Faster nerve regeneration after sciatic nerve injury in mice over-expressing basic fibroblast growth factor

Journal of Neurobiology

Volumn 66, Issue 9, 2006, Pages 940-948

  Jungnickel, Julia ^a   Haase, Kristina ^a   Konitzer, Jens ^a   Timmer, Marco ^a   Grothe, Claudia ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Dorsal root ganglion; FGF 2; Regeneration; Sciatic nerve injury; Transgenic mice

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BROXURIDINE; DNA; MYELIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENOTYPE; MORPHOMETRICS; MOTOR NERVE; MOUSE; NERVE FIBER GROWTH; NERVE FIBER TRANSECTION; NERVE INJURY; NERVE REGENERATION; NEUROMUSCULAR FUNCTION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMYELINIZATION; SCHWANN CELL; SCIATIC NERVE; SENSORY NERVE CELL; SPINAL GANGLION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; AXOTOMY; CELL DEATH; CELL DIVISION; FEMALE; FIBROBLAST GROWTH FACTOR 2; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; MYELIN SHEATH; NERVE FIBERS, MYELINATED; NERVE REGENERATION; NEURONS; NEURONS, AFFERENT; SCHWANN CELLS; SCIATIC NERVE;

EID: 33747124061     PISSN: 00223034     EISSN: 10974695     Source Type: Journal    
DOI: 10.1002/neu.20265     Document Type: Article

References (49)

