The neutrophil-activating protein of Helicobacter pylori down-modulates Th2 inflammation in ovalbumin-induced allergic asthma

Cellular Microbiology

Volumn 10, Issue 11, 2008, Pages 2355-2363

  Codolo, Gaia ^a,b   Mazzi, Paola ^c   Amedei, Amedeo ^d,e   Del Prete, Gianfranco ^d,e   Berton, Giorgio ^c   D'Elios, Mario Milco ^d,e   de Bernard, Marina ^a,b  

^a VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

^d UNIVERSITY OF FLORENCE   (Italy)

^e AOUC Careggi ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HELICOBACTER PYLORI NEUTROPHIL ACTIVATING PROTEIN; IMMUNOGLOBULIN E; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELICOBACTER PYLORI; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; LOEFFLER PNEUMONIA; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; TH2 CELL;

ANIMALS; ANTIGENS, BACTERIAL; ASTHMA; BACTERIAL PROTEINS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; HUMANS; IMMUNOGLOBULIN E; INFLAMMATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; OVALBUMIN; PULMONARY EOSINOPHILIA; TH2 CELLS;

ANIMALIA; HELICOBACTER PYLORI; MUS;

EID: 54149084001     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2008.01217.x     Document Type: Article

References (47)

1. Akdis, C.A., Kussebi, F., Pulendran, B., Akdis, M., Lauener, R.P., and Schmidt-Weber, C.B. (2003) Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides. Eur J Immunol 33: 2717-2726.
2. Amedei, A., Cappon, A., Codolo, G., Cabrelle, A., Polenghi, A., Benagiano, M., et al. (2006) The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J Clin Invest 116: 1092-1101.
3. Atkins, M.B., Robertson, M.J., Gordon, M., Lotze, M.T., De Coste, M., DuBois, J.S., et al. (1997) Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies. Clin Cancer Res 3: 409-417.
4. Banerjee, B., Kelly, K.J., Fink, J.N., Henderson, J.D., Jr, Bansal, N.K., and Kurup, V.P. (2004) Modulation of airway inflammation by immunostimulatory CpG oligonucleotides in a murine model of allergic aspergillosis. Infect Immun 72: 6087-6094.
5. Cates, E.C., Fattouh, R., Wattie, J., Inman, M.D., Goncharova, S., Coyle, A.J., et al. (2004) Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism. J Immunol 173: 6384-6392.
6. Chen, Y., and Blaser, M.J. (2007) Inverse associations of Helicobacter pylori with asthma and allergy. Arch Intern Med 167: 821-827.
7. Chilosi, M., Pizzolo, G., Fiore-Donati, L., Bofill, M., and Janossy, G. (1983) Routine immunofluorescent and histochemical analysis of bone marrow involvement of lymphoma/leukaemia: The use of cryostat sections. Br J Cancer 48: 763-775.
8. Chisholm, D., Libet, L., Hayashi, T., and Horner, A.A. (2004) Airway peptidoglycan and immunostimulatory DNA exposures have divergent effects on the development of airway allergen hypersensitivities. J Allergy Clin Immunol 113: 448-454.
9. Colombo, M.P., and Trinchieri, G. (2002) Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev 13: 155-168.
10. Corry, D.B., and Kheradmand, F. (1999) Induction and regulation of the IgE response. Nature 402: B18-B23.
11. D'Elios, M.M., Amedei, A., Cappon, A., Del Prete, G., and de Bernard, M. (2007) The neutrophil-activating protein of Helicobacter pylori (HP-NAP) as an immune modulating agent. FEMS Immunol Med Microbiol 50: 157-164.
12. Del Prete, G., De Carli, M., D'Elios, M.M., Maestrelli, P., Ricci, M., Fabbri, L., and Romagnani, S. (1993) Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur J Immunol 23: 1445-1449.
13. Drazen, J.M., Arm, J.P., and Austen, K.F. (1996) Sorting out the cytokines of asthma. J Exp Med 183: 1-5.
14. Estelle, F., Simons, R., Shikishima, Y., Van Nest, G., Eiden, J.J., and HayGlass, K.T. (2004) Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA. J Allergy Clin Immunol 113: 1144-1151.
15. Foster, P.S., Hogan, S.P., Ramsay, A.J., Matthaei, K.I., and Young, I.G. (1996) Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med 183: 195-201.
16. Freytag, L.C., and Clements, J.D. (2005) Mucosal adjuvants. Vaccine 23: 1804-1813.
17. Gangur, V., Simons, F.E.R., and HayGlass, K.T. (1999) IP-10 mediated reinforcement of human type 1 cytokine synthesis to environmental allergens among non-atopic subjects. Int Arch Allergy Immunol 118: 387-390.
18. Gonzalo, J.A., Lloyd, C.M., Kremer, L., Finger, E., Martinez, A.C., Siegelman, M.H., et al. (1996) Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors. J Clin Invest 98: 2332-2345.
