Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 21, 2004, Pages 5305-5308

  Nakamura, Toshio ^a   Ishii, Takaaki ^a   Miyata, Noriyuki ^a   Taniguchi, Kazuo ^a   Tomishima, Yasumitsu ^a   Ueki, Tomokazu ^a   Sato, Masakazu ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

20 HETE

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; CARBOXYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME P450 2D6; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; IMIDAZOLES; KIDNEY; MICROSOMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5344234479     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.025     Document Type: Article

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