메뉴 건너뛰기




Volumn 41, Issue 9, 2008, Pages 739-749

Asthma: Where is it going?

Author keywords

Asthma; Bronchial hyperresponsiveness; Epithelial mesenchymal unit; Remodeling

Indexed keywords

AIRWAY OBSTRUCTION; ASTHMA; BREATHING MUSCLE; BRONCHUS HYPERREACTIVITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LUNG ALVEOLUS EPITHELIUM; MESENCHYME; MORPHOGENESIS; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PHENOTYPE; RESPIRATORY TRACT INFLAMMATION; REVIEW; WOUND HEALING;

EID: 54349087638     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2008005000031     Document Type: Review
Times cited : (2)

References (60)
  • 3
    • 0032558685 scopus 로고    scopus 로고
    • A 15-year follow-up study of ventilatory function in adults with asthma
    • Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998; 339: 1194-1200.
    • (1998) N Engl J Med , vol.339 , pp. 1194-1200
    • Lange, P.1    Parner, J.2    Vestbo, J.3    Schnohr, P.4    Jensen, G.5
  • 4
    • 33747750597 scopus 로고    scopus 로고
    • The mechanisms, diagnosis, and management of severe asthma in adults
    • Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 2006; 368: 780-793.
    • (2006) Lancet , vol.368 , pp. 780-793
    • Holgate, S.T.1    Polosa, R.2
  • 6
    • 18844401152 scopus 로고    scopus 로고
    • Epithelial stress and structural remodelling in childhood asthma
    • Fedorov IA, Wilson SJ, Davies DE, Holgate ST. Epithelial stress and structural remodelling in childhood asthma. Thorax 2005; 60: 389-394.
    • (2005) Thorax , vol.60 , pp. 389-394
    • Fedorov, I.A.1    Wilson, S.J.2    Davies, D.E.3    Holgate, S.T.4
  • 8
    • 34250833472 scopus 로고    scopus 로고
    • Smooth muscle molecular mechanics in airway hyperresponsiveness and asthma
    • Gil FR, Lauzon AM. Smooth muscle molecular mechanics in airway hyperresponsiveness and asthma. Can J Physiol Pharmacol 2007; 85: 133-140.
    • (2007) Can J Physiol Pharmacol , vol.85 , pp. 133-140
    • Gil, F.R.1    Lauzon, A.M.2
  • 10
    • 33745618476 scopus 로고    scopus 로고
    • Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness?
    • An SS, Fabry B, Trepat X, Wang N, Fredberg JJ. Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? Am J Respir Cell Mol Biol 2006; 35: 55-64.
    • (2006) Am J Respir Cell Mol Biol , vol.35 , pp. 55-64
    • An, S.S.1    Fabry, B.2    Trepat, X.3    Wang, N.4    Fredberg, J.J.5
  • 11
    • 0026581867 scopus 로고
    • Bronchial smooth muscle mechanics of a canine model of allergic airway hyperresponsiveness
    • Jiang H, Rao K, Halayko AJ, Kepron W, Stephens NL. Bronchial smooth muscle mechanics of a canine model of allergic airway hyperresponsiveness. J Appl Physiol 1992; 72: 39-45.
    • (1992) J Appl Physiol , vol.72 , pp. 39-45
    • Jiang, H.1    Rao, K.2    Halayko, A.J.3    Kepron, W.4    Stephens, N.L.5
  • 12
    • 0041627689 scopus 로고    scopus 로고
    • Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
    • Fernandes DJ, Mitchell RW, Lakser O, Dowell M, Stewart AG, Solway J. Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma? J Appl Physiol 2003; 95: 844-853.
    • (2003) J Appl Physiol , vol.95 , pp. 844-853
    • Fernandes, D.J.1    Mitchell, R.W.2    Lakser, O.3    Dowell, M.4    Stewart, A.G.5    Solway, J.6
  • 13
    • 34248204113 scopus 로고    scopus 로고
    • Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma
    • An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, et al. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J 2007; 29: 834-860.
    • (2007) Eur Respir J , vol.29 , pp. 834-860
    • An, S.S.1    Bai, T.R.2    Bates, J.H.3    Black, J.L.4    Brown, R.H.5    Brusasco, V.6
