메뉴 건너뛰기




Volumn 29, Issue 4, 2008, Pages 643-654

The Heterogeneity of the Microcirculation in Critical Illness

Author keywords

Critical illness; Microcirculation; Multi organ failure; Orthogonal polarization spectral imaging; Sepsis; Shock; Sidestream dark field imaging

Indexed keywords

CRITICAL ILLNESS; DIAGNOSTIC IMAGING; FUNCTIONAL ANATOMY; HUMAN; INTENSIVE CARE; MICROCIRCULATION; MICROVASCULATURE; NONHUMAN; PATHOGENESIS; PERIOPERATIVE PERIOD; POINT OF CARE TESTING; PRIORITY JOURNAL; REVIEW; SEPSIS;

EID: 54049138483     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccm.2008.06.008     Document Type: Review
Times cited : (72)

References (71)
  • 1
    • 0037352616 scopus 로고    scopus 로고
    • Cardiovascular management of septic shock
    • Dellinger R.P. Cardiovascular management of septic shock. Crit Care Med 31 3 (2003) 946-955
    • (2003) Crit Care Med , vol.31 , Issue.3 , pp. 946-955
    • Dellinger, R.P.1
  • 2
    • 0035829842 scopus 로고    scopus 로고
    • Early goal-directed therapy in the treatment of severe sepsis and septic shock
    • Rivers E., Nguyen B., Havstad S., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345 19 (2001) 1368-1377
    • (2001) N Engl J Med , vol.345 , Issue.19 , pp. 1368-1377
    • Rivers, E.1    Nguyen, B.2    Havstad, S.3
  • 3
    • 4444233598 scopus 로고    scopus 로고
    • Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    • Sakr Y., Dubois M.J., De Backer D., et al. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32 9 (2004) 1825-1831
    • (2004) Crit Care Med , vol.32 , Issue.9 , pp. 1825-1831
    • Sakr, Y.1    Dubois, M.J.2    De Backer, D.3
  • 4
    • 33845872563 scopus 로고    scopus 로고
    • Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    • 98
    • Trzeciak S., Dellinger R.P., Parrillo J.E., et al. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 49 1 (2007) 88-98 98
    • (2007) Ann Emerg Med , vol.49 , Issue.1 , pp. 88-98
    • Trzeciak, S.1    Dellinger, R.P.2    Parrillo, J.E.3
  • 5
    • 36248992450 scopus 로고    scopus 로고
    • Sidestream dark field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation
    • Goedhart P., Khalilzada M., Bezemer R., et al. Sidestream dark field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. Opt Express 15 (2007) 15101-15114
    • (2007) Opt Express , vol.15 , pp. 15101-15114
    • Goedhart, P.1    Khalilzada, M.2    Bezemer, R.3
  • 6
    • 0032828956 scopus 로고    scopus 로고
    • Orthogonal polarization spectral imaging: a new method for study of the microcirculation
    • Groner W., Winkelman J.W., Harris A.G., et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 5 10 (1999) 1209-1212
    • (1999) Nat Med , vol.5 , Issue.10 , pp. 1209-1212
    • Groner, W.1    Winkelman, J.W.2    Harris, A.G.3
  • 7
    • 33749860102 scopus 로고    scopus 로고
    • Bidirectional control of CNS capillary diameter by pericytes
    • Peppiatt C.M., Howarth C., Mobbs P., et al. Bidirectional control of CNS capillary diameter by pericytes. Nature 443 7112 (2006) 700-704
    • (2006) Nature , vol.443 , Issue.7112 , pp. 700-704
    • Peppiatt, C.M.1    Howarth, C.2    Mobbs, P.3
  • 8
    • 0344486298 scopus 로고
    • Three-dimensional organization of microvascular beds as related to function
    • Kaley G., and Altura B.M. (Eds), University Park Press, Baltimore (MD)
