Lung Cancer , vol.4 , pp. 231-6
    • Latreille, J.1    Batist, G.2    Laberge, F.3
  • 87
    • 0142029001 scopus 로고    scopus 로고
    • Venous thromboembolism among patients with advanced lung cancer randomized to prinomastat or placebo, plus chemotherapy
    • Behrendt CE, Ruiz RB. Venous thromboembolism among patients with advanced lung cancer randomized to prinomastat or placebo, plus chemotherapy. Thromb. Haemost. 2003 90 : 734 7.
    • (2003) Thromb. Haemost. , vol.90 , pp. 734-7
    • Behrendt, C.E.1    Ruiz, R.B.2
  • 88
    • 20044388325 scopus 로고    scopus 로고
    • Phase III study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer
    • Bissett D, O'Byrne KJ, von Pawel J et al. Phase III study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer. J. Clin. Oncol. 2005 23 : 842 9.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 842-9
    • Bissett, D.1    O'Byrne, K.J.2    Von Pawel, J.3
  • 89
    • 33646594999 scopus 로고    scopus 로고
    • Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma
    • Heath EI, Burtness BA, Kleinberg L et al. Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma. Invest. New Drugs 2006 24 : 135 40.
    • (2006) Invest. New Drugs , vol.24 , pp. 135-40
    • Heath, E.I.1    Burtness, B.A.2    Kleinberg, L.3
  • 90
    • 0141688333 scopus 로고    scopus 로고
    • Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Hamm J, Dancey J et al. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 2003 21 : 3296 302.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3296-302
    • Moore, M.J.1    Hamm, J.2    Dancey, J.3
  • 91
    • 33745963397 scopus 로고    scopus 로고
    • A phase III randomized trial of BAY 12-9566 (tanomastat) as maintenance therapy in patients with advanced ovarian cancer responsive to primary surgery and paclitaxel/platinum containing chemotherapy: A National Cancer Institute of Canada Clinical Trials Group Study
    • Hirte H, Vergote IB, Jeffrey JR et al. A phase III randomized trial of BAY 12-9566 (tanomastat) as maintenance therapy in patients with advanced ovarian cancer responsive to primary surgery and paclitaxel/platinum containing chemotherapy: a National Cancer Institute of Canada Clinical Trials Group Study. Gynecol. Oncol. 2006 102 : 300 308.
    • (2006) Gynecol. Oncol. , vol.102 , pp. 300-308
    • Hirte, H.1    Vergote, I.B.2    Jeffrey, J.R.3
  • 93
    • 27744563296 scopus 로고    scopus 로고
    • Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumour perfusion
    • McNeel DG, Eickhoff J, Lee FT et al. Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumour perfusion. Clin. Cancer Res. 2005 11 : 7851 60.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7851-60
    • McNeel, D.G.1    Eickhoff, J.2    Lee, F.T.3
  • 94
    • 33846604223 scopus 로고    scopus 로고
    • A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD
    • 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer.
    • Friess H, Langrehr JM, Oettle H et al. A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer. BMC Cancer 2006 6 : 285 97.
    • (2006) BMC Cancer , vol.6 , pp. 285-97
    • Friess, H.1    Langrehr, J.M.2    Oettle, H.3
  • 95
    • 33745240059 scopus 로고    scopus 로고
    • Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta integrin antagonist, in patients with solid tumours
    • Cianfrocca ME, Kimmel KA, Gallo J et al. Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta integrin antagonist, in patients with solid tumours. Br. J. Cancer 2006 94 : 1621 6.
    • (2006) Br. J. Cancer , vol.94 , pp. 1621-6
    • Cianfrocca, M.E.1    Kimmel, K.A.2    Gallo, J.3
  • 96
    • 0033870756 scopus 로고    scopus 로고
    • Targeted antiangiogenic therapy for cancer using vitaxin: A humanized monoclonal antibody to the integrin alphavbeta3
    • Gutheil JC, Campbell TN, Pierce PR et al. Targeted antiangiogenic therapy for cancer using vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3. Clin. Cancer Res. 2000 6 : 3056 61.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3056-61
    • Gutheil, J.C.1    Campbell, T.N.2    Pierce, P.R.3
  • 97
    • 0002063294 scopus 로고    scopus 로고
    • Mechanistic insights into tumour angiogenesis
    • In: Bicknell, R., Lewis, C.E., Ferrara, N. (. eds). USA: Oxford University Press
    • Bicknell R. Mechanistic insights into tumour angiogenesis. In : Bicknell R, Lewis CE, Ferrara N (eds). Tumour Angiogenesis. USA : Oxford University Press, 1997 19 28.
