Aging elevates metabolic gene expression in brain cholinergic neurons

Neurobiology of Aging

Volumn 29, Issue 12, 2008, Pages 1874-1893

  Baskerville, Karen A ^a   Kent, Caroline ^a   Personett, David ^a   Lai, Weil R ^b   Park, Peter J ^b   Coleman, Paul ^c   McKinney, Michael ^a  

^a MAYO CLINIC   (United States)

^b LABORATORY FOR MOLECULAR MEDICINE   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Acetylcholine; Aging; Basal forebrain; Bioinformatics; Gene expression; Metabolic genes; Neuronal vulnerability

Indexed keywords

GA BINDING PROTEIN; GA BINDING PROTEIN ALPHA; MITOCHONDRIAL PROTEIN; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN METABOLISM; BRAIN NERVE CELL; BRAIN STEM; CELL FUNCTION; CELL METABOLISM; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; FOREBRAIN; GENE EXPRESSION; GENE IDENTIFICATION; NERVE CELL PLASTICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; UPREGULATION;

ACETYLCHOLINE; AGING; ANIMALS; BRAIN; GENE EXPRESSION REGULATION; NERVE TISSUE PROTEINS; NEURONS; PROSENCEPHALON; RATS; RATS, INBRED F344; UP-REGULATION;

EID: 53649089781     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.04.024     Document Type: Article

References (42)

