Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 3, 2008, Pages

  Irwin, David C ^a   Foreman, Ben ^a   Morris, Ken ^a   White, Molly ^a,b   Sullivan, Tim ^a   Jacobs, Robert ^b   Monnet, Eric ^b   Hackett, Tim ^b   TissotvanPatot, Martha C ^a   Hamilton, Karyn L ^b   Gotshall, Robert W ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b USA   (United States)

Author keywords

Cardiac output; Hemoglobin based oxygen carriers; Nitric oxide

Indexed keywords

DRUG CARRIER; HEMOGLOBIN; HEMOGLOBIN BASED OXYGEN CARRIER; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGEN; POLYMERIZED BOVINE HEMOGLOBIN; RINGER LACTATE SOLUTION; SCAVENGER; UNCLASSIFIED DRUG; BLOOD SUBSTITUTE; ENZYME INHIBITOR; METHEMOGLOBIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD FLOW; BLOOD TRANSFUSION; CONTROLLED STUDY; EXCHANGE BLOOD TRANSFUSION; HEART INDEX; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HYPERVOLEMIA; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN THERAPY; POLYMERIZATION; PRIORITY JOURNAL; RAT; TISSUE OXYGENATION; ANIMAL; ANOXIA; BLOOD; BLOOD GAS ANALYSIS; BLOOD PRESSURE; CATTLE; DRUG ANTAGONISM; DRUG EFFECT; HEART OUTPUT; LUNG CIRCULATION; OXYGEN CONSUMPTION; SPRAGUE DAWLEY RAT; VASCULAR RESISTANCE;

ANIMALS; ANOXIA; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BLOOD SUBSTITUTES; CARDIAC OUTPUT; CATTLE; ENZYME INHIBITORS; HEART RATE; MALE; METHEMOGLOBIN; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OXYGEN; OXYGEN CONSUMPTION; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; STROKE VOLUME; VASCULAR RESISTANCE;

EID: 54049146384     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00303.2008     Document Type: Article

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