  • 14
    • 0036893225 scopus 로고    scopus 로고
    • Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects
    • Ma X, Chang Z, Kong H, Wang Y, Unruh H, Stephens NL, et al. Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects. Ann J Physiol Lung Cell Mol Physiol 2002; 283: L1181-L1189.
    • (2002) Ann J Physiol Lung Cell Mol Physiol , vol.283
    • Ma, X.1    Chang, Z.2    Kong, H.3    Wang, Y.4    Unruh, H.5    Stephens, N.L.6
  • 15
    • 0025977594 scopus 로고
    • Abnormalities in airway smooth muscle in fatal asthma. A comparison between trachea and bronchus
    • Bai TR. Abnormalities in airway smooth muscle in fatal asthma. A comparison between trachea and bronchus. Am Rev Respir Dis 1991; 143: 441-443.
    • (1991) Am Rev Respir Dis , vol.143 , pp. 441-443
    • Bai, T.R.1
  • 16
    • 0026795551 scopus 로고
    • Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine
    • Bjorck T, Gustafsson LE, Dahlen SE. Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine. Am Rev Respir Dis 1992; 145: 1087-1091.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 1087-1091
    • Bjorck, T.1    Gustafsson, L.E.2    Dahlen, S.E.3
  • 17
    • 2442715233 scopus 로고    scopus 로고
    • The allergic mouse model of asthma: Normal smooth muscle in an abnormal lung?
    • Wagers S, Lundblad LK, Ekman M, Irvin CG, Bates JH. The allergic mouse model of asthma: normal smooth muscle in an abnormal lung? J Appl Physiol 2004; 96: 2019-2027.
    • (2004) J Appl Physiol , vol.96 , pp. 2019-2027
    • Wagers, S.1    Lundblad, L.K.2    Ekman, M.3    Irvin, C.G.4    Bates, J.H.5
  • 21
    • 0025327186 scopus 로고
    • Increased in vitro responses of tracheal smooth muscle from hyperresponsive guinea pigs
    • Ishida K, Pare PD, Thomson RJ, Schellenberg RR. Increased in vitro responses of tracheal smooth muscle from hyperresponsive guinea pigs. J Appl Physiol 1990; 68: 1316-1320.
    • (1990) J Appl Physiol , vol.68 , pp. 1316-1320
    • Ishida, K.1    Pare, P.D.2    Thomson, R.J.3    Schellenberg, R.R.4
  • 23
    • 0041525731 scopus 로고    scopus 로고
    • Mechanics and crossbridge kinetics of tracheal smooth muscle in two inbred rat strains
    • Blanc FX, Coirault C, Salmeron S, Chemla D, Lecarpentier Y. Mechanics and crossbridge kinetics of tracheal smooth muscle in two inbred rat strains. Eur Respir J 2003; 22: 227-234.
    • (2003) Eur Respir J , vol.22 , pp. 227-234
    • Blanc, F.X.1    Coirault, C.2    Salmeron, S.3    Chemla, D.4    Lecarpentier, Y.5
  • 26
    • 0033870435 scopus 로고    scopus 로고
    • Potent bronchoprotective effect of deep inspiration and its absence in asthma
    • Kapsali T, Permutt S, Laube B, Scichilone N, Togias A. Potent bronchoprotective effect of deep inspiration and its absence in asthma. J Appl Physiol 2000; 89: 711-720.
    • (2000) J Appl Physiol , vol.89 , pp. 711-720
    • Kapsali, T.1    Permutt, S.2    Laube, B.3    Scichilone, N.4    Togias, A.5
  • 27
    • 0017647176 scopus 로고
    • Effect of deep inspiration on airway conductance in subjects with allergic rhinitis and allergic asthma
    • Fish JE, Peterman VI, Cugell DW. Effect of deep inspiration on airway conductance in subjects with allergic rhinitis and allergic asthma. J Allergy Clin Immunol 1977; 60: 41-46.
    • (1977) J Allergy Clin Immunol , vol.60 , pp. 41-46
    • Fish, J.E.1    Peterman, V.I.2    Cugell, D.W.3
  • 28
    • 0023129274 scopus 로고
    • Effects of volume history during spontaneous and acutely induced air-flow obstruction in asthma
    • Lim TK, Pride NB, Ingram RH Jr. Effects of volume history during spontaneous and acutely induced air-flow obstruction in asthma. Am Rev Respir Dis 1987; 135: 591-596.
