Interaction of growth factors regulating chondrocyte differentiation in the developing embryo

Osteoarthritis and Cartilage

Volumn 9, Issue SUPPL. A, 2001, Pages

  Vortkamp, A ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; GROWTH FACTOR; PARATHYROID HORMONE RELATED PROTEIN; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; EMBRYO; EMBRYO DEVELOPMENT; ENCHONDRAL OSSIFICATION; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; OSSIFICATION; PERICHONDRIUM; PERIOSTEUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL DIVISION; CHONDROCYTES; GROWTH SUBSTANCES; HEDGEHOG PROTEINS; HUMANS; MICE; PARATHYROID HORMONE-RELATED PROTEIN; PEPTIDE FRAGMENTS; PROTEINS; TRANS-ACTIVATORS;

EID: 0034852850     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (92)

1. Toward a molecular understanding of skeletal development
2. The Development of the Vertebrate Limb
3. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
4. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
5. A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression
6. The world according to hedgehog
7. Recent advances in Hedgehog signalling
8. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair
9. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
10. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide
11. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth
12. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats
13. Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation
14. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene
15. A constitutively active mutant. PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia
16. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide
17. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation
18. The parathyroid hormone parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation
19. Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways
20. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
21. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
22. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
23. Maturational disturbance of chondrocytes in Cbfa1-deficient mice
24. Regulation of chondrocyte differentiation by Cbfa1
25. Cbfa1 is a positive regulatory factor in chondrocyte maturation
26. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
27. Biochemical evidence that patched is the Hedgehog receptor
28. Conservation in hedgehog signaling: Induction of a chicken patched homolog by Sonic hedgehog in the developing limb
29. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
30. The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate
31. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
32. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
33. Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)
34. The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes
35. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
36. The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms
37. What do BMPs do in mammals? Clues from the mouse short-ear mutation
38. Novel regulators of bone formation: Molecular clones and activities
39. Signal transduction by bone morphogenetic proteins
40. Bone morphogenetic protein receptors
41. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
42. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
43. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
44. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
45. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
46. Mice lacking BMP-6 function
47. BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice
48. The mouse short-ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFbeta superfamily
49. Limb alterations in brachypodism mice due to mutations in a new member of the TGF-b-superfamily
50. Combinatorial signaling through BMP receptor IB and GDF5: Shaping of the distal mouse limb and the genetics of distal limb diversity
51. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
52. Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family
53. Human type II receptor for bone morphogenic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
54. Characterization of type I receptors for transforming growth factor-beta and activin
55. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta
56. Involvement of bone-morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse
57. BMP signaling during bone pattern determination in the developing lim
58. Interaction of lhh and BMP/Noggin signaling during cartilage differentiation
59. Organogenesis and pattern formation in the mouse-RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A)
60. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage
61. Transcripts for two members of the transforming growth factor-beta superfamily BMP-3 and BMP-7 are expressed in developing rat embryos
62. Localization of osteogenic protein-1 (bone morphogenetic protein-7) during human embryonic development: High affinity binding to basement membranes
63. Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb
64. Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning
65. Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite
66. Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression
67. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
68. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
69. Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm
70. Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
71. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
72. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
73. Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning
74. Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling
75. BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes
76. Control of bone growth by fibroblast growth factors
77. FGF signaling in skeletal development
78. A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia
79. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia
80. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
81. Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3
82. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
83. Fibroblast growth factor receptor 3 is a negative regulator of bone growth
84. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
85. Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice
86. Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity
87. Receptor specificity of the fibroblast growth factor family
88. Isolation and localization of basic fibroblast growth factor-immunoreactive substance in the epiphyseal growth plate
89. Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice
90. Fibroblast growth factor 2 control of vascular tone
91. Spatio-temporal expression of FGFR 1, 2 and 3 genes during human embryo-fetal ossification
92. 2 FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse