Species differences between human and rat in the substrate specificity of cathepsin K

Journal of Biochemistry

Volumn 144, Issue 4, 2008, Pages 499-506

  Tada, Sachiyo ^a,b   Tsutsumi, Kae ^a   Ishihara, Hideki ^a,b   Suzuki, Kenji ^a,c   Gohda, Keigo ^a,b,d   Teno, Naoki ^a  

^a Novartis Institutes for BioMedical Research   (Japan)

^b SYSMEX CORPORATION   (Japan)

^c RITSUMEIKAN UNIVERSITY   (Japan)

^d Computer Aided Molecular Modeling Research Center Kansai ^*  (Japan)

Author keywords

Cathepsin K; Hydroxyproline; S2 P2 interaction; Species difference; Substrate specificity

Indexed keywords

CATHEPSIN K; COLLAGEN TYPE 1;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HYDROLYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; RAT; SPECIES DIFFERENCE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; CATHEPSINS; COLLAGEN TYPE I; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; DNA PRIMERS; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; RATS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

RATTUS;

EID: 53549094927     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn093     Document Type: Article

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