Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 287, Issue 6 56-6, 2004, Pages

  Cabrales, Pedro ^a   Tsai, Amy G ^a   Intaglietta, Marcos ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Blood substitutes; Functional capillary density; Methemoglobin; Microcirculation

Indexed keywords

HEMOGLOBIN; OXYGEN; POLYMERIZED BOVINE HEMOGLOBIN; UNCLASSIFIED DRUG; BLOOD SUBSTITUTE; CARBON DIOXIDE; METHEMOGLOBIN; POLYMERIZED HEMOGLOBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTERY DIAMETER; ARTICLE; BLOOD SUBSTITUTION; CAPILLARY DENSITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ERYTHROCYTE; EXCHANGE BLOOD TRANSFUSION; FLOW RATE; HAMSTER; HEMOGLOBIN DETERMINATION; METABOLIC REGULATION; MICROCIRCULATION; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TISSUE LEVEL; POLYMERIZATION; PRIORITY JOURNAL; VENULE; ANIMAL; BLOOD; BLOOD TRANSFUSION; HEMATOCRIT; PHYSIOLOGY; PRESSURE; SYRIAN HAMSTER;

ANIMALS; ARTERIOLES; BLOOD SUBSTITUTES; BLOOD TRANSFUSION; CARBON DIOXIDE; CRICETINAE; HEMATOCRIT; HEMOGLOBINS; MESOCRICETUS; METHEMOGLOBIN; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE;

EID: 16544392456     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00654.2004     Document Type: Article

References (50)

