Nutritional calcium modulates colonic expression of vitamin D receptor and pregnane X receptor target genes

Molecular Nutrition and Food Research

Volumn 52, Issue SUPPL. 1, 2008, Pages

  Nittke, Thomas ^a   Selig, Stephan ^a   Kallay, Enikö ^a   Cross, Heide S ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Caco 2 cells; CYP3A11; Gender specificity; Proximal colon; Vitamin D hydroxylases

Indexed keywords

MUS;

CALCITRIOL RECEPTOR; CALCIUM; CYCLOOXYGENASE 2; CYTOCHROME P450 3A; FOOD ADDITIVE; PREGNANE X RECEPTOR; PRIMER DNA; STEROID RECEPTOR;

ADENOCARCINOMA; ANIMAL; ARTICLE; C57BL MOUSE; COLON; DRUG EFFECT; GENETICS; HUMAN; INFLAMMATION; INTESTINE MUCOSA; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; CALCIUM; CELL LINE, TUMOR; COLON; CYCLOOXYGENASE 2; CYTOCHROME P-450 CYP3A; DNA PRIMERS; FOOD ADDITIVES; HUMANS; INFLAMMATION; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; RECEPTORS, CALCITRIOL; RECEPTORS, STEROID;

EID: 53449098889     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200700200     Document Type: Article

References (31)