    • Sobin S.S., and Tremer H.M. Three-dimensional organization of microvascular beds as related to function. In: Kaley G., and Altura B.M. (Eds). Microcirculation (1977), University Park Press, Baltimore (MD) 43-67
    • (1977) Microcirculation , pp. 43-67
    • Sobin, S.S.1    Tremer, H.M.2
  • 9
    • 84911539247 scopus 로고
    • The number and the distribution of capillaries in muscle with the calculation of the oxygen pressure necessary for supplying tissue
    • Krogh A. The number and the distribution of capillaries in muscle with the calculation of the oxygen pressure necessary for supplying tissue. J Physiol 52 (1919) 409-515
    • (1919) J Physiol , vol.52 , pp. 409-515
    • Krogh, A.1
  • 10
    • 0034967945 scopus 로고    scopus 로고
    • Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation
    • Mathura K.R., Vollebregt K.C., Boer K., et al. Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation. J Appl Physiol 91 1 (2001) 74-78
    • (2001) J Appl Physiol , vol.91 , Issue.1 , pp. 74-78
    • Mathura, K.R.1    Vollebregt, K.C.2    Boer, K.3
  • 11
    • 0035160328 scopus 로고    scopus 로고
    • Impaired vascular function in women with pre-eclampsia observed with orthogonal polarisation spectral imaging
    • Vollebregt K.C., Boer K., Mathura K.R., et al. Impaired vascular function in women with pre-eclampsia observed with orthogonal polarisation spectral imaging. BJOG 108 11 (2001) 1148-1153
    • (2001) BJOG , vol.108 , Issue.11 , pp. 1148-1153
    • Vollebregt, K.C.1    Boer, K.2    Mathura, K.R.3
  • 12
    • 0031154065 scopus 로고    scopus 로고
    • Blood flow in the cerebral capillary network: a review emphasizing observations with intravital microscopy
    • Hudetz A.G. Blood flow in the cerebral capillary network: a review emphasizing observations with intravital microscopy. Microcirculation 4 2 (1997) 233-252
    • (1997) Microcirculation , vol.4 , Issue.2 , pp. 233-252
    • Hudetz, A.G.1
  • 13
    • 0019847644 scopus 로고
    • Cortical blood vessels of the human brain
    • Duvernoy H.M., Delon S., and Vannson J.L. Cortical blood vessels of the human brain. Brain Res Bull 7 5 (1981) 519-579
    • (1981) Brain Res Bull , vol.7 , Issue.5 , pp. 519-579
    • Duvernoy, H.M.1    Delon, S.2    Vannson, J.L.3
  • 14
    • 33646884618 scopus 로고    scopus 로고
    • The pathways of oxygen in brain. I. Delivery and metabolism of oxygen
    • Gjedde A. The pathways of oxygen in brain. I. Delivery and metabolism of oxygen. Adv Exp Med Biol 566 (2005) 269-275
    • (2005) Adv Exp Med Biol , vol.566 , pp. 269-275
    • Gjedde, A.1
  • 15
    • 2542621531 scopus 로고    scopus 로고
    • Direct observation of the human cerebral microcirculation during aneurysm surgery reveals increased arteriolar contractility
    • Pennings F.A., Bouma G.J., and Ince C. Direct observation of the human cerebral microcirculation during aneurysm surgery reveals increased arteriolar contractility. Stroke 35 6 (2004) 1284-1288
    • (2004) Stroke , vol.35 , Issue.6 , pp. 1284-1288
    • Pennings, F.A.1    Bouma, G.J.2    Ince, C.3
  • 16
    • 33745776969 scopus 로고    scopus 로고
    • Continuous real-time visualization of the human cerebral microcirculation during arteriovenous malformation surgery using orthogonal polarization spectral imaging