1. Alayash AI. Effects of intra- and intermolecular crosslinking on the free radical reactions of bovine hemoglobins. Free Radic Biol Med 18: 295-301, 1995.
2. Alayash AI. Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants? Nat Biotechnol 17: 545-549, 1999.
3. Alayash AI. Oxygen therapeutics: can we tame haemoglobin? Nat Rev Drug Discov 3: 152-159, 2004.
4. Bosman RJ, Minten J, Lu HR, Van Aken H, and Flameng W. Free polymerized hemoglobin versus hydroxyethyl starch in resuscitation of hypovolemic dogs. Anesth Analg 75: 811-817, 1992.
5. Cabrales P, Tsai AG, Frangos JA, Briceno JC, and Intaglietta M. Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons. Am J Physiol Heart Circ Physiol 287: H320-H330, 2004.
6. 2 carrier. Am J Physiol Heart Circ Physiol 287: H363-H373, 2004.
7. Cai H and Harrison D. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844, 2000.
8. Cheung AT, Jahr JS, Driessen B, Duong PL, Chan MS, Lurie F, Golkaryeh MS, Kullar RK, and Gunther RA. The effects of hemoglobin glutamer-200 (bovine) on the microcirculation in a canine hypovolemia model: a noninvasive computer-assisted intravital microscopy study. Anesth Analg 93: 832-838, 2001.
9. Chevalier A, Guillochon D, Nedjar N, Piot JM, Vijayalakshmi MW, and Thomas D. Glutaraldehyde effect on hemoglobin: evidence for an ion environment modification based on electron paramagnetic resonance and Mossbauer spectroscopies. Biochem Cell Biol 68: 813-818, 1990.
10. Colantuoni A, Bertuglia S, and Intaglietta M. Quantitation of rhythmic diameter changes in arterial microcirculation. Am J Physiol Heart Circ Physiol 246: H508-H517, 1984.
11. 2/M arrest and apoptosis in cultured endothelial cells. Blood 98: 3315-3323, 2001.
12. Driessen B, Jahr JS, Lurie F, and Gunther RA. Inadequacy of low-volume resuscitation with hemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) in canine hypovolemia. J Vet Pharmacol Ther 24: 61-71, 2001.
13. Endrich B, Asaishi K, Götz A, and Messmer K. A new chamber technique for microvascular studies in unanaesthetized hamsters. Res Exp Med (Berl) 177: 125-134, 1980.
14. Federspiel WJ. Pulmonary diffusing capacity: implications of two-phase blood flow in capillaries. Respir Physiol 77: 119-134, 1989.
15. Frankel HL, Nguyen HB, Shea-Donohue T, Aiton LA, Ratigan J, and Malcolm DS. Diaspirin cross-linked hemoglobin is efficacious in gut resuscitation as measured by a GI tract optode. J Trauma 40: 231-241, 1996.
16. Friesenecker B, Tsai A, Dunser M, Mayr A, Martini J, Knotzer H, Hasibeder W, and Intaglietta M. Oxygen distribution in the microcirculation following arginine-vasopressin-induced arteriolar vasoconstriction. Am J Physiol Heart Circ Physiol H1792-H1800, 2004.
17. Guillochon D, Vijayalakshmi MW, Thiam-Sow A, and Thomas D. Effect of glutaraldehyde on hemoglobin: functional aspects and Mossbauer parameters. Biochem Cell Biol 64: 29-37, 1986.
18. Harringer W, Hodakowski GT, Svizzero T, Jacobs EE Jr, and Vlahakes GJ. Acute effects of massive transfusion of a bovine hemoglobin blood substitute in a canine model of hemorrhagic shock. Eur J Cardiothorac Surg 6: 649-654, 1992.
19. Intaglietta M, Silverman NR, and Tompkins WR. Capillary flow velocity measurements in vivo and in situ by television methods. Microvasc Res 10: 165-179, 1975.
20. Intaglietta M and Tompkins W. Microvascular measurements by video image shearing and splitting. Microvasc Res 5: 309-312, 1973.
21. 2 measurements by phosphorescence quenching: characteristics and applications of an automated system. Microvasc Res 65: 32-38, 2003.
22. Khan AK, Jahr JS, Nesargi S, Rothenberg SJ, Tang Z, Cheung A, Gunther RA, Kost GJ, and Driessen B. Does lead interfere with hemoglobin-based oxygen carrier (HBOC) function? A pilot study of lead concentrations in three approved or tested HBOCs and oxyhemoglobin dissociation with HBOCs and/or bovine blood with varying lead concentrations. Anesth Analg 96: 1813-1820, 2003.
23. Krieter H, Hagen G, Waschke KF, Kohler A, Wenneis B, Bruckner UB, and van Ackern K. Isovolemic hemodilution with a bovine hemoglobin-based oxygen carrier: effects on hemodynamics and oxygen transport in comparison with a non-oxygen-carrying volume substitute. J Cardiothorac Vasc Anesth 11: 3-9, 1997.
24. Lee DH, Bardossy L, Peterson N, and Blajchman MA. o-Raffinose cross-linked hemoglobin improves the hemostatic defect associated with anemia and thrombocytopenia in rabbits. Blood 96: 3630-3636, 2000.
