Colon-specific regulation of vitamin D hydroxylases - A possible approach for tumor prevention

Carcinogenesis

Volumn 26, Issue 9, 2005, Pages 1581-1589

  Kállay, Enikö ^a   Bises, Giovanna ^a   Bajna, Erika ^a   Bieglmayer, Christian ^a   Gerdenitsch, Waltraud ^a   Steffan, Ilse ^b   Kato, Shigeaki ^c   Armbrecht, H James ^d   Cross, Heide S ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c KYOTO UNIVERSITY   (Japan)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CALCIDIOL 24 OXYGENASE; CALCIUM; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLINE; MESSENGER RNA; OXYGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; ASCENDING COLON; CALCIUM HOMEOSTASIS; CALCIUM INTAKE; CALCIUM URINE LEVEL; CANCER CELL CULTURE; CANCER PREVENTION; CANCER RISK; CELL DIFFERENTIATION; CELL PROLIFERATION; COLON CARCINOGENESIS; COLON MUCOSA; COLORECTAL TUMOR; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIETARY INTAKE; ENZYME REGULATION; EXTRACELLULAR CALCIUM; FECES ANALYSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TUMOR LOCALIZATION;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; ANTICARCINOGENIC AGENTS; CALCIFEDIOL; CALCITRIOL; CALCIUM; CALCIUM, DIETARY; COLON; DIETARY SUPPLEMENTS; GENE EXPRESSION REGULATION; INTESTINAL MUCOSA; KIDNEY; MICE; MICE, INBRED C57BL; MIXED FUNCTION OXYGENASES; PROLIFERATING CELL NUCLEAR ANTIGEN; RNA, MESSENGER; STEROID HYDROXYLASES; VITAMIN D;

EID: 24144474647     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgi124     Document Type: Article

References (48)

