Determination of enantiomerization barriers by computer simulation of experimental elution profiles obtained by high-performance liquid chromatography on a chiral stationary phase

Journal of Chromatography A

Volumn 731, Issue 1-2, 1996, Pages 315-321

  Cabrera, Karin ^a   Jung, Martin ^b,c   Fluck, Markus ^b   Schurig, Volker ^b  

^a MERCK KGAA   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c CIBA GEIGY LTD   (Switzerland)

Author keywords

Chiral discrimination; Chlorothalidone; Computer simulation; Elution profiles; Enantiomerization; Oxazepam; PTH Phenylalanine; Racemization

Indexed keywords

AMINO ACID DERIVATIVE; CHLORTALIDONE; OXAZEPAM; PHENYLALANINE DERIVATIVE;

ARTICLE; COMPUTER SIMULATION; DRUG PURIFICATION; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL;

EID: 0029873490     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9673(95)01230-3     Document Type: Article

References (20)

1. R. Crossley, Tetrahedron, 48 (1992) 8155.
2. V. Schurig and W. Bürkle, J. Am. Chem. Soc., 104 (1982) 7573.
3. M. Reist, B. Testa, P.-A. Carrupt, M. Jung and V. Schurig, Chirality, 7 (1995) 396.
4. V. Schurig, W. Bürkle, A. Zlatkis and C.F. Poole, Naturwissenschaften, 66 (1979) 423.
5. W. Bürkle, H. Karfunkel and V. Schurig, J. Chromatogr., 288 (1984) 1.
6. V. Schurig, M. Jung, M. Schleimer and F.-G. Klärner, Chem. Ber., 125 (1992) 1301.
7. M. Jung and V. Schurig, J. Am. Chem. Soc., 114 (1992) 529.
8. M. Jung, M. Fluck and V. Schurig, Chirality, 6 (1994) 510.
9. B. Stephan, H. Zinner, F. Kastner and A. Mannschreck, Chimia, 44 (1990) 336.
10. H. Zinner, Doctoral Thesis, University of Regensburg, Germany, 1990, Ch. 8.
11. J. Veciana and M.I. Crespo, Angew. Chem. Int. Ed. Engl., 30 (1991) 74.
12. T. Jira, C. Vogt, G. Blaschke and T. Beyrich, Pharmazie, 48 (1993) 196.
13. A. Wännman, A. Walhagen and P. Erlandsson, J. Chromatogr., 603 (1992) 12
14. S. Boonkerd, M.R. Detaevernier, Y. Michotte and J. Vindevogel, J. Chromatogr. A, 704 (1995) 238.
15. M. Jung, QCPE Bulletin, 12 (1992) 52.
16. Y. Aso, S. Yoshioka, T. Shibazaki and M. Uchiyama, Chem. Pharm. Bull., 36 (1988) 1834.
17. S.K. Yang and X.-L. Lu, Chirality, 4 (1992) 443.
18. G. Severin, Chirality, 4 (1992) 222.
19. H. Mauser, Formale Kinetik, Bertelsmann Universitätverlag, Düsseldorf, 1974, p. 44.
20. S.K. Yang, personal communications.