Free radical scavenging, DNA protection, and inhibition of lipid peroxidation mediated by uric acid

Annals of Clinical and Laboratory Science

Volumn 35, Issue 1, 2005, Pages 37-45

  Stinefelt, Beth ^a   Leonard, Stephen S ^b   Blemings, Kenneth P ^a   Shi, Xianglin ^b   Klandorf, Hillar ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

DNA oxidation; Electron spin resonance; Lipid peroxidation; Oxidative stress; Uric acid

Indexed keywords

DNA; ETHIDIUM BROMIDE; HYDROXYL GROUP; LIPID; SCAVENGER; SILICON DIOXIDE; SUPEROXIDE; URIC ACID;

ACCURACY; AGAR GEL ELECTROPHORESIS; ARTICLE; CELL MEMBRANE; CONCENTRATION RESPONSE; DNA SYNTHESIS INHIBITION; ELECTRON SPIN RESONANCE; INCUBATION TIME; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; REDUCTION;

ANIMALS; DNA DAMAGE; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; HYDROXYL RADICAL; LIPID PEROXIDATION; MACROPHAGES, PERITONEAL; MICE; RESTRICTION MAPPING; SUPEROXIDES; URIC ACID;

EID: 15444371172     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Van Dyke K. Overview of oxidative stress. In: Luminescence Biotechnology (Van Dyke K, Van Dyke C, Woodfork K, Eds), CRC Press, New York, 2002; pp 381-383.
2. 2-free radicals. Photochem Photobiol 1978;28:645-649.
3. Smith R, Lawing L. Antioxidant activity of uric acid and 3-N-ribosyluric acid with unsaturated fatty acids and erythrocyte membranes. Arch Biochem Biophys 1983; 223:166-172.
4. Ischiropoulos H, Al-Mehdi A, Fisher A. Reactive species in ischemic rat injury: contribution of peroxynitrite. Am J Physiol 1995;269:L158-164.
5. Cohen A, Aberdoth R, Hochstein P. Inhibition of free radical-mediated DNA damage by uric acid. FEBS Lett 1984;174:147-150.
6. Kristal B, Yu B. An emerging hypothesis: synergistic induction of aging by free radicals and Maillard reactions. J Gerontol 1992;44:B107-114.
7. Dyer D, Blackledge J, Thorpe S, Baynes J. Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo. J Biol Chem 1991;266:11654-11660.
8. Pushkarsky T, Rourke L, Spiegel L, Seldin M, Bucala R. Molecular characterization of a mouse genomic element mobilized by advanced glycation endproduct modified-DNA (AGE-DNA). Mol Med 1997;3:740-749.
9. Benzie I. Lipid peroxidation: a review of causes, consequences, measurement and dietary influences. Int J Food Sci Nutr 1996;47:233-261.
10. Lindstedt S, Calder W. Body size and longevity in birds. Condor 1976;78:91-94.
11. Rolfe D, Brown G. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev 1997;77:731-758.
12. Barja G. Rate of generation of oxidative stress-related damage and animal longevity. Ann NY Acad Sci 1998; 854:224-238.
13. Ku H, Sohal R. Comparison of mitochondrial prooxidant generation and antioxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential. Mech Ageing Dev 1993;72:67-76.
14. Schreiber G, Tiemeyer W, Flurer C, Zucker H. Purine metabolites in serum of higher primates, including man. Im J Primatol 1986;7:521-531.
15. Roch-Ramel F, Peters G. In: Handbook of Experimental Pharmacology, (W. Kelley, I. Weiner, Eds). Springer-Verlag, Berlin, 1978; vol 51, pp 211-255.
16. Cutler R. Urate and ascorbate: their possible roles as anti-oxidants in determining longevity of mammalian species. Arch Gerontol Geriatr 1984;3:321-348.
17. Shapiro F, Mahagna M, Nir I. Stunting effect in broilers; effect of glucose or maltose supplementation on digestive organs, intestinal disaccharidases, and some blood metabolites. Poult Sci 1997;75:369-380.
18. Simoyi M, Van Dyke K, Klandorf H. Manipulation of plasma uric acid broiler chicks and its effect on leukocyte oxidative activity. Am J Physiol 2002;282:R791-796.
