Sensitization of nociceptive ion channels by inhaled anesthetics - A pain in the gas?

Molecular Pharmacology

Volumn 74, Issue 5, 2008, Pages 1180-1182

  Harrison, Neil ^a,b   Nau, Carla ^c  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; CAPSAICIN; ION CHANNEL; VANILLOID RECEPTOR 1;

CHANNEL GATING; HUMAN; NOCICEPTION; PAIN; PRIORITY JOURNAL; PROTEIN FUNCTION; SENSITIZATION; SHORT SURVEY; STIMULUS RESPONSE;

ANESTHETICS, INHALATION; HUMANS; ION CHANNELS; PAIN;

EID: 54349085841     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.051615     Document Type: Short Survey

References (16)

1. Bertaccini EJ, Trudell JR, and Franks NP (2007) The common chemical motifs within anesthetic binding sites. Anesth Analg 104:318-324.
2. Bhattacharya AA, Curry S, and Franks NP (2000) Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J Biol Chem 275:38731-38738.
3. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, and Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-824.
4. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, and Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306-313.
5. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, and Julius D (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411:957-962.
6. Cohen PJ (1975) History and theories of general anesthesia, in Goodman and Gilman's The Pharmacological Basis of Therapeutics, 5th ed (Goodman LS and Gilman A eds) pp 53-59, McGraw-Hill, New York.
7. Cornett PM, Matta JA, and Ahern GP (2008) General anesthetics sensitize the capsaicin receptor transient receptor potential V1. Mol Pharmacol 74:1261-1268.
8. Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, et al. (2000) Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183-187.
9. Evers AS and Crowder CM (2001) General anesthetics, in Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed (Hardman JG and Limbird LE eds) pp 337-366, McGraw-Hill, New York.
10. Franks NP (2008) General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 9:370-386 (2008).
11. Franks NP and Lieb WR (1994) Molecular and cellular mechanisms of general anaesthesia. Nature 367:607-614.
12. Matta JA, Cornett PM, Miyares RL, Abe K, Sahibzada N, and Ahern GP (2008) General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc Natl Acad Sci U S A 105:8784-8789.
13. Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, et al. (1997) Sites of alcohol and volatile anaesthetic action on GABA-A and glycine receptors. Nature 389:385-389.
14. Ramsey IS, Delling M, and Clapham DE (2006) An introduction to TRP channels. Annu Rev Physiol 68:619-647.
15. Seeman P (1972) The membrane actions of anesthetics and tranquilizers. Pharmacol Rev 24:583-655.
16. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, and Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531-543.