    • Pennings F.A., Ince C., and Bouma G.J. Continuous real-time visualization of the human cerebral microcirculation during arteriovenous malformation surgery using orthogonal polarization spectral imaging. Neurosurgery 59 1 (2006) 167-171
    • (2006) Neurosurgery , vol.59 , Issue.1 , pp. 167-171
    • Pennings, F.A.1    Ince, C.2    Bouma, G.J.3
  • 17
    • 0345074171 scopus 로고    scopus 로고
    • Noninvasive analysis of conjunctival microcirculation during carotid artery surgery reveals microvascular evidence of collateral compensation and stenosis-dependent adaptation
    • Schaser K.D., Settmacher U., Puhl G., et al. Noninvasive analysis of conjunctival microcirculation during carotid artery surgery reveals microvascular evidence of collateral compensation and stenosis-dependent adaptation. J Vasc Surg 37 4 (2003) 789-797
    • (2003) J Vasc Surg , vol.37 , Issue.4 , pp. 789-797
    • Schaser, K.D.1    Settmacher, U.2    Puhl, G.3
  • 18
    • 0035383777 scopus 로고    scopus 로고
    • Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease
    • Cheung A.T., Harmatz P., Wun T., et al. Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease. Blood 97 11 (2001) 3401-3404
    • (2001) Blood , vol.97 , Issue.11 , pp. 3401-3404
    • Cheung, A.T.1    Harmatz, P.2    Wun, T.3
  • 19
    • 0036624892 scopus 로고    scopus 로고
    • Microvascular abnormalities in sickle cell disease: a computer-assisted intravital microscopy study
    • Cheung A.T., Chen P.C., Larkin E.C., et al. Microvascular abnormalities in sickle cell disease: a computer-assisted intravital microscopy study. Blood 99 11 (2002) 3999-4005
    • (2002) Blood , vol.99 , Issue.11 , pp. 3999-4005
    • Cheung, A.T.1    Chen, P.C.2    Larkin, E.C.3
  • 20
    • 0023276436 scopus 로고
    • Low dose fluorescein angiography of the conjunctiva and episclera
    • Meyer P.A., and Watson P.G. Low dose fluorescein angiography of the conjunctiva and episclera. Br J Ophthalmol 71 1 (1987) 2-10
    • (1987) Br J Ophthalmol , vol.71 , Issue.1 , pp. 2-10
    • Meyer, P.A.1    Watson, P.G.2
  • 21
    • 9844232401 scopus 로고
    • Anatomical and physiological aspects of the capillary bed in the bulbar conjunctiva of man in health and disease
    • Lee R.E. Anatomical and physiological aspects of the capillary bed in the bulbar conjunctiva of man in health and disease. Angiology 6 4 (1955) 369-382
    • (1955) Angiology , vol.6 , Issue.4 , pp. 369-382
    • Lee, R.E.1
  • 22
    • 54049114598 scopus 로고
    • The peripheral vascular system in the bulbar conjunctiva of young normotensive adults at rest
    • Lee R.E., and Holze E.A. The peripheral vascular system in the bulbar conjunctiva of young normotensive adults at rest. J Clin Invest 29 2 (1950) 146-150
    • (1950) J Clin Invest , vol.29 , Issue.2 , pp. 146-150
    • Lee, R.E.1    Holze, E.A.2
  • 23
    • 33645102148 scopus 로고    scopus 로고
    • Sublingual capnometry tracks microcirculatory changes in septic patients
    • Creteur J., De Backer D., Sakr Y., et al. Sublingual capnometry tracks microcirculatory changes in septic patients. Intensive Care Med 32 4 (2006) 516-523
    • (2006) Intensive Care Med , vol.32 , Issue.4 , pp. 516-523
    • Creteur, J.1    De Backer, D.2    Sakr, Y.3
  • 24
    • 0034831025 scopus 로고    scopus 로고
    • Sublingual capnography: a clinical validation study
    • Marik P.E. Sublingual capnography: a clinical validation study. Chest 120 3 (2001) 923-927
    • (2001) Chest , vol.120 , Issue.3 , pp. 923-927
