-
1
-
-
0010243675
-
-
Meyer HH. Zur theorie der alkoholnarkose. I. Mit welch Eigenshaft der Anasthetika bedingt ihre narkotische Wirkung? Arch Exp Path Pharmakol (Naunyn Schmiedebergs) 1899;42:109-37.
-
Meyer HH. Zur theorie der alkoholnarkose. I. Mit welch Eigenshaft der Anasthetika bedingt ihre narkotische Wirkung? Arch Exp Path Pharmakol (Naunyn Schmiedebergs) 1899;42:109-37.
-
-
-
-
3
-
-
0017354752
-
A unitary theory of anesthesia based on lateral phase separations in nerve membranes
-
Trudell JR. A unitary theory of anesthesia based on lateral phase separations in nerve membranes. Anesthesiology 1977;46:5-10.
-
(1977)
Anesthesiology
, vol.46
, pp. 5-10
-
-
Trudell, J.R.1
-
4
-
-
0028140369
-
Molecular and cellular mechanisms of general anaesthesia
-
Franks NP, Lieb WR. Molecular and cellular mechanisms of general anaesthesia. Nature 1994;367:607-14.
-
(1994)
Nature
, vol.367
, pp. 607-614
-
-
Franks, N.P.1
Lieb, W.R.2
-
6
-
-
0344204115
-
Nonanesthetic polyhalogenated alkanes and deviations from the Meyer-Overton hypothesis
-
Koblin DD, Chortkoff BS, Laster MJ, et al. Nonanesthetic polyhalogenated alkanes and deviations from the Meyer-Overton hypothesis. Prog Anesth Mech 1995;3:451-6.
-
(1995)
Prog Anesth Mech
, vol.3
, pp. 451-456
-
-
Koblin, D.D.1
Chortkoff, B.S.2
Laster, M.J.3
-
7
-
-
0028307274
-
Can the stereoselective effects of the anesthetic isoflurane be accounted for by lipid solubility?
-
Dickinson R, Franks NP, Lieb WR. Can the stereoselective effects of the anesthetic isoflurane be accounted for by lipid solubility? Biophys J 1994;66:2019-23.
-
(1994)
Biophys J
, vol.66
, pp. 2019-2023
-
-
Dickinson, R.1
Franks, N.P.2
Lieb, W.R.3
-
9
-
-
0033821849
-
Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors
-
Downie DL, Franks NP, Lieb WR. Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors. Anesthesiology 2000;93:774-83.
-
(2000)
Anesthesiology
, vol.93
, pp. 774-783
-
-
Downie, D.L.1
Franks, N.P.2
Lieb, W.R.3
-
10
-
-
0032942670
-
Actions of fluorinated alkanols on GABA(A) receptors: Relevance to theories of narcosis
-
Ueno S, Trudell JR, Eger EI II, Harris RA. Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis. Anesth Analg 1999;88:877-83.
-
(1999)
Anesth Analg
, vol.88
, pp. 877-883
-
-
Ueno, S.1
Trudell, J.R.2
Eger II, E.I.3
Harris, R.A.4
-
11
-
-
0034255021
-
Specific binding sites for alcohols and anesthetics on ligand-gated ion channels
-
Mascia MP, Trudell JR, Harris RA. Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci USA 2000;97:9305-10.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9305-9310
-
-
Mascia, M.P.1
Trudell, J.R.2
Harris, R.A.3
-
12
-
-
13844315498
-
Homology modeling of a human glycine α-1 receptor reveals a plausible anesthetic binding site
-
Bertaccini E, Shapiro J, Brutlag D, Trudell JR. Homology modeling of a human glycine α-1 receptor reveals a plausible anesthetic binding site. J Chem Inf Model 2005;45:128-35.
-
(2005)
J Chem Inf Model
, vol.45
, pp. 128-135
-
-
Bertaccini, E.1
Shapiro, J.2
Brutlag, D.3
Trudell, J.R.4
-
13
-
-
4143088670
-
Comparative modeling of a GABAA a1 receptor using three crystal structures as templates
-
Trudell JR, Bertaccini E. Comparative modeling of a GABAA a1 receptor using three crystal structures as templates. J Mol Graph Model 2004;23:39-49.
-
(2004)
J Mol Graph Model
, vol.23
, pp. 39-49
-
-
Trudell, J.R.1
Bertaccini, E.2
-
14
-
-
0031784872
-
Structural basis for the inhibition of firefly luciferase by a general anesthetic
-
Franks NP, Jenkins A, Conti E, Lieb WR, Brick P. Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophys J 1998;75:2205-11.
-
(1998)
Biophys J
, vol.75
, pp. 2205-2211
-
-
Franks, N.P.1
Jenkins, A.2
Conti, E.3
Lieb, W.R.4
Brick, P.5
-
16
-
-
0027337615
-
Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase
-
Verschueren KH, Seljee F, Rozeboom HJ, Kalk KH, Dijkstra BW. Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase. Nature 1993;363:693-8.
-
(1993)
Nature
, vol.363
, pp. 693-698
-
-
Verschueren, K.H.1
Seljee, F.2
Rozeboom, H.J.3
Kalk, K.H.4
Dijkstra, B.W.5
-
17
-
-
84986492477
-
Atomic energies derived from semiempirical methods
-
Besler BH, Merz KM, Kollman PA. Atomic energies derived from semiempirical methods. J Comp Chem 1990;11:431-9.