    • (1997) Tumour Angiogenesis. , pp. 19-28
    • Bicknell, R.1
  • 98
    • 0141993064 scopus 로고    scopus 로고
    • A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia
    • Fiedler W, Mesters R, Tinnefeld H et al. A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia. Blood 2003 102 : 2763 7.
    • (2003) Blood , vol.102 , pp. 2763-7
    • Fiedler, W.1    Mesters, R.2    Tinnefeld, H.3
  • 99
    • 0038327794 scopus 로고    scopus 로고
    • Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma
    • Kuenen BC, Tabernero J, Baselga J et al. Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. Clin. Cancer Res. 2003 9 : 1648 55.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1648-55
    • Kuenen, B.C.1    Tabernero, J.2    Baselga, J.3
  • 100
    • 0032767386 scopus 로고    scopus 로고
    • Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma
    • Stadler WM, Kuzel T, Shapiro C, Sosman J, Clark J, Vogelzang NJ. Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma. J. Clin. Oncol. 1999 17 : 2541 5.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2541-5
    • Stadler, W.M.1    Kuzel, T.2    Shapiro, C.3    Sosman, J.4    Clark, J.5    Vogelzang, N.J.6
  • 101
    • 1642453748 scopus 로고    scopus 로고
    • Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma
    • Zangari M, Anaissie E, Stopeck A et al. Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma. Clin. Cancer Res. 2004 10 : 88 95.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 88-95
    • Zangari, M.1    Anaissie, E.2    Stopeck, A.3
  • 102
    • 0345829317 scopus 로고    scopus 로고
    • Improvement in efficacy of chemoradiotherapy by addition of an antiangiogenic agent in a murine tumour model
    • McDonnell CO, Holden G, Sheridan ME et al. Improvement in efficacy of chemoradiotherapy by addition of an antiangiogenic agent in a murine tumour model. J. Surg. Res. 2004 116 : 19 23.
    • (2004) J. Surg. Res. , vol.116 , pp. 19-23
    • McDonnell, C.O.1    Holden, G.2    Sheridan, M.E.3
  • 103
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumour vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumour vasculature: an emerging concept in antiangiogenic therapy. Science 2005 307 : 58 62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 104
    • 0037341360 scopus 로고    scopus 로고
    • Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis
    • Morioka H, Weissbach L, Vogel T et al. Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis. Clin. Cancer Res. 2003 9 : 1211 17.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1211-17
    • Morioka, H.1    Weissbach, L.2    Vogel, T.3
  • 105
    • 20944448672 scopus 로고    scopus 로고
    • Trimodal cancer treatment: Beneficial effects of combined antiangiogenesis, radiation, and chemotherapy
    • Huber PE, Bischof M, Jenne J et al. Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res. 2005 65 : 3643 55.
    • (2005) Cancer Res. , vol.65 , pp. 3643-55
    • Huber, P.E.1    Bischof, M.2    Jenne, J.3
  • 106
    • 0348134966 scopus 로고    scopus 로고
    • Chemotherapy and antiangiogenesis: Drug-specific effects on microvessel sprouting
    • Albertsson P, Lennernas B, Norrby K. Chemotherapy and antiangiogenesis: drug-specific effects on microvessel sprouting. APMIS 2003 111 : 995 1003.
    • (2003) APMIS , vol.111 , pp. 995-1003
    • Albertsson, P.1    Lennernas, B.2    Norrby, K.3
  • 107
    • 0037900611 scopus 로고    scopus 로고
    • Antiangiogenesis drug promising for metastatic colorectal cancer
    • McCarthy M. Antiangiogenesis drug promising for metastatic colorectal cancer. Lancet 2003 361 : 1959.
    • (2003) Lancet , vol.361 , pp. 1959
    • McCarthy, M.1
  • 108
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
    • Kerbel RS. Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science 2006 312 : 1171 5.
    • (2006) Science , vol.312 , pp. 1171-5
    • Kerbel, R.S.1
  • 109
    • 21044446644 scopus 로고    scopus 로고
    • Synergistic anti-tumour effect of recombinant human endostatin adenovirus combined with gemcitabine
    • Wu Y, Yang L, Hu B et al. Synergistic anti-tumour effect of recombinant human endostatin adenovirus combined with gemcitabine. Anticancer Drugs 2005 16 : 551 7.
    • (2005) Anticancer Drugs , vol.16 , pp. 551-7
    • Wu, Y.1    Yang, L.2    Hu, B.3
  • 110
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumours
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumours. Cancer Res. 2004 64 : 3731 6.