    • Marik, P.E.1
  • 25
    • 0017121005 scopus 로고
    • Changes in intestinal vascular diameter during norepinephrine vasoconstrictor escape
    • Guth P.H., Ross G., and Smith E. Changes in intestinal vascular diameter during norepinephrine vasoconstrictor escape. Am J Physiol 230 6 (1976) 1466-1468
    • (1976) Am J Physiol , vol.230 , Issue.6 , pp. 1466-1468
    • Guth, P.H.1    Ross, G.2    Smith, E.3
  • 26
    • 0009803142 scopus 로고
    • The splanchnic circulation
    • Patton H.D., Fuchs A.F., Hille B., et al. (Eds), W.B. Saunders Company, Philadelphia
    • Stephenson R.B. The splanchnic circulation. In: Patton H.D., Fuchs A.F., Hille B., et al. (Eds). Textbook of physiology (1989), W.B. Saunders Company, Philadelphia 911-923
    • (1989) Textbook of physiology , pp. 911-923
    • Stephenson, R.B.1
  • 27
    • 0026019068 scopus 로고
    • Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor
    • Fink M.P., Antonsson J.B., Wang H.L., et al. Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor. Arch Surg 126 2 (1991) 211-218
    • (1991) Arch Surg , vol.126 , Issue.2 , pp. 211-218
    • Fink, M.P.1    Antonsson, J.B.2    Wang, H.L.3
  • 28
    • 0025159181 scopus 로고
    • The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure
    • Deitch E.A. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch Surg 125 3 (1990) 403-404
    • (1990) Arch Surg , vol.125 , Issue.3 , pp. 403-404
    • Deitch, E.A.1
  • 29
    • 0030065143 scopus 로고    scopus 로고
    • Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis
    • Farquhar I., Martin C.M., Lam C., et al. Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis. J Surg Res 61 1 (1996) 190-196
    • (1996) J Surg Res , vol.61 , Issue.1 , pp. 190-196
    • Farquhar, I.1    Martin, C.M.2    Lam, C.3
  • 30
    • 0035888676 scopus 로고    scopus 로고
    • Microcirculation in intestinal villi: a comparison between hemorrhagic and endotoxin shock
    • Nakajima Y., Baudry N., Duranteau J., et al. Microcirculation in intestinal villi: a comparison between hemorrhagic and endotoxin shock. Am J Respir Crit Care Med 164 8 Pt 1 (2001) 1526-1530
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.8 PART 1 , pp. 1526-1530
    • Nakajima, Y.1    Baudry, N.2    Duranteau, J.3
  • 31
    • 38549109477 scopus 로고    scopus 로고
    • Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia
    • Dubin A., Edul V.S., Pozo M.O., et al. Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia. Crit Care Med 36 2 (2008) 535-542
    • (2008) Crit Care Med , vol.36 , Issue.2 , pp. 535-542
    • Dubin, A.1    Edul, V.S.2    Pozo, M.O.3
  • 32
    • 34247171377 scopus 로고    scopus 로고
    • Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis
    • Boerma E.C., van der Voort P.H., Spronk P.E., et al. Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. Crit Care Med 35 4 (2007) 1055-1060
    • (2007) Crit Care Med , vol.35 , Issue.4 , pp. 1055-1060
    • Boerma, E.C.1    van der Voort, P.H.2    Spronk, P.E.3
  • 33
    • 0029086601 scopus 로고
    • Dynamics of skin blood flow in human sepsis
    • Young J.D., and Cameron E.M. Dynamics of skin blood flow in human sepsis. Intensive Care Med 21 8 (1995) 669-674
    • (1995) Intensive Care Med , vol.21 , Issue.8 , pp. 669-674
    • Young, J.D.1    Cameron, E.M.2
  • 34
    • 0026112175 scopus 로고
