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Volumn 63, Issue 2, 2004, Pages 159-169

ApoE ε4 Genotype Is Accompanied by Lower Metabolic Activity in Nucleus Basalis of Meynert Neurons in Alzheimer Patients and Controls as Indicated by the Size of the Golgi Apparatus

Author keywords

Alzheimer disease; Apolipoprotein E; Basal nucleus of Meynert; Cholinergic; Golgi Apparatus; Metabolism; Risk factors

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E4; CELL SURFACE RECEPTOR; CHOLINE ACETYLTRANSFERASE; CYSTEINE RICH FIBROBLAST GROWTH FACTOR RECEPTOR; CYSTEINE-RICH FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; NERVE GROWTH FACTOR; SIALOGLYCOPROTEIN;

EID: 0842331312     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/63.2.159     Document Type: Article
Times cited : (31)

References (40)
  • 1
    • 0030767243 scopus 로고    scopus 로고
    • The cholinergic system in Alzheimer's disease
    • Kasa P, Rakonczay Z, Gulya K. The cholinergic system in Alzheimer's disease. Prog Neurobiol 1997;52:511-35
    • (1997) Prog Neurobiol , vol.52 , pp. 511-535
    • Kasa, P.1    Rakonczay, Z.2    Gulya, K.3
  • 2
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P, Maloney AJ. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 1976;2:1403
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, A.J.2
  • 3
    • 0029963924 scopus 로고    scopus 로고
    • Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease
    • Geula C, Mesulam MM. Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease. Cereb Cortex 1996;6:165-77
    • (1996) Cereb Cortex , vol.6 , pp. 165-177
    • Geula, C.1    Mesulam, M.M.2
  • 4
    • 0026756320 scopus 로고
    • Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: An in situ hybridization study
    • Strada O, Vyas S, Hirsch EC, et al. Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: An in situ hybridization study. Proc Natl Acad Sci U S A 1992;89:9549-53
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 9549-9553
    • Strada, O.1    Vyas, S.2    Hirsch, E.C.3
  • 5
    • 0021044702 scopus 로고
    • Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6)
    • Mesulam MM, Mufson EJ, Wainer BH, Levey AI. Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience 1983;10:1185-201
    • (1983) Neuroscience , vol.10 , pp. 1185-1201
    • Mesulam, M.M.1    Mufson, E.J.2    Wainer, B.H.3    Levey, A.I.4
  • 6
    • 0032845156 scopus 로고    scopus 로고
    • Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy
    • Smith DE, Roberts J, Gage FH, Tuszynski MH. Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc Natl Acad Sci U S A 1999;96:10893-98
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 10893-10898
    • Smith, D.E.1    Roberts, J.2    Gage, F.H.3    Tuszynski, M.H.4
  • 8
    • 0025739331 scopus 로고
    • Brain aging and Alzheimer's disease, "wear and tear" versus "use it or lose it"
    • Swaab DF. Brain aging and Alzheimer's disease, "wear and tear" versus "use it or lose it". Neurobiol Aging 1991;12:317-24
    • (1991) Neurobiol Aging , vol.12 , pp. 317-324
    • Swaab, D.F.1
  • 9
    • 0020313889 scopus 로고
    • Evidence that all newly synthesized proteins destined for fast axonal transport pass through the Golgi apparatus
    • Hammerschlag R, Stone GC, Bolen FA, Lindsey JD, Ellisman MH. Evidence that all newly synthesized proteins destined for fast axonal transport pass through the Golgi apparatus. J Cell Biol 1982;93:568-75
    • (1982) J Cell Biol , vol.93 , pp. 568-575
    • Hammerschlag, R.1    Stone, G.C.2    Bolen, F.A.3    Lindsey, J.D.4    Ellisman, M.H.5
  • 10
    • 0028271519 scopus 로고
    • Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus
    • Salehi A, Lucassen PJ, Pool CW, Gonatas NK, Ravid R, Swaab DF. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience 1994;59:871-80
    • (1994) Neuroscience , vol.59 , pp. 871-880
    • Salehi, A.1    Lucassen, P.J.2    Pool, C.W.3    Gonatas, N.K.4    Ravid, R.5    Swaab, D.F.6
  • 11
    • 0032530417 scopus 로고    scopus 로고
    • Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent
    • Salehi A, Dubelaar EJG, Mulder M, Swaab DF. Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent. Proc Natl Acad Sci U S A 1998;95:11445-49
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11445-11449
    • Salehi, A.1    Dubelaar, E.J.G.2    Mulder, M.3    Swaab, D.F.4
  • 12
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-23