    • (2004) Cancer Res. , vol.64 , pp. 3731-6
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 111
    • 0036294343 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-mediated angiogenesis inhibition and postoperative wound healing in rats
    • Roman CD, Choy H, Nanney L et al. Vascular endothelial growth factor-mediated angiogenesis inhibition and postoperative wound healing in rats. J. Surg. Res. 2002 105 : 43 7.
    • (2002) J. Surg. Res. , vol.105 , pp. 43-7
    • Roman, C.D.1    Choy, H.2    Nanney, L.3
  • 112
    • 0032997008 scopus 로고    scopus 로고
    • The clinical manipulation of angiogenesis: Pathology, side-effects, surprises, and opportunities with novel human therapies
    • Thompson WD, Li WW, Maragoudakis M. The clinical manipulation of angiogenesis: pathology, side-effects, surprises, and opportunities with novel human therapies. J. Pathol. 1999 187 : 503 10.
    • (1999) J. Pathol. , vol.187 , pp. 503-10
    • Thompson, W.D.1    Li, W.W.2    Maragoudakis, M.3
  • 113
    • 24344442899 scopus 로고    scopus 로고
    • Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab
    • Scappaticci FA, Fehrenbacher L, Cartwright T et al. Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab. J. Surg. Oncol. 2005 91 : 173 80.
    • (2005) J. Surg. Oncol. , vol.91 , pp. 173-80
    • Scappaticci, F.A.1    Fehrenbacher, L.2    Cartwright, T.3
  • 114
    • 33845433384 scopus 로고    scopus 로고
    • Angiogenesis inhibition with bevacizumab and the surgical management of colorectal cancer
    • Thornton AD, Ravn P, Winslet M, Chester K. Angiogenesis inhibition with bevacizumab and the surgical management of colorectal cancer. Br. J. Surg. 2006 93 : 1456 63.
    • (2006) Br. J. Surg. , vol.93 , pp. 1456-63
    • Thornton, A.D.1    Ravn, P.2    Winslet, M.3    Chester, K.4
  • 115
    • 0020081554 scopus 로고
    • Endothelial cell proliferation as a novel approach to targeting tumour therapy
    • Denekamp J. Endothelial cell proliferation as a novel approach to targeting tumour therapy. Br. J. Cancer 1982 45 : 136 9.
    • (1982) Br. J. Cancer , vol.45 , pp. 136-9
    • Denekamp, J.1
  • 116
    • 0021239705 scopus 로고
    • Endothelial proliferation in tumours and normal tissues: Continuous labelling studies
    • Hobson B, Denekamp J. Endothelial proliferation in tumours and normal tissues: continuous labelling studies. Br. J. Cancer 1984 49 : 405 13.
    • (1984) Br. J. Cancer , vol.49 , pp. 405-13
    • Hobson, B.1    Denekamp, J.2
  • 117
    • 0023909330 scopus 로고
    • Determinants of tumour blood flow: A review
    • Jain RK. Determinants of tumour blood flow: a review. Cancer Res. 1988 48 : 2641 58.
    • (1988) Cancer Res. , vol.48 , pp. 2641-58
    • Jain, R.K.1
  • 119
    • 0020449692 scopus 로고
    • Endothelial-cell proliferation in experimental tumours
    • Denekamp J, Hobson B. Endothelial-cell proliferation in experimental tumours. Br. J. Cancer 1982 46 : 711 20.
    • (1982) Br. J. Cancer , vol.46 , pp. 711-20
    • Denekamp, J.1    Hobson, B.2
  • 120
    • 3843090808 scopus 로고    scopus 로고
    • Combretastatin family member OXI4503 induces tumour vascular collapse through the induction of endothelial apoptosis
    • Sheng Y, Hua J, Pinney KG et al. Combretastatin family member OXI4503 induces tumour vascular collapse through the induction of endothelial apoptosis. Int. J. Cancer 2004 111 : 604 10.
    • (2004) Int. J. Cancer , vol.111 , pp. 604-10
    • Sheng, Y.1    Hua, J.2    Pinney, K.G.3
  • 121
    • 0001845395 scopus 로고    scopus 로고
    • Microregional tumour blood flow: Heterogeneity and therapeutic significance
    • In: Bicknell, R., Lewis, C.E., Ferrara, N. (. eds). Oxford University Press
    • Chaplin D, Trotter M, Dougherty GJ. Microregional tumour blood flow: heterogeneity and therapeutic significance. In : Bicknell R, Lewis CE, Ferrara N (eds). Tumour Angiogenesis. Oxford University Press, 1997 61 70.
    • (1997) Tumour Angiogenesis. , pp. 61-70
    • Chaplin, D.1    Trotter, M.2    Dougherty, G.J.3
  • 122
    • 0031443206 scopus 로고    scopus 로고
    • A cancer therapy resistant to resistance
    • Kerbel RS. A cancer therapy resistant to resistance. Nature 1997 390 : 335 6.