1. Pohl, C., Hombach, A., Kruis, W., Chronic inflammatory bowel disease and cancer, Hepatogastroenterology 2000, 47, 57-70.
2. Kudlacek, S., Schneider, B., Peterlik, M., Leb, G. et al., Assessment of vitamin D and calcium status in healthy adult Austrians, Eur. J. Clin. Invest. 2003, 33, 323-331.
3. Wargovich, M. J., Eng, V. W., Newmark, H. L., Bruce, W. R., Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium, Carcinogenesis 1983, 4, 1205-1207.
4. Kallay, E., Bajna, E., Wrba, F., Kriwanek, S. et al., Dietary calcium and growth modulation of human colon cancer cells: Role of the extracellular calcium-sensing receptor, Cancer Detect. Prev. 2000, 24, 127-136.
5. Kallay, E., Kifor, O., Chattopadhyay, N., Brown, E. M. et al., Calcium-dependent c-myc proto-oncogene expression and proliferation of Caco-2 cells: A role for a luminal extracellular calcium-sensing receptor, Biochem. Biophys. Res. Commun. 1997, 232, 80-83.
6. Zhu, Y., Mahon, B. D., Froicu, M., Cantorna, M. T., Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease, Eur. J. Immunol. 2005, 35, 217-224.
7. Kliewer, S. A., Goodwin, B., Willson, T. M., The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism, Endocr. Rev. 2002, 23, 687-702.
8. Langmann, T., Moehle, C., Mauerer, R., Scharl, M. et al., Loss of detoxification in inflammatory bowel disease: Dysregulation of pregnane X receptor target genes, Gastroenterology 2004, 127, 26-40.
9. Cross, H. S., Lipkin, M., Kallay, E., Nutrients regulate the colonic vitamin D system in mice: Relevance for human colon malignancy, J. Nutr. 2006, 136, 561-564.
10. Cross, H. S., Bises, G., Lechner, D., Manhardt, T., Kallay, E., The Vitamin D endocrine system of the gut - its possible role in colorectal cancer prevention, J. Steroid Biochem. Mol. Biol. 2005, 97, 121-128.
11. Newmark, H. L., Yang, K., Lipkin, M., Kopelovich, L. et al., A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice, Carcinogenesis 2001, 22, 1871-1875.
12. Lechner, D., Kallay, E., Cross, H. S., 1alpha,25-dihydroxyvitamin D3 downregulates CYP27B1 and induces CYP24A1 in colon cells, Mol. Cell. Endocrinol. 2007, 263, 55-64.
13. Brozek, W., Bises, G., Girsch, T., Cross, H. S. et al., Differentiation-dependent expression and mitogenic action of interleukin-6 in human colon carcinoma cells: Relevance for tumour progression, Eur. J. Cancer 2005, 41, 2347-2354.
14. Kallay, E., Bises, G., Bajna, E., Bieglmayer, C. et al., Colon-specific regulation of vitamin D hydroxylases - a possible approach for tumor prevention, Carcinogenesis 2005, 26, 1581-1589.
15. Bareis, P., Bises, G., Bischof, M. G., Cross, H. S., Peterlik, M., 25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression, Biochem. Biophys. Res. Commun. 2001, 285, 1012-1017.
16. Cross, H. S., Bareis, P., Hofer, H., Bischof, M. G. et al., 25-Hydroxyvitamin D(3)-1alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis, Steroids 2001, 66, 287-292.
17. Hofer, H., Ho, G., Peterlik, M., Uskokovic, M. R. et al., Biological effects of 1alpha-hydroxy- and 1beta-(hydroxymethyl)-vitamin D compounds relevant for potential colorectal cancer therapy, J. Pharmacol. Exp. Ther. 1999, 291, 450-455.
18. Evans, S. R., Nolla, J., Hanfelt, J., Shabahang, M. et al., Vitamin D receptor expression as a predictive marker of biological behavior in human colorectal cancer, Clin. Cancer Res. 1998, 4, 1591-1595.
19. Kaz, A. M., Brentnall, T. A., Genetic testing for colon cancer, Nat. Clin. Pract. Gastroenterol. Hepatol. 2006, 3, 670-679.
20. Eberhart, C. E., Coffey, R. J., Radhika, A., Giardiello, F. M. et al., Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas, Gastroenterology 1994, 107, 1183-1188.
21. Reddy, B. S., Hirose, Y., Lubet, R., Steele, V. et al., Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis, Cancer Res. 2000, 60, 293-297.
22. Lamprecht, S. A., Lipkin, M., Chemoprevention of colon cancer by calcium, vitamin D and folate: Molecular mechanisms, Nat. Rev. Cancer 2003, 3, 601-614.
23. Martinez, M. E., Marshall, J. R., Sampliner, R., Wilkinson, J., Alberts, D. S., Calcium, vitamin D, and risk of adenoma recurrence (United States), Cancer Causes Control 2002, 13, 213-220.
24. Feskanich, D., Ma, J., Fuchs, C. S., Kirkner, G. J. et al., Plasma vitamin D metabolites and risk of colorectal cancer in women, Cancer Epidemiol. Biomarkers Prev. 2004, 13, 1502-1508.
25. Kallay, E., Pietschmann, P., Toyokuni, S., Bajna, E. et al., Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage, Carcinogenesis 2001, 22, 1429-1435.
26. Schwartz, B., Smirnoff, P., Shany, S., Liel, Y., Estrogen controls expression and bioresponse of 1,25-dihydroxyvitamin D receptors in the rat colon, Mol. Cell. Biochem. 2000, 203, 87-93.
27. Beral, V., Banks, E., Reeves, G., Evidence from randomised trials on the long-term effects of hormone replacement therapy, Lancet 2002, 360, 942-944.
28. Bernstein, H., Bernstein, C., Payne, C. M., Dvorakova, K., Garewal, H., Bile acids as carcinogens in human gastrointestinal cancers, Mutat. Res. 2005, 589, 47-65.
29. Pascussi, J. M., Robert, A., Nguyen, M., Walrant-Debray, O. et al., Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia, J. Clin. Invest. 2005, 115, 177-186.
30. Verdu, E. F., Deng, Y., Bercik, P., Collins, S. M., Modulatory effects of estrogen in two murine models of experimental colitis, Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 283, G27-G36.
31. Fujii, S., Tominaga, K., Kitajima, K., Takeda, J. et al., Methylation of the oestrogen receptor gene in nonneoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis, Gut 2005, 54, 1287-1292.