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A reviewer's comment prompted us to reemphasize (see ref 5a) that Pd-mediated fluorination reactions reported by Sanford (aromatic),4c Sodeoka (aliphatic),4d and most recently Ritter (aromatic) 4e all employ electrophilic, so-called positive fluorine reagents for the C-F bond formation. This electrophilic fluorination methodology4c-e cannot be used for the highly sought displacement of X in nonactivated ArX (X, I, Br, d, OTf, etc, with fluoride and is therefore rather irrelevant to our approach to metal-catalyzed aromatic nucleophilic fluorination with the F, Scheme 1, Ritter's recent report4e describes the synthesis of fluoroarenes ArF by reacting Selectfluor with stoichiometric quantities of (σ-aryl)palladium reagents. The latter are prepared in five steps, with the overall yield of the ArF products for the entire reaction sequence being in the range of ca. 15-40, usually around 30
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18F-PET: Nature 2008,454,471.
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