    • (1997) Nature , vol.390 , pp. 335-6
    • Kerbel, R.S.1
  • 123
    • 24744453094 scopus 로고    scopus 로고
    • Taking down tumours: Vascular disrupting agents entering clinical trials
    • O'Hanlon LH. Taking down tumours: vascular disrupting agents entering clinical trials. J. Natl. Cancer Inst. 2005 97 : 1244 5.
    • (2005) J. Natl. Cancer Inst. , vol.97 , pp. 1244-5
    • O'Hanlon, L.H.1
  • 124
    • 2642571660 scopus 로고    scopus 로고
    • Vascular-targeting therapies for treatment of malignant disease
    • Siemann DW, Chaplin DJ, Horsman MR. Vascular-targeting therapies for treatment of malignant disease. Cancer 2004 100 : 2491 9.
    • (2004) Cancer , vol.100 , pp. 2491-9
    • Siemann, D.W.1    Chaplin, D.J.2    Horsman, M.R.3
  • 126
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin. Cancer Res. 2004 10 : 415 27.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 415-27
    • Thorpe, P.E.1
  • 127
    • 0027368441 scopus 로고
    • Eradication of large solid tumours in mice with an immunotoxin directed against tumour vasculature
    • Burrows FJ, Thorpe PE. Eradication of large solid tumours in mice with an immunotoxin directed against tumour vasculature. Proc. Natl. Acad. Sci. U. S. A. 1993 90 : 8996 9000.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 8996-9000
    • Burrows, F.J.1    Thorpe, P.E.2
  • 128
    • 0027470189 scopus 로고
    • Phase I/II study of murine monoclonal antibody-ricin a chain (XOMAZYME-Mel) immunoconjugate plus cyclosporine a in patients with metastatic melanoma
    • Selvaggi K, Saria EA, Schwartz R et al. Phase I/II study of murine monoclonal antibody-ricin A chain (XOMAZYME-Mel) immunoconjugate plus cyclosporine A in patients with metastatic melanoma. J. Immunother. 1993 13 : 201 7.
    • (1993) J. Immunother. , vol.13 , pp. 201-7
    • Selvaggi, K.1    Saria, E.A.2    Schwartz, R.3
  • 129
    • 0025180502 scopus 로고
    • Antimelanoma monoclonal antibody-ricin a chain immunoconjugate (XMMME-001-RTA) plus cyclophosphamide in the treatment of metastatic malignant melanoma: Results of a phase II trial
    • Oratz R, Speyer JL, Wernz JC et al. Antimelanoma monoclonal antibody-ricin A chain immunoconjugate (XMMME-001-RTA) plus cyclophosphamide in the treatment of metastatic malignant melanoma: results of a phase II trial. J. Biol. Response Modif. 1990 9 : 345 54.
    • (1990) J. Biol. Response Modif. , vol.9 , pp. 345-54
    • Oratz, R.1    Speyer, J.L.2    Wernz, J.C.3
  • 130
    • 0027984152 scopus 로고
    • A phase I/II study of the intralesional injection of ricin-monoclonal antibody conjugates in patients with hepatic metastases
    • Zalcberg JR, Pietersz G, Toohey B et al. A phase I/II study of the intralesional injection of ricin-monoclonal antibody conjugates in patients with hepatic metastases. Eur. J. Cancer. 1994 30A : 1227 31.
    • (1994) Eur. J. Cancer. , vol.30 , pp. 1227-31
    • Zalcberg, J.R.1    Pietersz, G.2    Toohey, B.3
  • 131
    • 0031783693 scopus 로고    scopus 로고
    • Phase II clinical trial of bolus infusion anti-B4 blocked ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma
    • Multani PS, O'Day S, Nadler LM, Grossbard ML. Phase II clinical trial of bolus infusion anti-B4 blocked ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma. Clin. Cancer Res. 1998 4 : 2599 604.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2599-604
    • Multani, P.S.1    O'Day, S.2    Nadler, L.M.3    Grossbard, M.L.4
  • 132
    • 0036198635 scopus 로고    scopus 로고
    • A phase II study of the immunotoxin N901-blocked ricin in small-cell lung cancer
    • Fidias P, Grossbard M, Lynch TJ Jr. A phase II study of the immunotoxin N901-blocked ricin in small-cell lung cancer. Clin. Lung Cancer 2002 3 : 219 22.
    • (2002) Clin. Lung Cancer , vol.3 , pp. 219-22
    • Fidias, P.1    Grossbard, M.2    Lynch Jr., T.J.3
  • 133
    • 0024406105 scopus 로고
    • Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma
    • Kerr DJ, Maughan T, Newlands E et al. Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma. Br. J. Cancer 1989 60 : 104 6.
