-
1
-
-
33745915883
-
-
Canadian Cancer Society/National Cancer Institute of Canada, Toronto: Canadian Cancer Society/National Cancer Institute of Canada
-
Canadian Cancer Society/National Cancer Institute of Canada. Canadian Cancer Statistics. 2006. Toronto: Canadian Cancer Society/National Cancer Institute of Canada.
-
Canadian Cancer Statistics. 2006
-
-
-
2
-
-
0023615975
-
Improved hospital morbidity, mortality, and survival after the Whipple procedure
-
Crist DW, Sitzmann JV, Cameron JL. Improved hospital morbidity, mortality, and survival after the Whipple procedure. Ann Surg 1987; 206: 358-365.
-
(1987)
Ann Surg
, vol.206
, pp. 358-365
-
-
Crist, D.W.1
Sitzmann, J.V.2
Cameron, J.L.3
-
3
-
-
0032985541
-
Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database
-
Sener SF, Fremgen A, Menck HR, Winchester DP. Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database. J Am Coll Surg 1999; 89: 1-7.
-
(1999)
J Am Coll Surg
, vol.89
, pp. 1-7
-
-
Sener, S.F.1
Fremgen, A.2
Menck, H.R.3
Winchester, D.P.4
-
4
-
-
0036883940
-
Pancreatc cancer biology and genetics
-
Bardeesy N, DePinho RA. Pancreatc cancer biology and genetics. Nat Rev Cancer 2002; 2: 897-909.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 897-909
-
-
Bardeesy, N.1
DePinho, R.A.2
-
5
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
-
Almoquera C, Shibata D, Forrester K et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988; 53: 549-554.
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoquera, C.1
Shibata, D.2
Forrester, K.3
-
6
-
-
0026500701
-
K-ras oncogene activation in pre-invasive pancreatic cancer
-
Lemoine NR, Jain S, Hughes CM et al. K-ras oncogene activation in pre-invasive pancreatic cancer. Gastroenterology 1992; 102: 230-236.
-
(1992)
Gastroenterology
, vol.102
, pp. 230-236
-
-
Lemoine, N.R.1
Jain, S.2
Hughes, C.M.3
-
7
-
-
33646058889
-
Hedgehog signaling in the normal and diseased pancreas
-
Kayed H, Kleeff J, Osman T et al. Hedgehog signaling in the normal and diseased pancreas. Pancreas 2006; 32: 119-129.
-
(2006)
Pancreas
, vol.32
, pp. 119-129
-
-
Kayed, H.1
Kleeff, J.2
Osman, T.3
-
8
-
-
18144425117
-
AURKA amplification, chromosome instability and chromosome abnormality in human pancreatic carcinoma cells
-
Zhu J, Abbruzzese JL, Izzo J et al. AURKA amplification, chromosome instability and chromosome abnormality in human pancreatic carcinoma cells. Cancer Genet Cytogenet 2005; 159: 10-17.
-
(2005)
Cancer Genet Cytogenet
, vol.159
, pp. 10-17
-
-
Zhu, J.1
Abbruzzese, J.L.2
Izzo, J.3
-
9
-
-
16844366286
-
RNA interference targeting aurora knase suppresses tumour growth and enhances the taxane chemosensitivity in human pancreatic cancer cells
-
Hata T, Furukawa T, Sunamura M et al. RNA interference targeting aurora knase suppresses tumour growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. Cancer Res 2005; 65: 2899-2905.
-
(2005)
Cancer Res
, vol.65
, pp. 2899-2905
-
-
Hata, T.1
Furukawa, T.2
Sunamura, M.3
-
10
-
-
0027769876
-
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
-
Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366: 704-707.
-
(1993)
Nature
, vol.366
, pp. 704-707
-
-
Serrano, M.1
Hannon, G.J.2
Beach, D.3
-
11
-
-
33745515023
-
Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer
-
BieTie B, Moses HL. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer 2006; 6: 506-520.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 506-520
-
-
BieTie, B.1
Moses, H.L.2
-
13
-
-
33845973397
-
Different patterns of p161NK4A and p53 protein expressions in intraductal papillary mucious neoplasm and pancreatic neoplasia
-
Abe K, Suda K, Arakawa A, Yamasaki S. Different patterns of p161NK4A and p53 protein expressions in intraductal papillary mucious neoplasm and pancreatic neoplasia. Pancreas 2007; 34: 85-91.
-
(2007)
Pancreas
, vol.34
, pp. 85-91
-
-
Abe, K.1
Suda, K.2
Arakawa, A.3
Yamasaki, S.4
-
14
-
-
33645824724
-
Both pl6(lnk4a)- p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
-
Bardeesy N, Aquirre AJ, Chu GC. Both pl6(lnk4a)- p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci USA 2006; 103: 5947-5952.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5947-5952
-
-
Bardeesy, N.1
Aquirre, A.J.2
Chu, G.C.3
-
15
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA III, Moore M, Anderson J et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 1997; 15: 2403-2413.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris III, H.A.1
Moore, M.2
Anderson, J.3
-
16
-
-
54349105358
-
-
Poplin E, Levy DE, Berlin J et al. Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed dose rate infusion) versus gemcitabine + oxaliplatin (GEMOX) in patents with advanced pancreatic cancer (E6201). Proc Am Soc Clin Oncol 2006: (abstract LBA4004).
