Prokineticin 2 influences subfornical organ neurons through regulation of MAP kinase and the modulation of sodium channels

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 3, 2008, Pages

  Fry, Mark ^a   Cottrell, G Trevor ^b   Ferguson, Alastair V ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b SHERIDAN COLLEGE   (Canada)

Author keywords

Circumventricular organs; Intracellular Ca2+; Mitogen activated protein kinase; Neuropeptides; Potassium current; Sodium current

Indexed keywords

CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NEUROPEPTIDE; NIFEDIPINE; PROKINETICIN 2; SODIUM CHANNEL; TETRODOTOXIN; THAPSIGARGIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; GASTROINTESTINAL HORMONE; POTASSIUM; PROKINETICIN 2, RAT; SODIUM;

ACTION POTENTIAL; AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; ENZYME REGULATION; EVOKED RESPONSE; EXTRACELLULAR CALCIUM; MALE; NERVE CELL EXCITABILITY; NONHUMAN; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CONDUCTANCE; SUBFORNICAL ORGAN; WHOLE CELL; ANIMAL; AUTONOMIC NERVOUS SYSTEM; CHANNEL GATING; CYTOLOGY; ENZYMOLOGY; METABOLISM; NERVE CELL; PATCH CLAMP; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; CALCIUM; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; GASTROINTESTINAL HORMONES; ION CHANNEL GATING; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPEPTIDES; PATCH-CLAMP TECHNIQUES; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SODIUM CHANNELS; SUBFORNICAL ORGAN;

EID: 54049145889     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00779.2007     Document Type: Article

References (36)