    • (1989) Br. J. Cancer , vol.60 , pp. 104-6
    • Kerr, D.J.1    Maughan, T.2    Newlands, E.3
  • 134
    • 0025282726 scopus 로고
    • Phase II trials with flavone acetic acid (NCS.
    • 347512, LM975) in patients with advanced carcinoma of the breast, colon, head and neck and melanoma.
    • Kaye SB, Clavel M, Dodion P et al. Phase II trials with flavone acetic acid (NCS. 347512, LM975) in patients with advanced carcinoma of the breast, colon, head and neck and melanoma. Invest. New Drugs 1990 8 (Suppl. 1 S95 9.
    • (1990) Invest. New Drugs , vol.8 , Issue.SUPPL. 1
    • Kaye, S.B.1    Clavel, M.2    Dodion, P.3
  • 135
    • 0025255485 scopus 로고
    • Recombinant interleukin-2 (rIL-2) with flavone acetic acid (FAA) in advanced malignant melanoma: A phase II study
    • Thatcher N, Dazzi H, Mellor M et al. Recombinant interleukin-2 (rIL-2) with flavone acetic acid (FAA) in advanced malignant melanoma: a phase II study. Br. J. Cancer 1990 61 : 618 21.
    • (1990) Br. J. Cancer , vol.61 , pp. 618-21
    • Thatcher, N.1    Dazzi, H.2    Mellor, M.3
  • 136
    • 0038575250 scopus 로고    scopus 로고
    • Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent
    • Jameson MB, Thompson PI, Baguley BC et al. Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent. Br. J. Cancer 2003 88 : 1844 50.
    • (2003) Br. J. Cancer , vol.88 , pp. 1844-50
    • Jameson, M.B.1    Thompson, P.I.2    Baguley, B.C.3
  • 137
    • 0038576231 scopus 로고    scopus 로고
    • 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: Phase I clinical and pharmacokinetic study
    • Rustin GJ, Bradley C, Galbraith S et al. 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study. Br. J. Cancer 2003 88 : 1160 67.
    • (2003) Br. J. Cancer , vol.88 , pp. 1160-67
    • Rustin, G.J.1    Bradley, C.2    Galbraith, S.3
  • 138
    • 33645732100 scopus 로고    scopus 로고
    • Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumours
    • Beerepoot LV, Radema SA, Witteveen EO et al. Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumours. J. Clin. Oncol. 2006 24 : 1491 8.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1491-8
    • Beerepoot, L.V.1    Radema, S.A.2    Witteveen, E.O.3
  • 139
    • 0037096814 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
    • Dowlati A, Robertson K, Cooney M et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res. 2002 62 : 3408 16.
    • (2002) Cancer Res. , vol.62 , pp. 3408-16
    • Dowlati, A.1    Robertson, K.2    Cooney, M.3
  • 140
    • 0042386700 scopus 로고    scopus 로고
    • Phase I clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results
    • Rustin GJ, Galbraith SM, Anderson H et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J. Clin. Oncol. 2003 21 : 2815 22.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2815-22
    • Rustin, G.J.1    Galbraith, S.M.2    Anderson, H.3
  • 141
    • 0642307227 scopus 로고    scopus 로고
    • Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumour blood flow
    • Stevenson JP, Rosen M, Sun W et al. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumour blood flow. J. Clin. Oncol. 2003 21 : 4428 38.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 4428-38
    • Stevenson, J.P.1    Rosen, M.2    Sun, W.3
  • 142
    • 27644466314 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate induces rapid regression of tumour neovessels and growth through interference with vascular endothelial-cadherin signaling
    • Vincent L, Kermani P, Young LM et al. Combretastatin A4 phosphate induces rapid regression of tumour neovessels and growth through interference with vascular endothelial-cadherin signaling. J. Clin. Invest. 2005 115 : 2992 3006.
    • (2005) J. Clin. Invest. , vol.115 , pp. 2992-3006
    • Vincent, L.1    Kermani, P.2    Young, L.M.3
  • 144
    • 0037085753 scopus 로고    scopus 로고
    • The tumour vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
    • Kanthou C, Tozer GM. The tumour vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells. Blood 2002 99 : 2060 69.
    • (2002) Blood , vol.99 , pp. 2060-69
    • Kanthou, C.1    Tozer, G.M.2
  • 145
    • 0034962379 scopus 로고    scopus 로고
    • Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumours
    • Murata R, Siemann DW, Overgaard J, Horsman MR. Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumours. Radiother. Oncol. 2001 60 : 155 61.
