Development and implementation of a stereoselective normal-phase liquid chromatography-tandem mass spectrometry method for the determination of intrinsic metabolic clearance in human liver microsomes

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 875, Issue 1, 2008, Pages 154-160

  Zhang, Yingru ^a   Caporuscio, Christian ^a   Dai, Jun ^a   Witkus, Michael ^a   Rose, Anne ^a   Santella, Joseph ^a   D'Arienzo, Celia ^a   Wang Iverson, David B ^a   Tymiak, Adrienne A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Chiral resolution; Enantiomeric separations; Ethoxynonafluorobutane (ENFB); In vitro intrinsic metabolic clearance; LC MS MS; NP HPLC MS MS

Indexed keywords

ANIMAL CELL CULTURE; ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; BIOCHEMISTRY; BIOMOLECULES; CATALYST ACTIVITY; CHROMATOGRAPHIC ANALYSIS; CONCENTRATION (PROCESS); DRUG PRODUCTS; DRUG PRODUCTS PLANTS; ETHANOL; HEPTANE; HEXANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; IONIZATION OF LIQUIDS; IONIZATION POTENTIAL; ISOMERS; KETONES; LIQUID CHROMATOGRAPHY; LIVER; MASS SPECTROMETRY; METABOLITES; METHANOL; NUCLEAR PROPULSION; ORGANIC COMPOUNDS; POLYSACCHARIDES; SENSITIVITY ANALYSIS; SEPARATION; SOLVENTS; STEREOCHEMISTRY;

CHIRAL RESOLUTION; ENANTIOMERIC SEPARATIONS; ETHOXYNONAFLUOROBUTANE (ENFB); IN VITRO INTRINSIC METABOLIC CLEARANCE; LC-MS-MS; NP-HPLC-MS-MS;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

ALCOHOL; BMS 812692 011; BMS 812692 693; BUTANE; DRUG METABOLITE; ETHOXYNONAFLUOROBUTANE; HEPTANE DERIVATIVE; HEXANE; KETONE DERIVATIVE; METHANOL; POLYSACCHARIDE; POTASSIUM DIHYDROGEN PHOSPHATE; SOLVENT; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; ATMOSPHERIC PRESSURE; DRUG INDUSTRY; DRUG RETENTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IONIZATION; ISOMER; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; METABOLIC CLEARANCE RATE; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STEREOCHEMISTRY; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; TEMPERATURE SENSITIVITY;

BUTANES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROCARBONS, FLUORINATED; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; PROPANOLS; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

EID: 54049089163     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.07.034     Document Type: Article

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