1. Attoor S., Dougherty E.R., Chen Y., Bittner M., and Trent J.M. Which is better for cDNA-microarray-based classification: ratios or direct intensities?. Bioinformatics 20 (2004) 2513-2520
2. Baskerville K.A., Kent C., Nicolle M., Gallagher M., and McKinney M. Aging causes partial loss of basal forebrain but not brainstem cholinergic neurons. NeuroReport 17 (2006) 1819-1823
3. Bild A., and Febbo P.G. Application of apriori established gene sets to discover biologically important differential expression in microarray data. Proc. Natl. Acad. Sci. USA 102 (2005) 15278-15279
4. Bonaventure P., Guo H., Tian B., Liu X., Bittner A., Roland B., Salunga R., Ma X.-J., Kamme F., Meurers B., Bakker M., Jurzak M., Leysen J.E., and Erlander M.G. Nuclei and subnuclei gene expression profiling in mammalian brain. Brain Res. 943 (2002) 38-47
5. Cheetham J.E., Coleman P.D., and Chow N. Isolation of single immunohistochemically identified whole neuronal cell bodies from post-mortem human brain for simultaneous analysis of multiple gene expression. J. Neurosci. Methods 77 (1997) 43-48
6. Chow N., Cox C., Callahan L.M., Weimer J.M., Guo L., and Coleman P.D. Expression profiles of multiple genes in single neurons of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 9620-9625
7. Chung C.Y., Seo H., Sonntag K.C., Brooks A., Lin L., and Isacson O. Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Hum. Mol. Genetics 14 (2005) 1709-1725
8. Cox W.G., Beaudet M.P., Agnew J.Y., and Ruth J.L. Possible sources of dye-related signal correlation bias in two-color DNA microarray assays. Anal. Biochem. 331 (2004) 243-254
9. Curtis R.K., Oresic M., and Vidal-Puig A. Pathways to the analysis of microarray data. Trends Biotechnol. 23 (2005) 429-435
10. DeKosky S.T., Ikonomovic M.D., Styren S.D., Beckett L., Wisniewski S., Bennett D.A., Cochran E.J., Kordower J.H., and Mufson E.J. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann. Neurol. 51 (2002) 145-155
11. Della-Maggiore V., Sekuler A.B., Grady C.L., Bennett P.J., Sekuler R., and McIntosh A.R. Corticolimbic interactions associated with performance on a short-term memory task are modified by age. J. Neurosci. 20 (2000) 8410-8416
12. Dubelaar E.G., Mufson E.J., ter Meulen W.G., Van Heerikhuize J.J., Verwer R.W.H., and Swaab D.F. Increased metabolic activity in nucleus basalis of Meynert neurons in elderly individuals with mild cognitive impairment as indicated by the size of the Golgi apparatus. J. Neuropathol. Exp. Neurol. 65 (2006) 257-266
13. Dubelaar E.J., Verwer R.W., Hofman M.A., van Heerikhuize J.J., Ravid R., and Swaab D.D. ApoE epsilon4 genotype is accompainied by lower metabolic activity in nucleus basalis of Meynert neurons in Alzheimer patients and controls as indicated by the size of the Golgi apparatus. J. Neuropathol. Exp. Neurol. 63 (2004) 159-169
14. Fass U., Panickar K., Personett D., Bryan D., Williams K., Gonzales J., Sugaya K., and McKinney M. Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess. NeuroReport 11 (2000) 931-936
15. Foster T.C. Biological markers of age-related memory deficits. CNS Drug 20 (2006) 153-156
16. Hernandez D., McGowan E., Sugaya K., Duff K., and McKinney M. Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes. NeuroReport 12 (2001) 1377-1384
17. Hoekstra M., Kruijt J.K., Van Eck M., and Van Berkel T.J. Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells. J. Biol. Chem. 278 (2003) 25448-25453
18. Livak K.T., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
19. Lo Conte G., Casamenti F., Bigl V., Milaneschi E., and Pepeu G. Effect of magnocellular forebrain nuclei lesions on acetylcholine output from the cerebral cortex, electrocorticogram, and behavior. Arch. Ital. Biol. 120 (1982) 176-188
20. Lottaz C., and Spang R. Molecular decomposition of complex clinical phenotypes using biologically structured analysis of microarray data. Bioinformatics 21 (2005) 1971-1978
21. Lu T., Pan Y., Kao S.-Y., Li C., Kohane I., Chan J., and Yanker B.A. Gene regulation and DNA damage in the ageing human brain. Nature 429 (2004) 883-891
22. Luo L., Salunga R.C., Guo H., Bittner A., Joy K.C., Galindo J.E., Xiao H., Rogers K.E., Wan J.S., Jackson M.R., and Erlander M.G. Gene expression profiles of laser-captured adjacent neuronal subtypes. Nat. Med. 5 (1999) 117-122
23. Markham A., Cameron I., Franklin P., and Spedding M. BDNF increases rat bran mitochondrial respiratory coupling at complex I, but not complex II. Eur. J. Neurosci. 20 (2004) 1189-1196
24. McKinney M. Brain cholinergic vulnerability: relevance to behavior and disease. Biochem. Pharmacol. 70 (2005) 1115-1124
25. McKinney M., Baskerville K., Personett D., Williams K., and Gonzalez J. Cholinergic plasticity and the meaning of death. In: Maiese K. (Ed). Neuronal and Vascular Plasticity: Elucidating Basic Cellular Mechanisms for Future Therapeutic Discovery (2003), Kluwer Academic Press, Norwell, MA 27-74
26. McKinney M., Williams K., Personett D., Kent C., Bryan D., Gonzalez J., and Baskerville K. Pontine cholinergic neurons depend on three neuroprotective systems to resist nitrosative stress. Brain Res. 1002 (2004) 100-109
27. McKinney M., and Coyle J.T. The potential for muscarinic receptor subtype-specific pharmacotherapy for Alzheimer's disease. Mayo Clin. Proc. 66 (1991) 1225-1237
28. Miasnikov A.A., Chen J.C., and Weinberger N.M. Rapid induction of specific associative behavioral memory by stimulation of the nucleus basalis in the rat. Neurobiol. Learn. Memory 86 (2006) 47-65
29. Mootha V.K., Lindgren C.M., Eriksson K.F., Subramanian A., Sihaq S., Lehar J., Puiqserver P., Carlsson E., Ridderstrale M., Laurila E., Houstis N., Daly M.J., Patterson N., Mesirov J.P., Golub T.R., Tamayo P., Spiegelman B., Lander E.S., Hirschhorn J.N., Altshuler D., and Groop L.C. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34 (2003) 267-273
30. Nicolle M.M., Gonzalez J., Sugaya K., Baskerville K.A., Bryan D., Lund K., Gallagher M., and McKinney M. Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents. Neuroscience 107 (2001) 415-431
31. Ongwijitwat S., Liang H.L., Graboyes E.M., and Wong-Riley M.T.T. Nuclear respiratory factor 2 senses changing cellular energy demands and its silencing down-regulates cytochrome oxidase and other target genes. Gene 374 (2006) 39-49
32. Park P.J., Cao Y.A., Lee S.Y., Kim J.-W., Chang M.S., Hart R., and Choi S. Current issues for DNA microarrays: platform comparison, double linear amplification, and universal RNA reference. J. Biotechnol. 112 (2004) 225-245
33. Piantadosi C.A., and Suliman H.B. Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. J. Biol. Chem. 281 (2006) 324-333
34. Salehi A., Lucassen P.J., Pool C.S., Gonatas N.K., Ravid R., and Swaab D.F. Decreased neurnal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience 59 (1994) 871-880
35. Scarpulla R.C. Nuclear control of respiratory gene expression in mammalian cells. J. Cell. Biochem. 97 (2006) 673-683
36. Tian L., Greenberg S.A., Kong S.W., Altschuler J., Kohane I.S., and Park P.J. Discovering statistically significant pathways in expression profiling studies. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 13544-13549
37. Troyanskaya O., Cantor M., Sherlock G., Brown P., Hastie T., Tibshirani R., Botstein D., and Altman R.B. Missing value estimation methods for DNA microarrays. Bioinformatics 17 (2001) 520-525
38. Van Gelder R.N., von Zastrow M.E., Yool A., Dement W.C., Barchas J.D., and Eberwine J.H. Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 1663-1667
39. Wang Y., Wang X., Guo X.-W., and Ghosh S. Conditions to ensure competitive hybridization in two-color microarray: a theoretical and experimental analysis. BioTechniques 32 (2002) 1342-131346
40. Woolf N.J., Jacobs R.W., and Butcher L.L. The pontomesencephalotegmental cholinergic system does not degenerate in Alzheimer's disease. Neurosci. Lett. 96 (1989) 277-282
41. Yang S.J., Liang H.L., Ning G., and Wong-Riley M.T.T. Ultrastructural study of depolarization-induced translocation of NRF-2 transcription factor in cultured rat visual cortical neurons. Eur. J. Neurosci. 19 (2004) 1153-1162
42. Yang S.J., Liang H.L., and Wong-Riley M.T.T. Activity-dependent transcriptional regulation of nuclear respiratory factor-1 in cultured rat visual cortical neurons. Neuroscience 141 (2006) 1181-1192