Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-γ and interleukin-10 production

International Archives of Allergy and Immunology

Volumn 148, Issue 3, 2009, Pages 239-250

  Sasaki, Yoshinori ^a   Ohtani, Tomoyuki ^a   Ito, Yumiko ^a   Mizuashi, Masato ^a   Nakagawa, Satoshi ^a   Furukawa, Toru ^a   Horii, Akira ^a   Aiba, Setsuya ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Diesel exhaust particles; Formaldehyde; Glucocorticoid induced leucine zipper; Growth arrest and DNA damage inducible gene 45 ; Human T lymphocytes; Interferon ; Interleukin 10

Indexed keywords

FORMALDEHYDE; GAMMA INTERFERON; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; STAT4 PROTEIN; TRANSCRIPTION FACTOR C MAF; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ADULT; ARTICLE; COLORIMETRY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXHAUST GAS; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; WESTERN BLOTTING;

ADULT; AIR POLLUTANTS; CELL CYCLE PROTEINS; FORMALDEHYDE; GENE EXPRESSION; HUMANS; I-KAPPA B PROTEINS; INTERFERON-GAMMA; INTERLEUKIN-10; LYMPHOCYTE ANTIGEN 96; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARTICULATE MATTER; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-MAF; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES; TRANSCRIPTION FACTORS; VEHICLE EMISSIONS; YOUNG ADULT;

EID: 53449102433     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000161584     Document Type: Article

References (29)

1. Ohtani T, Nakagawa S, Kurosawa M, Mizuashi M, Ozawa M, Aiba S: Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant response. J Immunol 2005;174:2412-2419.
2. Diaz-Sanchez D, Proietti L, Polosa R: Diesel fumes and the rising prevalence of atopy: an urban legend? Curr Allergy Asthma Rep 2003;3:146-152.
3. Nel AE, Diaz-Sanchez D, Ng D, Hiura T, Saxon A: Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol 1998;102:539-554.
4. Rumchev KB, Spickett JT, Bulsara MK, Phillips MR, Stick SM: Domestic exposure to formaldehyde significantly increases the risk of asthma in young children. Eur Respir J 2002;20:403-408.
5. Sadakane K, Takano H, Ichinose T, Yanagisawa R, Shibamoto T: Formaldehyde enhances mite allergen-induced eosinophilic inflammation in the murine airway. J Environ Pathol Toxicol Oncol 2002;21:267-276.
6. Sagai M, Saito H, Ichinose T, Kodama M, Mori Y: Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse. Free Radic Biol Med 1993;14:37-47.
7. Agnello D, Lankford CS, Bream J, Morinobu A, Gadina M, O'Shea JJ, Frucht DM: Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol 2003;23:147-161.
8. Kashiwakura J, Suzuki N, Nagafuchi H, Takeno M, Takeba Y, Shimoyama Y, Sakane T: Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. J Exp Med 1999;190:1147-1154.
9. H2-mediated allergic responses. Nat Med 2003;9:1047-1054.
10. Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka T, Kishimoto T, Yoshimura A, Kubo M: Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci USA 2002;99:13003-13008.
11. Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA: GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J 2004;23:1576-1586.
12. Kobayashi M, Yamamoto M: Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 2005;7:385-394.
13. Chanas SA, Jiang Q, McMahon M, McWalter GK, McLellan LI, Elcombe CR, Henderson CJ, Wolf CR, Moffat GJ, Itoh K, Yamamoto M, Hayes JD: Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem J 2002;365:405-416.
14. Rincon M: MAP-kinase signaling pathways in T cells. Curr Opin Immunol 2001;13:339-345.
15. Sica A, Dorman L, Viggiano V, Cippitelli M, Ghosh P, Rice N, Young HA: Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J Biol Chem 1997;272:30412-30420.
16. Aronica MA, Mora AL, Mitchell DB, Finn PW, Johnson JE, Sheller JR, Boothby MR: Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J Immunol 1999;163:5116-5124.
17. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH: Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 2002;295:338-342.
18. Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH: Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002;295:336-338.
19. Asselin-Labat ML, David M, Biola-Vidamment A, Lecoeuche D, Zennaro MC, Bertoglio J, Pallardy M: GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. Blood 2004;104:215-223.
20. Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS, Chiang LW, Greenberg ME: DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 2002;296:530-534.
21. Lee TS, Chau LY: Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 2002;8:240-246.
22. Brusko TM, Wasserfall CH, Agarwal A, Kapturczak MH, Atkinson MA: An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells. J Immunol 2005;174:5181-5186.
23. Salvador JM, Hollander MC, Nguyen AT, Kopp JB, Barisoni L, Moore JK, Ashwell JD, Fornace AJ Jr: Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 2002;16:499-508.
24. Salvador JM, Mittelstadt PR, Belova GI, Fornace AJ Jr, Ashwell JD: The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. Nat Immunol 2005;6:396-402.
25. Lu B, Yu H, Chow C, Li B, Zheng W, Davis RJ, Flavell RA: GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity 2001;14:583-590.
26. Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C: Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB. Blood 2001;98:743-753.
27. Zafarullah M, Li WQ, Sylvester J, Ahmad M: Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 2003;60:6-20.
28. National ambient air quality standards for particulate matter. Fed Regist 2006;71:61144-61233.
29. Gustafson P, Barregård L, Lindahl R, Sällsten G: Formaldehyde levels in Sweden: personal exposure, indoor, and outdoor concentrations. J Expo Anal Environ Epidemiol 2005;15:252-260.