-
Poplin E, Levy DE, Berlin J et al. Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed dose rate infusion) versus gemcitabine + oxaliplatin (GEMOX) in patents with advanced pancreatic cancer (E6201). Proc Am Soc Clin Oncol 2006: (abstract LBA4004).
-
-
-
-
17
-
-
27144530079
-
A phase III trial of pernetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer
-
Oettle H, Richards D, Ramanathan RK et al. A phase III trial of pernetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann Oncol 2005; 16: 1639-1645.
-
(2005)
Ann Oncol
, vol.16
, pp. 1639-1645
-
-
Oettle, H.1
Richards, D.2
Ramanathan, R.K.3
-
18
-
-
4644327989
-
Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer patients despite increased tumor response rate
-
Rocha Lima CM, Green M, Rotche R et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer patients despite increased tumor response rate. J Clin Oncol 2004; 22: 3776-3783.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3776-3783
-
-
Rocha Lima, C.M.1
Green, M.2
Rotche, R.3
-
19
-
-
23844517889
-
A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest Oncology Group (SWOG 9924) study
-
Macdonald JS, McCoy S, Whitehead RP et al. A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest Oncology Group (SWOG 9924) study. Invest New Drugs 2005; 23: 485-487.
-
(2005)
Invest New Drugs
, vol.23
, pp. 485-487
-
-
Macdonald, J.S.1
McCoy, S.2
Whitehead, R.P.3
-
20
-
-
2342645506
-
Phase III trial of gemcitabine plus tipifamib compared with gemcitabine plus placebo in advanced pancreatic cancer
-
Van Cutsem E, van de Velde H, Karasek P et al. Phase III trial of gemcitabine plus tipifamib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 2004; 22: 1430-1438.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1430-1438
-
-
Van Cutsem, E.1
van de Velde, H.2
Karasek, P.3
-
21
-
-
0034044162
-
Addition of matrix metalloproteinase inhibition to conventional cytotoxic therapy reduces tumor implantation and prolongs survival in a murine model of human pancreatic cancer
-
Haq M, Shafii A, Zervos EE, Rosemurgy AS. Addition of matrix metalloproteinase inhibition to conventional cytotoxic therapy reduces tumor implantation and prolongs survival in a murine model of human pancreatic cancer. Cancer Res 2000; 60: 3207-3211.
-
(2000)
Cancer Res
, vol.60
, pp. 3207-3211
-
-
Haq, M.1
Shafii, A.2
Zervos, E.E.3
Rosemurgy, A.S.4
-
22
-
-
0035424135
-
Marimastat as first-line therapy for patents with unresectable pancreatic cancer; a randomized trial
-
Bramhall SR, Rosemurgy A, Brown PD et al. Marimastat as first-line therapy for patents with unresectable pancreatic cancer; a randomized trial. J Clin Oncol 2001; 19: 3447-3455.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3447-3455
-
-
Bramhall, S.R.1
Rosemurgy, A.2
Brown, P.D.3
-
23
-
-
0037100983
-
A double-blind placebo-controlled, randomized study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patents with advanced pancreatic cancer
-
Bramhall SR, Schulz J, Nemunaitis J et al. A double-blind placebo-controlled, randomized study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patents with advanced pancreatic cancer. Br J Cancer 2002; 87: 161-167.
-
(2002)
Br J Cancer
, vol.87
, pp. 161-167
-
-
Bramhall, S.R.1
Schulz, J.2
Nemunaitis, J.3
-
24
-
-
0141688333
-
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas; a phase 3 trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Hamm J, Dancey J et al. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas; a phase 3 trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003; 21: 3296-3302.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3296-3302
-
-
Moore, M.J.1
Hamm, J.2
Dancey, J.3
-
25
-
-
6044241807
-
The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma
-
Ueda S, Ogata S, Tsuda H et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas 2004; 29: E1-E8.
-
(2004)
Pancreas
, vol.29
-
-
Ueda, S.1
Ogata, S.2
Tsuda, H.3
-
26
-
-
0034212763
-
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine knase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
-
Bruns CJ, Solorzano CC, Harbison MT et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine knase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 2000; 60: 2926-2935.
-
(2000)
Cancer Res
, vol.60
, pp. 2926-2935
-
-
Bruns, C.J.1
Solorzano, C.C.2
Harbison, M.T.3
-
27
-
-
0345205993
-
A phase IB trial of gemcitabine and erlotinib HCL in patients with advanced pancreatic adenocarcinoma and other potentially responsive malignancy
-
abstract 895
-
Dragovish T, Patnaik A, Rowinsky E et al. A phase IB trial of gemcitabine and erlotinib HCL in patients with advanced pancreatic adenocarcinoma and other potentially responsive malignancy. Proc Am Soc Clin Oncol 2003; (abstract 895).