    • Capillary blood cell velocity is reduced in fever without hypotension
    • Weinberg J.R., Boyle P., Thomas K., et al. Capillary blood cell velocity is reduced in fever without hypotension. Int J Microcirc Clin Exp 10 1 (1991) 13-19
    • (1991) Int J Microcirc Clin Exp , vol.10 , Issue.1 , pp. 13-19
    • Weinberg, J.R.1    Boyle, P.2    Thomas, K.3
  • 35
    • 0001577652 scopus 로고
    • Peripheral circulation and organ flow. Handbook of physiology
    • The American Physiological Society, Bethesda (MD)
    • Roddie I.C. Peripheral circulation and organ flow. Handbook of physiology. The cardiovascular system (1983), The American Physiological Society, Bethesda (MD) 285-317
    • (1983) The cardiovascular system , pp. 285-317
    • Roddie, I.C.1
  • 36
    • 39349102894 scopus 로고    scopus 로고
    • Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria
    • Dondorp A.M., Ince C., Charunwatthana P., et al. Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria. J Infect Dis 197 1 (2008) 79-84
    • (2008) J Infect Dis , vol.197 , Issue.1 , pp. 79-84
    • Dondorp, A.M.1    Ince, C.2    Charunwatthana, P.3
  • 37
    • 33846262949 scopus 로고    scopus 로고
    • Influence of the application of platelet-enriched plasma in oral mucosal wound healing
    • Lindeboom J.A., Mathura K.R., Aartman I.H., et al. Influence of the application of platelet-enriched plasma in oral mucosal wound healing. Clin Oral Implants Res 18 1 (2007) 133-139
    • (2007) Clin Oral Implants Res , vol.18 , Issue.1 , pp. 133-139
    • Lindeboom, J.A.1    Mathura, K.R.2    Aartman, I.H.3
  • 38
    • 0344687379 scopus 로고    scopus 로고
    • Noninvasive in vivo analysis of the human hepatic microcirculation using orthogonal polarization spectral imaging
    • Puhl G., Schaser K.D., Vollmar B., et al. Noninvasive in vivo analysis of the human hepatic microcirculation using orthogonal polarization spectral imaging. Transplantation 75 6 (2003) 756-761
    • (2003) Transplantation , vol.75 , Issue.6 , pp. 756-761
    • Puhl, G.1    Schaser, K.D.2    Vollmar, B.3
  • 39
    • 36049022415 scopus 로고    scopus 로고
    • In vivo visualization of early microcirculatory changes following ischemia/reperfusion injury in human kidney transplantation
    • Schmitz V., Schaser K.D., Olschewski P., et al. In vivo visualization of early microcirculatory changes following ischemia/reperfusion injury in human kidney transplantation. Eur Surg Res 40 1 (2008) 19-25
    • (2008) Eur Surg Res , vol.40 , Issue.1 , pp. 19-25
    • Schmitz, V.1    Schaser, K.D.2    Olschewski, P.3
  • 40
    • 0037374174 scopus 로고    scopus 로고
    • Noninvasive in vivo assessment of the pancreatic microcirculation: orthogonal polarization spectral imaging
    • von Dobschuetz E., Biberthaler P., Mussack T., et al. Noninvasive in vivo assessment of the pancreatic microcirculation: orthogonal polarization spectral imaging. Pancreas 26 2 (2003) 139-143
    • (2003) Pancreas , vol.26 , Issue.2 , pp. 139-143
    • von Dobschuetz, E.1    Biberthaler, P.2    Mussack, T.3
  • 41
    • 27144553471 scopus 로고    scopus 로고
    • The microcirculation is the motor of sepsis
    • Ince C. The microcirculation is the motor of sepsis. Crit Care 9 Suppl 4 (2005) S13-S19
    • (2005) Crit Care , vol.9 , Issue.SUPPL. 4
    • Ince, C.1
  • 42
    • 0036644655 scopus 로고    scopus 로고
    • Microvascular blood flow is altered in patients with sepsis