    • (2001) Radiother. Oncol. , vol.60 , pp. 155-61
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 146
    • 20044395276 scopus 로고    scopus 로고
    • Phase I trial of combretastatin a-4 phosphate with carboplatin
    • Bilenker JH, Flaherty KT, Rosen M et al. Phase I trial of combretastatin a-4 phosphate with carboplatin. Clin. Cancer Res. 2005 11 : 1527 33.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1527-33
    • Bilenker, J.H.1    Flaherty, K.T.2    Rosen, M.3
  • 147
    • 0022971018 scopus 로고
    • Activity of flavone acetic acid (NSC-347512) against solid tumours of mice
    • Corbett TH, Bissery MC, Wozniak A et al. Activity of flavone acetic acid (NSC-347512) against solid tumours of mice. Invest. New Drugs 1986 4 : 207 20.
    • (1986) Invest. New Drugs , vol.4 , pp. 207-20
    • Corbett, T.H.1    Bissery, M.C.2    Wozniak, A.3
  • 148
    • 0025076479 scopus 로고
    • Role of tumour necrosis factor in flavone acetic acid-induced tumour vasculature shutdown
    • Mahadevan V, Malik ST, Meager A, Fiers W, Lewis GP, Hart IR. Role of tumour necrosis factor in flavone acetic acid-induced tumour vasculature shutdown. Cancer Res. 1990 50 : 5537 42.
    • (1990) Cancer Res. , vol.50 , pp. 5537-42
    • Mahadevan, V.1    Malik, S.T.2    Meager, A.3    Fiers, W.4    Lewis, G.P.5    Hart, I.R.6
  • 149
    • 0026089375 scopus 로고
    • Tumour-dependent increased plasma nitrate concentrations as an indication of the antitumour effect of flavone-8-acetic acid and analogues in mice
    • Thomsen LL, Ching LM, Zhuang L, Gavin JB, Baguley BC. Tumour-dependent increased plasma nitrate concentrations as an indication of the antitumour effect of flavone-8-acetic acid and analogues in mice. Cancer Res. 1991 51 : 77 81.
    • (1991) Cancer Res. , vol.51 , pp. 77-81
    • Thomsen, L.L.1    Ching, L.M.2    Zhuang, L.3    Gavin, J.B.4    Baguley, B.C.5
  • 150
    • 0037341637 scopus 로고    scopus 로고
    • Antivascular therapy of cancer: DMXAA
    • Baguley BC. Antivascular therapy of cancer: DMXAA. Lancet Oncol. 2003 4 : 141 8.
    • (2003) Lancet Oncol. , vol.4 , pp. 141-8
    • Baguley, B.C.1
  • 151
    • 0024330132 scopus 로고
    • Flavone acetic acid-preclinical and clinical activity
    • Kerr DJ, Kaye SB. Flavone acetic acid-preclinical and clinical activity. Eur. J. Cancer Clin. Oncol. 1989 25 : 1271 2.
    • (1989) Eur. J. Cancer Clin. Oncol. , vol.25 , pp. 1271-2
    • Kerr, D.J.1    Kaye, S.B.2
  • 152
    • 0023608388 scopus 로고
    • Phase I and pharmacokinetic study of flavone acetic acid
    • Kerr DJ, Kaye SB, Cassidy J et al. Phase I and pharmacokinetic study of flavone acetic acid. Cancer Res. 1987 47 : 6776 81.
    • (1987) Cancer Res. , vol.47 , pp. 6776-81
    • Kerr, D.J.1    Kaye, S.B.2    Cassidy, J.3
  • 155
    • 0033791649 scopus 로고    scopus 로고
    • Structural insights into microtubule function
    • Nogales E. Structural insights into microtubule function. Annu. Rev. Biochem. 2000 69 : 277 302.
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 277-302
    • Nogales, E.1
  • 156
    • 0025824979 scopus 로고
    • Mechanism of inhibition of cell proliferation by Vinca alkaloids
    • Jordan MA, Thrower D, Wilson L. Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res. 1991 51 : 2212 22.
    • (1991) Cancer Res. , vol.51 , pp. 2212-22
    • Jordan, M.A.1    Thrower, D.2    Wilson, L.3
  • 157
    • 0001360783 scopus 로고
    • Effect of Colchicine on human carcinoma
    • Seed L, Slaughter D, Limarzi L. Effect of Colchicine on human carcinoma. Surgery 1939 7 : 696 709.
    • (1939) Surgery , vol.7 , pp. 696-709
    • Seed, L.1    Slaughter, D.2    Limarzi, L.3
  • 159
    • 0029044610 scopus 로고
    • Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs
    • Pettit GR, Temple C Jr., Narayanan VL et al. Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs. Anticancer Drug Des. 1995 10 : 299 309.
