PI3K/AKT, JNK, and ERK pathways are not crucial for the induction of cholesterol biosynthesis gene transcription in intestinal epithelial cells following treatment with the potato glycoalkaloid α-chaconine

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 18, 2008, Pages 8745-8752

  Mandimika, Tafadzwa ^a,b   Baykus, Hakan ^a   Poortman, Jenneke ^a   Garza, Cutberto ^c   Kuiper, Harry ^a   Peijnenburg, Ad ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b Department of Obstetrics Gynecology   (United States)

^c BOSTON COLLEGE   (United States)

Author keywords

chaconine; Cholesterol biosynthesis; Glycoalkaloids; MAPK; PI3K AKT

Indexed keywords

ALPHA CHACONINE; CHOLESTEROL; DRUG DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOLANINE; SREBF2 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; BIOSYNTHESIS; CELL STRAIN CACO 2; CHEMISTRY; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; HUMAN; INTESTINE; METABOLISM; PHOSPHORYLATION; POTATO;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CACO-2 CELLS; CHOLESTEROL; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; HUMANS; INTESTINES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SOLANINE; SOLANUM TUBEROSUM; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

MURINAE; SOLANUM TUBEROSUM;

EID: 53649084216     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf800911m     Document Type: Article

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