1. Garland,C.F., Comstock,G.W., Garland,F.C., Helsing,K.J., Shaw,E.K. and Gorham,E.D. (1989) Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet, 2, 1176-1178.
2. Grant,W.B. (2003) Ecologic studies of solar UV-B radiation and cancer mortality rates. Recent Results Cancer Res., 164, 371-377.
3. Tuohimaa,P., Tenkanen,L., Ahonen,M. et al. (2004) Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: A longitudinal, nested case-control study in the Nordic countries. Int. J. Cancer, 108, 104-108.
4. Sawada,N., Sakaki,T., Ohta,M. and Inouye,K. (2000) Metabolism of vitamin D(3) by human CYP27A1. Biochem. Biophys. Res. Commun., 273, 977-984.
5. Cheng,J.B., Motola,D.L., Mangelsdorf,D.J. and Russell,D.W. (2003) De-orphanization of cytochrome P450 2R1: A microsomal vitamin D 25-hydroxylase. J. Biol. Chem., 278, 38084-38093.
6. Holick,M.F. (2003) Vitamin D: A millenium perspective. J. Cell Biochem., 88, 296-307.
7. Kudlacek,S., Schneider,B., Peterlik,M., Leb,G., Klaushofer,K., Weber,K., Woloszczuk,W. and Willvonseder,R. (2003) Assessment of vitamin D and calcium status in healthy adult Austrians. Eur. J. Clin. Invest., 33, 323-331.
8. DeLuca,H.F. and Schnoes,H.K. (1976) Metabolism and mechanism of action of vitamin D. Annu Rev. Biochem., 45, 631-666.
9. Tanaka,Y. and DeLuca,H.F. (1981) Measurement of chick kidney 25-hydroxyvitamin D3-1 alpha-hydroxylase without use of radioactive substrate. Anal. Biochem., 110, 102-107.
10. Henry,H.L. and Norman,A.W. (1984) Vitamin D: Metabolism and biological actions. Annu. Rev. Nutr., 4, 493-520.
11. Murayama,A., Takeyama,K., Kitanaka,S., Kodera,Y., Kawaguchi,Y., Hosoya,T. and Kato,S. (1999) Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals. Endocrinology, 140, 2224-2231.
12. Zierold,C., Darwish,H.M. and DeLuca,H.F. (1994) Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene. Proc. Natl Acad. Sci. USA, 91, 900-902.
13. Ohyama,Y., Ozono,K., Uchida,M., Shinki,T., Kato,S., Suda,T., Yamamoto,O., Noshiro,M. and Kato,Y. (1994) Identification of a vitamin D-responsive element in the 5′-flanking region of the rat 25- hydroxyvitamin D3 24-hydroxylase gene. J. Biol. Chem., 269 10545-10550.
14. Zierold,C., Mings,J.A. and DeLuca,H.F. (2001) Parathyroid hormone regulates 25-hydroxyvitamin D(3)-24-hydroxylase mRNA by altering its stability. Proc. Natl Acad. Sci. USA, 98, 13572-13576.
15. Zierold,C., Mings,J.A. and DeLuca,H.F. (2003) Regulation of 25-hydroxyvitamin D3-24-hydroxylase mRNA by 1,25-dihydroxyvitamin D3 and parathyroid hormone. J. Cell Biochem., 88, 234-237.
16. Palmer,H.G., Gonzalez-Sancho,J.M., Espada,J., Berciano,M.T., Puig,I., Baulida,J., Quintanilla,M., Cano,A., de Herreros,A.G., Lafarga,M. and Munoz,A. (2001) Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J. Cell Biol., 154, 369-387.
17. Shabahang,M., Buras,R.R., Davoodi,F., Schumaker,L.M., Nauta,R.J., Uskokovic,M.R., Brenner,R.V. and Evans,S.R. (1994) Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3. Cancer Res., 54, 4057-4064.
18. Cross,H.S., Farsoudi,K.H. and Peterlik,M. (1993) Growth inhibition of human colon adenocarcinoma-derived Caco-2 cells by 1,25-dihydroxyvitamin D3 and two synthetic analogs: Relation to in vitro hypercalcemic potential. Naunyn Schmiedebergs Arch. Pharmacol., 347, 105-110.
19. Tangrea,J., Helzlsouer,K., Pietinen,P., Taylor,P., Hollis,B., Virtamo,J. and Albanes,D. (1997) Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men. Cancer Causes Control, 8, 615-625.
20. Cross,H.S., Peterlik,M., Reddy,G.S. and Schuster,I. (1997) Vitamin D metabolism in human colon adenocarcinoma-derived Caco-2 cells: expression of 25-hydroxyvitamin D3-1alpha-hydroxylase activity and regulation of side-chain metabolism. J. Steroid Biochem. Mol. Biol. 62, 21-28.
21. Bareis,P., Bises,G., Bischof,M.G., Cross,H.S. and Peterlik,M. (2001) 25-Hydroxyvitamin D metabolism in human colon cancer cells during tumor progression. Biochem. Biophys. Res. Commun., 285, 1012-1017.
22. Bareis,P., Kallay,E., Bischof,M.G., Bises,G., Hofer,H., Potzi,C., Manhardt,T., Bland,R. and Cross,H.S. (2002) Clonal differences in expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase, of 25-hydroxyvitamin D(3)-24-hydroxylase, and of the vitamin D receptor in human colon carcinoma cells: Effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D(3). Exp. Cell Res., 276, 320-327.
23. Cross,H.S., Bareis,P., Hofer,H., Bischof,M.G., Bajna,E., Kriwanek,S., Bonner,E. and Peterlik,M. (2001) 25-Hydroxyvitamin D(3)-1alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis. Steroids, 66, 287-292.
24. Bises,G., Kallay,E., Weiland,T., Wrba,F., Wenzl,E., Bonner,E., Kriwanek,S., Obrist,P. and Cross,H.S. (2004) 25-Hydroxyvitamin D3-1alpha-hydroxylase expression in normal and malignant human colon. J. Histochem. Cytochem., 52, 985-989.