19. Herz, U., Lacy, P., Renz, H., and Erb, K. (2000) The influence of infections on the development and severity of allergic disorders. Curr Opin Immunol 12: 632-640.
20. Hirota, K., Kazaoka, K., Niimoto, I., Kumihara, H., Sajiki, H., and Isobe, Y. (2002) Discovery of 8-hydroxyadenines as a novel type of interferon inducer. J Med Chem 45: 5419-5422.
21. Jacobsen, E.A., Ochkur, S.I., Pero, R.S., Taranova, A.G., Protheroe, C.A., Colbert, D.C., et al. (2008) Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J Exp Med 205: 699-710.
22. Kay, A.B. (2001) Allergy and allergic diseases. N Engl J Med 344: 109-113.
23. Lampinen, M., Carlson, M., Hakansson, L.D., and Venge, P. (2004) Cytokine-regulated accumulation of eosinophils in inflammatory disease. Allergy 59: 793-805.
24. Larché, M., Robinson, D.S., and Kay, A.B. (2003) The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 111: 450-463.
25. Leonard, J.P., Sherman, M.L., Fisher, G.L., Buchanan, L.J., Larsen, G., Atkins, M.B., et al. (1997) Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-γ production. Blood 90: 2541-2548.
26. Mazmanian, S.K., Liu, C.H., Tzianabos, A.O., and Kasper, D.L. (2005) An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122: 107-118.
27. Oppmann, B., Lesley, R., Blom, B., Timans, J.C., Xu, Y., Hunte, B., et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725.
28. Patel, M., Xu, D., Kewin, P., Choo-Kang, B., McSharry, C., and Thomson, N.C. (2005) TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells. J Immunol 174: 7558-7563.
29. Redecke, V., Hacker, H., Datta, S., Fermin, A., Pitha, P., and Broide, D. (2004) Cutting edge: Activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol 172: 2739-2743.
30. Robinson, D.S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A.M., et al. (1992) Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 326: 298-304.
31. Rothenberg, M.E. (1998) Eosinophilia. N Engl J Med 338: 1592-1600.
32. Sanderson, C.J. (1992) Interleukin-5, eosinophils, and disease. Blood 79: 3101-3109.
33. Simson, L., and Foster, P.S. (2000) Chemokine and cytokine cooperativity: Eosinophil migration in the asthmatic response. Immunol Cell Biol 78: 415-422.
34. Strachan, D.P. (1989) Hay fever, hygiene and household size. BMJ 299: 1259-1260.
35. Straus, W. (1979) Peroxidase procedures. Technical problems encountered during their application. J Histochem Cytochem 27: 1349-1351.
36. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-451.
37. Taylor, R.C., Richmond, P., and Upham, J.P. (2006) Toll-like receptor 2 ligands inhibit Th2 responses to mite allergen. J Allergy Clin Immunol 117: 1148-1154.
38. Tighe, H., Takabayashi, K., Schwartz, D., Van Nest, G., Tuck, S., Eiden, J.J., et al. (2000) Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity. J Allergy Clin Immunol 106: 124-134.
39. Till, S.J., Francis, J.N., Nouri-Aria, K., and Durham, S.R. (2004) Mechanisms of immunotherapy. J Allergy Clin Immunol 113: 1025-1034.
40. Trinchieri, G. (1995) Interleukin-12: A proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13: 251-276.
41. Trinchieri, G. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3: 133-146.
42. Trujillo-Vargas, C.M., Mayer, K.D., Bickert, T., Palmetshofer, A., Grunewald, S., Ramirez-Pineda, J.R., etal. (2005) Vaccinations with T-helper type 1 directing adjuvants have different suppressive effects on the development of allergen-induced T-helper type 2 responses. Clin Exp Allergy 35: 1003-1013.
43. Tulic, M.T., Fiset, P.-O., Christodoulopoulos, P., Vaillancourt, P., Desrosiers, M., and Lavigne, F. (2004) Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. J Allergy Clin Immunol 113: 235-241.
44. Turcanu, V., Maleki, S.J., and Lack, G. (2003) Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J Clin Invest 111: 1065-1072.
45. Vicentini, L., Mazzi, P., Caveggion, E., Continolo, S., Fumagalli, L., Lapinet-Vera, J.A., et al. (2002) Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. J Immunol 168: 6446-6454.
46. Wohlleben, G., and Erb, K.J. (2001) Atopic disorders: A vaccine around the corner? Trends Immunol 22: 618-626.
47. Wohlleben, G., and Erb, K.J. (2006) Immune stimulatory strategies for the prevention and treatment of asthma. Curr Pharm Des 12: 3281-3292.