-
(2003)
Proc Am Soc Clin Oncol
-
-
Dragovish, T.1
Patnaik, A.2
Rowinsky, E.3
-
28
-
-
33745651691
-
Erlotinib and gemcitabine in patients with unresectable pancreatic carcinoma: Results from a IB trial
-
abstract 4110
-
Porterfield BW, Dragovich T, Patnaik A et al. Erlotinib and gemcitabine in patients with unresectable pancreatic carcinoma: Results from a IB trial. Proc Am Soc Clin Oncol 2004; (abstract 4110).
-
(2004)
Proc Am Soc Clin Oncol
-
-
Porterfield, B.W.1
Dragovich, T.2
Patnaik, A.3
-
29
-
-
34249933404
-
Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, Hamm J et al. Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007; 25: 1960-1966.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
30
-
-
18844473781
-
Epidermal growth factor receptor blockage with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms
-
Bruns CJ, Harbison MT, Davis DW et al. Epidermal growth factor receptor blockage with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin Cancer Res 2000; 6: 1936-1948.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1936-1948
-
-
Bruns, C.J.1
Harbison, M.T.2
Davis, D.W.3
-
31
-
-
4344590997
-
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II Trial
-
Xiong HQ, Rosenberg A, LoBuglio A et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II Trial. J Clin Oncol 2004; 22: 2610-2666.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2610-2666
-
-
Xiong, H.Q.1
Rosenberg, A.2
LoBuglio, A.3
-
32
-
-
36549083856
-
Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study
-
abstract 4509
-
Philip P, Benedetti, J, Fenoglio-Preiser C et al. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study. Proc Am Soc Clin Oncol 2007; (abstract 4509).
-
(2007)
Proc Am Soc Clin Oncol
-
-
Philip, P.1
Benedetti, J.2
Fenoglio-Preiser, C.3
-
33
-
-
19944429073
-
Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neu
-
Safran H, Iannitti D, Ramanathan R et al. Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neu. Cancer Invest 2004; 22: 706-712.
-
(2004)
Cancer Invest
, vol.22
, pp. 706-712
-
-
Safran, H.1
Iannitti, D.2
Ramanathan, R.3
-
34
-
-
85013312416
-
Tumour angiogenesis: Therapeutic implications
-
Folkman J. Tumour angiogenesis: Therapeutic implications. New Engl J Med 1971; 285: 1182-1186.
-
(1971)
New Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
35
-
-
32944478346
-
Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
-
Kindler HL, Friburg G, Singh GA et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 2005; 23: 8033-8040.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8033-8040
-
-
Kindler, H.L.1
Friburg, G.2
Singh, G.A.3
-
36
-
-
35548941394
-
A double-blind, placebo controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC]: A preliminary analysis of Cancer and Leukemia Group B (CALGB) 80303
-
abstract 4508
-
Kindler HL, Niedzwiecki D, Hollis D et al. A double-blind, placebo controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC]: A preliminary analysis of Cancer and Leukemia Group B (CALGB) 80303. Proc Am Soc Clin Onool 2007; (abstract 4508).
-
(2007)
Proc Am Soc Clin Onool
-
-
Kindler, H.L.1
Niedzwiecki, D.2
Hollis, D.3
-
37
-
-
31544460436
-
Phase I trial of sorafenib and gemcitabine in advanced solid tumours with an expanded cohort in advanced pancreatic cancer
-
Siu LL, Awada A, Takimoto CH et al. Phase I trial of sorafenib and gemcitabine in advanced solid tumours with an expanded cohort in advanced pancreatic cancer. Clin Cancer Res 2006; 12: 144-151.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 144-151
-
-
Siu, L.L.1
Awada, A.2
Takimoto, C.H.3
-
38
-
-
34547952628
-
Sorafenib (S) plus gemcitabine (G) for advanced pancreatic cancer (PC): A phase II trial of the University of Chicago Phase II Consortium
-
abstract 137
-
Wallace JA et al. Sorafenib (S) plus gemcitabine (G) for advanced pancreatic cancer (PC): A phase II trial of the University of Chicago Phase II Consortium. 2007 Gastrointestinal Cancers Symposium; abstract 137.
-
(2007)
Gastrointestinal Cancers Symposium
-
-
Wallace, J.A.1
-
39
-
-
24944550952
-
Molecular therapeutics - lessons from the role of Src in cellular signaling
-
Tuhackova Z. Molecular therapeutics - lessons from the role of Src in cellular signaling. Folia Biol (Praha) 2005; 51: 114-120.
-
(2005)
Folia Biol (Praha)
, vol.51
, pp. 114-120
-
-
Tuhackova, Z.1
-
40
-
-
33846554255
-
Focal adhesion kinase: A potential target in cancer therapy
-
Nimwegan MJ, van de Water B. Focal adhesion kinase: A potential target in cancer therapy. Biochem Pharmacol 2007; 73: 597-609.
-
(2007)
Biochem Pharmacol
, vol.73
, pp. 597-609
-
-
Nimwegan, M.J.1
van de Water, B.2
|