Potent 2′-amino-, and 2′-fluoro-2-deoxyribonucleotide rna inhibitors of keratinocyte growth factor

Nature Biotechnology

Volumn 15, Issue 1, 1997, Pages 68-73

  Pagratis, Nikos C ^a   Bell, Carol ^a   Chang, Ying Fon ^a   Jennings, Susan ^a   Fitzwater, Tim ^a   Jellinek, Derek ^a,b   Dang, Chinh ^a  

^a NeXstar Pharmaceuticals   (Austria)

^b CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

In vitro evolution; KGF antagonists; Nuclease resistant aptamers; Pseudoknot; SELEX

Indexed keywords

2' AMINO 2' DEOXYPYRIMIDINE; 2' FLUORO 2' DEOXYPYRIMIDINE; CELL SURFACE RECEPTOR; DEOXYRIBONUCLEOTIDE; KERATINOCYTE GROWTH FACTOR; LIGAND; NUCLEASE; RECEPTOR BLOCKING AGENT; RNA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENTERITIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; LIGAND BINDING; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PSORIASIS; THERMOSTABILITY;

3T3 CELLS; ANIMALS; BASE SEQUENCE; BINDING SITES; DEOXYRIBONUCLEOTIDES; DRUG STABILITY; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; GROWTH SUBSTANCES; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RIBONUCLEASES; RNA; SUBSTRATE SPECIFICITY; TEMPERATURE;

EID: 0031012128     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0197-68     Document Type: Article

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