25. Garland,C.F., Garland,F.C. and Gorham,E.D. (1991) Can colon cancer incidence and death rates be reduced with calcium and vitamin D? Am. J. Clin. Nutr., 54, 193S-201S.
26. Cho,E., Smith-Warner,S.A., Spiegelman,D. et al. (2004) Dairy foods, calcium, and colorectal cancer: A pooled analysis of 10 cohort studies. J. Natl Cancer Inst., 96, 1015-22.
27. Kállay,E., Bajna,E., Wrba,F., Kriwanek,S., Peterlik,M. and Cross,H.S. (2000) Dietary calcium and growth modulation of human colon cancer cells: Role of the extracellular calcium-sensing receptor. Cancer Detect. Prev., 24, 127-136.
28. Yoshizawa,T., Handa,Y., Uematsu,Y. et al. (1997) Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat. Genet., 16, 391-396.
29. Kallay,E., Pietschmann,P., Toyokuni,S., Bajna,E., Hahn,P., Mazzucco,K., Bieglmayer,C., Kato,S. and Cross,H.S. (2001) Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage. Carcinogenesis, 22, 1429-1435.
30. Li,Y.C., Pirro,A.E., Amling,M., Delling,G., Baron,R., Bronson,R. and Demay,M.B. (1997) Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia. Proc. Natl Acad. Sci. USA, 94, 9831-9835.
31. Li,Y.C., Amling,M., Pirro,A.E., Priemel,M., Meuse,J., Baron,R., Delling,G. and Demay,M.B. (1998) Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology, 139, 4391-4396.
32. Amling,M., Priemel,M., Holzmann,T., Chapin,K., Rueger,J.M., Baron,R. and Demay,M.B. (1999) Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140, 4982-4987.
33. Newmark,H.L., Lipkin,M. and Maheshwari,N. (1991) Colonic hyperproliferation induced in rats and mice by nutritional-stress diets containing four components of a human Western-style diet (series 2). Am. J. Clin. Nutr., 54, 209S-214S.
34. Kallay,E., Kifor,O., Chattopadhyay,N., Brown,E.M., Bischof,M.G., Peterlik,M. and Cross,H.S. (1997) Calcium-dependent c-myc protooncogene expression and proliferation of Caco-2 cells: A role for a luminal extracellular calcium-sensing receptor. Biochem. Biophys. Res. Commun., 232, 80-83.
35. Garland,C.F., Garland,F.C. and Gorham,E.D. (1999) Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Ann. NY Acad. Sci., 889, 107-119.
36. Kallay,E., Adlercreutz,H., Farhan,H., Lechner,D., Bajna,E., Gerdenitsch,W., Campbell,M. and Cross,H.S. (2002) Phytoestrogens regulate vitamin D metabolism in the mouse colon: Relevance for colon tumor prevention and therapy. J. Nutr., 132, 3490S-3493S.
37. Feskanich,D., Ma,J., Fuchs,C.S., Kirkner,G.J., Hankinson,S.E., Hollis,B.W. and Giovannucci,E.L. (2004) Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev. 13, 1502-1508.
38. Grau,M.V., Baron,J.A., Sandler,R.S., Haile,R.W., Beach,M.L., Church,T.R. and Heber,D. (2003) Vitamin D, calcium supplementation, and colorectal adenomas: Results of a randomized trial. J. Natl Cancer Inst., 95, 1765-1771.
39. Lemay,J., Demers,C., Hendy,G.N., Delvin,E.E. and Gascon-Barre,M. (1995) Expression of the 1,25-dihydroxyvitamin D3-24-hydroxylase gene in rat intestine: Response to calcium, vitamin D3 and calcitriol administration in vivo. J. Bone Miner Res., 10, 1148-1157.
40. Demers,C., Lemay,J., Hendy,G.N. and Gascon-Barre,M. (1997) Comparative in vivo expression of the calcitriol-24-hydroxylase gene in kidney and intestine. J. Mol. Endocrinol., 18, 37-48.
41. Armbrecht,H.J., Boltz,M.A., Hodam,T.L. and Kumar,V.B. (2001) Differential responsiveness of intestinal epithelial cells to 1,25-dihydroxyvitamin D3 - role of protein kinase C. J. Endocrinol. 169, 145-151.
42. Shinki,J., Jin,C.H., Nishimura,A., Nagai,Y., Ohyama,Y., Noshiro,M., Okuda,K. and Suda,T. (1992) Parathyroid hormone inhibits 25-hydroxyvitamin D3-24-hydroxylase mRNA expression stimulated by 1alpha,25-dihydroxyvitamin D3 in rat kidney but not in intestine. J. Biol. Chem., 267, 13757-13762.
43. Neugut,A.I., Jacobson,J.S., Suh,S., Mukherjee,R. and Arber,N. (1998) The epidemiology of cancer of the small bowel. Cancer Epidemiol. Biomarkers Prev., 7, 243-251.
44. Gartel,A.L. and Tyner,A.L. (1999) Transcriptional regulation of the p21((WAF1/CIP1)) gene. Exp. Cell Res., 246, 280-289.
45. Jensen,S.S., Madsen,M.W., Lukas,J., Binderup,L. and Bartek,J. (2001) Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery. Mol. Endocrinol., 15, 1370-1380.
46. Yang,W.C., Mathew,J., Velcich,A., Edelmann,W., Kucherlapati,R., Lipkin,M., Yang,K. and Augenlicht,L.H. (2001) Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosa. Cancer Res., 61, 565-569.
47. -/- mice. Am. J. Pathol., 166, 1239-1246.
48. Cross,H.S., Kallay,E., Lechner,D., Gerdenitsch,W., Adlercreutz,H. and Armbrecht,H.J. (2004) Phytoestrogens and vitamin D metabolism: A new concept for the prevention and therapy of colorectal, prostate, and mammary carcinomas. J. Nutr., 134, 1207S-1212S.