1. Badman MK, Flier JS. The gut and energy balance: visceral allies in the obesity wars. Science 307: 1909-1914, 2005.
2. Boyd DF, Mathie A. Inhibition of the potassium current IK(SO), in cerebellar granule cells, by the inhibitors of MEK1 activation, PD 98059 and U 0126. Neuropharmacology 42: 221-228, 2002.
3. Bullock CM, Li JD, Zhou QY. Structural determinants required for the bioactivities of prokineticins and identification of prokineticin receptor antagonists. Mol Pharmacol 65: 582-588, 2004.
4. Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver DR, Leslie FM, Zhou QY. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417: 405-410, 2002.
5. Cheng MY, Leslie FM, Zhou QY. Expression of prokineticins and their receptors in the adult mouse brain. J Comp Neurol 498: 796-809, 2006.
6. Cottrell GT, Zhou QY, Ferguson AV. Prokineticin 2 modulates the excitability of subfornical organ neurons. J Neurosci 24: 2375-2379, 2004.
7. Cottrell GT, Ferguson AV. Sensory circumventricular organs: central roles in integrated autonomic regulation. Regul Pept 117: 11-23, 2004.
8. Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24: 155-163, 1999.
9. Desson SE, Ferguson AV. Interleukin 1beta modulates rat subfornical organ neurons as a result of activation of a non-selective cationic conductance. J Physiol 550: 113-122, 2003.
10. Ferguson AV, Bains JS. Electrophysiology of the circumventricular organs. Front Neuroendocrinol 17: 440-475, 1996.
11. Ferguson AV, Bicknell RJ, Carew MA, Mason WT. Dissociated adult rat subfornical organ neurons maintain membrane properties and angiotensin responsiveness for up to 6 days. Neuroendocrinology 66: 409-415, 1997.
12. Fry M, Ferguson AV. Subthreshold oscillations of membrane potential of rat subfornical organ neurons. Neuroreport 18: 1389-1393, 2007.
13. Fry M, Ferguson AV. The sensory circumventricular organs: brain targets for circulating signals controlling ingestive behavior. Physiol Behav 91: 413-423, 2007.
14. Fuller G, Veitch K, Ho LK, Cruise L, Morris BJ. Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase. Brain Res Mol Brain Res 89: 126-132, 2001.
15. Hu WP, Li JD, Zhang C, Boehmer L, Siegel JM, Zhou QY. Altered circadian and homeostatic sleep regulation in prokineticin 2-deficient mice. Sleep 30: 247-256, 2007.
16. Johnson AK, Thunhorst RL. The neuroendocrinology of thirst and salt appetite: visceral sensory signals and mechanisms of central integration. Front Neuroendocrinol 18: 292-353, 1997.
17. Krout KE, Kawano J, Mettenleiter TC, Loewy AD. CNS inputs to the suprachiasmatic nucleus of the rat. Neuroscience 110: 73-92, 2002.
18. LeCouter J, Lin R, Tejada M, Frantz G, Peale F, Hillan KJ, Ferrara N. The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: localization of Bv8 receptors to endothelial cells. Proc Natl Acad Sci USA 100: 2685-2690, 2003.
19. Li JD, Hu WP, Boehmer L, Cheng MY, Lee AG, Jilek A, Siegel JM, Zhou QY. Attenuated circadian rhythms in mice lacking the prokineticin 2 gene. J Neurosci 26: 11615-11623, 2006.
20. Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY. Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle. Mol Pharmacol 59: 692-698, 2001.
21. Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY. Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. J Biol Chem 277: 19276-19280, 2002.
22. Masuda Y, Takatsu Y, Terao Y, Kumano S, Ishibashi Y, Suenaga M, Abe M, Fukusumi S, Watanabe T, Shintani Y, Yamada T, Hinuma S, Inatomi N, Ohtaki T, Onda H, Fujino M. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Biochem Biophys Res Commun 293: 396-402, 2002.
23. Melchiorri D, Bruno V, Besong G, Ngomba RT, Cuomo L, De BA, Copani A, Moschella C, Storto M, Nicoletti F, Lepperdinger G, Passarelli F. The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways. Eur J Neurosci 13: 1694-1702, 2001.
24. Negri L, Lattanzi R, Giannini E, De FM, Colucci A, Melchiorri P. Bv8, the amphibian homologue of the mammalian prokineticins, modulates ingestive behaviour in rats. Br J Pharmacol 142: 181-191, 2004.
25. Negri L, Lattanzi R, Giannini E, Metere A, Colucci M, Barra D, Kreil G, Melchiorri P. Nociceptive sensitization by the secretory protein Bv8. Br J Pharmacol 137: 1147-1154, 2002.
26. Ono K, Honda E, Inenaga K. Angiotensin II induces inward currents in subfornical organ neurones of rats. J Neuroendocrinol 13: 517-523, 2001.
27. Prosser HM, Bradley A, Chesham JE, Ebling FJ, Hastings MH, Maywood ES. Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei. Proc Natl Acad Sci USA 104: 648-653, 2007.
28. Shao XM, Feldman JL. Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials. J Neurosci Methods 159: 108-115, 2007.
29. Soga T, Matsumoto S, Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K. Molecular cloning and characterization of prokineticin receptors. Biochim Biophys Acta 1579: 173-179, 2002.
30. Treiman M, Caspersen C, Christensen SB. A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases. Trends Pharmacol Sci 19: 131-135, 1998.
31. Vellani V, Colucci M, Lattanzi R, Giannini E, Negri L, Melchiorri P, McNaughton PA. Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8. J Neurosci 26: 5109-5116, 2006.
32. Washburn DL, Ferguson AV. Selective potentiation of N-type calcium channels by angiotensin II in rat subfornical organ neurones. J Physiol 536: 667-675, 2001.
33. Washburn DLS, Beedle AM, Ferguson AV. Inhibition of subfornical organ neuronal potassium channels by vasopressin. Neuroscience 93: 349-359, 1999.
34. Yang F, Feng L, Zheng F, Johnson SW, Du J, Shen L, Wu CP, Lu B. GDNF acutely modulates excitability and A-type K(+) channels in midbrain dopaminergic neurons. Nat Neurosci 4: 1071-1078, 2001.
35. + channels in hippocampus involves a mitogen-activated protein kinase pathway. J Neurosci 22: 4860-4868, 2002.
36. Zhou QY, Cheng MY. Prokineticin 2 and circadian clock output. FEBS J 272: 5703-5709, 2005.