On-column epimerization of dihydroartemisinin: An effective analytical approach to overcome the shortcomings of the International Pharmacopoeia monograph

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 875, Issue 1, 2008, Pages 180-191

  Cabri, Walter ^a   Ciogli, Alessia ^b   D'Acquarica, Ilaria ^b   Di Mattia, Michela ^a   Galletti, Bruno ^a   Gasparrini, Francesco ^b   Giorgi, Fabrizio ^a   Lalli, Silvana ^a   Pierini, Marco ^b   Simone, Patrizia ^b  

^a Sigma Tau SpA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Antimalarials; Computer simulation; Cryo HPLC; Dihydroartemisinin (DHA); Dynamic HPLC (DHPLC); Epimerization study

Indexed keywords

ACETONITRILE; COLUMNS (STRUCTURAL); COMPUTATIONAL METHODS; COMPUTER SIMULATION; DECOMPOSITION; ISOMERS; LIQUID CHROMATOGRAPHY; PHASE SEPARATION; PYROLYSIS; SEPARATION; SIZE SEPARATION;

ANALYTICAL APPROACHES; ANTIMALARIALS; ARTEMISININ; CHROMATOGRAPHIC SEPARATIONS; CRYO-HPLC; DIASTEREOSELECTIVE; DIHYDROARTEMISININ; DIHYDROARTEMISININ (DHA); EPIMERIZATION; EPIMERIZATION STUDY; EXPERIMENTAL CONDITIONS; INTERCONVERSION PROCESSES; LOW TEMPERATURES; PHASE CONDITIONS; SHORT-COMINGS; SIMULTANEOUS DETERMINATIONS; SYMMETRY C18; THERMAL DECOMPOSITIONS; ULTRAVIOLET DETECTIONS;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

ALDEHYDE DERIVATIVE; ALPHA DIHYDROARTEMISININ; ANTIMALARIAL AGENT; BETA DIHYDROARTEMISININ; DIHYDROARTEMISININ; DIHYDROARTEMISININ DERIVATIVE; DIKETOALDEHYDE; UNCLASSIFIED DRUG;

ARTICLE; COLUMN; COMPUTER SIMULATION; DECOMPOSITION; DEVICE; DIASTEREOISOMER; DRUG DETERMINATION; EPIMERIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LOW TEMPERATURE; PRIORITY JOURNAL; STEREOCHEMISTRY; ULTRAVIOLET SPECTROSCOPY;

ANTIMALARIALS; ARTEMISININS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; TEMPERATURE;

EID: 54149117998     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.06.037     Document Type: Article

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