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 13
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-72
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3
  • 14
    • 0029893405 scopus 로고    scopus 로고
    • Apolipoprotein E, memory and Alzheimer's disease
    • Soininen HS, Riekkinen PJ, Sr. Apolipoprotein E, memory and Alzheimer's disease. Trends Neurosci 1996;19:224-28
    • (1996) Trends Neurosci , vol.19 , pp. 224-228
    • Soininen, H.S.1    Riekkinen Sr., P.J.2
  • 16
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-59
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 17
    • 0026619925 scopus 로고
    • Brain banking and the human hypothalamus-factors to match for, pitfalls and potentials
    • Ravid R, Van Zwieten EJ, Swaab DF. Brain banking and the human hypothalamus-factors to match for, pitfalls and potentials. Prog Brain Res 1992;93:83-95
    • (1992) Prog Brain Res , vol.93 , pp. 83-95
    • Ravid, R.1    Van Zwieten, E.J.2    Swaab, D.F.3
  • 18
    • 0037954361 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon 4 in an autopsy series of various dementing disorders
    • Nielsen AS, Ravid R, Kamphorst W, Jorgensen OS. Apolipoprotein E epsilon 4 in an autopsy series of various dementing disorders. J Alzheimers Dis 2003;5:119-25
    • (2003) J Alzheimers Dis , vol.5 , pp. 119-125
    • Nielsen, A.S.1    Ravid, R.2    Kamphorst, W.3    Jorgensen, O.S.4
  • 19
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-44
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 20
    • 0019967975 scopus 로고
    • The Global Deterioration Scale for assessment of primary degenerative dementia
    • Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 1982;139:1136-39
    • (1982) Am J Psychiatry , vol.139 , pp. 1136-1139
    • Reisberg, B.1    Ferris, S.H.2    De Leon, M.J.3    Crook, T.4
  • 21
    • 0031847513 scopus 로고    scopus 로고
    • Comparison of beta-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: Amorphic plaques and cytoskeletal changes occur independently
    • Van de Nes JAP, Kamphorst W, Ravid R, Swaab DF. Comparison of beta-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: Amorphic plaques and cytoskeletal changes occur independently. Acta Neuropathol (Berl) 1998;96:129-38
    • (1998) Acta Neuropathol (Berl) , vol.96 , pp. 129-138
    • Van De Nes, J.A.P.1    Kamphorst, W.2    Ravid, R.3    Swaab, D.F.4
  • 22
    • 0035793960 scopus 로고    scopus 로고
    • Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing
    • Ishunina FA, Unmehopa UU, van Heerikhuize JJ, Pool CW, Swaab DF. Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing. Brain Res 2001;893:70-76
    • (2001) Brain Res , vol.893 , pp. 70-76
    • Ishunina, F.A.1    Unmehopa, U.U.2    Van Heerikhuize, J.J.3    Pool, C.W.4    Swaab, D.F.5
  • 23
    • 0030471472 scopus 로고    scopus 로고
    • Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus
    • Mourelatos Z, Gonatas JO, Cinato E, Gonatas NK. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. DNA Cell Biol 1996;15:1121-28
    • (1996) DNA Cell Biol , vol.15 , pp. 1121-1128
    • Mourelatos, Z.1    Gonatas, J.O.2    Cinato, E.3    Gonatas, N.K.4
  • 24
    • 0025829609 scopus 로고
    • Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections
    • Shi SR, Key ME, Kalra KL. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991;39:741-48
    • (1991) J Histochem Cytochem , vol.39 , pp. 741-748
    • Shi, S.R.1    Key, M.E.2    Kalra, K.L.3
  • 25
    • 0020676699 scopus 로고
    • Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey
    • Mesulam MM, Mufson EJ, Levey AI, Wainer BH. Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J Comp Neurol 1983;214:170-97
    • (1983) J Comp Neurol , vol.214 , pp. 170-197
    • Mesulam, M.M.1    Mufson, E.J.2    Levey, A.I.3    Wainer, B.H.4
  • 26
    • 34247990255 scopus 로고
    • On the Kolmogorov-Smirnov test for normality with mean and variance unknown
    • Lilliefors HW. On the Kolmogorov-Smirnov test for normality with mean and variance unknown. JASA 1967;62:399-402
    • (1967) JASA , vol.62 , pp. 399-402
    • Lilliefors, H.W.1
  • 27
    • 0032751523 scopus 로고    scopus 로고
    • Diminished neuronal metabolic activity in Alzheimer's disease
    • Salehi A, Swaab DF. Diminished neuronal metabolic activity in Alzheimer's disease. J Neural Transm 1999;106:955-86
    • (1999) J Neural Transm , vol.106 , pp. 955-986
    • Salehi, A.1    Swaab, D.F.2