-
(1990)
J Comp Chem
, vol.11
, pp. 431-439
-
-
Besler, B.H.1
Merz, K.M.2
Kollman, P.A.3
-
18
-
-
0000003059
-
Free energy calculation methods: A theoretical and empirical comparison of numerical errors and a new method for qualitative estimates of free energy changes
-
Radmer RJ, Kollman PA. Free energy calculation methods: a theoretical and empirical comparison of numerical errors and a new method for qualitative estimates of free energy changes. J Comp Chem 1997;18:902-18.
-
(1997)
J Comp Chem
, vol.18
, pp. 902-918
-
-
Radmer, R.J.1
Kollman, P.A.2
-
20
-
-
0029016182
-
Classical electrostatics in biology and chemistry
-
Honig B, Nicholls A. Classical electrostatics in biology and chemistry. Science 1995;268:1144-9.
-
(1995)
Science
, vol.268
, pp. 1144-1149
-
-
Honig, B.1
Nicholls, A.2
-
21
-
-
0018141853
-
Where do general anaesthetics act?
-
Franks NP, Lieb WR. Where do general anaesthetics act? Nature 1978;274:339-42.
-
(1978)
Nature
, vol.274
, pp. 339-342
-
-
Franks, N.P.1
Lieb, W.R.2
-
22
-
-
0034077948
-
A designed four-α-helix bundle that binds the volatile general anesthetic halothane with high affinity
-
Johansson JS, Scharf D, Davies LA, et al. A designed four-α-helix bundle that binds the volatile general anesthetic halothane with high affinity. Biophys J 2000;78:982-93.
-
(2000)
Biophys J
, vol.78
, pp. 982-993
-
-
Johansson, J.S.1
Scharf, D.2
Davies, L.A.3
-
23
-
-
0031848073
-
A molecular description of noble gas binding to a site of anesthetic action
-
Trudell JR, Koblin DD, Eger EI II. A molecular description of noble gas binding to a site of anesthetic action. Anesth Analg 1998;87:411-8.
-
(1998)
Anesth Analg
, vol.87
, pp. 411-418
-
-
Trudell, J.R.1
Koblin, D.D.2
Eger II, E.I.3
-
24
-
-
7244247302
-
Weak intermolecular associations and anesthesia
-
Sandorfy C. Weak intermolecular associations and anesthesia. Anesthesiology 2004;101:1225-7.
-
(2004)
Anesthesiology
, vol.101
, pp. 1225-1227
-
-
Sandorfy, C.1
-
25
-
-
0026037184
-
Role of hydrogen bonding in general anesthesia
-
Abraham MH, Lieb WR, Franks NP. Role of hydrogen bonding in general anesthesia. J Pharm Sci 1991;80:719-24.
-
(1991)
J Pharm Sci
, vol.80
, pp. 719-724
-
-
Abraham, M.H.1
Lieb, W.R.2
Franks, N.P.3
-
26
-
-
0035906457
-
Hydrogen bond structural group constants
-
Abraham MH, Platts JA. Hydrogen bond structural group constants. J Org Chem 2001;66:3484-91.
-
(2001)
J Org Chem
, vol.66
, pp. 3484-3491
-
-
Abraham, M.H.1
Platts, J.A.2
-
27
-
-
1642453924
-
Are sobriety and consciousness determined by water in protein cavities?
-
Trudell JR, Harris RA. Are sobriety and consciousness determined by water in protein cavities? Alcohol Clin Exp Res 2004;28:1-3.
-
(2004)
Alcohol Clin Exp Res
, vol.28
, pp. 1-3
-
-
Trudell, J.R.1
Harris, R.A.2
-
28
-
-
0029584688
-
What makes a binding site a binding site?
-
Ringe D. What makes a binding site a binding site? Curr Opin Struct Biol 1995;5:825-9.
-
(1995)
Curr Opin Struct Biol
, vol.5
, pp. 825-829
-
-
Ringe, D.1
-
30
-
-
0023899747
-
Energetics of charge-charge interactions in proteins
-
Gilson MK, Honig B. Energetics of charge-charge interactions in proteins. Proteins 1988;3:32-52.
-
(1988)
Proteins
, vol.3
, pp. 32-52
-
-
Gilson, M.K.1
Honig, B.2
-
31
-
-
0041819527
-
Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster
-
Kruse SW, Zhao R, Smith DP, Jones DN. Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster. Nat Struct Biol 2003;10:694-700.
-
(2003)
Nat Struct Biol
, vol.10
, pp. 694-700
-
-
Kruse, S.W.1
Zhao, R.2
Smith, D.P.3
Jones, D.N.4
-
33
-
-
33644534150
-
Determinants of volatile general anesthetic potency: A preliminary three-dimensional pharmacophore for halogenated anesthetics
-
Sewell JC, Sear JW. Determinants of volatile general anesthetic potency: a preliminary three-dimensional pharmacophore for halogenated anesthetics. Anesth Analg 2006;102:764-71.
-
(2006)
Anesth Analg
, vol.102
, pp. 764-771
-
-
Sewell, J.C.1
Sear, J.W.2
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