Allogeneic bone marrow transplantation restores liver function in Fah-knockout mice

Experimental Hematology

Volumn 36, Issue 11, 2008, Pages 1507-1513

  Eggenhofer, Elke ^a   Popp, Felix C ^a   Renner, Philipp ^a   Slowik, Pczemyslaw ^a   Neuwinger, Annette ^a   Piso, Pompiliu ^a   Geissler, Edward K ^a   Schlitt, Hans J ^a   Dahlke, Marc H ^a,b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b ANZAC Research Institute   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 NITRO 4 FLUOROMETHYLBENZOYL) 1,3 CYCLOHEXANEDIONE; CYCLOHEXANE DERIVATIVE; FUMARYLACETOACETASE; HISTOCOMPATIBILITY ANTIGEN; NITISONE; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 1; HYDROLASE;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUSION; CELL THERAPY; CONTROLLED STUDY; DONOR; DRUG WITHDRAWAL; ENZYME RECONSTITUTION; ENZYME THERAPY; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HEREDITARY TYROSINAEMIA TYPE 1; IMMUNOHISTOCHEMISTRY; IRRADIATION; ISOGRAFT; KNOCKOUT MOUSE; LIVER CELL; LIVER DISEASE; LIVER FUNCTION; LIVER TRANSPLANTATION; MAJOR HISTOCOMPATIBILITY COMPLEX; METABOLIC PARAMETERS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; T CELL DEPLETION; TYROSINEMIA; WHOLE BODY RADIATION; ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; BONE MARROW TRANSPLANTATION; GENETICS; LIVER; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALIA; MURINAE; MUS;

ANIMALS; BONE MARROW TRANSPLANTATION; HEPATOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HYDROLASES; LIVER; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; TRANSPLANTATION, HOMOLOGOUS;

EID: 53749094119     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2008.05.010     Document Type: Article

References (21)

1. Grompe M., al-Dhalimy M., Finegold M., et al. Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev 7 (1993) 2298-2307
2. Grompe M., Lindstedt S., al-Dhalimy M., et al. Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Nat Genet 10 (1995) 453-460
3. Alvarez-Dolado M., Pardal R., Garcia-Verdugo J.M., et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425 (2003) 968-973
4. Vassilopoulos G., Wang P.-R., and Russell D.W. Transplanted bone marrow regenerates liver by cell fusion. Nature 422 (2003) 901-904
5. Wang X., Willenbring H., Akkari Y., et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422 (2003) 897-901
6. Camargo F.D., Finegold M., and Goodell M.A. Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest 113 (2004) 1266-1270
7. Dahlke M.H., Loi R., Warren A., et al. Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. J Hepatol 44 (2006) 334-341
8. Lagasse E., Connors H., Al-Dhalimy M., et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6 (2000) 1229-1234
9. Reddy P. Pathophysiology of acute graft-versus-host disease. Hematol Oncol 21 (2003) 149-161
10. Shlomchik W.D., Couzens M.S., Tang C.B., et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science 285 (1999) 412-415
11. Min C.K., Kim B.G., Park G., Cho B., and Oh I.H. IL-10-transduced bone marrow mesenchymal stem cells can attenuate the severity of acute graft-versus-host disease after experimental allogeneic stem cell transplantation. Bone Marrow Transplant 39 (2007) 637-645
12. Mathe G., Thomas E.D., and Ferrebee J.W. The restoration of marrow function after lethal irradiation in man: a review. Transplant Bull 6 (1959) 407-409
13. Ferrari G., Cusella-De Angelis G., Coletta M., et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279 (1998) 1528-1530
14. Petersen B.E., Bowen W.C., Patrene K.D., et al. Bone marrow as a potential source of hepatic oval cells. Science 284 (1999) 1168-1170
15. Theise N.D., Nimmakayalu M., Gardner R., et al. Liver from bone marrow in humans. Hepatology 32 (2000) 11-16
16. Camargo F.D., Green R., Capetanaki Y., Jackson K.A., and Goodell M.A. Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat Med 9 (2003) 1520-1527
17. Doyonnas R., LaBarge M.A., Sacco A., Charlton C., and Blau H.M. Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. Proc Natl Acad Sci U S A 101 (2004) 13507-13512
18. Willenbring H., Bailey A.S., Foster M., et al. Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nat Med 10 (2004) 744-748
19. Kanazawa Y., and Verma I.M. Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver. Proc Natl Acad Sci U S A 100 Suppl 1 (2003) 11850-11853
20. Wang X., Montini E., Al-Dhalimy M., Lagasse E., Finegold M., and Grompe M. Kinetics of liver repopulation after bone marrow transplantation. Am J Pathol 161 (2002) 565-574
21. Fandrich F., Lin X., Chai G.X., et al. Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning. Nat Med 8 (2002) 171-178