1. Aebischer P, Salessiotis AN, Winn SR. 1989. Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps. J Neurosci Res 23:282-289.
2. Archer FR, Doherty P, Collins D, Bolsover SR. 1999. CAMs and FGF cause a local submembrane calcium signal promoting axon outgrowth without a rise in bulk calcium concentration. Eur J Neurosci 11:3565-3573.
3. Armstrong RC, Le TQ, Frost EE, Borke RC, Vana AC. 2002. Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter. J Neurosci 22:8574-8585.
4. Bain JR, Mackinnon SE, Hunter DA. 1989. Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast Reconstr Surg 83:129-138.
5. Bansal R, Pfeiffer SE. 1997. FGF-2 converts mature oligodendrocytes to a novel phenotype. J Neurosci Res 50:215-228.
6. Butt AM, Dinsdale J. 2005. Fibroblast growth factor 2 induces loss of adult oligodendrocytes and myelin in vivo. Exp Neurol 192:125-133.
7. Chan JR, Cosgaya JM, Wu YJ, Shooter EM. 2001. Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc Natl Acad Sci USA 98:14661-14668.
8. Cheng C, Zochodne DW. 2002. In vivo proliferation, migration and phenotypic changes of Schwann cells in the presence of myelinated fibers. Neuroscience 115:321-329.
9. Coffin JD, Florkiewicz RZ, Neumann J, Mort-Hopkins T, Dorn GW, 2nd, Lightfoot P, German R, et al. 1995. Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol Biol Cell 6:1861-1873.
10. Coggeshall RE, La Forte R, Klein CM. 1990. Calibration of methods for determining numbers of dorsal root ganglion cells. J Neurosci Meth 35:187-194.
11. Danielsen N, Pettmann B, Vahlsing HL, Manthorpe M, Varon S. 1988. Fibroblast growth factor effects on peripheral nerve regeneration in a silicone chamber model. J Neurosci Res 20:320-330.
12. Davis JB, Stroobant P. 1990. Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells. J Cell Biol 110:1353-1360.
13. De Koning P, Brakkee JH, Gispen WH. 1986. Methods for producing a reproducible crush in the sciatic and tibial nerve of the rat and rapid and precise testing of return of sensory function. Beneficial effects of melanocortins. J Neurol Sci 74:237-246.
14. de Medinaceli L. 1995. Interpreting nerve morphometry data after experimental traumatic lesions. J Neurosci Methods 58:29-37.
15. de Medinaceli L, Freed WJ, Wyatt RJ. 1982. An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol 77:634-643.
16. Derby A, Engleman VW, Frierdich GE, Neises G, Rapp SR, Roufa DG. 1993. Nerve growth factor facilitates regeneration across nerve gaps: morphological and behavioral studies in rat sciatic nerve. Exp Neurol 119:176-191.
17. Dong Z, Sinanan A, Parkinson D, Parmantier E, Mirsky R, Jessen KR. 1999. Schwann cell development in embryonic mouse nerves. J Neurosci Res 56:334-348.
18. Fawcett JW, Keynes RJ. 1990. Peripheral nerve regeneration. Annu Rev Neurosci 13:43-60.
19. Fujimoto E, Mizoguchi A, Hanada K, Yajima M, Ide C. 1997. Basic fibroblast growth factor promotes extension of regenerating axons of peripheral nerve. In vivo experiments using a Schwann cell basal lamina tube model. J Neurocytol 26:511-528.
20. Goddard DR, Berry M, Kirvell SL, Butt AM. 2001. Fibroblast growth factor-2 inhibits myelin production by oligodendrocytes in vivo. Mol Cell Neurosci 18:557-569.
21. Grothe C, Meisinger C, Claus P. 2001. In vivo expression and localization of the fibroblast growth factor system in the intact and lesioned rat peripheral nerve and spinal ganglia. J Comp Neurol 434:342-357.
22. Grothe C, Meisinger C, Hertenstein A, Kurz H, Wewetzer K. 1997. Expression of fibroblast growth factor-2 and fibroblast growth factor receptor 1 messenger RNAs in spinal ganglia and sciatic nerve: regulation after peripheral nerve lesion. Neuroscience 76:123-135.
23. Grothe C, Nikkhah G. 2001. The role of basic fibroblast growth factor in peripheral nerve regeneration. Anat Embryol (Berl) 204:171-177.
24. Haastert K, Lipokatic E, Fischer M, Timmer M, Grothe C. 2006. Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms. Neurobiol Dis 21:138-153.
25. Harari D, Finkelstein D, Bernard O. 1997. FGF plays a subtle role in oligodendrocyte maintenance in vivo. J Neurosci Res 49:404-415.
26. Jungnickel J, Claus P, Gransalke K, Timmer M, Grothe C. 2004a. Targeted disruption of the FGF-2 gene affects the response to peripheral nerve injury. Mol Cell Neurosci 25:444-452.
27. Jungnickel J, Gransalke K, Timmer M, Grothe C. 2004b. Fibroblast growth factor receptor 3 signaling regulates injury-related effects in the peripheral nervous system. Mol Cell Neurosci 25:21-29.