25. Lee R, Atsumi N, Jacobs EE Jr, Austen WG, and Vlahakes GJ. Ultrapure, stroma-free, polymerized bovine hemoglobin solution: evaluation of renal toxicity. J Surg Res 47: 407-411, 1989.
26. Linberg R, Conover CD, Shum KL, and Shorr RG. Hemoglobin-based oxygen carriers: how much methemoglobin is too much? Artif Cells Blood Substit Immobil Biotechnol 26: 133-148, 1998.
27. Lipowsky HH and Zweifach BW. Application of the "two-slit" photometric technique to the measurement of microvascular volumetric flow rates. Microvasc Res 15: 93-101, 1978.
28. Marks DH, Moore GL, Medina F, Boswell G, Zieske LR, Bolin RB, and Zegna AI. Optimization and synthesis of pyridoxalated polymerized stroma-free hemoglobin solution. Mil Med 153: 44-49, 1988.
29. McCarthy M. Engineering Parameters in the Evaluation of Hemoglobin-Based Blood Substitutes (Dissertation). San Diego, CA: University of California, 1997.
30. Moro MA, Darley-Usmar VM, Goodwin DA, Read NG, Zamora-Pino R, Feelisch M, Radomski MW, and Moncada S. Paradoxical fate and biological action of peroxynitrite on human platelets. Proc Natl Acad Sci USA 91: 6702-6706, 1994.
31. Motterlini R, Foresti R, Intaglietta M, and Winslow RM. NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium. Am J Physiol Heart Circ Physiol 270: H107-H114, 1996.
32. Motterlini R, Vandegriff KD, and Winslow RM. Hemoglobin-nitric oxide interaction and its implications. Transfus Med Rev 10: 77-84, 1996.
33. Olsen SB, Tang DB, Jackson MR, Gomez ER, Ayala B, and Alving BM. Enhancement of platelet deposition by cross-linked hemoglobin in a rat carotid endarterectomy model. Circulation 93: 327-332, 1996.
34. Page TC, Light WR, McKay CB, and Heliums JD. Oxygen transport by erythrocyte/hemoglobin solution mixtures in an in vitro capillary as a model of hemoglobin-based oxygen carrier performance. Microvasc Res 55: 54-64, 1998.
35. Pearce BL and Gawryl MS. Blood Substitutes: Principles, Methods, Products, and Clinical Trials. Basel, Switzerland: Karger Landes Systems, 1998.
36. Standl T, Horn P, Wilhelm S, Greim C, Freitag M, Freitag U, Sputteck A, Jacobs E, and Schulte am Esch J. Bovine haemoglobin is more potent than autologous red blood cells in restoring muscular tissue oxygenation after profound isovolaemic haemodilution in dogs. Can J Anaesth 43: 714-723, 1996.
37. Standl TG, Reeker W, Redmann G, Kochs E, Werner C, and Schulte am Esch J. Haemodynamic changes and skeletal muscle oxygen tension during complete blood exchange with ultrapurified polymerized bovine haemoglobin. Intensive Care Med 23: 865-872, 1997.
38. 2 measurements by phosphorescence decay method. Am J Physiol Heart Circ Physiol 265: H1434-H1438, 1993.
39. Tsai AG. Influence of cell-free hemoglobin on local tissue perfusion and oxygenation after acute anemia after isovolemic hemodilution. Transfusion 41: 1290-1298, 2001.
40. Tsai AG, Cabrales P, Winslow RM, and Intaglietta M. Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia. Am J Physiol Heart Circ Physiol 285: H1537-H1545, 2003.
41. Tsai AG, Friesenecker B, Mazzoni MC, Kerger H, Buerk DG, Johnson PC, and Intaglietta M. Microvascular and tissue oxygen gradients in the rat mesentery. Proc Natl Acad Sci USA 95: 6590-6595, 1998.
42. Tsai AG, Friesenecker B, McCarthy M, Sakai H, and Intaglietta M. Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skin fold model. Am J Physiol Heart Circ Physiol 275: H2170-H2180, 1998.
43. 2 therapeutics. Am J Physiol Heart Circ Physiol 285: H1411-H1419, 2003.
44. Van Iterson M, Sinaasappel M, Burhop K, Trouwborst A, and Ince C. Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine. J Lab Clin Med 132: 421-431, 1998.
45. Webb AR, Barclay SA, and Bennett ED. In vitro colloid osmotic pressure of commonly used plasma expanders and substitutes: a study of the diffusibility of colloid molecules. Intensive Care Med 15: 116-120, 1989.
46. Winslow RM. Potential clinical applications for blood substitutes. Biomater Artif Cells Immobilization Biotechnol 20: 205-217, 1992.
47. Winslow RM, Vandegriff KD, and Intaglietta M. Hemoglobin Oxygen Affinity and the Design of Red Cell Substitutes. Boston, MA: Birkhauser, 1997.
48. Winterbourn CC. Oxidative reactions of hemoglobin. Methods Enzymol 186: 265-272, 1990.
49. Ye JM, Colquhoun EQ, and Clark MG. A comparison of vasopressin and noradrenaline on oxygen uptake by perfused rat hindlimb, intestine, and mesenteric arcade suggests that it is in part due to contractile work by blood vessels. Gen Pharmacol 21: 805-810, 1990.
50. Yeh L and Alayash A. Redox side reactions of haemoglobin and cell signalling mechanisms. J Intern Med 253: 518-526, 2003.