Bovine hemoglobin-based oxygen-carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure

Microsurgery

Volumn 26, Issue 3, 2006, Pages 203-206

  Ortegon, Delio P ^a,c   Davis, Michael R ^b   Sampson, James B ^b   Dick, Edward J ^b   Kashyap, Vikram ^b   Kerby, Jeffrey D ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b WILFORD HALL MEDICAL CENTER   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; OXYGEN; POLYMERIZED HEMOGLOBIN; RINGER LACTATE SOLUTION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; EPIGASTRIC SKIN FLAP; EUTHANASIA; FASCIOCUTANEOUS FLAP; FLAP FAILURE; GRAFT FAILURE; HEMODILUTION; MALE; NECROSIS; NONHUMAN; PEDICLED SKIN FLAP; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RAT; SKIN FLAP SURVIVAL;

ANIMALS; BLOOD SUBSTITUTES; GRAFT SURVIVAL; HEMOGLOBINS; ISCHEMIA; MALE; MODELS, ANIMAL; NECROSIS; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; RHEOLOGY; SURGICAL FLAPS;

EID: 33645752703     PISSN: 07381085     EISSN: 10982752     Source Type: Journal    
DOI: 10.1002/micr.20221     Document Type: Article

References (17)

1. Kroll SS, Reece GP, Miller MJ, Schusterman MA. Comparison of the rectus abdominus free flap with the pectoralis major myocutaneous flap for reconstructions of the head and neck. Am J Surg 1992; 164:615-617.
2. Zhang F, Fischer K, Komorowksa-Timek E, Guo M, Cui D, Dorsett-Martin W, Bunke HJ, Lineaweaver WC. Improvement of skin paddle survival by application of vascular endothelial growth factor in a rat TRAM flap model. Ann Plastic Surg 2001;46:314-319.
3. Krapohl BD, Siemionow M, Zins JE. Tissue-plasminogen activator restores muscle flap perfusion in the rat. J Hand Surg [Am] 1999;24: 1036-1044.
4. Banbury J, Sieminow M, Porvasnik S, Petras S, Browne E. Improved perfusion after subcritical ischemia in muscle flaps treated with vascular endothelial growth factor. Plast Reconstr Surg 2000;106:1541-1546.
5. Padubidri A, Browne E. Effect of vascular endothlial growth factor on survival in random extension of axial pattern skin flaps in the rat. Ann Plast Surg 1996;37:604-611.
6. Ichioka S, Nakatsuka T, Ohura N, Sato Y, Harii K. Clinical use of amrinone (a selective phosphodiesterase III inhibitor) in reconstructive surgery. Plast Reconstr Surg 2001;108:1932-1937.
7. Karacaoglan N, Akbas H. Effect of parenteral pentoxifylline and topical nitroglycerin on skin flap survival. Otolarygol Head Neck Surg 1999;120:272-274.
8. Roth AG, Briggs PC, Jones EW, Heckler FR. Augmentatin of skin flap survival by parenteral pentoxifilline. Br J Plast Surg 1988;41:515-520.
9. Ramasastry SS, Waterman P, Angel MF, Futrell JW. Effect of Fluosol Da (20%) on skin flap survival in rats. Ann Plast Surg 1985;15:436-442.
10. Hamilton RG, Kelly N, Gawryl MS, Rentko VT. Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs. Transfusion 2001;41:219-225.
11. Horn EP, Standl T, Wilhelm S, Jacobs EE, Freitag U, Freitag M, Schulte am Esch J. Bovine hemoglobin increases skeletal muscle oxygenation during 95% artificial arterial stenosis. Surgery 1997;121: 411-418.
12. McNeil JD, Smith DL, Jenkins DH, York GB, Josephs JD. Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism. J Trauma Injury Infect Crit Care 2001;50:1063-1075.
13. Padubidri AN, Browne E. Modification in flap design of the epigastric arttery flap in rats-a new experimental flap model. Ann Plast Surg 1997;39:500-503.
14. Hughes GS, Antal EJ, Locker PK, Francom SG, Adams WJ, Jacobs EE. Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. Crit Care Med 1996;24:756-764.
15. Page TC, Light WR, McKay CB, Hellums JD. Oxygen transport by erythrocyte/hemoglobin solution mixture in an in vitro capillary as as model of hemoglobin-based oxygen carrier performance. Microvasc Res 1998;55:54-64.
16. Buehler PW, Alayash AI. Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems. Transfusion 2004;44: 1516-1530.
17. Ortegon DP, Davis MR, Dixon PS, Smith DL, Josephs JD, Mueller DL, Jenkins DH, Kerby JK. The polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) is not toxic to neural cells in culture. J Trauma Infect Crit Care 2002;53:1068-1072.