    • (1995) Anticancer Drug Des. , vol.10 , pp. 299-309
    • Pettit, G.R.1    Temple Jr., C.2    Narayanan, V.L.3
  • 160
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumour vasculature
    • Dark GG, Hill SA, Prise VE, Tozer GM, Pettit GR, Chaplin DJ. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumour vasculature. Cancer Res. 1997 57 : 1829 34.
    • (1997) Cancer Res. , vol.57 , pp. 1829-34
    • Dark, G.G.1    Hill, S.A.2    Prise, V.E.3    Tozer, G.M.4    Pettit, G.R.5    Chaplin, D.J.6
  • 162
    • 27944510554 scopus 로고    scopus 로고
    • Combretastatin A-4 resistance in H460 human lung carcinoma demonstrates distinctive alterations in beta-tubulin isotype expression
    • Wehbe H, Kearney CM, Pinney KG. Combretastatin A-4 resistance in H460 human lung carcinoma demonstrates distinctive alterations in beta-tubulin isotype expression. Anticancer Res. 2005 25 : 3865 70.
    • (2005) Anticancer Res. , vol.25 , pp. 3865-70
    • Wehbe, H.1    Kearney, C.M.2    Pinney, K.G.3
  • 163
    • 0025824134 scopus 로고
    • Post-translational modification of microtubules is a component of synergic alterations of cytoskeleton leading to formation of cytoplasmic processes in fibroblasts
    • Tint IS, Bershadsky AD, Gelfand IM, Vasiliev JM. Post-translational modification of microtubules is a component of synergic alterations of cytoskeleton leading to formation of cytoplasmic processes in fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 1991 88 : 6318 22.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 6318-22
    • Tint, I.S.1    Bershadsky, A.D.2    Gelfand, I.M.3    Vasiliev, J.M.4
  • 164
  • 165
    • 12344312042 scopus 로고    scopus 로고
    • Cellular abnormalities of blood vessels as targets in cancer
    • Baluk P, Hashizume H, McDonald DM. Cellular abnormalities of blood vessels as targets in cancer. Curr. Opin. Genet. Dev. 2005 15 : 102 11.
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 102-11
    • Baluk, P.1    Hashizume, H.2    McDonald, D.M.3
  • 166
    • 0032006842 scopus 로고    scopus 로고
    • Control of reorganization of the actin cytoskeleton by Rho family small GTP-binding proteins in yeast
    • Tanaka K, Takai Y. Control of reorganization of the actin cytoskeleton by Rho family small GTP-binding proteins in yeast. Curr. Opin. Cell Biol. 1998 10 : 112 16.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 112-16
    • Tanaka, K.1    Takai, Y.2
  • 167
    • 0030612748 scopus 로고    scopus 로고
    • Rho effectors and reorganization of actin cytoskeleton
    • Narumiya S, Ishizaki T, Watanabe N. Rho effectors and reorganization of actin cytoskeleton. FEBS Lett. 1997 410 : 68 72.
    • (1997) FEBS Lett. , vol.410 , pp. 68-72
    • Narumiya, S.1    Ishizaki, T.2    Watanabe, N.3
  • 168
    • 0035417875 scopus 로고    scopus 로고
    • Mechanisms associated with tumour vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability
    • Tozer GM, Prise VE, Wilson J et al. Mechanisms associated with tumour vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Res. 2001 61 : 6413 22.
    • (2001) Cancer Res. , vol.61 , pp. 6413-22
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 169
    • 0035064594 scopus 로고    scopus 로고
    • Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo
    • Galbraith SM, Chaplin DJ, Lee F et al. Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo. Anticancer Res. 2001 21 : 93 102.
    • (2001) Anticancer Res. , vol.21 , pp. 93-102
    • Galbraith, S.M.1    Chaplin, D.J.2    Lee, F.3
  • 170
    • 0032758736 scopus 로고    scopus 로고
    • In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
    • Grosios K, Holwell SE, McGown AT, Pettit GR, Bibby MC. In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug. Br. J. Cancer 1999 81 : 1318 27.
    • (1999) Br. J. Cancer , vol.81 , pp. 1318-27
    • Grosios, K.1    Holwell, S.E.2    McGown, A.T.3    Pettit, G.R.4    Bibby, M.C.5
  • 171
    • 0036891515 scopus 로고    scopus 로고
    • The development of combretastatin A4 phosphate as a vascular targeting agent
    • Chaplin DJ, Hill SA. The development of combretastatin A4 phosphate as a vascular targeting agent. Int. J. Radiat. Oncol. Biol. Phys. 2002 54 : 1491 6.