19. Klandorf H, Rathore D, Iqbal M, Shi X, Simoyi M, Van Dyke K. Acceleration of tissue aging in chickens caused by oxidative stress using allopurinol and detected by cellular humoral chemiluminescence. In: Luminescence Biotechnology (Van Dyke K, Van Dyke C, Woodfork K, Eds), CRC Press, New York, 2002; pp 393-407.
20. Klandorf H, Rathore D, Iqbal M, Shi X, Simoyi M, Van Dyke K. Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. Comp Biochem Phys 2001;129C:93-104.
21. Simic M, Jovanovic S. Antioxidation mechanisms of uric acid. J Amer Chem Soc 1989;111:5778-5782.
22. Howell R, Wyngaarden J. On the mechanism of peroxidation of uric acids by hemeoproteins. J Biol Chem 1960; 235:3544-3550.
23. Willson R, Dunster C, Forni L, Gee C, Kittridge K. Organic free radicals and proteins in biochemical injury: electron- or hydrogen-transfer reactions? Philos Trans R Soc Lond B Biol Sci 1985;311:545-562.
24. Leonard S, Cutler D, Ding M, Vallyathan V, Castranova V, Shi X. Antioxidant properties of fruit and vegetable juices: more to the story than ascorbic acid. Ann Clin Lab Sci 2002;32:193-200.
25. Daniel L, Mao Y, Saffiotti U. Oxidative DNA damage by crystalline silica. Free Radic Biol Med 1995;14:463-472.
26. Guo Q, Sian S, Mason R. Separation and identification of DMPO adducts of oxygen-centered radicals formed from organic hydroperoxides by HPLC-ESR, ESI-MS and MS/MS. J Am Soc Mass Spectrom 2003;14:862-871.
27. Sohal R, Svensson I, Sohal B, Brunk U. Superoxide anion radical production in different animal species. Mech Ageing Devel 1989;49:129-135.
28. Becker B, Reinholtz N, Ozcelik T, Leipert B, Gerlach E. Uric acid as a radical scavenger and antioxidant in the heart. Pflugers Arch 1989;415:127-135.
29. Santus R, Patterson L, Filipe P, Morliere P, Hug G, Fernandes A, Maziere J. Redox reactions of the urate radical/urate couple with the superoxide radical anion, the tryptophan neutral radical and selected flavonoids in neutral aqueous solutions. Free Radic Res 2001;35:139-136.
30. Becker B. Towards the physiological function of uric acid. Free Radic Biol Med 1993;14:615-631.
31. Singh S, Asad S, Hadi S. Uric acid inhibits L-DOPA-Cu(II) mediated DNA cleavage. Neurosci Lett 1998;258: 689-672.
32. Shearman C, Kalf G. DNA replication by a membrane-DNA complex from rat liver mitochondria. Arch Biochem Biophys 1977;182:573-586.
33. Richter C, Park J, Ames B. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. PNAS USA 1977;85:6565-6567.
34. 8gd in the genomic DNA of rats and pigeons and maximum longevity. Ann NY Acad Sci 1998;854:224-238.
35. Barja G. Rate of generation of oxidative stress-related damage and animal longevity. Free Radic Med Biol 2002; 33:1167-1172.
36. Herrero A, Barja G. Effect of aging on mitochondrial and nuclear DNA damage in the heart and brain throughout the life-span of a rat. J Am Aging Assoc 2001;24:45-50.
37. Ozawa T. Mitochondrial DNA mutations associated with aging and degenerative diseases. Exp Gerontol 1995;30: 269-290.
38. Ames B, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis. PNAS USA 1981;78:6858-6862.
39. Castranova V. Generation of oxygen radicals and mechanisms of injury prevention. Environ Health Perspect 1994; 102:565-68.
40. Pamplona R, Prat J, Cadenas S, Rojass C, Perez-Campo R, Lopez-Torres M, Barja G. Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from longevous species: the pigeon and human case. Mech Ageing Dev 1996;86:53-66.
41. Pamplona R, Portero-Otin M, Requena J, Thorpe S, Herrero A, Barja G. A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondia of the longevous pigeon than in the short-lived rat. Mech Ageing Dev 1999;106:283-296.
42. Santos C, Anjos E, Augusto O. Uric acid oxid-ation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation. Arch Biochem Biophys 1999;372:285-294.