    • De Backer D., Creteur J., Preiser J.C., et al. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166 1 (2002) 98-104
    • (2002) Am J Respir Crit Care Med , vol.166 , Issue.1 , pp. 98-104
    • De Backer, D.1    Creteur, J.2    Preiser, J.C.3
  • 43
    • 38349058657 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    • Dellinger R.P., Levy M.M., Carlet J.M., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 34 1 (2008) 17-60
    • (2008) Intensive Care Med , vol.34 , Issue.1 , pp. 17-60
    • Dellinger, R.P.1    Levy, M.M.2    Carlet, J.M.3
  • 44
    • 0033064993 scopus 로고    scopus 로고
    • Increased rigidity and priming of polymorphonuclear leukocytes in sepsis
    • Drost E.M., Kassabian G., Meiselman H.J., et al. Increased rigidity and priming of polymorphonuclear leukocytes in sepsis. Am J Respir Crit Care Med 159 6 (1999) 1696-1702
    • (1999) Am J Respir Crit Care Med , vol.159 , Issue.6 , pp. 1696-1702
    • Drost, E.M.1    Kassabian, G.2    Meiselman, H.J.3
  • 45
    • 0028088044 scopus 로고
    • Leukocyte sequestration in the microvasculature in normal and low flow states
    • Eppihimer M.J., and Lipowsky H.H. Leukocyte sequestration in the microvasculature in normal and low flow states. Am J Physiol 267 3 Pt 2 (1994) H1122-H1134
    • (1994) Am J Physiol , vol.267 , Issue.3 PART 2
    • Eppihimer, M.J.1    Lipowsky, H.H.2
  • 47
    • 0034979392 scopus 로고    scopus 로고
    • Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis
    • Bateman R.M., Jagger J.E., Sharpe M.D., et al. Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis. Am J Physiol Heart Circ Physiol 280 6 (2001) H2848-H2856
    • (2001) Am J Physiol Heart Circ Physiol , vol.280 , Issue.6
    • Bateman, R.M.1    Jagger, J.E.2    Sharpe, M.D.3
  • 49
    • 34447500485 scopus 로고    scopus 로고
    • Microvascular and capillary perfusion following glycocalyx degradation
    • Cabrales P., Vazquez B.Y., Tsai A.G., et al. Microvascular and capillary perfusion following glycocalyx degradation. J Appl Physiol 102 6 (2007) 2251-2259
    • (2007) J Appl Physiol , vol.102 , Issue.6 , pp. 2251-2259
    • Cabrales, P.1    Vazquez, B.Y.2    Tsai, A.G.3
  • 50
    • 33745311155 scopus 로고    scopus 로고
    • Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes
    • Nieuwdorp M., Mooij H.L., Kroon J., et al. Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes. Diabetes 55 4 (2006) 1127-1132
    • (2006) Diabetes , vol.55 , Issue.4 , pp. 1127-1132
    • Nieuwdorp, M.1    Mooij, H.L.2    Kroon, J.3
  • 51
    • 33644759419 scopus 로고    scopus 로고
    • Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo
    • Nieuwdorp M., van Haeften T.W., Gouverneur M.C., et al. Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo. Diabetes 55 2 (2006) 480-486
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 480-486
    • Nieuwdorp, M.1    van Haeften, T.W.2    Gouverneur, M.C.3
  • 52
    • 54049084896 scopus 로고    scopus 로고
    • Nieuwdorp M, Meuwese MC, Mooj HL, et al. Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation. Arteriosclerosis 2008; Epub ahead of print.
    • Nieuwdorp M, Meuwese MC, Mooj HL, et al. Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation. Arteriosclerosis 2008; Epub ahead of print.
  • 53
    • 0034115430 scopus 로고    scopus 로고
    • The red blood cell as an oxygen sensor: What is the evidence?