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 1491-6
    • Chaplin, D.J.1    Hill, S.A.2
  • 172
    • 0031742231 scopus 로고    scopus 로고
    • Targeting the tumour vasculature with combretastatin A-4 disodium phosphate: Effects on radiation therapy
    • Li L, Rojiani A, Siemann DW. Targeting the tumour vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 1998 42 : 899 903.
    • (1998) Int. J. Radiat. Oncol. Biol. Phys. , vol.42 , pp. 899-903
    • Li, L.1    Rojiani, A.2    Siemann, D.W.3
  • 173
    • 0034109559 scopus 로고    scopus 로고
    • Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma
    • Grosios K, Loadman PM, Swaine DJ, Pettit GR, Bibby MC. Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma. Anticancer Res. 2000 20 : 229 33.
    • (2000) Anticancer Res. , vol.20 , pp. 229-33
    • Grosios, K.1    Loadman, P.M.2    Swaine, D.J.3    Pettit, G.R.4    Bibby, M.C.5
  • 174
    • 0033955698 scopus 로고    scopus 로고
    • The new tubulin-inhibitor combretastatin A-4 enhances thermal damage in the BT4An rat glioma
    • Eikesdal HP, Schem BC, Mella O, Dahl O. The new tubulin-inhibitor combretastatin A-4 enhances thermal damage in the BT4An rat glioma. Int. J. Radiat. Oncol. Biol. Phys. 2000 46 : 645 52.
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.46 , pp. 645-52
    • Eikesdal, H.P.1    Schem, B.C.2    Mella, O.3    Dahl, O.4
  • 175
    • 0035233996 scopus 로고    scopus 로고
    • Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma
    • Nelkin BD, Ball DW. Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma. Oncol. Rep. 2001 8 : 157 60.
    • (2001) Oncol. Rep. , vol.8 , pp. 157-60
    • Nelkin, B.D.1    Ball, D.W.2
  • 176
    • 0035874889 scopus 로고    scopus 로고
    • Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate
    • Pedley RB, Hill SA, Boxer GM et al. Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate. Cancer Res. 2001 61 : 4716 22.
    • (2001) Cancer Res. , vol.61 , pp. 4716-22
    • Pedley, R.B.1    Hill, S.A.2    Boxer, G.M.3
  • 177
    • 0035204801 scopus 로고    scopus 로고
    • Tumour vasculature is targeted by the combination of combretastatin A-4 and hyperthermia
    • Eikesdal HP, Bjerkvig R, Raleigh JA, Mella O, Dahl O. Tumour vasculature is targeted by the combination of combretastatin A-4 and hyperthermia. Radiother. Oncol. 2001 61 : 313 20.
    • (2001) Radiother. Oncol. , vol.61 , pp. 313-20
    • Eikesdal, H.P.1    Bjerkvig, R.2    Raleigh, J.A.3    Mella, O.4    Dahl, O.5
  • 178
    • 0035889331 scopus 로고    scopus 로고
    • Combretastatin A-4 disodium phosphate: A vascular targeting agent that improves that improves the anti-tumour effects of hyperthermia, radiation, and mild thermoradiotherapy
    • Murata R, Overgaard J, Horsman MR. Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves that improves the anti-tumour effects of hyperthermia, radiation, and mild thermoradiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2001 51 : 1018 24.
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.51 , pp. 1018-24
    • Murata, R.1    Overgaard, J.2    Horsman, M.R.3
  • 179
    • 0034958723 scopus 로고    scopus 로고
    • Combretastatin A-4 and hyperthermia; A potent combination for the treatment of solid tumours
    • Eikesdal HP, Bjerkvig R, Mella O, Dahl O. Combretastatin A-4 and hyperthermia; a potent combination for the treatment of solid tumours. Radiother. Oncol. 2001 60 : 147 54.
    • (2001) Radiother. Oncol. , vol.60 , pp. 147-54
    • Eikesdal, H.P.1    Bjerkvig, R.2    Mella, O.3    Dahl, O.4
  • 180
    • 0036215178 scopus 로고    scopus 로고
    • Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma
    • Li L, Rojiani AM, Siemann DW. Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma. Acta Oncol. 2002 41 : 91 7.
    • (2002) Acta Oncol. , vol.41 , pp. 91-7
    • Li, L.1    Rojiani, A.M.2    Siemann, D.W.3
  • 181
    • 0036891440 scopus 로고    scopus 로고
    • Combination of vascular targeting agents with thermal or radiation therapy
    • Horsman MR, Murata R. Combination of vascular targeting agents with thermal or radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 2002 54 : 1518 23.
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 1518-23
    • Horsman, M.R.1    Murata, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.