    • (1987) Am Rev Respir Dis , vol.135 , pp. 591-596
    • Lim, T.K.1    Pride, N.B.2    Ingram Jr., R.H.3
  • 29
    • 0024450919 scopus 로고
    • The effects of deep inhalation on maximal expiratory flow during intensive treatment of spontaneous asthmatic episodes
    • Lim TK, Ang SM, Rossing TH, Ingenito EP, Ingram RH Jr. The effects of deep inhalation on maximal expiratory flow during intensive treatment of spontaneous asthmatic episodes. Am Rev Respir Dis 1989; 140: 340-343.
    • (1989) Am Rev Respir Dis , vol.140 , pp. 340-343
    • Lim, T.K.1    Ang, S.M.2    Rossing, T.H.3    Ingenito, E.P.4    Ingram Jr., R.H.5
  • 30
    • 0025376288 scopus 로고    scopus 로고
    • Gunst SJ, Stropp JQ, Service J. Mechanical modulation of pressure-characteristics of contracted canine airways in vitro. J Appl Physiol 1990; 68: 2223-2229.
    • Gunst SJ, Stropp JQ, Service J. Mechanical modulation of pressure-volume characteristics of contracted canine airways in vitro. J Appl Physiol 1990; 68: 2223-2229.
  • 31
    • 0033057083 scopus 로고    scopus 로고
    • Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm
    • Fredberg JJ, Inouye DS, Mijailovich SM, Butler JP. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med 1999; 159: 959-967.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 959-967
    • Fredberg, J.J.1    Inouye, D.S.2    Mijailovich, S.M.3    Butler, J.P.4
  • 32
    • 33644915002 scopus 로고    scopus 로고
    • Airway smooth muscle as a regulator of immune responses and bronchomotor tone
    • vi
    • Lazaar AL, Panettieri RA Jr. Airway smooth muscle as a regulator of immune responses and bronchomotor tone. Clin Chest Med 2006; 27: 53-69, vi.
    • (2006) Clin Chest Med , vol.27 , pp. 53-69
    • Lazaar, A.L.1    Panettieri Jr., R.A.2
  • 35
    • 0141634110 scopus 로고    scopus 로고
    • Regulation of airway smooth muscle cell immunomodulatory function: Role in asthma
    • Hirst SJ. Regulation of airway smooth muscle cell immunomodulatory function: role in asthma. Respir Physiol Neurobiol 2003; 137: 309-326.
    • (2003) Respir Physiol Neurobiol , vol.137 , pp. 309-326
    • Hirst, S.J.1
  • 37
    • 0036846991 scopus 로고    scopus 로고
    • Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation
    • Leigh R, Ellis R, Wattie J, Southam DS, De Hoogh M, Gauldie J, et al. Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation. Am J Respir Cell Mol Biol 2002; 27: 526-535.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 526-535
    • Leigh, R.1    Ellis, R.2    Wattie, J.3    Southam, D.S.4    De Hoogh, M.5    Gauldie, J.6
  • 38
    • 0028173026 scopus 로고
    • Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity
    • DiCosmo BF, Geba GP, Picarella D, Elias JA, Rankin JA, Stripp BR, et al. Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest 1994; 94: 2028-2035.
    • (1994) J Clin Invest , vol.94 , pp. 2028-2035
    • DiCosmo, B.F.1    Geba, G.P.2    Picarella, D.3    Elias, J.A.4    Rankin, J.A.5    Stripp, B.R.6
  • 39
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999; 103: 779-788.
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6
  • 40
    • 14944346763 scopus 로고    scopus 로고
    • Airway remodeling in asthma: Therapeutic implications of mechanisms
    • Homer RJ, Elias JA. Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology 2005; 20: 28-35.
    • (2005) Physiology , vol.20 , pp. 28-35
    • Homer, R.J.1    Elias, J.A.2
  • 42
    • 32044453362 scopus 로고    scopus 로고
    • Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells: Role of vascular endothelial growth factor genotype
