Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats

Pakistan Journal of Biological Sciences

Volumn 11, Issue 14, 2008, Pages 1779-1784

  Haidari, Fatemeh ^a   Rashidi, Mohammad Reza ^b   Keshavarz, Seid Ali ^a   Mahboob, Soltan Ali ^c   Eshraghian, Mohammad Reza ^a   Shahi, Majid Mohamad ^c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Hyperuricemia; Onion; Uric acid; Xanthine dehydrogenase; Xanthine oxidase

Indexed keywords

ALLIUM CEPA; ANIMALIA; RATTUS;

URIC ACID; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE;

ANIMAL; ARTICLE; BLOOD; ENZYMOLOGY; HYPERURICEMIA; LIVER; MALE; METABOLISM; ONION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; HYPERURICEMIA; LIVER; MALE; ONIONS; RATS; RATS, SPRAGUE-DAWLEY; URIC ACID; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE;

EID: 54049106185     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2008.1779.1784     Document Type: Article

References (32)

1. Candi, D., V.C. Trenerry, S. Rochfort, S. Duong, D. Laugher and R. Jones, 2007. Profiling and quantifying quercetin glucosides in onion (Allium cepa L.) varieties using capillary zone electrophoresis and high performance liquid chromatography. Food Chem., 105: 691-699.
2. Carroll, J.J., H.C. Roberta Douglass and A.L. Babson, 1971. A simplified alkaline phosphotungstate assay for uric acid in serum. Clin. Chem., 17: 158-160.
3. Choi, H.K. and E.S. Ford, 2007. Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am. J. Med., 120: 442-447.
4. Fels, E. and J.S. Sundy, 2008. Refractory gout: What is it and what to do about it? Curr. Opin. Rheumatol., 20: 198-202.
5. Finnegan, J.R., B. Rooney, K. Viswanath, P. Elmer, K. Graves, J. Baxter, J. Hertog, R. Mullis and J. Potter, 1992. Process evaluation of a home-based program to reduce diet-related cancer risk. Health Edu. J., 19: 233-248.
6. Franzese, T.A., 2004. Medical Nutrition Therapy for Rheumatic Disorders. In: Krause's Food, Nutrition and Diet Therapy, L.K. Mahan and S. Escott (Eds.). Stump. W.B. Saunders, Philadelphia, ISBN-13: 978-0-7216-9784-0 (9780721697840), pp: 980-982.
7. Hall, I.H., J.P. Scoville, D.J. Reynolds, R. Simlot and P. Duncan, 1990. Substituted cyclic imides as potential anti-gout agents. Life Sci., 46: 1923-1927.
8. Hertog, M.G.L., P.C.H. Holmann, M.N. Katan and D. Kromhout, 1993. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr. Cancer, 20: 21-29.
9. Kinoshita, T., Z. Lepp, Y. Kawai, J. Terao and H. Chuman, 2006. An integrated database of flavonoids. Biofactors, 26: 179-188.
10. Kong, L.D., C. Yang, F. Ge, H.D. Wang and Y. Song Guo, 2004. A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice. J. Ethnopharmacol., 93: 325-330.
11. Lee, S.J. and R.A. Terkeltaub, 1996. New developments in clinically relevant mechanisms and treatment of hyperuricemia. Curr. Rheumatol. Rep., 8: 224-230.
12. Lin, C.M., C.S. Chen, C.T. Chen, Y.C. Liang and J.K. Lin, 2002. Molecular modeling of flavonoids that inhibits XO. Biochem. Biophys. Res. Commun., 294: 167-172.
13. Liote, F., 2003. Hyperuricemia and gout. Curr. Rheumatol. Rep., 5: 227-234.
14. Miean, K.H. and S. Mohamed, 2001. Flavonoid (myricetin, quercetin, kaempferol, luteolin and apigenin) content of edible tropical plants. J. Agric. Food Chem., 49: 3106-3112.
15. Muraoka, S. and T. Mura, 2003. Inhibition by uric acid of free radicals that damage biological molecules. Pharmacol. Toxicol., 93: 284-289.
16. Murota, K. and J. Terao, 2003. Antioxidative flavonoid quercetin: Implication of its intestinal absorption and metabolism. Arch. Biochem. Biophys., 417: 12-17.
17. Nguyen, M.T.T., S. Awale, Y. Tezuka, Q.L. Tran, H. Watanabe and S. Kadota, 2004. Xanthine oxidase inhibitory activity of Vietnamese medicinal plants. Biol. Pharm. Bull., 27: 1414-1421.
18. Nuki, G., 2006. Gout. Medicine, 34: 417-423.
19. Okamoto, K., 2008. Inhibitors of xanthine oxidoreductase. Nippon Rinsho, 66: 748-753.
20. Potapovich, A.I. and V.A. Kostyuk, 2003. Comparative study of antioxidant properties and cytoprotective activity of flavonoids. Biochemistry, 68: 514-519.
21. Slimestad R., T. Fossen and I.M. Vagen, 2007. Onions: A source of unique dietary flavonoids. J. Agric. Food. Chem., 55: 10067-10080.
22. Smith, P.K., R.I. Krohn, G.T. Hermanson, A.K. Mallia, F.H. Gartner, M.D. Provenzano, E.K. Fujimoto, N.M. Goeke, B.J. Olson and C. Klenk, 1985. Measurement of protein using bicinchoninic acid. Anal. Biochem., 150: 76-85.
23. Stavric, B., S. Clayman, R.E.A. Gradd and D. Hebert, 1975. Some in vivo effects in the rat induced by chlorprothixene and potassium oxonate. Pharmacol. Res. Comm., 7: 117-124.
24. Stinefelt, B., S.S. Leonard, K.P. Blemings, X. Shi and H. Klandorf, 2005. Free radical scavenging, DNA protection and inhibition of lipid peroxidation mediated by uric acid. Ann. Clin. Lab. Sci., 35: 37-45.
25. Strazzullo, P. and J.G. Puig, 2007. Uric acid and oxidative stress: relative impact on cardiovascular risk. Nutr. Metab. Cardiovasc. Dis., 17: 409-414.
26. Terkeltabu, R., 2006. Gout in 2006: The perfect storm. Bull. Joint Dis., 64: 82-86.
27. Van Hoorn, D.E.C., R.J. Nijveldt, P.A.M. Van Leeuwen, Z. Hofman, L. M'Rabet, D.B.A. De Bont and K. Van Norren, 2002. Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids. Eur. J. Pharmacol., 451: 111-118.
28. Wang, Y., J.X. Zhu L.D. Kong, C. Yang, C.H.K. Cheng and X. Zhang, 2004. Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic XDH/XO activities in oxonate-treated mice. Basic Clin. Pharmacol. Toxicol., 94: 232-237.
29. Yoshisue, K., H. Masuda, E. Matsushima, K. Ikeda, S. Nagayama and Y. Kawaguchi, 2000. Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine and potassium oxonate) to rats. Drug Metab. Dispos., 28: 1162-1167.
30. Yu, Z., W.P. Fong and C.H. Cheng, 2007. Morin (3,5,7,2′,4′- pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells. Drug. Metab. Dispos., 35: 981-986.
31. Zhao, X., J.X. Zhu S.F. Mo, Y. Pan and L.D. Kong, 2006. Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J. Ethnopharmacol., 103: 357-365.
32. Zhu, J.X., Y. Wang, L.D. Kong, C. Yang and X. Zhang, 2004. Effects of Biota orientalis extract an dits flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J. Ethnopharmacol., 93: 133-140.