  • 29
    • 0007691164 scopus 로고
    • Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease
    • Poirier J, Delisle MC, Quirion R, et al. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. Proc Natl Acad Sci U S A 1995;92:12260-64
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 12260-12264
    • Poirier, J.1    Delisle, M.C.2    Quirion, R.3
  • 30
    • 0032544377 scopus 로고    scopus 로고
    • Apolipoprotein E polymorphism influences the cerebral metabolic pattern in Alzheimer's disease
    • Mielke R, Zerres K, Uhlhaas S, Kessler J, Heiss WD. Apolipoprotein E polymorphism influences the cerebral metabolic pattern in Alzheimer's disease. Neurosci Lett 1998;254:49-52
    • (1998) Neurosci Lett , vol.254 , pp. 49-52
    • Mielke, R.1    Zerres, K.2    Uhlhaas, S.3    Kessler, J.4    Heiss, W.D.5
  • 31
    • 0031565944 scopus 로고    scopus 로고
    • Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype
    • Allen SJ, MacGowan SH, Tyler S, et al. Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype. Neurosci Lett 1997;239:33-36
    • (1997) Neurosci Lett , vol.239 , pp. 33-36
    • Allen, S.J.1    MacGowan, S.H.2    Tyler, S.3
  • 32
    • 0028950856 scopus 로고
    • Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease
    • Small GW, Mazziotta JC, Collins MT, et al. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. JAMA 1995;273:942-47
    • (1995) JAMA , vol.273 , pp. 942-947
    • Small, G.W.1    Mazziotta, J.C.2    Collins, M.T.3
  • 33
    • 0029970342 scopus 로고    scopus 로고
    • Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E
    • Reiman EM, Caselli RJ, Yun LS, et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 1996;334:752-58
    • (1996) N Engl J Med , vol.334 , pp. 752-758
    • Reiman, E.M.1    Caselli, R.J.2    Yun, L.S.3
  • 34
    • 12944259210 scopus 로고    scopus 로고
    • Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease
    • Small GW, Ercoli LM, Silverman DH, et al. Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc Natl Acad Sci U S A 2000;97:6037-42
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6037-6042
    • Small, G.W.1    Ercoli, L.M.2    Silverman, D.H.3
  • 35
    • 0037194718 scopus 로고    scopus 로고
    • Cognitive change and the APOE epsilon 4 allele
    • Deary IJ, Whiteman MC, Pattie A, et al. Cognitive change and the APOE epsilon 4 allele. Nature 2002;418:932
    • (2002) Nature , vol.418 , pp. 932
    • Deary, I.J.1    Whiteman, M.C.2    Pattie, A.3
  • 36
    • 0036156958 scopus 로고    scopus 로고
    • Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    • DeKosky ST, Ikonomovic MD, Styren SD, et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 2002;51:145-55
    • (2002) Ann Neurol , vol.51 , pp. 145-155
    • DeKosky, S.T.1    Ikonomovic, M.D.2    Styren, S.D.3
  • 37
    • 0037426289 scopus 로고    scopus 로고
    • The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging
    • Bretsky P, Guralnik JM, Launer L, Albert M, Seeman TE. The role of APOE-epsilon4 in longitudinal cognitive decline: MnacArthur Studies of Successful Aging. Neurology 2003;60:1077-81
    • (2003) Neurology , vol.60 , pp. 1077-1081
    • Bretsky, P.1    Guralnik, J.M.2    Launer, L.3    Albert, M.4    Seeman, T.E.5
  • 38
    • 0023737618 scopus 로고
    • Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?
    • Hoyer S, Oesterreich K, Wagner O. Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type? J Neurol 1988;235:143-38
    • (1988) J Neurol , vol.235 , pp. 143-138
    • Hoyer, S.1    Oesterreich, K.2    Wagner, O.3
  • 39
    • 0025106123 scopus 로고
    • Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia
    • Braak H, Braak E. Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia. Acta Neuropathol 1990;80:479-86
    • (1990) Acta Neuropathol , vol.80 , pp. 479-486
    • Braak, H.1    Braak, E.2
  • 40
    • 0031664361 scopus 로고    scopus 로고
    • High frequency of apolipoprotein E epsilon4 allele in young individuals with very mild Alzheimer's disease-related neurofibrillary changes
    • Ghebremedhin E, Schultz C, Braak E, Braak H. High frequency of apolipoprotein E epsilon4 allele in young individuals with very mild Alzheimer's disease-related neurofibrillary changes. Exp Neurol 1998;153152-55.
    • (1998) Exp Neurol , pp. 153152-153155
    • Ghebremedhin, E.1    Schultz, C.2    Braak, E.3    Braak, H.4


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