28. Jungnickel J, Klutzny A, Guhr S, Meyer K, Grothe C. 2005. Regulation of neuronal death and calcitonin gene-related peptide by fibroblast growth factor-2 and FGFR3 after peripheral nerve injury: evidence from mouse mutants. Neuroscience 134:1343-1350.
29. Keilhoff G, Fansa H, Wolf G. 2002. Differences in peripheral nerve degeneration/regeneration between wild-type and neuronal nitric oxide synthase knockout mice. J Neurosci Res 68:432-441.
30. Klapdor K, Dulfer BG, Hammann A, Van der Staay FJ. 1997. A low-cost method to analyse footprint patterns. J Neurosci Methods 75:49-54.
31. Klimaschewski L, Nindl W, Feurle J, Kavakebi P, Kostron H. 2004. Basic fibroblast growth factor isoforms promote axonal elongation and branching of adult sensory neurons in vitro. Neuroscience 126:347-353.
32. Kuzis K, Coffin JD, Eckenstein FP. 1999. Time course and age dependence of motor neuron death following facial nerve crush injury: role of fibroblast growth factor. Exp Neurol 157:77-87.
33. Liu RY, Snider WD. 2001. Different signaling pathways mediate regenerative versus developmental sensory axon growth. J Neurosci 21:1-5.
34. Meisinger C, Grothe C. 1997. Differential regulation of fibroblast growth factor (FGF)-2 and FGF receptor 1 mRNAs and FGF-2 isoforms in spinal ganglia and sciatic nerve after peripheral nerve lesion. J Neurochem 68:1150-1158.
35. Morgan L, Jessen KR, Mirsky R. 1994. Negative regulation of the P0 gene in Schwann cells: suppression of P0 mRNA and protein induction in cultured Schwann cells by FGF2 and TGF beta 1, TGF beta 2 and TGF beta 3. Development 120:1399-1409.
36. Murray M. 1982. A quantitative study of regenerative sprouting by optic axons in goldfish. J Comp Neurol 209:352-362.
37. Nakamura T, Inada Y, Fukuda S, Yoshitani M, Nakada A, Itoi S, Kanemaru S, et al. 2004. Experimental study on the regeneration of peripheral nerve gaps through a polyglycolic acid-collagen (PGA-collagen) tube. Brain Res 1027:18-29.
38. Otto D, Unsicker K, Grothe C. 1987. Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia. Neurosci Lett 83:156-160.
39. Romero MI, Rangappa N, Li L, Lightfoot E, Garry MG, Smith GM. 2000. Extensive sprouting of sensory afferents and hyperalgesia induced by conditional expression of nerve growth factor in the adult spinal cord. J Neurosci 20:4435-4445.
40. Sahni M, Raz R, Coffin JD, Levy D, Basilico C. 2001. STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128:2119-2129.
41. Schultze O. 1910. Über die Anwendung von Osmiumsäure und eine neue Osmium-hs̈matoxylinmethode. Z wiss Mikr 27:465-475.
42. Sobue T, Naganawa T, Xiao L, Okada Y, Tanaka Y, Ito M, Okimoto N, et al. 2005. Over-expression of fibroblast growth factor-2 causes defective bone mineralization and osteopenia in transgenic mice. J Cell Biochem 95:83-94.
43. Streppel M, Azzolin N, Dohm S, Guntinas-Lichius O, Haas C, Grothe C, Wevers A, et al. 2002. Focal application of neutralizing antibodies to soluble neurotrophic factors reduces collateral axonal branching after peripheral nerve lesion. Eur J Neurosci 15:1327-1342.
44. Szebenyi G, Dent EW, Callaway JL, Seys C, Lueth H, Kalil K. 2001. Fibroblast growth factor-2 promotes axon branching of cortical neurons by influencing morphology and behavior of the primary growth cone. J Neurosci 21:3932-3941.
45. Timmer M, Robben S, Muller-Ostermeyer F, Nikkhah G, Grothe C. 2003. Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2. Cell Transplant 12:265-277.
46. Tolwani RJ, Cosgaya JM, Varma S, Jacob R, Kuo LE, Shooter EM. 2004. BDNF overexpression produces a long-term increase in myelin formation in the peripheral nervous system. J Neurosci Res 77:662-669.
47. Watabe K, Fukuda T, Tanaka J, Toyohara K, Sakai O. 1994. Mitogenic effects of platelet-derived growth factor, fibroblast growth factor, transforming growth factor-beta, and heparin-binding serum factor for adult mouse Schwann cells. J Neurosci Res 39:525-534.
48. Young C, Miller E, Nicklous DM, Hoffman JR. 2001. Nerve growth factor and neurotrophin-3 affect functional recovery following peripheral nerve injury differently. Restor Neurol Neurosci 18:167-175.
49. Zanazzi G, Einheber S, Westreich R, Hannocks MJ, Bedell-Hogan D, Marchionni MA, Salzer JL. 2001. Glial growth factor/neuregulin inhibits Schwann cell myelination and induces demyelination. J Cell Biol 152:1289-1299.