    • Faffe DS, Flynt L, Bourgeois K, Panettieri RA Jr, Shore SA. Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells: role of vascular endothelial growth factor genotype. Am J Respir Cell Mol Biol 2006; 34: 213-218.
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 213-218
    • Faffe, D.S.1    Flynt, L.2    Bourgeois, K.3    Panettieri Jr, R.A.4    Shore, S.A.5
  • 45
    • 0034521654 scopus 로고    scopus 로고
    • The production of extracellular matrix proteins by human passively sensitized airway smooth-muscle cells in culture: The effect of beclomethasone
    • Johnson PR, Black JL, Carlin S, Ge Q, Underwood PA. The production of extracellular matrix proteins by human passively sensitized airway smooth-muscle cells in culture: the effect of beclomethasone. Am J Respir Crit Care Med 2000; 162: 2145-2151.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2145-2151
    • Johnson, P.R.1    Black, J.L.2    Carlin, S.3    Ge, Q.4    Underwood, P.A.5
  • 46
    • 0035158686 scopus 로고    scopus 로고
    • Human airway smooth muscle cells secrete vascular endothelial growth factor: Up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism
    • Knox AJ, Corbett L, Stocks J, Holland E, Zhu YM, Pang L. Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism. FASEB J 2001; 15: 2480-2488.
    • (2001) FASEB J , vol.15 , pp. 2480-2488
    • Knox, A.J.1    Corbett, L.2    Stocks, J.3    Holland, E.4    Zhu, Y.M.5    Pang, L.6
  • 47
    • 3242743550 scopus 로고    scopus 로고
    • Progression of asthma measured by lung function in the childhood asthma management program
    • Covar RA, Spahn JD, Murphy JR, Szefier SJ. Progression of asthma measured by lung function in the childhood asthma management program. Am J Respir Crit Care Med 2004; 170: 234-241.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 234-241
    • Covar, R.A.1    Spahn, J.D.2    Murphy, J.R.3    Szefier, S.J.4
  • 52
    • 33644928417 scopus 로고    scopus 로고
    • Airway remodeling from bench to bedside: Current perspectives
    • vi
    • Slade DJ, Kraft M. Airway remodeling from bench to bedside: current perspectives. Clin Chest Med 2006; 27: 71-85, vi.
    • (2006) Clin Chest Med , vol.27 , pp. 71-85
    • Slade, D.J.1    Kraft, M.2
  • 53
    • 30744470159 scopus 로고    scopus 로고
    • The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma
    • Boxall C, Holgate ST, Davies DE. The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J 2006; 27: 208-229.
    • (2006) Eur Respir J , vol.27 , pp. 208-229
    • Boxall, C.1    Holgate, S.T.2    Davies, D.E.3
  • 54
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112: 1776-1784.
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 55
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006; 7: 131-142.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 57
    • 2342569639 scopus 로고    scopus 로고
    • Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?
    • Knight DA, Lane CL, Stick SM. Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow? Curr Opin Pharmacol 2004; 4: 251-256.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 251-256
    • Knight, D.A.1    Lane, C.L.2    Stick, S.M.3
  • 58
    • 0035149573 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway
    • Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Maruoka S, Horie T. Transforming growth factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway. Am J Respir Crit Care Med 2001; 163: 152-157.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 152-157
    • Hashimoto, S.1    Gon, Y.2    Takeshita, I.3    Matsumoto, K.4    Maruoka, S.5    Horie, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.