Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 3, 2008, Pages

  Irwin, David C ^a   Foreman, Ben ^a   Morris, Ken ^a   White, Molly ^a,b   Sullivan, Tim ^a   Jacobs, Robert ^b   Monnet, Eric ^b   Hackett, Tim ^b   TissotvanPatot, Martha C ^a   Hamilton, Karyn L ^b   Gotshall, Robert W ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b James L Voss Veterinary Teaching Hospital   (United States)

Author keywords

Cardiac output; Hemoglobin based oxygen carriers; Nitric oxide

Indexed keywords

DRUG CARRIER; HEMOGLOBIN; HEMOGLOBIN BASED OXYGEN CARRIER; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGEN; POLYMERIZED BOVINE HEMOGLOBIN; RINGER LACTATE SOLUTION; SCAVENGER; UNCLASSIFIED DRUG; BLOOD SUBSTITUTE; ENZYME INHIBITOR; METHEMOGLOBIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD FLOW; BLOOD TRANSFUSION; CONTROLLED STUDY; EXCHANGE BLOOD TRANSFUSION; HEART INDEX; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HYPERVOLEMIA; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN THERAPY; POLYMERIZATION; PRIORITY JOURNAL; RAT; TISSUE OXYGENATION; ANIMAL; ANOXIA; BLOOD; BLOOD GAS ANALYSIS; BLOOD PRESSURE; CATTLE; DRUG ANTAGONISM; DRUG EFFECT; HEART OUTPUT; LUNG CIRCULATION; OXYGEN CONSUMPTION; SPRAGUE DAWLEY RAT; VASCULAR RESISTANCE;

ANIMALS; ANOXIA; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BLOOD SUBSTITUTES; CARDIAC OUTPUT; CATTLE; ENZYME INHIBITORS; HEART RATE; MALE; METHEMOGLOBIN; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OXYGEN; OXYGEN CONSUMPTION; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; STROKE VOLUME; VASCULAR RESISTANCE;

EID: 54049146384     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00303.2008     Document Type: Article

References (26)

1. Alayash AI. Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants? Nat Biotechnol 17: 545-549, 1999.
2. Alayash AI. Oxygen therapeutics: can we tame haemoglobin? Nat Rev Drug Discovery 3: 152-159, 2004.
3. Buehler PW, Boykins RA, Jia Y, Norris S, Freedberg DI, Alayash AI. Structual and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions. Anal Chem 77: 3466-3478, 2005.
4. Burhop K, Gordon D, Estep T. Review of hemoglobin-induced myocardial lesions. Artif Cells Blood Substit Immobil Biotechnol 32: 353-374, 2004.
5. 2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin. Am J Physiol Heart Circ Physiol 287: H2825-H2833, 2004.
6. Doherty DH, Doyle MP, Curry SR, Vali RJ, Fattor TJ, Olson JS, Lemon DD. Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nat Biotechnol 16: 672-676, 1998.
7. Glasgow SC, Shah AS, Noone RB, Gottfried MR, Eachempati SR, Talarico TL, Vaslef SN. Comparison of various hemoglobin polyoxethylene conjugate solutions as resuscitative fluids after hemorragic shock. J Trauma 48: 884-893, 2000.
8. Guyton A, Jones C, Coleman T. Circulatory Physiology: Cardiac Output and Its Regulation. Philidelphia, PA: WB Saunders, 1973.
9. Hess JR, MacDonald VW, Brinkley WW. Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol 74: 1769-1778, 1993.
10. Hughes GS, Francome SF, Antal EJ, Adams WJ, Locker PK, Yancey EP, Jacobs EE Jr. Hematologic effects of a novel hemoglobin-based oxygen carrierr in normal male and femal subjects. J Lab Clin Med 126: 444-451, 1995.
11. Hultgren H. High Altitude Medicine. Stanford, CA: Hultgren, 1997, p. 520.
12. Jahr JS, Lurie F, Driessen B, Tang Z, Lourie RF, Kost G. Validation of oxygen saturation measurements in a canine model of hemoglobin-based oxygen carrier infusion. Am J Ther 10: 21-28, 2003.
13. Lee R, Neya K, Svizzero TA, Vlahakes GJ. Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions. J Appl Physiol 79: 236-242, 1995.
14. Migita R, Gonzales A, Gonzales ML, Vandegriff KD, Winslow RM. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. J Appl Physiol 82: 1995-2002, 1997.
15. Moore EE, Johnson JL, Cheng AM, Masuno T, Banerjee A. Insights from the studies of blood substitutes in trauma. Shock 24: 197-205, 2005.
16. Nemoto M, Mito T, Brinigar W, Fronticelli C, Koehler RC. Salvage of focal cerebral ischemic damage by transfusion of high O2-affinity recombinant hemoglobin polymers in mouse. J Appl Physiol 100: 1688-1691, 2006.
17. Olson JS, Foley EW, Rogge C, Tsai AL, Doyle MP, Lemon DD. NO scavenging and the hypertensive effect of hemoglobin-based blood substitutes. Free Radic Biol Med 36: 685-697, 2004.
18. Ortegon DP, Davis MR, Sampson JB, Dick E, Kashyap V, Kerby J. Bovine hemoglobin-based oxygen-carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure. Microsurgery 26: 203-206, 2006.
19. Privalle C, Talarico T, Keng T, DeAngelo J. Pyridoxalated hemoglobin polyoxyethylene: a nitric oxide scavenger with antioxidant activity for the treatment of nitric oxide-induced shock. Free Radic Biol Med 28: 1507-1517, 2000.
20. Raat NJH, Liu JF, Doyle MP, Burhop KE, Klein J, Ince C. Effects of recombinant-hemoglobin solutions rHb2.0 and rHb11 on blood pressure, intestinal blood flow, and gut oxygenation in a rat model of hemorrhagic shock. J Lab Clin Med 145: 21-32, 2005.
21. Sawyer GJ, Dong X, Whitehorne M, Grehan A, Seddon M, Shah AM, Zhang X, Fabre JW. Cardiovascular function following acute volume overload for hydrodynamic gene delivery to the liver. Gene Ther 15: 452-462, 2007.
22. Spahn DR, Kocian R. Artificial O2 carriers: Status in 2005. Curr Pharm Des 11: 4099-4114, 2005.
23. Tsai AG, Cabrales P, Manjula BN, Acharya SA, Winslow RM, Intaglietta M. Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood 108: 3603-3610, 2006.
24. Vaslef SN, Kaminski BJ, Talarico TL. Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine. J Trauma 51: 1153-1160, 2001.
25. Walsh MP, Marshall JM. The early effects of chronic hypoxia on the cardiovascular system in the rat: role of nitric oxide. J Physiol 575: 263-275, 2006.
26. Winslow RM. Current status of blood substitute research; towards a new paradigm. J Int Med Res 253: 508-517, 2003.