    • Ellsworth M.L. The red blood cell as an oxygen sensor: What is the evidence?. Acta Physiol Scand 168 4 (2000) 551-559
    • (2000) Acta Physiol Scand , vol.168 , Issue.4 , pp. 551-559
    • Ellsworth, M.L.1
  • 54
    • 0034121166 scopus 로고    scopus 로고
    • Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle
    • Gocan N.C., Scott J.A., and Tyml K. Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle. Am J Physiol Heart Circ Physiol 278 5 (2000) H1480-H1489
    • (2000) Am J Physiol Heart Circ Physiol , vol.278 , Issue.5
    • Gocan, N.C.1    Scott, J.A.2    Tyml, K.3
  • 55
    • 0027477592 scopus 로고
    • Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats
    • Hollenberg S.M., Cunnion R.E., and Zimmerberg J. Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats. Am J Physiol 264 2 Pt 2 (1993) H660-H663
    • (1993) Am J Physiol , vol.264 , Issue.2 PART 2
    • Hollenberg, S.M.1    Cunnion, R.E.2    Zimmerberg, J.3
  • 56
    • 33745245604 scopus 로고    scopus 로고
    • Microcirculatory recruitment maneuvers correct tissue CO2 abnormalities in sepsis
    • Almac E., Siegemund M., Demirci C., et al. Microcirculatory recruitment maneuvers correct tissue CO2 abnormalities in sepsis. Minerva Anestesiol 72 6 (2006) 507-519
    • (2006) Minerva Anestesiol , vol.72 , Issue.6 , pp. 507-519
    • Almac, E.1    Siegemund, M.2    Demirci, C.3
  • 57
    • 0032790876 scopus 로고    scopus 로고
    • Microcirculatory oxygenation and shunting in sepsis and shock
    • Ince C., and Sinaasappel M. Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 27 7 (1999) 1369-1377
    • (1999) Crit Care Med , vol.27 , Issue.7 , pp. 1369-1377
    • Ince, C.1    Sinaasappel, M.2
  • 58
    • 0037010370 scopus 로고    scopus 로고
    • Nitroglycerin in septic shock after intravascular volume resuscitation
    • Spronk P.E., Ince C., Gardien M.J., et al. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 360 9343 (2002) 1395-1396
    • (2002) Lancet , vol.360 , Issue.9343 , pp. 1395-1396
    • Spronk, P.E.1    Ince, C.2    Gardien, M.J.3
  • 59
    • 0015140098 scopus 로고
    • Proposed reclassification of shock states with special reference to distributive defects
    • Weil M.H., and Shubin H. Proposed reclassification of shock states with special reference to distributive defects. Adv Exp Med Biol 23 (1971) 13-23
    • (1971) Adv Exp Med Biol , vol.23 , pp. 13-23
    • Weil, M.H.1    Shubin, H.2
  • 60
    • 0026683240 scopus 로고
    • In vivo effects of Escherichia coli endotoxemia on diaphragmatic microcirculation in rats
    • Boczkowski J., Vicaut E., and Aubier M. In vivo effects of Escherichia coli endotoxemia on diaphragmatic microcirculation in rats. J Appl Physiol 72 6 (1992) 2219-2224
    • (1992) J Appl Physiol , vol.72 , Issue.6 , pp. 2219-2224
    • Boczkowski, J.1    Vicaut, E.2    Aubier, M.3
  • 61
    • 0023142538 scopus 로고
    • Skeletal microcirculatory responses to hyperdynamic Escherichia coli sepsis in unanesthetized rats
    • Cryer H.M., Garrison R.N., Kaebnick H.W., et al. Skeletal microcirculatory responses to hyperdynamic Escherichia coli sepsis in unanesthetized rats. Arch Surg 122 1 (1987) 86-92
    • (1987) Arch Surg , vol.122 , Issue.1 , pp. 86-92
    • Cryer, H.M.1    Garrison, R.N.2    Kaebnick, H.W.3
  • 62
    • 0024596078 scopus 로고
    • Hypoperfusion of the intestinal microcirculation without decreased cardiac output during live Escherichia coli sepsis in rats
    • Whitworth P.W., Cryer H.M., Garrison R.N., et al. Hypoperfusion of the intestinal microcirculation without decreased cardiac output during live Escherichia coli sepsis in rats. Circ Shock 27 2 (1989) 111-122
    • (1989) Circ Shock , vol.27 , Issue.2 , pp. 111-122
    • Whitworth, P.W.1    Cryer, H.M.2    Garrison, R.N.3
  • 63
    • 0028053865 scopus 로고
    • Microvascular perfusion is impaired in a rat model of normotensive sepsis
    • Lam C., Tyml K., Martin C., et al. Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94 5 (1994) 2077-2083
    • (1994) J Clin Invest , vol.94 , Issue.5 , pp. 2077-2083
    • Lam, C.1    Tyml, K.2    Martin, C.3
  • 64
    • 31344453457 scopus 로고    scopus 로고
    • The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
    • De Backer D., Creteur J., Dubois M.J., et al. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 34 2 (2006) 403-408
    • (2006) Crit Care Med , vol.34 , Issue.2 , pp. 403-408
    • De Backer, D.1    Creteur, J.2    Dubois, M.J.3
  • 65
    • 33751094014 scopus 로고    scopus 로고
    • Comparison of buccal microcirculation between septic and hemorrhagic shock
    • Fang X., Tang W., Sun S., et al. Comparison of buccal microcirculation between septic and hemorrhagic shock. Crit Care Med 34 Suppl 12 (2006) S447-S453
    • (2006) Crit Care Med , vol.34 , Issue.SUPPL. 12
    • Fang, X.1    Tang, W.2    Sun, S.3
  • 66
    • 54049100304 scopus 로고    scopus 로고
    • Sublingual microcirculatory improvement with fluid loading in preload-dependent ICU patients
    • Deruddre S., Pottecher J., Georger J., et al. Sublingual microcirculatory improvement with fluid loading in preload-dependent ICU patients. Intensive Care Med 33 Suppl 2 (2007) S253
    • (2007) Intensive Care Med , vol.33 , Issue.SUPPL. 2
    • Deruddre, S.1    Pottecher, J.2    Georger, J.3
  • 67
    • 21744461894 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase inhibition improves intestinal microcirculatory oxygenation and CO2 balance during endotoxemia in pigs
    • Siegemund M., van Bommel J., Schwarte L.A., et al. Inducible nitric oxide synthase inhibition improves intestinal microcirculatory oxygenation and CO2 balance during endotoxemia in pigs. Intensive Care Med 31 7 (2005) 985-992
    • (2005) Intensive Care Med , vol.31 , Issue.7 , pp. 985-992
    • Siegemund, M.1    van Bommel, J.2    Schwarte, L.A.3
  • 68
    • 4444273012 scopus 로고    scopus 로고
    • Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock
    • Lopez A., Lorente J.A., Steingrub J., et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32 1 (2004) 21-30
    • (2004) Crit Care Med , vol.32 , Issue.1 , pp. 21-30
    • Lopez, A.1    Lorente, J.A.2    Steingrub, J.3
  • 69
    • 13444303827 scopus 로고    scopus 로고
    • Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model
    • Iba T., Kidokoro A., Fukunaga M., et al. Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model. Crit Care Med 33 2 (2005) 368-372
    • (2005) Crit Care Med , vol.33 , Issue.2 , pp. 368-372
    • Iba, T.1    Kidokoro, A.2    Fukunaga, M.3
  • 70
    • 34249083323 scopus 로고    scopus 로고
    • Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat
    • Lehmann C., Meissner K., Knock A., et al. Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat. Crit Care 10 6 (2006) R157
    • (2006) Crit Care , vol.10 , Issue.6
    • Lehmann, C.1    Meissner, K.2    Knock, A.3
  • 71
    • 33745603201 scopus 로고    scopus 로고
    • Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis
    • De Backer D., Verdant C., Chierego M., et al. Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med 34 7 (2006) 1918-1924
    • (2006) Crit Care Med , vol.34 , Issue.7 , pp. 1918-1924
    • De Backer, D.1    Verdant, C.2    Chierego, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.